Vinblastine (sulfate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CREB5 cAMP responsive element binding protein 5 0.101027
SPTBN1 spectrin, beta, non-erythrocytic 1 0.072861
PDE10A phosphodiesterase 10A 0.0609871
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0442591
DTNA dystrobrevin, alpha 0.0410485
MAST4 microtubule associated serine/threonine kinase family member 4 0.0410223
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0395913
TXNRD1 thioredoxin reductase 1 0.0367179
RHOQ ras homolog family member Q 0.0359059
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.035412
ELL2 elongation factor, RNA polymerase II, 2 0.0344144
PDE4B phosphodiesterase 4B, cAMP-specific 0.0343545
SNAP25 synaptosomal-associated protein, 25kDa 0.0342651
MAP7 microtubule-associated protein 7 0.0328593
SDK1 sidekick cell adhesion molecule 1 0.0328367
IGF1R insulin-like growth factor 1 receptor 0.0328342
SASH1 SAM and SH3 domain containing 1 0.0323787
COL22A1 collagen, type XXII, alpha 1 0.0322364
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0312604
VGF VGF nerve growth factor inducible 0.0302291
SMOC1 SPARC related modular calcium binding 1 0.0291988
EXT1 exostosin glycosyltransferase 1 0.0282015
EML6 echinoderm microtubule associated protein like 6 0.0279101
AKAP12 A kinase (PRKA) anchor protein 12 0.0266758
SLC44A5 solute carrier family 44, member 5 0.0261329
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.025647
GRB10 growth factor receptor-bound protein 10 0.0246881
AOPEP aminopeptidase O (putative) 0.0246761
PEG10 paternally expressed 10 0.0243042
ERRFI1 ERBB receptor feedback inhibitor 1 0.0237597
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0230654
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.0229606
PCM1 pericentriolar material 1 0.022678
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0217017
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0215414
PSD3 pleckstrin and Sec7 domain containing 3 0.021049
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0209957
MYH9 myosin, heavy chain 9, non-muscle 0.0208985
ASPH aspartate beta-hydroxylase 0.0208312
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.02066
PDE4D phosphodiesterase 4D, cAMP-specific 0.0203231
MACF1 microtubule-actin crosslinking factor 1 0.0202244
NCAM1 neural cell adhesion molecule 1 0.0200511
GOLM1 golgi membrane protein 1 0.0196494
RFX7 regulatory factor X, 7 0.0196062
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0194848
SUMF1 sulfatase modifying factor 1 0.0194542
SOX11 SRY (sex determining region Y)-box 11 0.0192363
ZNF407 zinc finger protein 407 0.0187016
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0186738
SINHCAF SIN3-HDAC complex associated factor 0.0183695
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.018302
PIAS2 protein inhibitor of activated STAT, 2 0.0180315
RUNX1 runt-related transcription factor 1 0.0179874
HLTF helicase-like transcription factor 0.0179499
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0178244
ARHGAP21 Rho GTPase activating protein 21 0.0174291
MYO1B myosin IB 0.0166837
DST dystonin 0.0163387
NCOR1 nuclear receptor corepressor 1 0.0158379
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0156167
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0153355
FMNL2 formin-like 2 0.015335
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0152205
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0150583
TARS1 threonyl-tRNA synthetase 1 0.0149712
ATAD2B ATPase family, AAA domain containing 2B 0.0149614
CNBD1 cyclic nucleotide binding domain containing 1 0.0148889
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0148575
ARHGAP5 Rho GTPase activating protein 5 0.0146509
EXOC2 exocyst complex component 2 0.0145753
ARHGAP26 Rho GTPase activating protein 26 0.014573
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0144895
MCM8 minichromosome maintenance complex component 8 0.0144191
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143028
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0142817
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0141815
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0141084
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0140686
SCAF11 SR-related CTD-associated factor 11 0.0138476
SLK STE20-like kinase 0.0136196
TIMP2 TIMP metallopeptidase inhibitor 2 0.0135773
UBAC2 UBA domain containing 2 0.0134268
FBXL4 F-box and leucine-rich repeat protein 4 0.0133089
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.0131381
MDN1 MDN1, midasin homolog (yeast) 0.0131346
HP1BP3 heterochromatin protein 1, binding protein 3 0.0130318
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0129703
TBC1D5 TBC1 domain family, member 5 0.0129373
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0128315
ATXN10 ataxin 10 0.012812
RPTOR regulatory associated protein of MTOR, complex 1 0.0127265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0127042
NIN ninein (GSK3B interacting protein) 0.0126599
DOCK3 dedicator of cytokinesis 3 0.0125764
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0125442
