Vinblastine (sulfate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD6 FERM domain containing 6 0.0956909
INTS6 integrator complex subunit 6 0.0445575
HMGA2 high mobility group AT-hook 2 0.0402992
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0364401
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0322652
SP100 SP100 nuclear antigen 0.0279487
ZC3H12B zinc finger CCCH-type containing 12B 0.0272455
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0268286
GPHN gephyrin 0.0267718
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0251958
RIGI RNA sensor RIG-I 0.0246988
PTPRG protein tyrosine phosphatase, receptor type, G 0.0241093
DLC1 DLC1 Rho GTPase activating protein 0.023941
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235498
RCOR1 REST corepressor 1 0.0226923
NABP1 nucleic acid binding protein 1 0.0221333
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0215081
PRELID2 PRELI domain containing 2 0.0214712
ZEB1 zinc finger E-box binding homeobox 1 0.0207397
STAU2 staufen double-stranded RNA binding protein 2 0.0207195
TTC3 tetratricopeptide repeat domain 3 0.0199408
ASXL1 additional sex combs like transcriptional regulator 1 0.0198335
TTC17 tetratricopeptide repeat domain 17 0.0197717
WNT2B wingless-type MMTV integration site family, member 2B 0.0191672
SCFD1 sec1 family domain containing 1 0.0184338
PUM1 pumilio RNA-binding family member 1 0.0179667
GPATCH2L G patch domain containing 2-like 0.0178261
GDI2 GDP dissociation inhibitor 2 0.0176714
SETX senataxin 0.0174446
KMT2E lysine (K)-specific methyltransferase 2E 0.0172216
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0171069
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0170874
AKAP9 A kinase (PRKA) anchor protein 9 0.0170252
SAMD4A sterile alpha motif domain containing 4A 0.0158758
IFI6 interferon, alpha-inducible protein 6 0.0154519
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0153072
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0149422
STK4 serine/threonine kinase 4 0.0147909
SPIDR scaffolding protein involved in DNA repair 0.0146284
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0145326
RABGAP1L RAB GTPase activating protein 1-like 0.014512
ARL15 ADP-ribosylation factor-like 15 0.0145061
DDR2 discoidin domain receptor tyrosine kinase 2 0.0144807
EHBP1 EH domain binding protein 1 0.0144295
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0143458
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0143333
CAMKMT calmodulin-lysine N-methyltransferase 0.0142125
BPTF bromodomain PHD finger transcription factor 0.0141396
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0140644
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0140522
UTRN utrophin 0.0140413
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0139884
GPR75-ASB3 GPR75-ASB3 readthrough 0.0137712
AEBP2 AE binding protein 2 0.0137245
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0137123
GOLGB1 golgin B1 0.0135126
LOC102724023 ES1 protein homolog, mitochondrial 0.0131462
UBAP2 ubiquitin associated protein 2 0.0131014
AHI1 Abelson helper integration site 1 0.0130495
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0130392
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.013035
ANKRD17 ankyrin repeat domain 17 0.0129387
R3HDM1 R3H domain containing 1 0.0128111
COPA coatomer protein complex, subunit alpha 0.0126931
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0125268
MX1 MX dynamin-like GTPase 1 0.0124446
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0124271
CCDC18 coiled-coil domain containing 18 0.0123271
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.012277
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0122021
FNDC3B fibronectin type III domain containing 3B 0.0120887
PIBF1 progesterone immunomodulatory binding factor 1 0.0119768
AHCYL2 adenosylhomocysteinase-like 2 0.0119705
METTL15 methyltransferase like 15 0.0119613
AGO3 argonaute RISC catalytic component 3 0.0119355
VCL vinculin 0.0118896
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0118408
SEC31A SEC31 homolog A (S. cerevisiae) 0.011807
ADIPOR2 adiponectin receptor 2 0.0117951
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0117578
PAXBP1 PAX3 and PAX7 binding protein 1 0.0116202
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0114533
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0114076
EXOC4 exocyst complex component 4 0.0113109
AKAP13 A kinase (PRKA) anchor protein 13 0.0112797
SPDYA speedy/RINGO cell cycle regulator family member A 0.0112041
PHF3 PHD finger protein 3 0.0110936
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0109835
LRMDA leucine rich melanocyte differentiation associated 0.0109483
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0109474
NCAPG2 non-SMC condensin II complex, subunit G2 0.0109375
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0109285
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0108056
MIS18BP1 MIS18 binding protein 1 0.0107902
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0107437
