Vinblastine (sulfate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0771004
ZEB1 zinc finger E-box binding homeobox 1 0.0724775
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0667126
QKI QKI, KH domain containing, RNA binding 0.0594854
ECT2 epithelial cell transforming 2 0.0578421
ZNF292 zinc finger protein 292 0.0571609
EML4 echinoderm microtubule associated protein like 4 0.057088
SSBP2 single-stranded DNA binding protein 2 0.0563932
KMT2E lysine (K)-specific methyltransferase 2E 0.055286
RBM39 RNA binding motif protein 39 0.0501779
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0433798
NAMPT nicotinamide phosphoribosyltransferase 0.0423447
WAC WW domain containing adaptor with coiled-coil 0.0406605
ADAM9 ADAM metallopeptidase domain 9 0.0393419
ZFAND3 zinc finger, AN1-type domain 3 0.039133
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0386207
CCNL1 cyclin L1 0.0385555
DSCAM Down syndrome cell adhesion molecule 0.038159
TSC22D2 TSC22 domain family, member 2 0.0378047
KDM3A lysine (K)-specific demethylase 3A 0.0376626
CDC73 cell division cycle 73 0.0371032
RTN4 reticulon 4 0.0362704
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0344286
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0343698
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0341706
WDR43 WD repeat domain 43 0.0333048
CRY1 cryptochrome circadian clock 1 0.0330884
PICALM phosphatidylinositol binding clathrin assembly protein 0.0323131
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0322556
TFG TRK-fused gene 0.0321747
NUP58 nucleoporin 58 0.0319741
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0317803
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0317091
IARS1 isoleucyl-tRNA synthetase 1 0.0310831
COPA coatomer protein complex, subunit alpha 0.0307886
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0307876
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0307197
GARS1 glycyl-tRNA synthetase 1 0.0300556
KDM6A lysine (K)-specific demethylase 6A 0.0298673
CAMTA1 calmodulin binding transcription activator 1 0.0294587
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0288963
ARID1A AT rich interactive domain 1A (SWI-like) 0.0285347
YAP1 Yes-associated protein 1 0.0284911
ELOVL5 ELOVL fatty acid elongase 5 0.0279975
PUM2 pumilio RNA-binding family member 2 0.0277016
TRIO trio Rho guanine nucleotide exchange factor 0.0274276
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0273148
RYBP RING1 and YY1 binding protein 0.0269862
CORO1C coronin, actin binding protein, 1C 0.0266747
NCKAP1 NCK-associated protein 1 0.0264796
CNOT1 CCR4-NOT transcription complex, subunit 1 0.026464
RNF145 ring finger protein 145 0.0264253
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0263964
MYOF myoferlin 0.0263022
ZSWIM6 zinc finger, SWIM-type containing 6 0.0261062
GLS2 glutaminase 2 (liver, mitochondrial) 0.0258618
PTBP2 polypyrimidine tract binding protein 2 0.0255773
POU2F1 POU class 2 homeobox 1 0.0255725
CYTH3 cytohesin 3 0.0254605
NCEH1 neutral cholesterol ester hydrolase 1 0.0251753
MEF2A myocyte enhancer factor 2A 0.0251546
ZNF207 zinc finger protein 207 0.0249206
FBXO11 F-box protein 11 0.0248178
USP24 ubiquitin specific peptidase 24 0.0247692
SPRED2 sprouty-related, EVH1 domain containing 2 0.0243661
EPS8 epidermal growth factor receptor pathway substrate 8 0.0242288
HELZ helicase with zinc finger 0.0241312
ZNF644 zinc finger protein 644 0.0238887
ATOSA atos homolog A 0.0237363
GSK3B glycogen synthase kinase 3 beta 0.0236486
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0236433
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0232595
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0231562
JMJD1C jumonji domain containing 1C 0.0229268
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0227767
RAB1A RAB1A, member RAS oncogene family 0.0227676
SAMD4A sterile alpha motif domain containing 4A 0.0226738
PDS5B PDS5 cohesin associated factor B 0.0225957
NBAS neuroblastoma amplified sequence 0.0225529
USP3 ubiquitin specific peptidase 3 0.0223927
TENT2 terminal nucleotidyltransferase 2 0.0223591
ASXL1 additional sex combs like transcriptional regulator 1 0.0221139
SPAG9 sperm associated antigen 9 0.0220823
PUM1 pumilio RNA-binding family member 1 0.0220148
NCOA3 nuclear receptor coactivator 3 0.0216797
RHEB Ras homolog enriched in brain 0.0216753
RAB18 RAB18, member RAS oncogene family 0.0214684
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0212879
FXR1 fragile X mental retardation, autosomal homolog 1 0.0211027
ZCCHC8 zinc finger, CCHC domain containing 8 0.0209837
MED13L mediator complex subunit 13-like 0.0209351
MATR3 matrin 3 0.0208598
SEC23A Sec23 homolog A (S. cerevisiae) 0.0208302
