Vinblastine (sulfate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0963139
FAM13A family with sequence similarity 13, member A 0.0875165
SEC31A SEC31 homolog A (S. cerevisiae) 0.0798164
PRKCA protein kinase C, alpha 0.0751361
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0724755
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0691068
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0668415
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0662883
SMAD3 SMAD family member 3 0.0658896
PDE4D phosphodiesterase 4D, cAMP-specific 0.0646982
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0642365
ANKRD11 ankyrin repeat domain 11 0.0629843
JMJD1C jumonji domain containing 1C 0.0617772
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0616601
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0597519
EXT1 exostosin glycosyltransferase 1 0.0588713
ANKRD17 ankyrin repeat domain 17 0.0586127
USP34 ubiquitin specific peptidase 34 0.0581927
CSNK1A1 casein kinase 1, alpha 1 0.0571404
TRIO trio Rho guanine nucleotide exchange factor 0.0539738
MYOF myoferlin 0.0528934
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0517548
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0515707
ZSWIM6 zinc finger, SWIM-type containing 6 0.0511763
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0499354
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0493382
ACTN4 actinin, alpha 4 0.0479602
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0478982
CDC73 cell division cycle 73 0.0471077
FLNB filamin B, beta 0.0464445
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0457703
AKAP13 A kinase (PRKA) anchor protein 13 0.0452933
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0450523
KDM4C lysine (K)-specific demethylase 4C 0.0448487
ATXN1 ataxin 1 0.0441214
EFNA5 ephrin-A5 0.0440962
FMNL2 formin-like 2 0.0428259
ANKRD12 ankyrin repeat domain 12 0.0423697
RBM39 RNA binding motif protein 39 0.0420136
ADNP activity-dependent neuroprotector homeobox 0.0417852
SBF2 SET binding factor 2 0.0417149
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0416809
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0414123
ARHGAP29 Rho GTPase activating protein 29 0.0413817
UGCG UDP-glucose ceramide glucosyltransferase 0.0409137
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0405939
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0395442
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0395188
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0394996
SSBP2 single-stranded DNA binding protein 2 0.0392165
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0381958
FN1 fibronectin 1 0.0381718
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0380796
SAMD4A sterile alpha motif domain containing 4A 0.0377909
MYO10 myosin X 0.0375722
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0372936
LRP12 low density lipoprotein receptor-related protein 12 0.0372607
SEC24D SEC24 family member D 0.0365939
IWS1 IWS1 homolog (S. cerevisiae) 0.0365302
GIGYF2 GRB10 interacting GYF protein 2 0.0360276
MED13 mediator complex subunit 13 0.0359957
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0359407
FXR1 fragile X mental retardation, autosomal homolog 1 0.0353599
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0340254
COL6A3 collagen, type VI, alpha 3 0.0339558
WNK1 WNK lysine deficient protein kinase 1 0.0338744
NAV2 neuron navigator 2 0.0337787
CLINT1 clathrin interactor 1 0.0333886
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0333183
FMN1 formin 1 0.0329092
HELZ helicase with zinc finger 0.0328431
DST dystonin 0.0327829
TP53BP2 tumor protein p53 binding protein 2 0.0323629
RBM33 RNA binding motif protein 33 0.0319017
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0318674
FLNA filamin A, alpha 0.0317069
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0315903
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0314534
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.031391
NAP1L1 nucleosome assembly protein 1-like 1 0.0313777
HDLBP high density lipoprotein binding protein 0.0313667
TJP1 tight junction protein 1 0.0313541
ELL2 elongation factor, RNA polymerase II, 2 0.0312227
ARHGAP35 Rho GTPase activating protein 35 0.0307132
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0306786
NUP98 nucleoporin 98kDa 0.0304459
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0302894
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0302214
FRYL FRY-like 0.0300383
TES testin LIM domain protein 0.0297143
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0294628
GNAS GNAS complex locus 0.0287469
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0287355
BBX bobby sox homolog (Drosophila) 0.0283562
ZMIZ1 zinc finger, MIZ-type containing 1 0.0282518
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0282445
SND1 staphylococcal nuclease and tudor domain containing 1 0.028214
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0281416
RRBP1 ribosome binding protein 1 0.0280861
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0279842

