Vinblastine (sulfate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.26998
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.173567
ELL2 elongation factor, RNA polymerase II, 2 0.0976837
SAMD4A sterile alpha motif domain containing 4A 0.0947313
GRB10 growth factor receptor-bound protein 10 0.091557
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0900965
TSC22D2 TSC22 domain family, member 2 0.0889709
AHNAK AHNAK nucleoprotein 0.0835209
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0780674
FNDC3B fibronectin type III domain containing 3B 0.0773823
DSPP dentin sialophosphoprotein 0.0741692
PLEC plectin 0.071389
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0650212
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0639776
ZSWIM6 zinc finger, SWIM-type containing 6 0.0631033
DTNA dystrobrevin, alpha 0.0614449
TRIO trio Rho guanine nucleotide exchange factor 0.0597517
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0580857
APLP2 amyloid beta (A4) precursor-like protein 2 0.0567973
ERRFI1 ERBB receptor feedback inhibitor 1 0.0562618
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0532047
IGFBP3 insulin-like growth factor binding protein 3 0.0524442
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0512937
DST dystonin 0.0507912
FAM13A family with sequence similarity 13, member A 0.0504365
FHIT fragile histidine triad 0.0491818
RYBP RING1 and YY1 binding protein 0.0475896
SQSTM1 sequestosome 1 0.0472655
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0468367
NAV2 neuron navigator 2 0.0457729
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.045709
MYH9 myosin, heavy chain 9, non-muscle 0.0452291
ENO1 enolase 1, (alpha) 0.0448495
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0439607
CANX calnexin 0.0439428
UPP1 uridine phosphorylase 1 0.0439273
PTK2 protein tyrosine kinase 2 0.0438765
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0424697
MACF1 microtubule-actin crosslinking factor 1 0.0421522
FXR1 fragile X mental retardation, autosomal homolog 1 0.0398639
HSPA8 heat shock 70kDa protein 8 0.0376636
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0369174
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0364657
EGFR epidermal growth factor receptor 0.0362674
MAP1B microtubule-associated protein 1B 0.0361042
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0356052
SSBP2 single-stranded DNA binding protein 2 0.0352597
NAMPT nicotinamide phosphoribosyltransferase 0.0349426
KIAA1217 KIAA1217 0.0346911
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0340384
MYO5B myosin VB 0.034023
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0337636
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0336004
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0335167
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0332114
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0326796
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0323979
USP53 ubiquitin specific peptidase 53 0.0319878
ZFAND3 zinc finger, AN1-type domain 3 0.0313175
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.030758
SPAG9 sperm associated antigen 9 0.0307556
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0307197
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0304959
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0303305
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0302723
KTN1 kinectin 1 (kinesin receptor) 0.0301793
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0298004
PPARD peroxisome proliferator-activated receptor delta 0.0297464
CXCL8 chemokine (C-X-C motif) ligand 8 0.0297155
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0296403
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0294215
DSG2 desmoglein 2 0.0291322
ALCAM activated leukocyte cell adhesion molecule 0.0288646
TXNRD1 thioredoxin reductase 1 0.0287131
QKI QKI, KH domain containing, RNA binding 0.0284323
IQGAP1 IQ motif containing GTPase activating protein 1 0.028415
G0S2 G0/G1 switch 2 0.0281224
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0280986
ADAM9 ADAM metallopeptidase domain 9 0.0275119
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0270856
MEF2A myocyte enhancer factor 2A 0.0268273
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0268115
PTPRJ protein tyrosine phosphatase, receptor type, J 0.026736
MCL1 myeloid cell leukemia 1 0.0266764
SGMS2 sphingomyelin synthase 2 0.0266141
AKAP13 A kinase (PRKA) anchor protein 13 0.0265473
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0264346
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0261355
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0260289
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0260258
HILPDA hypoxia inducible lipid droplet-associated 0.0259216
PCBP2 poly(rC) binding protein 2 0.0258446
MYO10 myosin X 0.0258339
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0256707
SP100 SP100 nuclear antigen 0.0256551
