Vinblastine (sulfate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

156 genes differentially expressed following the Vinblastine (sulfate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.303868
ZFAND3 zinc finger, AN1-type domain 3 0.140693
KANSL1 KAT8 regulatory NSL complex subunit 1 0.133684
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.121932
SLTM SAFB-like, transcription modulator 0.115407
FLNB filamin B, beta 0.115402
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.110245
RTN4 reticulon 4 0.0966005
KTN1 kinectin 1 (kinesin receptor) 0.0917356
FNDC3B fibronectin type III domain containing 3B 0.0882005
AK1 adenylate kinase 1 0.0877309
RAP1B RAP1B, member of RAS oncogene family 0.0863524
ANKRD12 ankyrin repeat domain 12 0.085569
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0850418
ANXA2 annexin A2 0.0842593
PRRC2C proline-rich coiled-coil 2C 0.0815565
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.078603
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0773844
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0765345
CREB5 cAMP responsive element binding protein 5 0.0764888
NCOR1 nuclear receptor corepressor 1 0.0763622
NAP1L1 nucleosome assembly protein 1-like 1 0.0763212
GPC6 glypican 6 0.0730386
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0726259
NAMPT nicotinamide phosphoribosyltransferase 0.0722682
RORA RAR-related orphan receptor A 0.0710635
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0695389
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.068228
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0668549
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0653217
TXNRD1 thioredoxin reductase 1 0.0608019
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0587619
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0586289
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0585797
ERRFI1 ERBB receptor feedback inhibitor 1 0.0569382
PTPRM protein tyrosine phosphatase, receptor type, M 0.0545817
ANKRD11 ankyrin repeat domain 11 0.0530853
NEK7 NIMA-related kinase 7 0.0483968
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0470885
AHNAK AHNAK nucleoprotein 0.0453856
COL4A5 collagen, type IV, alpha 5 0.0448268
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0445681
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0444424
DSCAM Down syndrome cell adhesion molecule 0.0442195
JMJD1C jumonji domain containing 1C 0.0438929
GSK3B glycogen synthase kinase 3 beta 0.0432956
EEF2 eukaryotic translation elongation factor 2 0.0429054
AKAP13 A kinase (PRKA) anchor protein 13 0.0422617
KMT2E lysine (K)-specific methyltransferase 2E 0.0411953
DTNA dystrobrevin, alpha 0.0411831
PDLIM5 PDZ and LIM domain 5 0.0377426
ACTN4 actinin, alpha 4 0.0358873
WDR43 WD repeat domain 43 0.0358005
MACF1 microtubule-actin crosslinking factor 1 0.034702
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0338379
AKAP12 A kinase (PRKA) anchor protein 12 0.0334134
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0333903
SEC31A SEC31 homolog A (S. cerevisiae) 0.0328905
POTEF POTE ankyrin domain family, member F 0.0317185
SND1 staphylococcal nuclease and tudor domain containing 1 0.0292105
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.028664
DST dystonin 0.0282728
RAB7A RAB7A, member RAS oncogene family 0.0280457
GOLGA4 golgin A4 0.0264923
GDA guanine deaminase 0.0261627
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0256252
MYO1E myosin IE 0.0253289
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.023764
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0235421
RUNX1 runt-related transcription factor 1 0.0218257
COL5A2 collagen, type V, alpha 2 0.0207102
PARD3 par-3 family cell polarity regulator 0.0206401
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0187577
BMERB1 bMERB domain containing 1 0.0162582
FMNL2 formin-like 2 0.0141404
DOCK4 dedicator of cytokinesis 4 0.0133541
TFPI2 tissue factor pathway inhibitor 2 0.013279
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.010872
MED13 mediator complex subunit 13 0.00944275
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00847705
SAMD4A sterile alpha motif domain containing 4A 0.00703216
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00664487
ELL2 elongation factor, RNA polymerase II, 2 0.00541385
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00421018
SMYD3 SET and MYND domain containing 3 0.00419364
FTL ferritin, light polypeptide 0.00350404
MAML3 mastermind-like 3 (Drosophila) 0.00341817
TJP1 tight junction protein 1 0.00228274

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.168278
HMGA2 high mobility group AT-hook 2 -0.16082
CDH13 cadherin 13 -0.157802
VIM vimentin -0.152676
EXT1 exostosin glycosyltransferase 1 -0.141644
TPT1 tumor protein, translationally-controlled 1 -0.141317
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140297
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.12675
MT2A metallothionein 2A -0.125831
TRIO trio Rho guanine nucleotide exchange factor -0.120513
NALF1 NALCN channel auxiliary factor 1 -0.11145
IGFBP3 insulin-like growth factor binding protein 3 -0.105036
RPS12 ribosomal protein S12 -0.0980654
STC1 stanniocalcin 1 -0.086766
PDE4D phosphodiesterase 4D, cAMP-specific -0.0854571
RPL35A ribosomal protein L35a -0.0753353
IGF2 insulin-like growth factor 2 -0.0725585
B2M beta-2-microglobulin -0.072331
RPL37A ribosomal protein L37a -0.0719571
DIAPH2 diaphanous-related formin 2 -0.0714754
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.069961
RPL23 ribosomal protein L23 -0.0696175
RPL12 ribosomal protein L12 -0.0688764
COL5A1 collagen, type V, alpha 1 -0.0688382
CEMIP cell migration inducing protein, hyaluronan binding -0.0677322
RPL9 ribosomal protein L9 -0.0668471
RPL19 ribosomal protein L19 -0.0654717
RPS25 ribosomal protein S25 -0.0645304
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0630942
RPS19 ribosomal protein S19 -0.0604111
FN1 fibronectin 1 -0.0567417
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0554406
RPL34 ribosomal protein L34 -0.0531172
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0529735
RPS6 ribosomal protein S6 -0.0506232
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0490583
VCL vinculin -0.0481687
NPEPPS aminopeptidase puromycin sensitive -0.047127
NAV2 neuron navigator 2 -0.0466648
RPS8 ribosomal protein S8 -0.0455228
RPS23 ribosomal protein S23 -0.0431874
ASPH aspartate beta-hydroxylase -0.0380874
ENO1 enolase 1, (alpha) -0.0375137
MCL1 myeloid cell leukemia 1 -0.0374359
PDE10A phosphodiesterase 10A -0.0361649
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0308423
RPLP1 ribosomal protein, large, P1 -0.0300515
RPS3 ribosomal protein S3 -0.0300133
PRKCA protein kinase C, alpha -0.0273263
RPL26 ribosomal protein L26 -0.0261536
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0256395
PTMA prothymosin, alpha -0.0224913
NKD1 naked cuticle homolog 1 (Drosophila) -0.012343
LMO7 LIM domain 7 -0.0121927
LAMB3 laminin, beta 3 -0.0120984
LDHA lactate dehydrogenase A -0.0111612
PSD3 pleckstrin and Sec7 domain containing 3 -0.0109001
EIF1 eukaryotic translation initiation factor 1 -0.0100645
EFNA5 ephrin-A5 -0.00977654
NDRG1 N-myc downstream regulated 1 -0.00909178
ERBIN erbb2 interacting protein -0.00765166
ZBTB20 zinc finger and BTB domain containing 20 -0.00487477
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00476992
FTH1 ferritin, heavy polypeptide 1 -0.00421355
RIMS2 regulating synaptic membrane exocytosis 2 -0.00347844
SPIRE1 spire-type actin nucleation factor 1 -0.0029633
ACTG1 actin gamma 1 -0.00267824
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -6.233E-4