Vinblastine (sulfate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.0869463
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0607125
NRXN3 neurexin 3 0.0583433
VEGFC vascular endothelial growth factor C 0.0410005
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.040352
KYNU kynureninase 0.0363399
COL6A3 collagen, type VI, alpha 3 0.0335278
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0294911
VCL vinculin 0.0286059
HIP1 huntingtin interacting protein 1 0.0283014
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.028211
DIAPH3 diaphanous-related formin 3 0.0269983
MKI67 marker of proliferation Ki-67 0.0268486
AHR aryl hydrocarbon receptor 0.0259228
RUNX1 runt-related transcription factor 1 0.0250036
PTPRK protein tyrosine phosphatase, receptor type, K 0.0244673
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.024299
MBNL2 muscleblind-like splicing regulator 2 0.0242772
FNIP1 folliculin interacting protein 1 0.022116
TTC3 tetratricopeptide repeat domain 3 0.021826
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0216749
PICALM phosphatidylinositol binding clathrin assembly protein 0.0212438
CSNK1A1 casein kinase 1, alpha 1 0.0212143
ARHGAP24 Rho GTPase activating protein 24 0.0210192
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0210049
UBA6 ubiquitin-like modifier activating enzyme 6 0.0208023
LOX lysyl oxidase 0.0205393
INTS6 integrator complex subunit 6 0.0203856
XPO1 exportin 1 0.0202805
PRELID2 PRELI domain containing 2 0.020121
BBS9 Bardet-Biedl syndrome 9 0.0198578
DST dystonin 0.0195034
NBEAL1 neurobeachin-like 1 0.0194255
AEBP2 AE binding protein 2 0.0192976
HP1BP3 heterochromatin protein 1, binding protein 3 0.0192969
TNPO3 transportin 3 0.0192276
PRKCE protein kinase C, epsilon 0.0190764
ZMIZ1 zinc finger, MIZ-type containing 1 0.0190725
KMT2C lysine (K)-specific methyltransferase 2C 0.0190256
ASPH aspartate beta-hydroxylase 0.0189704
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0189532
ANKRD28 ankyrin repeat domain 28 0.0189484
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0189451
NUDCD3 NudC domain containing 3 0.0188896
SAMD4A sterile alpha motif domain containing 4A 0.0188499
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0188021
PGM3 phosphoglucomutase 3 0.0187621
SND1 staphylococcal nuclease and tudor domain containing 1 0.0186603
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0186502
TPM1 tropomyosin 1 (alpha) 0.0186211
MARCHF7 membrane associated ring-CH-type finger 7 0.0184196
SETX senataxin 0.0183313
CCNT2 cyclin T2 0.0183266
DMTF1 cyclin D binding myb-like transcription factor 1 0.0182335
RAD51B RAD51 paralog B 0.018227
ARHGAP35 Rho GTPase activating protein 35 0.0182139
ERBIN erbb2 interacting protein 0.0179605
MACF1 microtubule-actin crosslinking factor 1 0.0178607
JPH2 junctophilin 2 0.0178545
GTDC1 glycosyltransferase-like domain containing 1 0.0178396
SUCO SUN domain containing ossification factor 0.0178388
TENT5A terminal nucleotidyltransferase 5A 0.0177973
ZBTB20 zinc finger and BTB domain containing 20 0.0177816
OXSR1 oxidative stress responsive 1 0.0177225
DIDO1 death inducer-obliterator 1 0.0176727
TRRAP transformation/transcription domain-associated protein 0.0176566
RRM2 ribonucleotide reductase M2 0.0175045
HSPA13 heat shock protein 70kDa family, member 13 0.0174979
ZSWIM6 zinc finger, SWIM-type containing 6 0.0174218
MRTFA myocardin related transcription factor A 0.017174
SOX5 SRY (sex determining region Y)-box 5 0.0169419
FHIT fragile histidine triad 0.0168482
COG5 component of oligomeric golgi complex 5 0.0168355
SPDYA speedy/RINGO cell cycle regulator family member A 0.016808
FAF1 Fas (TNFRSF6) associated factor 1 0.0166057
MAGED1 melanoma antigen family D1 0.0164749
BIRC6 baculoviral IAP repeat containing 6 0.0163743
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0163405
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0162925
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0162859
TRA2A transformer 2 alpha homolog (Drosophila) 0.0162378
MAPK8 mitogen-activated protein kinase 8 0.0162113
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0161538
EXOC6B exocyst complex component 6B 0.0161486
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0160866
GOLGB1 golgin B1 0.0159787
UBE3C ubiquitin protein ligase E3C 0.0159751
TMEM167A transmembrane protein 167A 0.0159682
ZNF83 zinc finger protein 83 0.0158638
GPATCH2L G patch domain containing 2-like 0.0158078
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0157165
SDK1 sidekick cell adhesion molecule 1 0.015709
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0156717
BCAR3 breast cancer anti-estrogen resistance 3 0.0156652
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0156617
ECPAS Ecm29 proteasome adaptor and scaffold 0.0154895
