Vinblastine (sulfate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.117728
TSC22D2 TSC22 domain family, member 2 0.0968193
TRIO trio Rho guanine nucleotide exchange factor 0.0798467
ANKRD33B ankyrin repeat domain 33B 0.0764591
FNDC3B fibronectin type III domain containing 3B 0.0665835
DST dystonin 0.0640612
KMT2E lysine (K)-specific methyltransferase 2E 0.0634552
CHD1 chromodomain helicase DNA binding protein 1 0.0600951
JMJD1C jumonji domain containing 1C 0.0542293
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0452077
FBXO11 F-box protein 11 0.0440995
ZSWIM6 zinc finger, SWIM-type containing 6 0.0430588
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0399549
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0389187
SAMD4A sterile alpha motif domain containing 4A 0.0372723
GLS2 glutaminase 2 (liver, mitochondrial) 0.0366012
ZNF292 zinc finger protein 292 0.0365752
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0340476
CDH19 cadherin 19, type 2 0.0340015
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0323229
ZFAND3 zinc finger, AN1-type domain 3 0.0319629
TRPS1 trichorhinophalangeal syndrome I 0.031161
PUM2 pumilio RNA-binding family member 2 0.0304283
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0302374
ANK2 ankyrin 2, neuronal 0.0288065
TENM3 teneurin transmembrane protein 3 0.0283791
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0275853
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0275221
TJP1 tight junction protein 1 0.0271294
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0265115
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0263391
SREBF2 sterol regulatory element binding transcription factor 2 0.0261562
YAP1 Yes-associated protein 1 0.0259577
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0258399
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0257142
CHD7 chromodomain helicase DNA binding protein 7 0.0254783
MATR3 matrin 3 0.0252238
RBM39 RNA binding motif protein 39 0.0252022
FN1 fibronectin 1 0.0249622
RYBP RING1 and YY1 binding protein 0.0244179
XPO1 exportin 1 0.0236846
CUL3 cullin 3 0.0232229
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0228431
WWC2 WW and C2 domain containing 2 0.0227125
VGLL4 vestigial-like family member 4 0.022591
USP53 ubiquitin specific peptidase 53 0.0225442
CNOT1 CCR4-NOT transcription complex, subunit 1 0.02231
OGA O-GlcNAcase 0.0222896
SFPQ splicing factor proline/glutamine-rich 0.021829
MEMO1 mediator of cell motility 1 0.0216085
APP amyloid beta (A4) precursor protein 0.0215474
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0212137
SERTAD2 SERTA domain containing 2 0.021156
ZEB2 zinc finger E-box binding homeobox 2 0.0210349
TRAK1 trafficking protein, kinesin binding 1 0.0209741
BLTP1 bridge-like lipid transfer protein family member 1 0.02089
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0205155
NCKAP1 NCK-associated protein 1 0.0204409
CDC73 cell division cycle 73 0.0203661
FIGN fidgetin 0.0202412
AKAP13 A kinase (PRKA) anchor protein 13 0.020206
PLPP1 phospholipid phosphatase 1 0.0200455
ENAH enabled homolog (Drosophila) 0.0200189
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0200002
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0199921
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0198857
OSBPL8 oxysterol binding protein-like 8 0.0197801
FXR1 fragile X mental retardation, autosomal homolog 1 0.0197151
MB21D2 Mab-21 domain containing 2 0.0196308
CALCR calcitonin receptor 0.0194648
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0192101
TPD52 tumor protein D52 0.0191608
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0190247
DENND4C DENN/MADD domain containing 4C 0.0189379
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0187737
VMP1 vacuole membrane protein 1 0.0187345
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0187115
FRYL FRY-like 0.0186538
RICTOR RPTOR independent companion of MTOR, complex 2 0.0186118
PTK2 protein tyrosine kinase 2 0.0185284
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0185234
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0184867
NALF1 NALCN channel auxiliary factor 1 0.0184744
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0184123
UBE3A ubiquitin protein ligase E3A 0.0183964
CSRNP3 cysteine-serine-rich nuclear protein 3 0.0183805
ERRFI1 ERBB receptor feedback inhibitor 1 0.0182588
INTS6 integrator complex subunit 6 0.0182374
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0180755
RBM33 RNA binding motif protein 33 0.0180504
SETD2 SET domain containing 2 0.0179508
GSK3B glycogen synthase kinase 3 beta 0.0178961
HELZ helicase with zinc finger 0.01789
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0178201
MTMR3 myotubularin related protein 3 0.0177256
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0175859
PLK2 polo-like kinase 2 0.0175818
