Vinblastine (sulfate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.120264
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.105767
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104984
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.104794
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0933908
VCL vinculin 0.0925703
TRIO trio Rho guanine nucleotide exchange factor 0.0910882
FNDC3B fibronectin type III domain containing 3B 0.067537
PDIA3 protein disulfide isomerase family A, member 3 0.0638988
MACF1 microtubule-actin crosslinking factor 1 0.062868
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.060702
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0573771
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0567379
PTK2 protein tyrosine kinase 2 0.0558471
DST dystonin 0.053946
CENPF centromere protein F, 350/400kDa 0.0512906
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0507118
ENO1 enolase 1, (alpha) 0.0492276
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0489945
NUP98 nucleoporin 98kDa 0.0463025
ANKRD11 ankyrin repeat domain 11 0.0451219
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0448772
CANX calnexin 0.0447472
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0438527
AHNAK AHNAK nucleoprotein 0.0426618
HMGA2 high mobility group AT-hook 2 0.0419736
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0402013
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0399778
BZW1 basic leucine zipper and W2 domains 1 0.0393039
MKI67 marker of proliferation Ki-67 0.039168
SMC4 structural maintenance of chromosomes 4 0.0387349
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0378883
TPM3 tropomyosin 3 0.037727
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0376328
SEPTIN7 septin 7 0.0375189
TPX2 TPX2, microtubule-associated 0.0369855
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0368653
EXOC4 exocyst complex component 4 0.0362765
NF1 neurofibromin 1 0.036044
TRIP12 thyroid hormone receptor interactor 12 0.0352681
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0352626
RIGI RNA sensor RIG-I 0.0350228
JMJD1C jumonji domain containing 1C 0.0346845
ZFAND3 zinc finger, AN1-type domain 3 0.0345993
RASAL2 RAS protein activator like 2 0.0343351
RNF220 ring finger protein 220 0.034287
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0341316
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0341289
NAV2 neuron navigator 2 0.0338163
AKAP13 A kinase (PRKA) anchor protein 13 0.0337391
LDHA lactate dehydrogenase A 0.0325562
UBAP2 ubiquitin associated protein 2 0.0324318
RRM2 ribonucleotide reductase M2 0.032353
KIF5B kinesin family member 5B 0.0318542
CSNK1A1 casein kinase 1, alpha 1 0.0316888
ATM ATM serine/threonine kinase 0.0316821
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0316017
FAF1 Fas (TNFRSF6) associated factor 1 0.0312374
TPM1 tropomyosin 1 (alpha) 0.0311553
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0301751
CCDC88A coiled-coil domain containing 88A 0.0301302
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0297287
KPNB1 karyopherin (importin) beta 1 0.0293385
CUX1 cut-like homeobox 1 0.0292518
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0292147
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0292073
SRRM2 serine/arginine repetitive matrix 2 0.0289638
ERBIN erbb2 interacting protein 0.0289108
SLC35F3 solute carrier family 35, member F3 0.0286862
RAD51B RAD51 paralog B 0.0286576
HDAC9 histone deacetylase 9 0.0276129
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0274126
TNS3 tensin 3 0.0267664
MSRB3 methionine sulfoxide reductase B3 0.026704
GOLGB1 golgin B1 0.026639
SIK3 SIK family kinase 3 0.0263114
DIAPH2 diaphanous-related formin 2 0.0260511
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0259729
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0259634
TCF12 transcription factor 12 0.0255491
HYOU1 hypoxia up-regulated 1 0.0254061
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0250772
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.02496
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0247762
PKM pyruvate kinase, muscle 0.0246997
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0245867
HM13 histocompatibility (minor) 13 0.0245628
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0245304
BIRC3 baculoviral IAP repeat containing 3 0.0245079
ZNF644 zinc finger protein 644 0.0244183
SFPQ splicing factor proline/glutamine-rich 0.0238959
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0238222
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0236185
ASXL1 additional sex combs like transcriptional regulator 1 0.0235499
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.023474
