Vinblastine (sulfate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.17724
SOD2 superoxide dismutase 2, mitochondrial 0.17648
TRIO trio Rho guanine nucleotide exchange factor 0.123798
VCL vinculin 0.118459
HDAC9 histone deacetylase 9 0.113953
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.113141
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.10502
VCAN versican 0.0902169
MYH9 myosin, heavy chain 9, non-muscle 0.0856513
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0768795
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0648602
DST dystonin 0.0620218
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0591297
PLIN2 perilipin 2 0.0585589
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0580796
HMGA2 high mobility group AT-hook 2 0.0570898
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0568522
B2M beta-2-microglobulin 0.0567128
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.056455
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0527518
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0519757
VEGFA vascular endothelial growth factor A 0.0504914
LAMP2 lysosomal-associated membrane protein 2 0.048765
LDHA lactate dehydrogenase A 0.0483673
ZSWIM6 zinc finger, SWIM-type containing 6 0.0473867
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0473042
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0471364
PDIA3 protein disulfide isomerase family A, member 3 0.045778
FNDC3B fibronectin type III domain containing 3B 0.0457743
APLP2 amyloid beta (A4) precursor-like protein 2 0.0442795
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0427986
RIGI RNA sensor RIG-I 0.0422911
CALR calreticulin 0.041647
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0405912
WWOX WW domain containing oxidoreductase 0.0402014
GPC6 glypican 6 0.0398756
MSN moesin 0.0395384
OPTN optineurin 0.039043
ENO1 enolase 1, (alpha) 0.0384917
BICC1 BicC family RNA binding protein 1 0.0381397
AKAP9 A kinase (PRKA) anchor protein 9 0.0379988
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0379598
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0371345
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0368285
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0360561
VMP1 vacuole membrane protein 1 0.0360419
RAD51B RAD51 paralog B 0.0353731
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.035132
PALLD palladin, cytoskeletal associated protein 0.0346563
TENT5A terminal nucleotidyltransferase 5A 0.0336791
SAMD9 sterile alpha motif domain containing 9 0.0336315
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0330925
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0330472
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0329031
SFTPA2 surfactant protein A2 0.0322139
ATXN1 ataxin 1 0.032082
IFI6 interferon, alpha-inducible protein 6 0.0317991
MX1 MX dynamin-like GTPase 1 0.0316653
MACF1 microtubule-actin crosslinking factor 1 0.0307452
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0304978
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0304193
PKM pyruvate kinase, muscle 0.0303975
PCBP2 poly(rC) binding protein 2 0.0300354
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0297021
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0292293
FBXL7 F-box and leucine-rich repeat protein 7 0.0290046
FHIT fragile histidine triad 0.0285796
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0281678
SVIL supervillin 0.0279263
PDIA6 protein disulfide isomerase family A, member 6 0.0278175
TRIP12 thyroid hormone receptor interactor 12 0.0277219
GOLGB1 golgin B1 0.027393
INTS6 integrator complex subunit 6 0.0264384
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0260752
IGFBP7 insulin-like growth factor binding protein 7 0.0256424
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0254257
PRELID2 PRELI domain containing 2 0.0249462
FNIP1 folliculin interacting protein 1 0.024547
TIMP2 TIMP metallopeptidase inhibitor 2 0.0244625
PDLIM5 PDZ and LIM domain 5 0.0244208
SFRP1 secreted frizzled-related protein 1 0.0243143
PMP22 peripheral myelin protein 22 0.024267
AUTS2 autism susceptibility candidate 2 0.0239032
SOX5 SRY (sex determining region Y)-box 5 0.0237992
SETX senataxin 0.0234144
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.023346
TGFBI transforming growth factor, beta-induced, 68kDa 0.023183
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0231568
TNIP1 TNFAIP3 interacting protein 1 0.0231531
COL1A2 collagen, type I, alpha 2 0.0230218
NAV1 neuron navigator 1 0.0228941
COL8A1 collagen, type VIII, alpha 1 0.0227805
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0227472
HELZ helicase with zinc finger 0.0226552
C6ORF62 chromosome 6 open reading frame 62 0.0222142
SP100 SP100 nuclear antigen 0.0220459
SQSTM1 sequestosome 1 0.022029