MARCHF7 membrane associated ring-CH-type finger 7 0.0173794
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0172681
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0171133

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.321514
TMSB10 thymosin beta 10 -0.179157
PTMA prothymosin, alpha -0.132669
PCLO piccolo presynaptic cytomatrix protein -0.0985161
RPS16 ribosomal protein S16 -0.0944128
RPS8 ribosomal protein S8 -0.0928037
COL11A1 collagen, type XI, alpha 1 -0.0892088
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0812191
TPT1 tumor protein, translationally-controlled 1 -0.0798572
COL1A2 collagen, type I, alpha 2 -0.079843
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0773495
RPS6 ribosomal protein S6 -0.0756606
CADM2 cell adhesion molecule 2 -0.0748998
ITGAV integrin, alpha V -0.0666882
MDK midkine (neurite growth-promoting factor 2) -0.0654622
RPL35A ribosomal protein L35a -0.0624421
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0601689
RPS12 ribosomal protein S12 -0.059809
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0583973
RPLP1 ribosomal protein, large, P1 -0.0570333
GPC3 glypican 3 -0.0554413
RPL23 ribosomal protein L23 -0.0546746
B2M beta-2-microglobulin -0.0522511
ANKRD12 ankyrin repeat domain 12 -0.0520572
GNAS GNAS complex locus -0.0516468
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0514515
PEG10 paternally expressed 10 -0.0512131
COL3A1 collagen, type III, alpha 1 -0.050424
PCDH9 protocadherin 9 -0.0500078
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0491019
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0486885
RPS21 ribosomal protein S21 -0.0485875
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0485107
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0478745
CNRIP1 cannabinoid receptor interacting protein 1 -0.0478697
RPL5 ribosomal protein L5 -0.0477362
ISG15 ISG15 ubiquitin-like modifier -0.0465325
RPL37A ribosomal protein L37a -0.0461888
MYL12B myosin, light chain 12B, regulatory -0.0454761
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0450426
FTL ferritin, light polypeptide -0.0446301
RPS19 ribosomal protein S19 -0.0434187
ENO1 enolase 1, (alpha) -0.0428949
RPL37 ribosomal protein L37 -0.042516
CALR calreticulin -0.0424058
TMSB4X thymosin beta 4, X-linked -0.0418878
RPS3 ribosomal protein S3 -0.0404519
ACTG1 actin gamma 1 -0.0401883
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0398919
RPL11 ribosomal protein L11 -0.0397741
EIF1 eukaryotic translation initiation factor 1 -0.0392794
KCTD16 potassium channel tetramerization domain containing 16 -0.0391385
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0388019
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0379068
WSB1 WD repeat and SOCS box containing 1 -0.0378312
ATP5F1E ATP synthase F1 subunit epsilon -0.0371167
RPS13 ribosomal protein S13 -0.0369857
RPLP0 ribosomal protein, large, P0 -0.0369533
RPL36A ribosomal protein L36a -0.0367571
ATP5F1B ATP synthase F1 subunit beta -0.0366078
ADGRL2 adhesion G protein-coupled receptor L2 -0.0361897
RPL9 ribosomal protein L9 -0.0360406
RPL31 ribosomal protein L31 -0.0359006
RPS27A ribosomal protein S27a -0.0353551
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0350503
RPL26 ribosomal protein L26 -0.0348375
RPL12 ribosomal protein L12 -0.0347427
HMCN1 hemicentin 1 -0.0346861
NACA nascent polypeptide-associated complex alpha subunit -0.0339197
PFN1 profilin 1 -0.0335
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.033327
SNX6 sorting nexin 6 -0.033076
SERF2 small EDRK-rich factor 2 -0.0320061
RPS29 ribosomal protein S29 -0.03174
RPLP2 ribosomal protein, large, P2 -0.0311548
RPL36 ribosomal protein L36 -0.0305026
RPS24 ribosomal protein S24 -0.0303301
LRRC4C leucine rich repeat containing 4C -0.030294
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0301606
H1-0 H1.0 linker histone -0.0298396
RPL34 ribosomal protein L34 -0.0295283
PRELID2 PRELI domain containing 2 -0.0294472
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.029104
FBL fibrillarin -0.0290406
S100A10 S100 calcium binding protein A10 -0.028966
PRRC2C proline-rich coiled-coil 2C -0.0286431
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0286361
RPS14 ribosomal protein S14 -0.0286335
SRRM2 serine/arginine repetitive matrix 2 -0.0283039
SOX2 SRY (sex determining region Y)-box 2 -0.0280598
RPS25 ribosomal protein S25 -0.0278675
IFIH1 interferon induced with helicase C domain 1 -0.0277501
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0270968
POTEF POTE ankyrin domain family, member F -0.0266625
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0265252
CAVIN1 caveolae associated protein 1 -0.0254901
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0250756
SAMD4B sterile alpha motif domain containing 4B -0.0249344
SLIT2 slit homolog 2 (Drosophila) -0.0245307
RPL7 ribosomal protein L7 -0.0244631