Vinblastine (sulfate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.0652969
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0508202
TRIO trio Rho guanine nucleotide exchange factor 0.0496437
NABP1 nucleic acid binding protein 1 0.0338401
COPB1 coatomer protein complex, subunit beta 1 0.0336298
FRMD6 FERM domain containing 6 0.0330539
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.031152
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0306271
CAPRIN2 caprin family member 2 0.0295265
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0293332
RPL35A ribosomal protein L35a 0.0285864
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0281694
CREB5 cAMP responsive element binding protein 5 0.0275989
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.026725
ARHGAP29 Rho GTPase activating protein 29 0.0244934
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0244739
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0244305
MAN2A1 mannosidase, alpha, class 2A, member 1 0.024156
KDM3A lysine (K)-specific demethylase 3A 0.0237098
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0236495
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0233107
PBX3 pre-B-cell leukemia homeobox 3 0.0231903
TUT7 terminal uridylyl transferase 7 0.0218757
TLE4 transducin-like enhancer of split 4 0.0215277
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.0212172
ARF4 ADP-ribosylation factor 4 0.0211815
LPIN1 lipin 1 0.020682
TUBB tubulin, beta class I 0.0196699
SGO2 shugoshin 2 0.0194911
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0192846
INTS6 integrator complex subunit 6 0.0191059
UBXN7 UBX domain protein 7 0.0190863
PTGES2 prostaglandin E synthase 2 0.0190704
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0190532
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0190446
LARS1 leucyl-tRNA synthetase 1 0.0189516
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0187837
TXNRD1 thioredoxin reductase 1 0.0187468
ASPH aspartate beta-hydroxylase 0.0184728
RAB1A RAB1A, member RAS oncogene family 0.018406
BICD1 bicaudal D homolog 1 (Drosophila) 0.0183596
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0180767
HDAC9 histone deacetylase 9 0.0179923
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0178416
TSC22D2 TSC22 domain family, member 2 0.0177374
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 0.0176455
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0175871
EXT1 exostosin glycosyltransferase 1 0.0175766
FAM53C family with sequence similarity 53, member C 0.0173425
DNM1L dynamin 1-like 0.0171225
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0170855
AFAP1 actin filament associated protein 1 0.0170425
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.0169915
GPSM2 G-protein signaling modulator 2 0.0169029
CAVIN1 caveolae associated protein 1 0.0168654
UBB ubiquitin B 0.0166704
ZBTB43 zinc finger and BTB domain containing 43 0.0166445
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.016639
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0166203
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0165587
ZEB1 zinc finger E-box binding homeobox 1 0.0164928
CLIP1 CAP-GLY domain containing linker protein 1 0.0163357
SUCO SUN domain containing ossification factor 0.0163112
PTTG1 pituitary tumor-transforming 1 0.0162716
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0162528
SUB1 SUB1 homolog (S. cerevisiae) 0.0162492
TTC14 tetratricopeptide repeat domain 14 0.0161776
GPR75-ASB3 GPR75-ASB3 readthrough 0.0161576
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0161008
NPC1 Niemann-Pick disease, type C1 0.0161004
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0160433
FRMD4A FERM domain containing 4A 0.0158074
HBEGF heparin-binding EGF-like growth factor 0.0157997
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0155176
RAP1A RAP1A, member of RAS oncogene family 0.0154466
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0152519
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0152509
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.0150441
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0150129
RPL27 ribosomal protein L27 0.0149704
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0149446
SLC35F3 solute carrier family 35, member F3 0.0147755
ANKMY2 ankyrin repeat and MYND domain containing 2 0.0147069
SECISBP2L SECIS binding protein 2-like 0.0146824
APLF aprataxin and PNKP like factor 0.0145112
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.0144406
SCFD2 sec1 family domain containing 2 0.0144388
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.0143478
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.0143389
ZBTB21 zinc finger and BTB domain containing 21 0.0143388
IL31RA interleukin 31 receptor A 0.0141953
SH3D19 SH3 domain containing 19 0.0141615
PRR11 proline rich 11 0.0141573
MIS18BP1 MIS18 binding protein 1 0.0141497
ETV5 ets variant 5 0.014136
WDR26 WD repeat domain 26 0.0140879
MACF1 microtubule-actin crosslinking factor 1 0.0140815
PDHX pyruvate dehydrogenase complex, component X 0.0140449
TUFT1 tuftelin 1 0.0140216