JMJD1C jumonji domain containing 1C 0.0218196
BBS9 Bardet-Biedl syndrome 9 0.0216203
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0215727

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.177079
VIM vimentin -0.161122
TPT1 tumor protein, translationally-controlled 1 -0.154757
TMSB10 thymosin beta 10 -0.134389
MT2A metallothionein 2A -0.131602
NAMPT nicotinamide phosphoribosyltransferase -0.114265
NDRG1 N-myc downstream regulated 1 -0.0884903
UGCG UDP-glucose ceramide glucosyltransferase -0.0774778
NAP1L1 nucleosome assembly protein 1-like 1 -0.0680674
PTMA prothymosin, alpha -0.0654809
RPS24 ribosomal protein S24 -0.0652451
RPS3 ribosomal protein S3 -0.063251
PGK1 phosphoglycerate kinase 1 -0.0611684
RPL35A ribosomal protein L35a -0.0598669
WSB1 WD repeat and SOCS box containing 1 -0.0578378
GNAS GNAS complex locus -0.0550905
ZMYND8 zinc finger, MYND-type containing 8 -0.0546947
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0538141
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0535319
IER3 immediate early response 3 -0.0535115
KDM3A lysine (K)-specific demethylase 3A -0.0534007
HLA-B major histocompatibility complex, class I, B -0.0529411
ADM adrenomedullin -0.0523089
ELL2 elongation factor, RNA polymerase II, 2 -0.0510418
BTG1 B-cell translocation gene 1, anti-proliferative -0.0499028
RPL26 ribosomal protein L26 -0.0484808
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0477438
ACTG1 actin gamma 1 -0.0465869
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0462667
RPL9 ribosomal protein L9 -0.0450262
RPL36A ribosomal protein L36a -0.0444856
SLC38A1 solute carrier family 38, member 1 -0.0435039
RPL23 ribosomal protein L23 -0.0426311
RPS8 ribosomal protein S8 -0.0420902
RPS19 ribosomal protein S19 -0.0409661
RPS21 ribosomal protein S21 -0.0407821
RAI1 retinoic acid induced 1 -0.0405222
KLF6 Kruppel-like factor 6 -0.039645
RPL12 ribosomal protein L12 -0.0396058
RPL37A ribosomal protein L37a -0.0394156
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0393497
RPL11 ribosomal protein L11 -0.0389221
BASP1 brain abundant, membrane attached signal protein 1 -0.0388396
RPS6 ribosomal protein S6 -0.0386645
RPLP1 ribosomal protein, large, P1 -0.0384858
IGFBP3 insulin-like growth factor binding protein 3 -0.0381763
RPS4X ribosomal protein S4, X-linked -0.0380365
CAVIN1 caveolae associated protein 1 -0.0377159
KPNB1 karyopherin (importin) beta 1 -0.0375927
EIF1 eukaryotic translation initiation factor 1 -0.0375004
MT1X metallothionein 1X -0.036922
NT5C2 5'-nucleotidase, cytosolic II -0.0364236
NPEPPS aminopeptidase puromycin sensitive -0.0356197
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0355904
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0354347
WDFY1 WD repeat and FYVE domain containing 1 -0.0353454
RACK1 receptor for activated C kinase 1 -0.0346315
RPS27A ribosomal protein S27a -0.0344587
RPL31 ribosomal protein L31 -0.0338035
ATP13A3 ATPase type 13A3 -0.0335124
RPLP2 ribosomal protein, large, P2 -0.0334925
FTL ferritin, light polypeptide -0.0331556
MXI1 MAX interactor 1, dimerization protein -0.032881
RPS23 ribosomal protein S23 -0.0327167
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0323147
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0322812
EGFR epidermal growth factor receptor -0.0321163
RPL38 ribosomal protein L38 -0.031717
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0315087
RTN4 reticulon 4 -0.0314626
RPL37 ribosomal protein L37 -0.0310163
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0303963
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.030318
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0287009
DEK DEK proto-oncogene -0.0286396
RPS13 ribosomal protein S13 -0.0285556
RPL32 ribosomal protein L32 -0.0278656
SDC4 syndecan 4 -0.0278624
SNX14 sorting nexin 14 -0.0271788
RPL5 ribosomal protein L5 -0.0270576
YBX3 Y box binding protein 3 -0.0270071
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0267361
ANLN anillin, actin binding protein -0.0266889
CADM1 cell adhesion molecule 1 -0.0265422
RPL27A ribosomal protein L27a -0.0265376
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0262435
RPL35 ribosomal protein L35 -0.0262353
RPL19 ribosomal protein L19 -0.0261014
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0260451
RPL30 ribosomal protein L30 -0.0257902
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0256954
TPM4 tropomyosin 4 -0.0254234
RPL36 ribosomal protein L36 -0.025339
PTPRF protein tyrosine phosphatase, receptor type, F -0.0251508
LMNA lamin A/C -0.0250072
WDR45B WD repeat domain 45B -0.0248533
RPL34 ribosomal protein L34 -0.0246397
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.024602
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0245161
RPS12 ribosomal protein S12 -0.0244846