Vinblastine (sulfate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vinblastine (sulfate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.191567
MCL1 myeloid cell leukemia 1 0.14222
AKAP12 A kinase (PRKA) anchor protein 12 0.123616
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122669
AFF3 AF4/FMR2 family, member 3 0.0802878
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0748074
WWOX WW domain containing oxidoreductase 0.0691311
ERRFI1 ERBB receptor feedback inhibitor 1 0.0680844
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0662895
AEBP2 AE binding protein 2 0.0646968
IFI6 interferon, alpha-inducible protein 6 0.061393
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0604911
PRELID2 PRELI domain containing 2 0.0604262
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0590656
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0588359
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0578654
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0559276
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0535937
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.053228
INTS6 integrator complex subunit 6 0.0516559
ZSWIM6 zinc finger, SWIM-type containing 6 0.0494571
POTEF POTE ankyrin domain family, member F 0.0485674
DOCK5 dedicator of cytokinesis 5 0.0479852
HMGA2 high mobility group AT-hook 2 0.0477289
ATXN1 ataxin 1 0.047411
PRH1 proline-rich protein HaeIII subfamily 1 0.0465487
TPM3 tropomyosin 3 0.0454939
PRKCE protein kinase C, epsilon 0.0453561
RIMS2 regulating synaptic membrane exocytosis 2 0.0452992
ZCCHC7 zinc finger, CCHC domain containing 7 0.044392
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0442347
PDLIM5 PDZ and LIM domain 5 0.0436216
PDIA3 protein disulfide isomerase family A, member 3 0.0427959
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0423265
PDE10A phosphodiesterase 10A 0.0413024
VMP1 vacuole membrane protein 1 0.0412782
PDE4D phosphodiesterase 4D, cAMP-specific 0.0403653
EXOC4 exocyst complex component 4 0.0392164
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0381935
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0379211
FNDC3B fibronectin type III domain containing 3B 0.0371996
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367797
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0344042
WWTR1 WW domain containing transcription regulator 1 0.0342913
EGR1 early growth response 1 0.0333678
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.033065
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0329079
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0326485
LOC102724023 ES1 protein homolog, mitochondrial 0.0317679
CUX1 cut-like homeobox 1 0.0316836
SVIL supervillin 0.0315821
HOMER1 homer scaffolding protein 1 0.031002
TRIM9 tripartite motif containing 9 0.0304857
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0300588
GPATCH2L G patch domain containing 2-like 0.0300024
SETX senataxin 0.029522
EGFR epidermal growth factor receptor 0.0292219
NLGN1 neuroligin 1 0.0291196
THSD4 thrombospondin, type I, domain containing 4 0.028746
RAB7A RAB7A, member RAS oncogene family 0.0285935
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0282757
NEK10 NIMA-related kinase 10 0.0282748
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0280905
DIAPH2 diaphanous-related formin 2 0.0279355
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0278688
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0276042
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0274789
BRD2 bromodomain containing 2 0.0265615
PYGL phosphorylase, glycogen, liver 0.0260685
VCL vinculin 0.0253427
CPNE1 copine I 0.0252992
BNC2 basonuclin 2 0.0248338
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0244891
DSPP dentin sialophosphoprotein 0.0244306
SND1 staphylococcal nuclease and tudor domain containing 1 0.024387
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0240127
EPAS1 endothelial PAS domain protein 1 0.024001
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0237583
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.0235787
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0234868
MCTP1 multiple C2 domains, transmembrane 1 0.0233739
RYR3 ryanodine receptor 3 0.0233729
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0232741
FBXO11 F-box protein 11 0.0231511
COPA coatomer protein complex, subunit alpha 0.0231243
AGO3 argonaute RISC catalytic component 3 0.0230096
YAP1 Yes-associated protein 1 0.022993
RABGAP1L RAB GTPase activating protein 1-like 0.0228702
NPAS2 neuronal PAS domain protein 2 0.0227935
MBD5 methyl-CpG binding domain protein 5 0.0225313
TPM4 tropomyosin 4 0.0224209
C6ORF62 chromosome 6 open reading frame 62 0.0224044
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0223798
NBEAL1 neurobeachin-like 1 0.0221021
CALR calreticulin 0.0220373
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0218874
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0218544
