Vinblastine (sulfate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.060229
INTS6 integrator complex subunit 6 0.0441952
ZSWIM6 zinc finger, SWIM-type containing 6 0.043675
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0393768
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0347451
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0337619
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0313634
RUNX1 runt-related transcription factor 1 0.0291446
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0262341
SUCO SUN domain containing ossification factor 0.0254633
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0244025
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0241043
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0232321
ELL2 elongation factor, RNA polymerase II, 2 0.0230165
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0229209
FAT1 FAT atypical cadherin 1 0.0216421
CTBP2 C-terminal binding protein 2 0.0215329
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0213466
COG5 component of oligomeric golgi complex 5 0.0211793
SPAG9 sperm associated antigen 9 0.0207933
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0193304
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0192357
FOXO3 forkhead box O3 0.0189241
OGA O-GlcNAcase 0.018774
LRRC23 leucine rich repeat containing 23 0.0187126
ATF6 activating transcription factor 6 0.018589
IFRD1 interferon-related developmental regulator 1 0.0182742
ZFC3H1 zinc finger, C3H1-type containing 0.018206
GLS2 glutaminase 2 (liver, mitochondrial) 0.0178669
NPTN neuroplastin 0.0178078
FMNL2 formin-like 2 0.0177335
HILPDA hypoxia inducible lipid droplet-associated 0.0176401
TUFT1 tuftelin 1 0.0172094
CCDC138 coiled-coil domain containing 138 0.0171296
COG6 component of oligomeric golgi complex 6 0.0169362
WAC WW domain containing adaptor with coiled-coil 0.0164599
KDM3A lysine (K)-specific demethylase 3A 0.0164122
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0158334
HELZ helicase with zinc finger 0.0157915
COPA coatomer protein complex, subunit alpha 0.0157239
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0156797
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0155455
ZNF451 zinc finger protein 451 0.0152783
TRA2A transformer 2 alpha homolog (Drosophila) 0.0151872
MYO6 myosin VI 0.0150249
UBA6 ubiquitin-like modifier activating enzyme 6 0.0149493
TTC3 tetratricopeptide repeat domain 3 0.0149003
RNF145 ring finger protein 145 0.0148379
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0148177
RYBP RING1 and YY1 binding protein 0.0146211
GOLGA4 golgin A4 0.0145563
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0145205
RCOR1 REST corepressor 1 0.0144026
UBAP2 ubiquitin associated protein 2 0.014314
FAM13A family with sequence similarity 13, member A 0.0142212
SMYD3 SET and MYND domain containing 3 0.0142012
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0137523
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0136424
PICALM phosphatidylinositol binding clathrin assembly protein 0.0136371
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0135818
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0135163
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0133192
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.013237
FLNB filamin B, beta 0.0132082
FERMT2 fermitin family member 2 0.0131058
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0130413
SEC31A SEC31 homolog A (S. cerevisiae) 0.0130271
CPNE1 copine I 0.0129972
ZCCHC7 zinc finger, CCHC domain containing 7 0.0129705
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.012734
USP53 ubiquitin specific peptidase 53 0.0126927
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0126601
MYOF myoferlin 0.0126567
ZEB1 zinc finger E-box binding homeobox 1 0.0125888
PDIA5 protein disulfide isomerase family A, member 5 0.0125551
MON2 MON2 homolog (S. cerevisiae) 0.0125438
LCORL ligand dependent nuclear receptor corepressor-like 0.0125141
CD109 CD109 molecule 0.0123589
PUM2 pumilio RNA-binding family member 2 0.0122159
MYO1E myosin IE 0.0120339
XPO1 exportin 1 0.0119202
SOD2 superoxide dismutase 2, mitochondrial 0.0118502
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0118227
GPR75-ASB3 GPR75-ASB3 readthrough 0.0117853
DSCAM Down syndrome cell adhesion molecule 0.0116646
CAMTA1 calmodulin binding transcription activator 1 0.0115011
FNDC3A fibronectin type III domain containing 3A 0.0113874
FGF18 fibroblast growth factor 18 0.0113847
RASA2 RAS p21 protein activator 2 0.0113424
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0112555
WNK1 WNK lysine deficient protein kinase 1 0.0112263
ASXL1 additional sex combs like transcriptional regulator 1 0.0112213
SENP5 SUMO1/sentrin specific peptidase 5 0.0111645
YAP1 Yes-associated protein 1 0.0111083
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0110905
KLHL29 kelch-like family member 29 0.0110266