EFL1 elongation factor like GTPase 1 0.0140119

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.395641
VIM vimentin -0.164852
FNDC3B fibronectin type III domain containing 3B -0.122058
TMSB10 thymosin beta 10 -0.116525
PTMA prothymosin, alpha -0.114782
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.105797
LDHA lactate dehydrogenase A -0.0899219
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0825532
PKM pyruvate kinase, muscle -0.0796236
CD44 CD44 molecule (Indian blood group) -0.0776319
DST dystonin -0.0748561
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.071249
PRKCA protein kinase C, alpha -0.0711296
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0704176
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0692684
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0690098
ZMYND8 zinc finger, MYND-type containing 8 -0.0689843
BIRC3 baculoviral IAP repeat containing 3 -0.0688842
FTH1 ferritin, heavy polypeptide 1 -0.0681381
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0648795
RAD51B RAD51 paralog B -0.0642059
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0637871
ZBTB20 zinc finger and BTB domain containing 20 -0.0605878
IGFBP3 insulin-like growth factor binding protein 3 -0.0594566
BASP1 brain abundant, membrane attached signal protein 1 -0.0584377
ANKRD11 ankyrin repeat domain 11 -0.0583196
ENO1 enolase 1, (alpha) -0.0569842
LOC112694756 uncharaterized LOC112694756 -0.0554359
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0546617
POTEF POTE ankyrin domain family, member F -0.0516833
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0513267
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0507546
PHF20 PHD finger protein 20 -0.0500922
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0498164
AKAP13 A kinase (PRKA) anchor protein 13 -0.0498061
SMYD3 SET and MYND domain containing 3 -0.0491056
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0479703
RORA RAR-related orphan receptor A -0.0479405
RIGI RNA sensor RIG-I -0.047661
NDRG1 N-myc downstream regulated 1 -0.0475045
PRR16 proline rich 16 -0.0473226
IGF2 insulin-like growth factor 2 -0.0468347
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0468313
FMNL2 formin-like 2 -0.0467146
ANGPTL4 angiopoietin-like 4 -0.0460837
FAM3C family with sequence similarity 3, member C -0.0437519
NT5E 5'-nucleotidase, ecto (CD73) -0.0429821
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.042585
UBC ubiquitin C -0.0420801
N4BP2L2 NEDD4 binding protein 2-like 2 -0.041639
DSCAM Down syndrome cell adhesion molecule -0.0416354
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0412938
ATM ATM serine/threonine kinase -0.0407838
ATXN1 ataxin 1 -0.0402949
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0398525
OSMR oncostatin M receptor -0.0396879
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.039672
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0396207
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0395208
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.039168
AHNAK AHNAK nucleoprotein -0.0390691
SOD2 superoxide dismutase 2, mitochondrial -0.0386096
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0378371
DNER delta/notch-like EGF repeat containing -0.0372007
TPT1 tumor protein, translationally-controlled 1 -0.0370051
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0369015
ATG7 autophagy related 7 -0.0366545
RTN4 reticulon 4 -0.0365851
ANKRD28 ankyrin repeat domain 28 -0.0365028
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.035874
SVIL supervillin -0.0356885
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0356645
PNISR PNN-interacting serine/arginine-rich protein -0.0355162
VMP1 vacuole membrane protein 1 -0.0352126
NAP1L1 nucleosome assembly protein 1-like 1 -0.0351465
SH3KBP1 SH3-domain kinase binding protein 1 -0.0346146
SPAG9 sperm associated antigen 9 -0.0342874
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0341954
EGR1 early growth response 1 -0.0341507
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0336049
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.03359
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0334638
RSF1 remodeling and spacing factor 1 -0.0333645
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0328662
ZNF292 zinc finger protein 292 -0.0326102
EFNA5 ephrin-A5 -0.0324417
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0320529
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.031768
NCOR1 nuclear receptor corepressor 1 -0.0315528
TCF12 transcription factor 12 -0.0314868
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0313886
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0312042
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0311341
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0309859
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0309737
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0309278
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.030501
B2M beta-2-microglobulin -0.0298644
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0296667
ANO6 anoctamin 6 -0.0294713