SUMF1 sulfatase modifying factor 1 0.0215136
FMNL2 formin-like 2 0.0214846
NRDC nardilysin convertase 0.021473

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.199474
TFPI2 tissue factor pathway inhibitor 2 -0.155062
TMSB10 thymosin beta 10 -0.109163
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0747261
MYL12B myosin, light chain 12B, regulatory -0.0711077
RPL37 ribosomal protein L37 -0.0700116
RPL12 ribosomal protein L12 -0.0668998
RPL26 ribosomal protein L26 -0.0654685
RTN4 reticulon 4 -0.0598376
TPI1 triosephosphate isomerase 1 -0.0593927
RPS21 ribosomal protein S21 -0.0585094
RPL35A ribosomal protein L35a -0.0573738
RPS3 ribosomal protein S3 -0.0572421
KDM3A lysine (K)-specific demethylase 3A -0.0553204
RPL23 ribosomal protein L23 -0.0544515
NAP1L1 nucleosome assembly protein 1-like 1 -0.0525809
TRIO trio Rho guanine nucleotide exchange factor -0.0522461
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0517706
EEF2 eukaryotic translation elongation factor 2 -0.051732
TM4SF1 transmembrane 4 L six family member 1 -0.0506892
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0495724
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0489318
EIF1 eukaryotic translation initiation factor 1 -0.0474503
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0472213
RPLP1 ribosomal protein, large, P1 -0.0468632
RPS8 ribosomal protein S8 -0.0466805
XPO1 exportin 1 -0.0448706
PGK1 phosphoglycerate kinase 1 -0.0436402
OGA O-GlcNAcase -0.0418336
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0412377
AHNAK AHNAK nucleoprotein -0.0399584
RBM25 RNA binding motif protein 25 -0.0399118
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0397156
SINHCAF SIN3-HDAC complex associated factor -0.0394024
RPS19 ribosomal protein S19 -0.0393434
ZFR zinc finger RNA binding protein -0.0392579
KLF6 Kruppel-like factor 6 -0.0390462
CALD1 caldesmon 1 -0.0385567
GARS1 glycyl-tRNA synthetase 1 -0.0382641
RPL5 ribosomal protein L5 -0.0381794
CSDE1 cold shock domain containing E1, RNA-binding -0.0377954
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0375544
RACK1 receptor for activated C kinase 1 -0.0374584
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.037039
PTPRF protein tyrosine phosphatase, receptor type, F -0.0367696
PHIP pleckstrin homology domain interacting protein -0.0367131
GOLGA4 golgin A4 -0.0365313
RPL11 ribosomal protein L11 -0.0363871
RPS4X ribosomal protein S4, X-linked -0.0363316
TPT1 tumor protein, translationally-controlled 1 -0.0355717
CCND2 cyclin D2 -0.0354166
RPL9 ribosomal protein L9 -0.035273
RPS27A ribosomal protein S27a -0.0352621
RPL34 ribosomal protein L34 -0.0348203
NACA nascent polypeptide-associated complex alpha subunit -0.0342901
RUSC2 RUN and SH3 domain containing 2 -0.0339431
CAVIN1 caveolae associated protein 1 -0.0335446
RPL37A ribosomal protein L37a -0.0332258
RPLP2 ribosomal protein, large, P2 -0.0330679
HMGA1 high mobility group AT-hook 1 -0.0329775
MKI67 marker of proliferation Ki-67 -0.0328288
RPL32 ribosomal protein L32 -0.0327188
MIS18BP1 MIS18 binding protein 1 -0.0323817
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0319045
RPS24 ribosomal protein S24 -0.0316899
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0316776
PRRC2C proline-rich coiled-coil 2C -0.0315195
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0311922
PCNX1 pecanex 1 -0.0310664
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0309676
RPLP0 ribosomal protein, large, P0 -0.0307271
RB1CC1 RB1-inducible coiled-coil 1 -0.030578
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0303995
RPL19 ribosomal protein L19 -0.0299864
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0299244
SSB Sjogren syndrome antigen B (autoantigen La) -0.0297359
RAD21 RAD21 homolog (S. pombe) -0.0294882
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0291616
STAT1 signal transducer and activator of transcription 1, 91kDa -0.028903
RPL8 ribosomal protein L8 -0.0286656
H1-0 H1.0 linker histone -0.0281871
MARCHF4 membrane associated ring-CH-type finger 4 -0.0281392
TUBB tubulin, beta class I -0.0279818
COG5 component of oligomeric golgi complex 5 -0.0278162
RPS27 ribosomal protein S27 -0.0277771
VDAC1 voltage-dependent anion channel 1 -0.0275917
BRWD3 bromodomain and WD repeat domain containing 3 -0.0269184
ZNF292 zinc finger protein 292 -0.026788
ATP5F1B ATP synthase F1 subunit beta -0.0263211
NCOR1 nuclear receptor corepressor 1 -0.0263209
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.026146
TNPO3 transportin 3 -0.0260801
WSB1 WD repeat and SOCS box containing 1 -0.0256037
NOP58 NOP58 ribonucleoprotein -0.0255033
RNF169 ring finger protein 169 -0.0255017
EML4 echinoderm microtubule associated protein like 4 -0.025467
EPN2 epsin 2 -0.0254613
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0253932
YBX3 Y box binding protein 3 -0.0253818
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0252749