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0124584
LTBP1 latent transforming growth factor beta binding protein 1 0.0124011
METAP2 methionyl aminopeptidase 2 0.0122146
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0121228

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.101436
NALF1 NALCN channel auxiliary factor 1 -0.0986816
ENO1 enolase 1, (alpha) -0.0967639
GPC6 glypican 6 -0.094047
MCL1 myeloid cell leukemia 1 -0.0826222
RPS3 ribosomal protein S3 -0.0811725
MT2A metallothionein 2A -0.0791005
RORA RAR-related orphan receptor A -0.0737553
RPL37A ribosomal protein L37a -0.0708664
NDRG1 N-myc downstream regulated 1 -0.0707122
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0684452
RPS27A ribosomal protein S27a -0.0666411
ACTG1 actin gamma 1 -0.0654069
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0630313
RPS25 ribosomal protein S25 -0.0592269
RPL26 ribosomal protein L26 -0.0581813
RPL37 ribosomal protein L37 -0.056997
RPL23 ribosomal protein L23 -0.0567202
MCTP1 multiple C2 domains, transmembrane 1 -0.0546714
CALCA calcitonin-related polypeptide alpha -0.0540765
LOC112694756 uncharaterized LOC112694756 -0.050318
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0501318
UBC ubiquitin C -0.0491878
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0487655
TPT1 tumor protein, translationally-controlled 1 -0.0485441
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0482958
NRG1 neuregulin 1 -0.0477873
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0473853
RPL31 ribosomal protein L31 -0.0472297
RIMS2 regulating synaptic membrane exocytosis 2 -0.0467265
SNTG1 syntrophin, gamma 1 -0.0460282
EEF2 eukaryotic translation elongation factor 2 -0.0453066
PTCHD4 patched domain containing 4 -0.0450936
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.044815
RPS8 ribosomal protein S8 -0.0435974
IFI6 interferon, alpha-inducible protein 6 -0.0430883
GPC5 glypican 5 -0.042481
KIF26B kinesin family member 26B -0.040898
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0407887
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0406132
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0400365
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0398742
RPL8 ribosomal protein L8 -0.0397677
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0383221
RPS12 ribosomal protein S12 -0.0378067
IGFBP5 insulin-like growth factor binding protein 5 -0.0375571
RPS16 ribosomal protein S16 -0.0369691
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0366543
KTN1 kinectin 1 (kinesin receptor) -0.0365589
RPS17 ribosomal protein S17 -0.035833
ESRRG estrogen-related receptor gamma -0.0350251
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0346559
HOMER1 homer scaffolding protein 1 -0.0338838
RPS21 ribosomal protein S21 -0.0337995
DENND4A DENN/MADD domain containing 4A -0.0336087
TSHZ2 teashirt zinc finger homeobox 2 -0.0333018
RPL11 ribosomal protein L11 -0.0332096
RPS27 ribosomal protein S27 -0.0331614
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0331509
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0331138
RPS5 ribosomal protein S5 -0.0329736
RPL36 ribosomal protein L36 -0.0329468
EGR1 early growth response 1 -0.0326102
KLHL29 kelch-like family member 29 -0.032589
RPL30 ribosomal protein L30 -0.0323392
TMSB10 thymosin beta 10 -0.0321611
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0319643
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0318757
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0312012
ATP5F1E ATP synthase F1 subunit epsilon -0.031129
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0309529
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0309177
SMYD3 SET and MYND domain containing 3 -0.0304147
RPLP1 ribosomal protein, large, P1 -0.0303048
PDIA6 protein disulfide isomerase family A, member 6 -0.0301801
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0300613
NAP1L1 nucleosome assembly protein 1-like 1 -0.0300612
CPE carboxypeptidase E -0.0294344
CNTNAP2 contactin associated protein-like 2 -0.0286635
CALR calreticulin -0.0285076
RACK1 receptor for activated C kinase 1 -0.0281017
B2M beta-2-microglobulin -0.0280126
RPS14 ribosomal protein S14 -0.0279759
RPS6 ribosomal protein S6 -0.027926
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0278542
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0274739
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.0273585
APP amyloid beta (A4) precursor protein -0.0269128
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0261057
LDHA lactate dehydrogenase A -0.025876
RPS13 ribosomal protein S13 -0.0255728
NAV1 neuron navigator 1 -0.0251709
RPL28 ribosomal protein L28 -0.0249888
CSNK1A1 casein kinase 1, alpha 1 -0.0248502
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0247962
FTL ferritin, light polypeptide -0.0246558
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0246151
EEF1G eukaryotic translation elongation factor 1 gamma -0.0245556
RPL19 ribosomal protein L19 -0.024324
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -0.0242748