Vinblastine (sulfate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.15789
GRAMD1B GRAM domain containing 1B 0.101807
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0880535
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0865511
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0712007
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0707351
ANTXR1 anthrax toxin receptor 1 0.0653583
BZW1 basic leucine zipper and W2 domains 1 0.0623014
CENPF centromere protein F, 350/400kDa 0.0608034
TGFBR1 transforming growth factor, beta receptor 1 0.0588175
COL8A1 collagen, type VIII, alpha 1 0.0570225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0549899
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0543274
TPM3 tropomyosin 3 0.0522569
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0511742
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0486894
PDIA3 protein disulfide isomerase family A, member 3 0.0481233
SH3KBP1 SH3-domain kinase binding protein 1 0.0456507
LDHA lactate dehydrogenase A 0.0448363
ENO1 enolase 1, (alpha) 0.0421767
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0420661
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0404528
TXNRD1 thioredoxin reductase 1 0.0401387
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0375973
PM20D1 peptidase M20 domain containing 1 0.0372846
MYOF myoferlin 0.0367408
HSPA8 heat shock 70kDa protein 8 0.0354656
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0346839
CANX calnexin 0.0332091
DOCK4 dedicator of cytokinesis 4 0.0330526
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0325384
MKI67 marker of proliferation Ki-67 0.0312678
SMC4 structural maintenance of chromosomes 4 0.0312464
SET SET nuclear proto-oncogene 0.0308247
RGS2 regulator of G-protein signaling 2 0.0307497
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0304338
CD109 CD109 molecule 0.0294339
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.028926
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0282495
IGFBP3 insulin-like growth factor binding protein 3 0.0280271
NEK7 NIMA-related kinase 7 0.0277961
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0277727
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0272761
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0254663
CEP350 centrosomal protein 350kDa 0.0254308
NCAM1 neural cell adhesion molecule 1 0.0251583
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0248552
ZEB2 zinc finger E-box binding homeobox 2 0.0247522
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0246009
EPHA4 EPH receptor A4 0.0243889
TPR translocated promoter region, nuclear basket protein 0.0231717
ZBTB38 zinc finger and BTB domain containing 38 0.0227956
MALT1 MALT1 paracaspase 0.0224714
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0220777
CHSY3 chondroitin sulfate synthase 3 0.0218172
RPL3 ribosomal protein L3 0.0217998
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0216539
COL5A2 collagen, type V, alpha 2 0.0216219
RIGI RNA sensor RIG-I 0.0215691
CDK6 cyclin-dependent kinase 6 0.0215246
BDNF brain-derived neurotrophic factor 0.0212478
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0211938
WARS1 tryptophanyl-tRNA synthetase 1 0.0211602
PDLIM5 PDZ and LIM domain 5 0.0209263
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0208727
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0208287
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0207621
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.020434
DIAPH3 diaphanous-related formin 3 0.020229
CKAP5 cytoskeleton associated protein 5 0.0198774
PGM2L1 phosphoglucomutase 2-like 1 0.019686
TENM2 teneurin transmembrane protein 2 0.0195808
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0191416
KYNU kynureninase 0.0190672
PRICKLE1 prickle homolog 1 (Drosophila) 0.0190184
MAP7 microtubule-associated protein 7 0.0189743
SLF1 SMC5-SMC6 complex localization factor 1 0.018937
SERBP1 SERPINE1 mRNA binding protein 1 0.0189101
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.018859
NRCAM neuronal cell adhesion molecule 0.0187308
IPO7 importin 7 0.0186763
KPNB1 karyopherin (importin) beta 1 0.0186544
ASPH aspartate beta-hydroxylase 0.0184597
OASL 2'-5'-oligoadenylate synthetase-like 0.0182903
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0179933
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0179687
GOLGA4 golgin A4 0.0179666
PGK1 phosphoglycerate kinase 1 0.0177232
PSD3 pleckstrin and Sec7 domain containing 3 0.0176471
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0173915
TMX4 thioredoxin-related transmembrane protein 4 0.017335
ANLN anillin, actin binding protein 0.017219
FNDC3A fibronectin type III domain containing 3A 0.0169901
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0169616
BCLAF1 BCL2-associated transcription factor 1 0.0169089
ITPRID2 ITPR interacting domain containing 2 0.0168056