PDIA6 protein disulfide isomerase family A, member 6 0.0232615
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0231752
MTDH metadherin 0.0231696
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0230448
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0229904

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.290056
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188061
AKAP12 A kinase (PRKA) anchor protein 12 -0.115404
TMSB10 thymosin beta 10 -0.114477
VIM vimentin -0.0904506
MT2A metallothionein 2A -0.0695127
TM4SF1 transmembrane 4 L six family member 1 -0.061332
RPL35A ribosomal protein L35a -0.0532205
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0525967
ZFP36 ZFP36 ring finger protein -0.0522046
TXNRD1 thioredoxin reductase 1 -0.0508992
RPS24 ribosomal protein S24 -0.044017
RPLP2 ribosomal protein, large, P2 -0.0419333
RPL12 ribosomal protein L12 -0.0385989
S100A6 S100 calcium binding protein A6 -0.0381811
GARS1 glycyl-tRNA synthetase 1 -0.0366479
RPL23 ribosomal protein L23 -0.0363249
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.034084
ACTG1 actin gamma 1 -0.0335415
RPS3 ribosomal protein S3 -0.031925
RPS5 ribosomal protein S5 -0.0317757
RPL28 ribosomal protein L28 -0.0301738
RPL26 ribosomal protein L26 -0.0294292
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0279531
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0277051
ACTN4 actinin, alpha 4 -0.0272448
RPS19 ribosomal protein S19 -0.0264208
FTL ferritin, light polypeptide -0.0257107
RPS21 ribosomal protein S21 -0.0250168
RPL36A ribosomal protein L36a -0.0249921
SBF2 SET binding factor 2 -0.0247494
RPL37A ribosomal protein L37a -0.0241436
RPLP0 ribosomal protein, large, P0 -0.0237233
EIF1 eukaryotic translation initiation factor 1 -0.0231385
RPL31 ribosomal protein L31 -0.0230968
RPS13 ribosomal protein S13 -0.0230462
RPS14 ribosomal protein S14 -0.0229735
FBL fibrillarin -0.0226118
RPL37 ribosomal protein L37 -0.0219289
TUBB tubulin, beta class I -0.0214259
SLC38A2 solute carrier family 38, member 2 -0.0212828
RPL34 ribosomal protein L34 -0.0211423
RPL36 ribosomal protein L36 -0.0211
NDRG1 N-myc downstream regulated 1 -0.0208136
KLF6 Kruppel-like factor 6 -0.0207158
FOSL1 FOS-like antigen 1 -0.0206526
RPL8 ribosomal protein L8 -0.0205599
RPS25 ribosomal protein S25 -0.0204542
RPL21 ribosomal protein L21 -0.020395
RPL9 ribosomal protein L9 -0.0200234
RPS23 ribosomal protein S23 -0.0198517
RPS17 ribosomal protein S17 -0.0197335
YBX3 Y box binding protein 3 -0.0191507
HLA-A major histocompatibility complex, class I, A -0.0191375
RPS12 ribosomal protein S12 -0.0190579
UGCG UDP-glucose ceramide glucosyltransferase -0.0180825
CD44 CD44 molecule (Indian blood group) -0.0175669
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0174729
SAMD4A sterile alpha motif domain containing 4A -0.0174131
HMGA1 high mobility group AT-hook 1 -0.0171881
RPL27A ribosomal protein L27a -0.0169892
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0169677
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0167705
MSMO1 methylsterol monooxygenase 1 -0.0163484
DDIT4 DNA-damage-inducible transcript 4 -0.0163165
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0162906
RPS27 ribosomal protein S27 -0.01613
ICAM1 intercellular adhesion molecule 1 -0.0159598
SOD2 superoxide dismutase 2, mitochondrial -0.0159158
WDR45B WD repeat domain 45B -0.0158928
MYL12B myosin, light chain 12B, regulatory -0.0158425
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.015502
RPL32 ribosomal protein L32 -0.0153891
RPLP1 ribosomal protein, large, P1 -0.0153139
RPL30 ribosomal protein L30 -0.0152884
FLNB filamin B, beta -0.0152312
UBC ubiquitin C -0.0151933
RACK1 receptor for activated C kinase 1 -0.0150375
RPS8 ribosomal protein S8 -0.0148655
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0148178
SFTPA2 surfactant protein A2 -0.0147836
TAPBP TAP binding protein (tapasin) -0.0147246
SNX14 sorting nexin 14 -0.0147167
ARRDC3 arrestin domain containing 3 -0.0147051
ASTN2 astrotactin 2 -0.0144838
TPT1 tumor protein, translationally-controlled 1 -0.0144027
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0143567
CD59 CD59 molecule, complement regulatory protein -0.0143142
PFN1 profilin 1 -0.0142629
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0140562
C15ORF48 chromosome 15 open reading frame 48 -0.014047
S100A9 S100 calcium binding protein A9 -0.013944
TMEM123 transmembrane protein 123 -0.0137767
PTMA prothymosin, alpha -0.0136351
TUBA1B tubulin, alpha 1b -0.0135534
RPL19 ribosomal protein L19 -0.0135472
WASF2 WAS protein family, member 2 -0.0135335
RPS27A ribosomal protein S27a -0.0134359
RPS4X ribosomal protein S4, X-linked -0.0132098
RPL27 ribosomal protein L27 -0.0129465