Vinblastine (sulfate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.115076
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0833473
NAV2 neuron navigator 2 0.0744458
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0641428
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0617557
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0600985
FNDC3B fibronectin type III domain containing 3B 0.0570416
NAMPT nicotinamide phosphoribosyltransferase 0.0546875
EFNA5 ephrin-A5 0.0540869
RBM39 RNA binding motif protein 39 0.0539194
TRIO trio Rho guanine nucleotide exchange factor 0.0499975
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0494407
PCBP2 poly(rC) binding protein 2 0.0478776
SAMD4A sterile alpha motif domain containing 4A 0.0457745
SMAD3 SMAD family member 3 0.045664
PRELID2 PRELI domain containing 2 0.0448639
ELL2 elongation factor, RNA polymerase II, 2 0.0436822
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0410666
GOLGA4 golgin A4 0.040747
RUNX1 runt-related transcription factor 1 0.0392508
ZEB1 zinc finger E-box binding homeobox 1 0.0392462
FAM13A family with sequence similarity 13, member A 0.0384552
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0358502
ZNF638 zinc finger protein 638 0.0358323
OGA O-GlcNAcase 0.0355885
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0340656
GRB10 growth factor receptor-bound protein 10 0.0338051
RARB retinoic acid receptor, beta 0.0333086
ZCCHC7 zinc finger, CCHC domain containing 7 0.0329322
SPAG9 sperm associated antigen 9 0.0319021
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0317891
EPS8 epidermal growth factor receptor pathway substrate 8 0.0297754
NBAS neuroblastoma amplified sequence 0.0297149
ATXN1 ataxin 1 0.0294589
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0290335
ZFC3H1 zinc finger, C3H1-type containing 0.0288541
FBXL13 F-box and leucine-rich repeat protein 13 0.0287215
ZNF292 zinc finger protein 292 0.0285323
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0278225
TTC3 tetratricopeptide repeat domain 3 0.0276743
DOCK5 dedicator of cytokinesis 5 0.0271131
USP34 ubiquitin specific peptidase 34 0.0270601
ARHGAP32 Rho GTPase activating protein 32 0.0270167
ASPH aspartate beta-hydroxylase 0.0269015
PTK2 protein tyrosine kinase 2 0.0267886
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0264158
UBA6 ubiquitin-like modifier activating enzyme 6 0.0261713
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.026098
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.025913
ADD3 adducin 3 (gamma) 0.0258964
ZBTB38 zinc finger and BTB domain containing 38 0.0258678
CCSER1 coiled-coil serine-rich protein 1 0.0256229
COG5 component of oligomeric golgi complex 5 0.0255146
CPNE1 copine I 0.0254387
XPO1 exportin 1 0.0253899
STRN3 striatin, calmodulin binding protein 3 0.0250122
ZFAND3 zinc finger, AN1-type domain 3 0.0248605
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0247754
HELZ helicase with zinc finger 0.0247668
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0246869
CTNND1 catenin (cadherin-associated protein), delta 1 0.024675
WAC WW domain containing adaptor with coiled-coil 0.0246379
USP3 ubiquitin specific peptidase 3 0.0246088
GPHN gephyrin 0.0245767
CXCL8 chemokine (C-X-C motif) ligand 8 0.0243696
MON2 MON2 homolog (S. cerevisiae) 0.024213
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0241182
KDM2A lysine (K)-specific demethylase 2A 0.0240445
EGFR epidermal growth factor receptor 0.0239517
CTBP2 C-terminal binding protein 2 0.0231362
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0230927
ALCAM activated leukocyte cell adhesion molecule 0.0230166
ZC3H12C zinc finger CCCH-type containing 12C 0.0230081
ATP13A3 ATPase type 13A3 0.0228643
PIAS2 protein inhibitor of activated STAT, 2 0.0227726
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0227134
SH3KBP1 SH3-domain kinase binding protein 1 0.0226952
RB1CC1 RB1-inducible coiled-coil 1 0.0226285
ITCH itchy E3 ubiquitin protein ligase 0.0225456
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0225043
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0223707
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0222295
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.022219
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0221896
EZR ezrin 0.022117
TOP1 topoisomerase (DNA) I 0.0220865
FER fer (fps/fes related) tyrosine kinase 0.0219967
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0219471
DTNA dystrobrevin, alpha 0.0219238
FBXO32 F-box protein 32 0.0218337
COPA coatomer protein complex, subunit alpha 0.0218162
IPO7 importin 7 0.0217831
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0217771
BBX bobby sox homolog (Drosophila) 0.0217008
KDM3A lysine (K)-specific demethylase 3A 0.0216504
TENT4A terminal nucleotidyltransferase 4A 0.0215838
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0215681
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0212597