FAM13B family with sequence similarity 13, member B 0.0154352
COL4A1 collagen, type IV, alpha 1 0.0153499
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0152912
MCPH1 microcephalin 1 0.0151877

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.290631
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.252112
TMSB10 thymosin beta 10 -0.24177
VIM vimentin -0.15342
FTL ferritin, light polypeptide -0.112245
HLA-B major histocompatibility complex, class I, B -0.112177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108147
MT1X metallothionein 1X -0.0805471
B2M beta-2-microglobulin -0.0718233
SDC4 syndecan 4 -0.0697211
UBC ubiquitin C -0.0684274
PTMA prothymosin, alpha -0.0646227
NAMPT nicotinamide phosphoribosyltransferase -0.0572609
AKAP12 A kinase (PRKA) anchor protein 12 -0.0562146
CCNI cyclin I -0.0547471
ENO1 enolase 1, (alpha) -0.0520097
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0513158
TPT1 tumor protein, translationally-controlled 1 -0.0504685
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0498185
RPLP1 ribosomal protein, large, P1 -0.045796
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0447092
CALD1 caldesmon 1 -0.0444986
RPL37A ribosomal protein L37a -0.0437205
RPS27A ribosomal protein S27a -0.0430788
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0426691
RPS6 ribosomal protein S6 -0.0426005
PRRC2C proline-rich coiled-coil 2C -0.0414908
ANXA5 annexin A5 -0.0405896
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0403985
CDH13 cadherin 13 -0.0400931
S100A10 S100 calcium binding protein A10 -0.0392023
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0391806
EIF1 eukaryotic translation initiation factor 1 -0.0391715
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0372322
RTN4 reticulon 4 -0.0372047
TMSB4X thymosin beta 4, X-linked -0.0371056
RPL34 ribosomal protein L34 -0.0368249
RRBP1 ribosome binding protein 1 -0.0367212
S100A9 S100 calcium binding protein A9 -0.0363571
PKM pyruvate kinase, muscle -0.0362904
STC1 stanniocalcin 1 -0.0362451
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0357914
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.035745
F3 coagulation factor III (thromboplastin, tissue factor) -0.0354625
S100A6 S100 calcium binding protein A6 -0.0352684
CALR calreticulin -0.03469
EEF2 eukaryotic translation elongation factor 2 -0.0334057
COL6A1 collagen, type VI, alpha 1 -0.033246
RPL36 ribosomal protein L36 -0.0325506
RPL11 ribosomal protein L11 -0.0319571
IL6 interleukin 6 -0.0319331
H3-3B H3.3 histone B -0.0317909
RPL28 ribosomal protein L28 -0.0316148
LGALS1 lectin, galactoside-binding, soluble, 1 -0.030628
RPS8 ribosomal protein S8 -0.0303349
AHNAK AHNAK nucleoprotein -0.0301599
TRIO trio Rho guanine nucleotide exchange factor -0.0299425
MAP1B microtubule-associated protein 1B -0.0293174
DDIT4 DNA-damage-inducible transcript 4 -0.0287767
NDRG1 N-myc downstream regulated 1 -0.0286397
RPL23 ribosomal protein L23 -0.0285015
GRB10 growth factor receptor-bound protein 10 -0.0284401
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0281944
RPS11 ribosomal protein S11 -0.0281885
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0277744
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0277202
SRRM2 serine/arginine repetitive matrix 2 -0.0277044
HLA-A major histocompatibility complex, class I, A -0.0276113
CAVIN1 caveolae associated protein 1 -0.0274778
TPM2 tropomyosin 2 (beta) -0.0269202
RPL26 ribosomal protein L26 -0.026754
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0265914
RPL32 ribosomal protein L32 -0.0263512
ACTG1 actin gamma 1 -0.0263366
RPL35A ribosomal protein L35a -0.0263269
RPS19 ribosomal protein S19 -0.0261602
SERINC3 serine incorporator 3 -0.0261182
JUN jun proto-oncogene -0.0261126
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0260346
SMAD3 SMAD family member 3 -0.0257148
ZNF395 zinc finger protein 395 -0.0256595
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0255363
RPS14 ribosomal protein S14 -0.0253728
SKP1 S-phase kinase-associated protein 1 -0.0251785
LMNA lamin A/C -0.025171
RPL8 ribosomal protein L8 -0.024947
GNAS GNAS complex locus -0.0245999
RPS25 ribosomal protein S25 -0.0245624
TXNIP thioredoxin interacting protein -0.0243369
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0242528
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0242157
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0241659
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0241182
LDHA lactate dehydrogenase A -0.0240682
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.023869
RPL5 ribosomal protein L5 -0.0237785
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0236826
WTAP Wilms tumor 1 associated protein -0.0236813
CLMP CXADR-like membrane protein -0.0235124
FLNB filamin B, beta -0.0234515