Vinblastine (sulfate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.2676
PDE4D phosphodiesterase 4D, cAMP-specific 0.105829
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0883994
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0875591
THSD4 thrombospondin, type I, domain containing 4 0.0852475
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0764036
SLTM SAFB-like, transcription modulator 0.0588388
ASPH aspartate beta-hydroxylase 0.0580376
FNDC3B fibronectin type III domain containing 3B 0.0544115
DOCK5 dedicator of cytokinesis 5 0.0533231
LMO7 LIM domain 7 0.0513281
PM20D1 peptidase M20 domain containing 1 0.0510272
GRAMD1B GRAM domain containing 1B 0.0493805
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0489296
PTPRM protein tyrosine phosphatase, receptor type, M 0.0481912
INTS6 integrator complex subunit 6 0.0477329
MCL1 myeloid cell leukemia 1 0.0476314
CEMIP cell migration inducing protein, hyaluronan binding 0.0471901
ERRFI1 ERBB receptor feedback inhibitor 1 0.0411108
EFNA5 ephrin-A5 0.0388301
MYOF myoferlin 0.0383354
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0351231
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0347228
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0327459
PDIA3 protein disulfide isomerase family A, member 3 0.032344
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.032153
VEGFC vascular endothelial growth factor C 0.0317828
MCTP1 multiple C2 domains, transmembrane 1 0.0315011
NPAS2 neuronal PAS domain protein 2 0.0314642
CCSER1 coiled-coil serine-rich protein 1 0.031213
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0296928
RNF213 ring finger protein 213 0.0296183
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.028957
RIMS2 regulating synaptic membrane exocytosis 2 0.0285833
VCL vinculin 0.028236
NABP1 nucleic acid binding protein 1 0.0282052
SCEL sciellin 0.0269976
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0268163
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262594
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0262094
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.026086
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0260814
ZSWIM6 zinc finger, SWIM-type containing 6 0.025899
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0257807
ZNF638 zinc finger protein 638 0.0256235
APLP2 amyloid beta (A4) precursor-like protein 2 0.0250096
BCAR3 breast cancer anti-estrogen resistance 3 0.0249378
SUMF1 sulfatase modifying factor 1 0.0244669
RCOR1 REST corepressor 1 0.0242318
RAD51B RAD51 paralog B 0.0237749
FNDC3A fibronectin type III domain containing 3A 0.023585
IGFBP5 insulin-like growth factor binding protein 5 0.0226256
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0223444
SMAD3 SMAD family member 3 0.0222414
FOXP1 forkhead box P1 0.0220546
AHR aryl hydrocarbon receptor 0.0219457
FAM13A family with sequence similarity 13, member A 0.0218466
CPE carboxypeptidase E 0.0217421
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.02162
EPAS1 endothelial PAS domain protein 1 0.0214801
DSPP dentin sialophosphoprotein 0.0211984
PRKCA protein kinase C, alpha 0.0210611
AREG amphiregulin 0.0208262
HOMER1 homer scaffolding protein 1 0.0208143
VMP1 vacuole membrane protein 1 0.0207055
TOP1 topoisomerase (DNA) I 0.0206885
TRIP12 thyroid hormone receptor interactor 12 0.0206502
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.020595
GRB10 growth factor receptor-bound protein 10 0.0202309
RAB27B RAB27B, member RAS oncogene family 0.0199969
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0199239
TUFT1 tuftelin 1 0.0198006
KYNU kynureninase 0.0193399
MACF1 microtubule-actin crosslinking factor 1 0.0193396
SETX senataxin 0.0192878
WWOX WW domain containing oxidoreductase 0.0192405
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0185502
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0182042
MAML3 mastermind-like 3 (Drosophila) 0.0180298
EGR1 early growth response 1 0.0180173
EXOC4 exocyst complex component 4 0.0179022
CD163L1 CD163 molecule-like 1 0.017792
UBA6 ubiquitin-like modifier activating enzyme 6 0.01767
NTSR1 neurotensin receptor 1 (high affinity) 0.0174985
ANKRD11 ankyrin repeat domain 11 0.0174204
SMYD3 SET and MYND domain containing 3 0.0173716
MBNL2 muscleblind-like splicing regulator 2 0.0172531
BABAM2 BRISC and BRCA1 A complex member 2 0.0170765
SLK STE20-like kinase 0.0170701
ELL2 elongation factor, RNA polymerase II, 2 0.0170514
AKAP13 A kinase (PRKA) anchor protein 13 0.0169932
SLC38A2 solute carrier family 38, member 2 0.0169089
COPA coatomer protein complex, subunit alpha 0.016725
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0167088
DYNC2I1 dynein 2 intermediate chain 1 0.0166968
ATP11A ATPase, class VI, type 11A 0.0165749