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.021104
SRP54 signal recognition particle 54kDa 0.0210691

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.196162
TMSB10 thymosin beta 10 -0.192138
FN1 fibronectin 1 -0.171282
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103958
TFPI2 tissue factor pathway inhibitor 2 -0.0998065
LOX lysyl oxidase -0.0959297
STC1 stanniocalcin 1 -0.0904988
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0859754
MT2A metallothionein 2A -0.0806331
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0779186
DPYD dihydropyrimidine dehydrogenase -0.0742693
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0740245
PDE4D phosphodiesterase 4D, cAMP-specific -0.0712464
AKAP12 A kinase (PRKA) anchor protein 12 -0.0711854
S100A6 S100 calcium binding protein A6 -0.061069
IGFBP3 insulin-like growth factor binding protein 3 -0.0586275
TPT1 tumor protein, translationally-controlled 1 -0.0494356
RPLP1 ribosomal protein, large, P1 -0.0490446
TMSB4X thymosin beta 4, X-linked -0.045523
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0453231
RPS19 ribosomal protein S19 -0.0451967
OSMR oncostatin M receptor -0.0443756
B2M beta-2-microglobulin -0.0437979
FTL ferritin, light polypeptide -0.0434039
PSD3 pleckstrin and Sec7 domain containing 3 -0.0408793
NRG1 neuregulin 1 -0.0395817
IFI6 interferon, alpha-inducible protein 6 -0.0389555
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0388714
CLMP CXADR-like membrane protein -0.0387463
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0385977
RPS12 ribosomal protein S12 -0.0361636
GPC6 glypican 6 -0.0351073
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0338406
IL1B interleukin 1, beta -0.0338293
PRRX1 paired related homeobox 1 -0.0335778
RAI14 retinoic acid induced 14 -0.0331593
RPS29 ribosomal protein S29 -0.032746
RPL36 ribosomal protein L36 -0.0321568
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.031707
EIF1 eukaryotic translation initiation factor 1 -0.0312671
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0312654
RPLP2 ribosomal protein, large, P2 -0.0312644
MTSS1 metastasis suppressor 1 -0.0309774
HMGA1 high mobility group AT-hook 1 -0.0305415
RPL31 ribosomal protein L31 -0.0302924
NDRG1 N-myc downstream regulated 1 -0.0302679
LOC112694756 uncharaterized LOC112694756 -0.0298458
GLIS3 GLIS family zinc finger 3 -0.0298453
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.029204
EGR1 early growth response 1 -0.0291194
RPS27 ribosomal protein S27 -0.0290244
FBN1 fibrillin 1 -0.0286954
FAM20C family with sequence similarity 20, member C -0.0285581
RPL35A ribosomal protein L35a -0.0285054
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0277166
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0274163
RPL37A ribosomal protein L37a -0.0266954
RPS3 ribosomal protein S3 -0.0262181
PRSS23 protease, serine, 23 -0.0260902
RPS21 ribosomal protein S21 -0.0259519
PLAT plasminogen activator, tissue -0.0259291
HLA-B major histocompatibility complex, class I, B -0.0254461
COL7A1 collagen, type VII, alpha 1 -0.0254166
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0250652
RPL37 ribosomal protein L37 -0.0249668
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0246664
S100A10 S100 calcium binding protein A10 -0.0237396
SAMD9 sterile alpha motif domain containing 9 -0.0234474
LOC102724023 ES1 protein homolog, mitochondrial -0.0233561
IER3 immediate early response 3 -0.0229963
RPS17 ribosomal protein S17 -0.0229239
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0227955
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0227273
ARL4C ADP-ribosylation factor-like 4C -0.0226793
ANTXR2 anthrax toxin receptor 2 -0.0226278
RPL34 ribosomal protein L34 -0.0217991
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0217622
RPS8 ribosomal protein S8 -0.0216478
SOX4 SRY (sex determining region Y)-box 4 -0.0216436
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0214629
TM4SF1 transmembrane 4 L six family member 1 -0.0212134
RAB13 RAB13, member RAS oncogene family -0.0210284
RPL28 ribosomal protein L28 -0.0209874
MX2 MX dynamin-like GTPase 2 -0.0209599
RIGI RNA sensor RIG-I -0.0209488
SEC61G Sec61 gamma subunit -0.0208217
RNF213 ring finger protein 213 -0.0205267
FTH1 ferritin, heavy polypeptide 1 -0.0204177
CUX1 cut-like homeobox 1 -0.0199109
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0198591
CDK14 cyclin-dependent kinase 14 -0.0198096
ENO2 enolase 2 (gamma, neuronal) -0.0197137
RPS14 ribosomal protein S14 -0.0195842
C1R complement component 1, r subcomponent -0.0194825
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -0.0194527
PTPRF protein tyrosine phosphatase, receptor type, F -0.0192637
MECOM MDS1 and EVI1 complex locus -0.0192316
HLA-A major histocompatibility complex, class I, A -0.0191421
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0190838
RACK1 receptor for activated C kinase 1 -0.0189128