Vinblastine (sulfate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0850908
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0729478
FNDC3B fibronectin type III domain containing 3B 0.0688462
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0553449
MAML2 mastermind-like 2 (Drosophila) 0.0494928
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0494175
CEMIP cell migration inducing protein, hyaluronan binding 0.0478748
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.045411
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0435335
GMDS GDP-mannose 4,6-dehydratase 0.0411684
SDK1 sidekick cell adhesion molecule 1 0.040574
SAMD4A sterile alpha motif domain containing 4A 0.0391774
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0386498
VCL vinculin 0.0370863
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0353244
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.034035
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0336512
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.033437
EHBP1 EH domain binding protein 1 0.0325876
TRIO trio Rho guanine nucleotide exchange factor 0.0317402
CTBP2 C-terminal binding protein 2 0.0317137
NEBL nebulette 0.0313487
SMAD3 SMAD family member 3 0.0311654
FAT1 FAT atypical cadherin 1 0.0308694
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0302838
INTS6 integrator complex subunit 6 0.0302213
PICALM phosphatidylinositol binding clathrin assembly protein 0.0298754
MYO1E myosin IE 0.0297186
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0293277
ZSWIM6 zinc finger, SWIM-type containing 6 0.0287817
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0280992
EXOC4 exocyst complex component 4 0.027641
BCL2L1 BCL2-like 1 0.0274777
OSBPL10 oxysterol binding protein-like 10 0.0270762
IFRD1 interferon-related developmental regulator 1 0.0269687
CDK13 cyclin-dependent kinase 13 0.0269203
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0268874
ANKRD11 ankyrin repeat domain 11 0.0265828
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.026266
CADPS Ca++-dependent secretion activator 0.0258256
NCEH1 neutral cholesterol ester hydrolase 1 0.0255955
LPP LIM domain containing preferred translocation partner in lipoma 0.0255889
USP9X ubiquitin specific peptidase 9, X-linked 0.0250567
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0247985
ARHGAP26 Rho GTPase activating protein 26 0.0242365
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0238748
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0236282
KDM6A lysine (K)-specific demethylase 6A 0.0234632
PDLIM5 PDZ and LIM domain 5 0.0229281
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0227024
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0225143
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0223809
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.022316
RCOR1 REST corepressor 1 0.0222164
SND1 staphylococcal nuclease and tudor domain containing 1 0.022136
EXT1 exostosin glycosyltransferase 1 0.0220629
SHB Src homology 2 domain containing adaptor protein B 0.021893
GOLGB1 golgin B1 0.0215125
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0214847
ITGA6 integrin, alpha 6 0.0214152
PTPRK protein tyrosine phosphatase, receptor type, K 0.0213758
EPS8 epidermal growth factor receptor pathway substrate 8 0.0212959
RAD51B RAD51 paralog B 0.0211388
GLS2 glutaminase 2 (liver, mitochondrial) 0.0210922
CEMIP2 cell migration inducing hyaluronidase 2 0.0209263
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0208393
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0207902
MED13L mediator complex subunit 13-like 0.0206492
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0204753
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0204423
TGFA transforming growth factor, alpha 0.0204175
YAP1 Yes-associated protein 1 0.0204138
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0201575
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0199233
PSME4 proteasome (prosome, macropain) activator subunit 4 0.019858
HDAC4 histone deacetylase 4 0.0195684
RUNX1 runt-related transcription factor 1 0.0194423
CUX1 cut-like homeobox 1 0.0193226
NKD1 naked cuticle homolog 1 (Drosophila) 0.0192322
MSI2 musashi RNA-binding protein 2 0.0189967
AKAP13 A kinase (PRKA) anchor protein 13 0.0189636
LIMS1 LIM and senescent cell antigen-like domains 1 0.0189165
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0189007
TMCC1 transmembrane and coiled-coil domain family 1 0.0187975
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.018511
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0183974
APLP2 amyloid beta (A4) precursor-like protein 2 0.0183806
UBAP2 ubiquitin associated protein 2 0.0183711
ARHGAP32 Rho GTPase activating protein 32 0.0183702
SETX senataxin 0.0182541
FNDC3A fibronectin type III domain containing 3A 0.0182511
PPARD peroxisome proliferator-activated receptor delta 0.0182364