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0165653
TRAPPC9 trafficking protein particle complex 9 0.0161114
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0159997
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0157454

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233171
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.162262
TMSB10 thymosin beta 10 -0.146941
TXNRD1 thioredoxin reductase 1 -0.142379
TPT1 tumor protein, translationally-controlled 1 -0.127081
LAMB3 laminin, beta 3 -0.104148
DTNA dystrobrevin, alpha -0.103735
MT2A metallothionein 2A -0.0825388
FTL ferritin, light polypeptide -0.0793226
RPLP1 ribosomal protein, large, P1 -0.0724641
PTMA prothymosin, alpha -0.0706966
RPS3 ribosomal protein S3 -0.0676152
RPL35A ribosomal protein L35a -0.0674025
EXT1 exostosin glycosyltransferase 1 -0.0664754
H1-0 H1.0 linker histone -0.0637267
LAMC2 laminin, gamma 2 -0.0557349
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0549969
RPL34 ribosomal protein L34 -0.0535001
EIF1 eukaryotic translation initiation factor 1 -0.052943
SEC61G Sec61 gamma subunit -0.0526461
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0520313
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0520184
RPS8 ribosomal protein S8 -0.0517537
PRRC2C proline-rich coiled-coil 2C -0.0515997
LOC112694756 uncharaterized LOC112694756 -0.0510352
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0499982
SLC38A1 solute carrier family 38, member 1 -0.0493666
RPS24 ribosomal protein S24 -0.0465572
MYH9 myosin, heavy chain 9, non-muscle -0.0457214
FTH1 ferritin, heavy polypeptide 1 -0.0449354
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.044892
NAMPT nicotinamide phosphoribosyltransferase -0.0442883
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0442726
PGK1 phosphoglycerate kinase 1 -0.0441275
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0434934
RNF169 ring finger protein 169 -0.0432226
RPS25 ribosomal protein S25 -0.042348
CAPN2 calpain 2, (m/II) large subunit -0.0420383
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0420081
ANKRD10 ankyrin repeat domain 10 -0.0411509
S100A10 S100 calcium binding protein A10 -0.0399427
CALD1 caldesmon 1 -0.0391155
B2M beta-2-microglobulin -0.0389735
MYO1D myosin ID -0.0388579
KDM3A lysine (K)-specific demethylase 3A -0.038819
AHNAK AHNAK nucleoprotein -0.0384148
RPL31 ribosomal protein L31 -0.0380903
SAMD4A sterile alpha motif domain containing 4A -0.0375131
RPS27A ribosomal protein S27a -0.0370519
RPLP0 ribosomal protein, large, P0 -0.0363803
UBC ubiquitin C -0.0360771
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0356803
RPL8 ribosomal protein L8 -0.0356774
RPL19 ribosomal protein L19 -0.035027
CREB5 cAMP responsive element binding protein 5 -0.0327915
RPS23 ribosomal protein S23 -0.0327824
MACC1 metastasis associated in colon cancer 1 -0.0327141
TPD52 tumor protein D52 -0.0325784
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0324223
RAB7A RAB7A, member RAS oncogene family -0.032369
DENND4A DENN/MADD domain containing 4A -0.032227
HDLBP high density lipoprotein binding protein -0.0322187
RPL11 ribosomal protein L11 -0.0321053
WDR45B WD repeat domain 45B -0.0320496
RACK1 receptor for activated C kinase 1 -0.0318975
EMP1 epithelial membrane protein 1 -0.031773
RPL12 ribosomal protein L12 -0.0315242
RPL37A ribosomal protein L37a -0.031493
RAD21 RAD21 homolog (S. pombe) -0.0311203
RAB1A RAB1A, member RAS oncogene family -0.0308311
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0304936
NDRG1 N-myc downstream regulated 1 -0.0302946
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0298112
RPS19 ribosomal protein S19 -0.0295267
OGA O-GlcNAcase -0.0293879
SOD2 superoxide dismutase 2, mitochondrial -0.0293709
GM2A GM2 ganglioside activator -0.0293646
RTN4 reticulon 4 -0.0292196
ACTG1 actin gamma 1 -0.0290099
TKT transketolase -0.0286051
AKAP12 A kinase (PRKA) anchor protein 12 -0.0281186
RPS14 ribosomal protein S14 -0.0279822
RPS29 ribosomal protein S29 -0.0279152
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.027911
RPS27 ribosomal protein S27 -0.0278915
RPL4 ribosomal protein L4 -0.0276685
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0275419
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0275316
UVRAG UV radiation resistance associated -0.0273455
RLF rearranged L-myc fusion -0.0273305
RPS6 ribosomal protein S6 -0.0271564
CSTB cystatin B (stefin B) -0.027128
RPS21 ribosomal protein S21 -0.0267087
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0265682
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0264461
ABLIM1 actin binding LIM protein 1 -0.0263409
MYO5B myosin VB -0.0262307
MXI1 MAX interactor 1, dimerization protein -0.0261542
AFF1 AF4/FMR2 family, member 1 -0.0258951
CD99 CD99 molecule -0.0258194