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0255705
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0255503
SMAD3 SMAD family member 3 0.0255152
SNX9 sorting nexin 9 0.0253094
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0252577

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.17501
TMSB10 thymosin beta 10 -0.128538
TPT1 tumor protein, translationally-controlled 1 -0.082685
ACTG1 actin gamma 1 -0.0699884
PTMA prothymosin, alpha -0.066551
FN1 fibronectin 1 -0.06341
SOX4 SRY (sex determining region Y)-box 4 -0.0550116
S100A6 S100 calcium binding protein A6 -0.0479816
POTEF POTE ankyrin domain family, member F -0.0468144
RPS3 ribosomal protein S3 -0.0461785
RPL9 ribosomal protein L9 -0.0449139
RPL35A ribosomal protein L35a -0.0394067
RPS12 ribosomal protein S12 -0.0393946
IFI6 interferon, alpha-inducible protein 6 -0.0371991
CLDN4 claudin 4 -0.0366379
CSTB cystatin B (stefin B) -0.0359616
LMO7 LIM domain 7 -0.035226
TMEM165 transmembrane protein 165 -0.0331301
RPLP2 ribosomal protein, large, P2 -0.0302471
MYL12B myosin, light chain 12B, regulatory -0.0286553
RPL37A ribosomal protein L37a -0.028379
HLA-B major histocompatibility complex, class I, B -0.0283617
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0282543
ISG15 ISG15 ubiquitin-like modifier -0.0281414
LIMCH1 LIM and calponin homology domains 1 -0.0279377
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0267259
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0262937
CCND1 cyclin D1 -0.0262059
ITCH itchy E3 ubiquitin protein ligase -0.0255285
RACK1 receptor for activated C kinase 1 -0.0250756
MT2A metallothionein 2A -0.024324
RPL37 ribosomal protein L37 -0.0241231
TPM4 tropomyosin 4 -0.0241187
IFI27 interferon, alpha-inducible protein 27 -0.0238809
RPS19 ribosomal protein S19 -0.0238211
FBXO32 F-box protein 32 -0.0234734
RPL15 ribosomal protein L15 -0.0234626
RPL31 ribosomal protein L31 -0.0233661
SACK1A scaffolding CK1 anchoring protein A -0.0231606
RPL36AL ribosomal protein L36a-like -0.0230412
RPS29 ribosomal protein S29 -0.0229833
RPS13 ribosomal protein S13 -0.0226597
RPS17 ribosomal protein S17 -0.0223436
COX6C cytochrome c oxidase subunit VIc -0.021828
FAM3C family with sequence similarity 3, member C -0.0214017
RPL30 ribosomal protein L30 -0.0212118
RPL34 ribosomal protein L34 -0.0212084
RPL26 ribosomal protein L26 -0.0210215
C15ORF48 chromosome 15 open reading frame 48 -0.0209022
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0208284
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0204667
CRABP2 cellular retinoic acid binding protein 2 -0.0204287
RPL36A ribosomal protein L36a -0.0203763
TMSB4X thymosin beta 4, X-linked -0.0203302
RPL36 ribosomal protein L36 -0.0199198
BASP1 brain abundant, membrane attached signal protein 1 -0.0197456
CD9 CD9 molecule -0.0195038
MACC1 metastasis associated in colon cancer 1 -0.0194911
TMEM263 transmembrane protein 263 -0.0194175
RPS24 ribosomal protein S24 -0.019043
S100A11 S100 calcium binding protein A11 -0.0183021
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0181292
RPS16 ribosomal protein S16 -0.018081
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0178168
RPS8 ribosomal protein S8 -0.0177067
RPS25 ribosomal protein S25 -0.0176493
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0172337
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0171692
RPS14 ribosomal protein S14 -0.0171627
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.017068
RPS27 ribosomal protein S27 -0.0170366
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0169912
PLAUR plasminogen activator, urokinase receptor -0.0165847
FBXO34 F-box protein 34 -0.0164643
ZFAND6 zinc finger, AN1-type domain 6 -0.0164032
TM4SF1 transmembrane 4 L six family member 1 -0.0163496
RPL12 ribosomal protein L12 -0.0161823
IFITM3 interferon induced transmembrane protein 3 -0.0161034
JUP junction plakoglobin -0.016096
BLZF1 basic leucine zipper nuclear factor 1 -0.0160227
HMGA1 high mobility group AT-hook 1 -0.0159279
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -0.0158475
KRT7 keratin 7, type II -0.0157945
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0157245
NPC2 Niemann-Pick disease, type C2 -0.0156579
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0156525
NACA nascent polypeptide-associated complex alpha subunit -0.0156276
KMT2C lysine (K)-specific methyltransferase 2C -0.0155346
HLA-A major histocompatibility complex, class I, A -0.0153191
PTPRF protein tyrosine phosphatase, receptor type, F -0.0152742
CD2AP CD2-associated protein -0.0152491
F11R F11 receptor -0.0151028
RPL23 ribosomal protein L23 -0.0150751
IFITM1 interferon induced transmembrane protein 1 -0.0150721
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0147061
SEC24D SEC24 family member D -0.0146476
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0146108
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0146108
LOC112694756 uncharaterized LOC112694756 -0.0145957
ENO2 enolase 2 (gamma, neuronal) -0.0144776