HBS1L HBS1-like translational GTPase 0.0208286
ANKRD11 ankyrin repeat domain 11 0.0208235
CHD1 chromodomain helicase DNA binding protein 1 0.0205845
GATA6 GATA binding protein 6 0.0204521
FNIP1 folliculin interacting protein 1 0.0204504
TLK2 tousled-like kinase 2 0.0204132
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0203944

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.375113
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.248293
RPS6 ribosomal protein S6 -0.125819
TPT1 tumor protein, translationally-controlled 1 -0.125032
RPS8 ribosomal protein S8 -0.106743
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0899775
RPL35A ribosomal protein L35a -0.0887259
ACTG1 actin gamma 1 -0.0849716
RPLP1 ribosomal protein, large, P1 -0.0757204
RPL12 ribosomal protein L12 -0.0755282
RPL37A ribosomal protein L37a -0.0726728
FOXP1 forkhead box P1 -0.072638
BMP10 bone morphogenetic protein 10 -0.0714268
S100A6 S100 calcium binding protein A6 -0.0695764
PDE4B phosphodiesterase 4B, cAMP-specific -0.0693986
RPL31 ribosomal protein L31 -0.0683379
PKM pyruvate kinase, muscle -0.0665549
RPLP2 ribosomal protein, large, P2 -0.0665377
TMSB4X thymosin beta 4, X-linked -0.0663321
ENO1 enolase 1, (alpha) -0.0652612
RPS19 ribosomal protein S19 -0.0644817
RPL34 ribosomal protein L34 -0.0629611
ARL4C ADP-ribosylation factor-like 4C -0.0619901
RPL26 ribosomal protein L26 -0.0608983
RPL11 ribosomal protein L11 -0.0607921
RPS3 ribosomal protein S3 -0.0602336
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0580501
RPS13 ribosomal protein S13 -0.0573242
NBEA neurobeachin -0.0547702
CCND1 cyclin D1 -0.0542494
RPS12 ribosomal protein S12 -0.0538253
RPLP0 ribosomal protein, large, P0 -0.0527142
RPL7A ribosomal protein L7a -0.0520733
MYL12B myosin, light chain 12B, regulatory -0.052058
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0519016
AHNAK AHNAK nucleoprotein -0.0502861
RPS23 ribosomal protein S23 -0.049292
S100A4 S100 calcium binding protein A4 -0.0478489
EIF1 eukaryotic translation initiation factor 1 -0.0478018
RPS27A ribosomal protein S27a -0.0477055
RPL19 ribosomal protein L19 -0.0474901
RPL9 ribosomal protein L9 -0.0474434
RPL23 ribosomal protein L23 -0.0471009
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0464839
RPL36 ribosomal protein L36 -0.0459065
RPL13A ribosomal protein L13a -0.0458006
LDHA lactate dehydrogenase A -0.0450923
VCL vinculin -0.043599
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0427961
RPS29 ribosomal protein S29 -0.042025
TXNRD1 thioredoxin reductase 1 -0.0411632
PDE4D phosphodiesterase 4D, cAMP-specific -0.0410321
KPNB1 karyopherin (importin) beta 1 -0.0408859
RPS25 ribosomal protein S25 -0.0400574
RPS27 ribosomal protein S27 -0.0384831
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0381861
S100A9 S100 calcium binding protein A9 -0.0381639
RPL37 ribosomal protein L37 -0.0374915
STAT1 signal transducer and activator of transcription 1, 91kDa -0.037148
PFN1 profilin 1 -0.0361048
HSPB1 heat shock 27kDa protein 1 -0.0360763
RPS16 ribosomal protein S16 -0.0356644
SBF2 SET binding factor 2 -0.0353199
RPL32 ribosomal protein L32 -0.0346557
RPS21 ribosomal protein S21 -0.0341582
TPM4 tropomyosin 4 -0.0337821
RACK1 receptor for activated C kinase 1 -0.0337236
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0335698
TMSB10 thymosin beta 10 -0.0334458
RPL27A ribosomal protein L27a -0.0328447
PRDX2 peroxiredoxin 2 -0.032733
RPL36A ribosomal protein L36a -0.0321618
MKI67 marker of proliferation Ki-67 -0.0319813
CENPF centromere protein F, 350/400kDa -0.0318932
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.031681
RPS24 ribosomal protein S24 -0.0316767
RPS11 ribosomal protein S11 -0.0315412
RPS15 ribosomal protein S15 -0.0314907
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0314097
S100A10 S100 calcium binding protein A10 -0.0311256
RPL10A ribosomal protein L10a -0.0310416
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0307629
RPL30 ribosomal protein L30 -0.0306882
RPL8 ribosomal protein L8 -0.0305697
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0299791
RPS14 ribosomal protein S14 -0.0299648
RPS17 ribosomal protein S17 -0.0297037
LOC112694756 uncharaterized LOC112694756 -0.0295797
EBNA1BP2 EBNA1 binding protein 2 -0.0295215
RPL7 ribosomal protein L7 -0.0293867
MT2A metallothionein 2A -0.0291839
EMP3 epithelial membrane protein 3 -0.0282453
RPL35 ribosomal protein L35 -0.0280954
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0278209
CUX1 cut-like homeobox 1 -0.0278171
NPAS2 neuronal PAS domain protein 2 -0.0277977
GPHN gephyrin -0.0276225
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0273582
SMYD3 SET and MYND domain containing 3 -0.0271062
DUSP4 dual specificity phosphatase 4 -0.0266615