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0167196
CENPE centromere protein E, 312kDa 0.016684
LSAMP limbic system-associated membrane protein 0.0166825
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0166638

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.186961
VIM vimentin -0.124229
EFNA5 ephrin-A5 -0.109425
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.102521
TPT1 tumor protein, translationally-controlled 1 -0.102159
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101703
SMYD3 SET and MYND domain containing 3 -0.08793
RPS19 ribosomal protein S19 -0.0797997
RPL12 ribosomal protein L12 -0.0750332
RPS6 ribosomal protein S6 -0.0743471
RPL35A ribosomal protein L35a -0.0734097
RPL31 ribosomal protein L31 -0.0694212
RPS24 ribosomal protein S24 -0.0689733
RPS21 ribosomal protein S21 -0.068951
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0676021
RPL26 ribosomal protein L26 -0.0671766
BASP1 brain abundant, membrane attached signal protein 1 -0.0657741
RPS23 ribosomal protein S23 -0.065557
RPL23 ribosomal protein L23 -0.0641814
FTL ferritin, light polypeptide -0.062432
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0576078
PTMA prothymosin, alpha -0.0573577
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0562815
RPL37A ribosomal protein L37a -0.0550411
S100A6 S100 calcium binding protein A6 -0.0550042
RPLP1 ribosomal protein, large, P1 -0.0530868
RPL19 ribosomal protein L19 -0.0516962
ADGRD1 adhesion G protein-coupled receptor D1 -0.0516287
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0507712
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0503177
RPS8 ribosomal protein S8 -0.0501549
RPL34 ribosomal protein L34 -0.049916
RPL36A ribosomal protein L36a -0.0498269
RPS14 ribosomal protein S14 -0.0488016
RPLP2 ribosomal protein, large, P2 -0.048666
NALF1 NALCN channel auxiliary factor 1 -0.0475696
NDRG1 N-myc downstream regulated 1 -0.0473562
RPL9 ribosomal protein L9 -0.0472834
AUTS2 autism susceptibility candidate 2 -0.0461897
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0454702
RPL36 ribosomal protein L36 -0.0433906
PCBP3 poly(rC) binding protein 3 -0.0416523
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.041498
RPS12 ribosomal protein S12 -0.0413923
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0405885
HLA-B major histocompatibility complex, class I, B -0.0405747
RPS16 ribosomal protein S16 -0.0392732
TBXT T-box transcription factor T -0.0389472
TM4SF1 transmembrane 4 L six family member 1 -0.0385242
RPL37 ribosomal protein L37 -0.0380987
RPS3 ribosomal protein S3 -0.0379092
STC1 stanniocalcin 1 -0.0377706
PDE10A phosphodiesterase 10A -0.037392
PDE4D phosphodiesterase 4D, cAMP-specific -0.0370597
RPS27A ribosomal protein S27a -0.0368252
BCAS3 breast carcinoma amplified sequence 3 -0.0367907
NAP1L1 nucleosome assembly protein 1-like 1 -0.0362256
RPS27 ribosomal protein S27 -0.036183
SLC38A2 solute carrier family 38, member 2 -0.0358116
CUX1 cut-like homeobox 1 -0.0353851
AKAP12 A kinase (PRKA) anchor protein 12 -0.0353019
ASTN2 astrotactin 2 -0.0351498
RPL32 ribosomal protein L32 -0.0350408
FMNL2 formin-like 2 -0.0347934
CDH13 cadherin 13 -0.0347417
FLNB filamin B, beta -0.0342047
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0340681
SOX4 SRY (sex determining region Y)-box 4 -0.0337718
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0337227
RPS17 ribosomal protein S17 -0.0334781
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0334199
RPL18 ribosomal protein L18 -0.032613
RPS29 ribosomal protein S29 -0.032136
RPL5 ribosomal protein L5 -0.0320775
NPAS2 neuronal PAS domain protein 2 -0.0320123
MCL1 myeloid cell leukemia 1 -0.0319706
NAMPT nicotinamide phosphoribosyltransferase -0.0306787
RPS25 ribosomal protein S25 -0.0306048
IGF1R insulin-like growth factor 1 receptor -0.0303347
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0301596
COL4A5 collagen, type IV, alpha 5 -0.0301582
RPS13 ribosomal protein S13 -0.0301201
MFSD12 major facilitator superfamily domain containing 12 -0.0299223
WSB1 WD repeat and SOCS box containing 1 -0.0299167
RPS4X ribosomal protein S4, X-linked -0.0298678
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0297426
HLA-A major histocompatibility complex, class I, A -0.0296223
THSD4 thrombospondin, type I, domain containing 4 -0.0285783
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0284577
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0284093
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.028096
EGR1 early growth response 1 -0.0278783
RPS11 ribosomal protein S11 -0.027771
TTC28 tetratricopeptide repeat domain 28 -0.0271359
RPL27A ribosomal protein L27a -0.0270624
RPL28 ribosomal protein L28 -0.0270104
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0267843
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.026697
GREM2 gremlin 2, DAN family BMP antagonist -0.0266844
GNAS GNAS complex locus -0.0265961