SMAD2 SMAD family member 2 0.0181032
NUP98 nucleoporin 98kDa 0.0180922
ADAM19 ADAM metallopeptidase domain 19 0.018074
EGFR epidermal growth factor receptor 0.0179471
ZFAND3 zinc finger, AN1-type domain 3 0.0178834
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0177784
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0176316
FAM107B family with sequence similarity 107, member B 0.0175861

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.328415
PTMA prothymosin, alpha -0.20838
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173032
TMSB10 thymosin beta 10 -0.164425
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0951602
RPL35A ribosomal protein L35a -0.0928132
B2M beta-2-microglobulin -0.0907702
RPS6 ribosomal protein S6 -0.0900651
RPL12 ribosomal protein L12 -0.0868809
RPLP1 ribosomal protein, large, P1 -0.0851349
LOC102724023 ES1 protein homolog, mitochondrial -0.0834796
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0759032
RPS19 ribosomal protein S19 -0.0755052
EIF1 eukaryotic translation initiation factor 1 -0.075273
CST3 cystatin C -0.0745175
RPLP2 ribosomal protein, large, P2 -0.071377
TPT1 tumor protein, translationally-controlled 1 -0.0686201
RPS21 ribosomal protein S21 -0.0680769
FTH1 ferritin, heavy polypeptide 1 -0.0673289
RPL23 ribosomal protein L23 -0.0661014
RPS3 ribosomal protein S3 -0.0652991
RPS13 ribosomal protein S13 -0.0639968
RPL28 ribosomal protein L28 -0.063359
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0625441
GSTP1 glutathione S-transferase pi 1 -0.0589004
RPL37A ribosomal protein L37a -0.0572145
RPL31 ribosomal protein L31 -0.0563361
RPL8 ribosomal protein L8 -0.0532245
RPL18 ribosomal protein L18 -0.0518681
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0511851
RPL19 ribosomal protein L19 -0.0508849
RPS12 ribosomal protein S12 -0.0494565
RPL32 ribosomal protein L32 -0.0493416
RPL36 ribosomal protein L36 -0.0485722
S100A10 S100 calcium binding protein A10 -0.0474538
S100A6 S100 calcium binding protein A6 -0.0473939
RPS5 ribosomal protein S5 -0.0468253
RPS25 ribosomal protein S25 -0.0460066
ACTG1 actin gamma 1 -0.0446508
RPS8 ribosomal protein S8 -0.044195
RPS14 ribosomal protein S14 -0.0441559
EPCAM epithelial cell adhesion molecule -0.0439218
LOC112694756 uncharaterized LOC112694756 -0.0425585
RPS11 ribosomal protein S11 -0.0422458
KRT18 keratin 18, type I -0.0416384
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0412882
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0411054
KRT8 keratin 8, type II -0.040791
RPLP0 ribosomal protein, large, P0 -0.0407548
RPL37 ribosomal protein L37 -0.0404213
RPS27A ribosomal protein S27a -0.0392458
RPL26 ribosomal protein L26 -0.0383361
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0378425
RPS17 ribosomal protein S17 -0.0377584
ATP5F1E ATP synthase F1 subunit epsilon -0.0373567
RPL7A ribosomal protein L7a -0.0369237
RPL13A ribosomal protein L13a -0.03641
RPS16 ribosomal protein S16 -0.0361647
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0357686
PERP PERP, TP53 apoptosis effector -0.035373
RPS29 ribosomal protein S29 -0.0350983
H1-0 H1.0 linker histone -0.0350959
HLA-A major histocompatibility complex, class I, A -0.0348838
KRT19 keratin 19, type I -0.0347863
RPL15 ribosomal protein L15 -0.0345222
RACK1 receptor for activated C kinase 1 -0.0344996
RPL35 ribosomal protein L35 -0.0343622
GNAS GNAS complex locus -0.0343493
RPS15 ribosomal protein S15 -0.0340484
RPS24 ribosomal protein S24 -0.0337298
RPL30 ribosomal protein L30 -0.0335816
SLC38A1 solute carrier family 38, member 1 -0.0331615
RPS27 ribosomal protein S27 -0.0330864
RPL36A ribosomal protein L36a -0.0329784
UBC ubiquitin C -0.0323178
CLDN4 claudin 4 -0.0322692
RPL27A ribosomal protein L27a -0.03217
IFITM3 interferon induced transmembrane protein 3 -0.0319422
RPL11 ribosomal protein L11 -0.0318494
TMSB4X thymosin beta 4, X-linked -0.0307665
MYL12B myosin, light chain 12B, regulatory -0.0305744
H3-3B H3.3 histone B -0.0301051
IFITM1 interferon induced transmembrane protein 1 -0.0300475
GOLGA4 golgin A4 -0.0291584
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0291552
RPL34 ribosomal protein L34 -0.028892
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0286306
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0282087
EGR1 early growth response 1 -0.0268963
LDHA lactate dehydrogenase A -0.0268152
RPS23 ribosomal protein S23 -0.0263753
RPL9 ribosomal protein L9 -0.02634
RPS4X ribosomal protein S4, X-linked -0.0256952
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0256474
EIF5B eukaryotic translation initiation factor 5B -0.025646
SQSTM1 sequestosome 1 -0.0256051
NACA nascent polypeptide-associated complex alpha subunit -0.0248549
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0244771
RBM25 RNA binding motif protein 25 -0.024047
PLAUR plasminogen activator, urokinase receptor -0.0238706