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.128033
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119337
IFIH1 interferon induced with helicase C domain 1 -0.0829418
LMO7 LIM domain 7 -0.0815876
TMSB10 thymosin beta 10 -0.0718281
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0688162
TPT1 tumor protein, translationally-controlled 1 -0.0657481
BACE2 beta-site APP-cleaving enzyme 2 -0.0628751
CEMIP cell migration inducing protein, hyaluronan binding -0.061345
KATNBL1 katanin p80 subunit B-like 1 -0.0605713
KRT17 keratin 17, type I -0.0573089
AKAP12 A kinase (PRKA) anchor protein 12 -0.0564586
FTL ferritin, light polypeptide -0.0506352
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0499178
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.049272
POTEF POTE ankyrin domain family, member F -0.0485011
SPAG9 sperm associated antigen 9 -0.048286
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0475994
RPL19 ribosomal protein L19 -0.0469563
PERP PERP, TP53 apoptosis effector -0.0437886
BZW1 basic leucine zipper and W2 domains 1 -0.0431951
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0427394
STC1 stanniocalcin 1 -0.0425168
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0424447
ENO1 enolase 1, (alpha) -0.0418331
RNF149 ring finger protein 149 -0.0414692
S100A6 S100 calcium binding protein A6 -0.0409143
RTN4 reticulon 4 -0.0403271
PTMA prothymosin, alpha -0.038734
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0387013
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.038389
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0368916
OASL 2'-5'-oligoadenylate synthetase-like -0.0362881
SYT1 synaptotagmin I -0.0357318
BTG1 B-cell translocation gene 1, anti-proliferative -0.0349124
RPL12 ribosomal protein L12 -0.0347926
TM4SF1 transmembrane 4 L six family member 1 -0.0343459
RPL35A ribosomal protein L35a -0.034223
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0340622
RIGI RNA sensor RIG-I -0.0339145
SOX4 SRY (sex determining region Y)-box 4 -0.0338776
RPS19 ribosomal protein S19 -0.0336207
MUC16 mucin 16, cell surface associated -0.033
FTH1 ferritin, heavy polypeptide 1 -0.0325952
STK17A serine/threonine kinase 17a -0.0320692
JUP junction plakoglobin -0.0320552
TRIP12 thyroid hormone receptor interactor 12 -0.0319043
FHIT fragile histidine triad -0.0318908
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0318349
TMEM41B transmembrane protein 41B -0.0318246
RPL15 ribosomal protein L15 -0.031824
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0318223
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.031315
PICALM phosphatidylinositol binding clathrin assembly protein -0.031269
NRG1 neuregulin 1 -0.0304456
MPRIP myosin phosphatase Rho interacting protein -0.0304108
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 -0.0301726
LITAF lipopolysaccharide-induced TNF factor -0.0300032
ACTG1 actin gamma 1 -0.0299898
RPL37 ribosomal protein L37 -0.0296726
FNDC3B fibronectin type III domain containing 3B -0.0296145
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0295238
EXOC4 exocyst complex component 4 -0.0294573
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0291122
H1-0 H1.0 linker histone -0.0290791
RPLP0 ribosomal protein, large, P0 -0.0290497
MORC3 MORC family CW-type zinc finger 3 -0.0287841
WWC1 WW and C2 domain containing 1 -0.0286587
SEPTIN2 septin 2 -0.0286282
RPS6 ribosomal protein S6 -0.0283338
KLF6 Kruppel-like factor 6 -0.0282038
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0281769
SERBP1 SERPINE1 mRNA binding protein 1 -0.0280297
RPL36 ribosomal protein L36 -0.0279396
ANKRD28 ankyrin repeat domain 28 -0.0278072
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.027727
BRD4 bromodomain containing 4 -0.0271978
WSB1 WD repeat and SOCS box containing 1 -0.0271185
KMT2E lysine (K)-specific methyltransferase 2E -0.027057
KIAA1217 KIAA1217 -0.0270015
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0268324
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0267292
TXNRD1 thioredoxin reductase 1 -0.0265758
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0265335
LPP LIM domain containing preferred translocation partner in lipoma -0.0264728
MED13L mediator complex subunit 13-like -0.0261754
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0260741
DIAPH1 diaphanous-related formin 1 -0.0256944
BHLHE40 basic helix-loop-helix family, member e40 -0.0256629
HMGA1 high mobility group AT-hook 1 -0.0256537
ATP11B ATPase, class VI, type 11B -0.0255696
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0255482
WAC WW domain containing adaptor with coiled-coil -0.0254272
TMOD3 tropomodulin 3 (ubiquitous) -0.0253831
RPL26 ribosomal protein L26 -0.0251389
UBE2B ubiquitin-conjugating enzyme E2B -0.0251036
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0250892
LARP4B La ribonucleoprotein domain family, member 4B -0.0250335
IGFBP5 insulin-like growth factor binding protein 5 -0.0248892
CD46 CD46 molecule, complement regulatory protein -0.0247759