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0109936
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0109457
ANO10 anoctamin 10 0.010926
USP37 ubiquitin specific peptidase 37 0.0109204

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.259403
FN1 fibronectin 1 -0.248559
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.163424
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145157
HMGA2 high mobility group AT-hook 2 -0.142398
TMEM156 transmembrane protein 156 -0.130747
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.124815
TMSB10 thymosin beta 10 -0.112746
ITGA1 integrin, alpha 1 -0.109442
IFI27 interferon, alpha-inducible protein 27 -0.103729
MT2A metallothionein 2A -0.102592
ASPH aspartate beta-hydroxylase -0.100653
STC2 stanniocalcin 2 -0.0982653
S100A6 S100 calcium binding protein A6 -0.0903158
AKAP12 A kinase (PRKA) anchor protein 12 -0.0885235
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0771073
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.075106
GLIS3 GLIS family zinc finger 3 -0.073419
OSMR oncostatin M receptor -0.0733537
NRP1 neuropilin 1 -0.0686224
VIM vimentin -0.0685485
SYT1 synaptotagmin I -0.0672607
TMSB4X thymosin beta 4, X-linked -0.0645951
HLA-B major histocompatibility complex, class I, B -0.0629983
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0619425
MAP1B microtubule-associated protein 1B -0.0616203
KLHL5 kelch-like family member 5 -0.0615786
B2M beta-2-microglobulin -0.0596402
FTL ferritin, light polypeptide -0.0590888
NAMPT nicotinamide phosphoribosyltransferase -0.0588962
SOX4 SRY (sex determining region Y)-box 4 -0.0588192
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0571034
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.055388
PTMA prothymosin, alpha -0.0518439
CANX calnexin -0.0485374
POTEF POTE ankyrin domain family, member F -0.0458632
SFTPA2 surfactant protein A2 -0.0449582
FTH1 ferritin, heavy polypeptide 1 -0.0446129
TPI1 triosephosphate isomerase 1 -0.042194
RAI14 retinoic acid induced 14 -0.0421846
HIPK2 homeodomain interacting protein kinase 2 -0.0415907
TXNIP thioredoxin interacting protein -0.0414364
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0404409
MYH9 myosin, heavy chain 9, non-muscle -0.0400952
HMGA1 high mobility group AT-hook 1 -0.0393247
LOC102724023 ES1 protein homolog, mitochondrial -0.0388607
FOXP1 forkhead box P1 -0.0388129
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0380403
TXNRD1 thioredoxin reductase 1 -0.0370109
ACTG1 actin gamma 1 -0.036466
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0364388
ETV1 ets variant 1 -0.0363698
TMEM165 transmembrane protein 165 -0.0361343
PRRC2C proline-rich coiled-coil 2C -0.0358562
RACK1 receptor for activated C kinase 1 -0.0350318
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.034835
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0345136
DNAH5 dynein, axonemal, heavy chain 5 -0.0339849
ENO1 enolase 1, (alpha) -0.033416
LMNA lamin A/C -0.0330289
VEGFA vascular endothelial growth factor A -0.0329707
EFNA5 ephrin-A5 -0.0328609
BASP1 brain abundant, membrane attached signal protein 1 -0.0327983
S100A9 S100 calcium binding protein A9 -0.0322107
PKM pyruvate kinase, muscle -0.0321205
RPS19 ribosomal protein S19 -0.032036
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0315315
RPS27 ribosomal protein S27 -0.0313213
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0309538
ZMYND8 zinc finger, MYND-type containing 8 -0.0309421
MAML2 mastermind-like 2 (Drosophila) -0.0309127
CAPN2 calpain 2, (m/II) large subunit -0.0308711
IFI16 interferon, gamma-inducible protein 16 -0.0306793
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0304601
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0300282
RUNX2 runt-related transcription factor 2 -0.0289547
S100A10 S100 calcium binding protein A10 -0.0288132
TSC22D1 TSC22 domain family, member 1 -0.0284081
MCTP2 multiple C2 domains, transmembrane 2 -0.0281573
MRPS6 mitochondrial ribosomal protein S6 -0.0278337
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0277334
RANBP17 RAN binding protein 17 -0.0275114
RPLP1 ribosomal protein, large, P1 -0.0271829
RPS6 ribosomal protein S6 -0.027167
LOC112694756 uncharaterized LOC112694756 -0.0269448
RNF213 ring finger protein 213 -0.0268507
LY6E lymphocyte antigen 6 complex, locus E -0.0264089
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0260444
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0259744
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0252926
UBXN4 UBX domain protein 4 -0.0251416
ETV6 ets variant 6 -0.0251148
RPL31 ribosomal protein L31 -0.025072
PDE4D phosphodiesterase 4D, cAMP-specific -0.025005
CENPF centromere protein F, 350/400kDa -0.0248048
ACTN4 actinin, alpha 4 -0.0247925
TFPI2 tissue factor pathway inhibitor 2 -0.02474
TAGLN2 transgelin 2 -0.0242162
RPL36 ribosomal protein L36 -0.0241292
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0240946