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.010702
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0106781
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 0.0106207
RAD51B RAD51 paralog B 0.0106065
BCAS3 breast carcinoma amplified sequence 3 0.0105845

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.114797
RPS6 ribosomal protein S6 -0.107812
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0964506
ACTG1 actin gamma 1 -0.0933048
RPL35A ribosomal protein L35a -0.086476
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0842224
LAMB3 laminin, beta 3 -0.0828751
EEF2 eukaryotic translation elongation factor 2 -0.0780306
RPL8 ribosomal protein L8 -0.0695941
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0639333
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -0.0628532
NAV3 neuron navigator 3 -0.0623117
CREB5 cAMP responsive element binding protein 5 -0.0613111
TPM4 tropomyosin 4 -0.0580261
RPL23 ribosomal protein L23 -0.0558194
RPLP1 ribosomal protein, large, P1 -0.0522438
FLNB filamin B, beta -0.0510496
STC1 stanniocalcin 1 -0.0509433
TXNRD1 thioredoxin reductase 1 -0.0506653
GARS1 glycyl-tRNA synthetase 1 -0.0506561
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.049822
RPL12 ribosomal protein L12 -0.0494746
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0493964
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0492354
FRMD4A FERM domain containing 4A -0.0483744
TPT1 tumor protein, translationally-controlled 1 -0.0480898
RPL35 ribosomal protein L35 -0.047782
TMSB10 thymosin beta 10 -0.0470422
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0463831
RPL26 ribosomal protein L26 -0.0438902
RPS19 ribosomal protein S19 -0.0436065
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0424296
ZNF438 zinc finger protein 438 -0.0420369
AHNAK AHNAK nucleoprotein -0.0402335
POTEF POTE ankyrin domain family, member F -0.0399623
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0397688
RPL19 ribosomal protein L19 -0.0393586
RPS21 ribosomal protein S21 -0.0390368
TRIO trio Rho guanine nucleotide exchange factor -0.0387227
S100A6 S100 calcium binding protein A6 -0.0387089
RPS8 ribosomal protein S8 -0.0383147
MT2A metallothionein 2A -0.0371906
ENO1 enolase 1, (alpha) -0.0365148
RPS12 ribosomal protein S12 -0.0363955
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0363168
GOLGA4 golgin A4 -0.0352093
MYH9 myosin, heavy chain 9, non-muscle -0.0351231
KPNB1 karyopherin (importin) beta 1 -0.0346626
RACK1 receptor for activated C kinase 1 -0.034625
RPL36 ribosomal protein L36 -0.0345835
SHANK1 SH3 and multiple ankyrin repeat domains 1 -0.0344019
TTR transthyretin -0.034074
RPLP2 ribosomal protein, large, P2 -0.0337332
RPL7 ribosomal protein L7 -0.0335718
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0323185
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0321991
PALM2AKAP2 PALM2 and AKAP2 fusion -0.031858
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0318391
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0314337
SRRM2 serine/arginine repetitive matrix 2 -0.0310075
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0309338
RPL3 ribosomal protein L3 -0.0302741
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.029732
CAPN2 calpain 2, (m/II) large subunit -0.0293835
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.029213
RPS3 ribosomal protein S3 -0.0291939
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0291901
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0291059
SBF2 SET binding factor 2 -0.0289592
FTL ferritin, light polypeptide -0.0288356
HSPA8 heat shock 70kDa protein 8 -0.0287233
RPL34 ribosomal protein L34 -0.0286508
CD44 CD44 molecule (Indian blood group) -0.0285823
RTN4 reticulon 4 -0.0284192
TUBB4B tubulin, beta 4B class IVb -0.0277601
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0274096
RPL30 ribosomal protein L30 -0.0269347
ZBTB20 zinc finger and BTB domain containing 20 -0.0268592
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0263992
PGK1 phosphoglycerate kinase 1 -0.0263032
PFN1 profilin 1 -0.0262504
TOX4 TOX high mobility group box family member 4 -0.0259816
CELF1 CUGBP, Elav-like family member 1 -0.0257149
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.025478
ADAM9 ADAM metallopeptidase domain 9 -0.0253477
RPL7A ribosomal protein L7a -0.0252926
RPL31 ribosomal protein L31 -0.0252732
PFDN2 prefoldin subunit 2 -0.0249232
RPL32 ribosomal protein L32 -0.0248213
RB1CC1 RB1-inducible coiled-coil 1 -0.0246457
EIF1 eukaryotic translation initiation factor 1 -0.0245769
CD274 CD274 molecule -0.0244777
LIMA1 LIM domain and actin binding 1 -0.0244593
ARHGAP22 Rho GTPase activating protein 22 -0.0244524
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0244501
MTDH metadherin -0.0241365
NUDC nudC nuclear distribution protein -0.0240306
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0237519
LPP LIM domain containing preferred translocation partner in lipoma -0.023634
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.023557