Vinblastine (sulfate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.170303
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.115355
CD36 CD36 molecule (thrombospondin receptor) 0.0866008
AREG amphiregulin 0.0766466
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0725963
GOLGA4 golgin A4 0.0690429
OXR1 oxidation resistance 1 0.0680206
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0607773
TOP1 topoisomerase (DNA) I 0.0589906
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0586513
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0585128
RNF43 ring finger protein 43 0.0543085
PDIA3 protein disulfide isomerase family A, member 3 0.0533849
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0528208
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0520963
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0511927
CENPF centromere protein F, 350/400kDa 0.0462961
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0458159
USP3 ubiquitin specific peptidase 3 0.0452228
WAC WW domain containing adaptor with coiled-coil 0.0451067
KTN1 kinectin 1 (kinesin receptor) 0.0427223
RNF145 ring finger protein 145 0.0424659
GARS1 glycyl-tRNA synthetase 1 0.0424
GCLC glutamate-cysteine ligase, catalytic subunit 0.0418596
CKAP5 cytoskeleton associated protein 5 0.0417564
ANXA1 annexin A1 0.0413118
BRWD1 bromodomain and WD repeat domain containing 1 0.0406207
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0405368
NEK7 NIMA-related kinase 7 0.0396225
KDM6A lysine (K)-specific demethylase 6A 0.0389533
PDE4B phosphodiesterase 4B, cAMP-specific 0.0377313
KMT2E lysine (K)-specific methyltransferase 2E 0.0362161
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0356751
IGFBP3 insulin-like growth factor binding protein 3 0.0355497
UBA6 ubiquitin-like modifier activating enzyme 6 0.03518
NUP58 nucleoporin 58 0.0347341
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0346991
SLMAP sarcolemma associated protein 0.0344514
NAMPT nicotinamide phosphoribosyltransferase 0.0328333
MYO5B myosin VB 0.0326696
STRN3 striatin, calmodulin binding protein 3 0.0323445
FAT1 FAT atypical cadherin 1 0.0323339
NAV2 neuron navigator 2 0.0321564
RPL3 ribosomal protein L3 0.031882
EREG epiregulin 0.0315416
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.031417
MACF1 microtubule-actin crosslinking factor 1 0.0312709
BIRC6 baculoviral IAP repeat containing 6 0.0312562
OGA O-GlcNAcase 0.0309919
HILPDA hypoxia inducible lipid droplet-associated 0.0305445
YTHDC1 YTH domain containing 1 0.0301427
EGLN1 egl-9 family hypoxia-inducible factor 1 0.030101
COG5 component of oligomeric golgi complex 5 0.0296294
XPO1 exportin 1 0.0296262
COPA coatomer protein complex, subunit alpha 0.0293749
PUM2 pumilio RNA-binding family member 2 0.029038
TXNIP thioredoxin interacting protein 0.0287855
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0286895
TPR translocated promoter region, nuclear basket protein 0.028425
SPAG9 sperm associated antigen 9 0.0282478
NCKAP1 NCK-associated protein 1 0.0276441
SQSTM1 sequestosome 1 0.0274985
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0274331
DDIT4 DNA-damage-inducible transcript 4 0.0272439
TXNRD1 thioredoxin reductase 1 0.027208
EGFR epidermal growth factor receptor 0.0268267
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.026717
KDM2A lysine (K)-specific demethylase 2A 0.0265555
WDR43 WD repeat domain 43 0.0262685
SRP54 signal recognition particle 54kDa 0.0261027
NKTR natural killer cell triggering receptor 0.0258962
NBAS neuroblastoma amplified sequence 0.0258034
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0256807
SEC24D SEC24 family member D 0.0256683
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.025415
ESRP1 epithelial splicing regulatory protein 1 0.0252573
ARHGAP42 Rho GTPase activating protein 42 0.0251146
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0251068
CENPE centromere protein E, 312kDa 0.0248026
TAOK1 TAO kinase 1 0.0246424
IPO7 importin 7 0.0245446
PTBP2 polypyrimidine tract binding protein 2 0.0244731
ZFR zinc finger RNA binding protein 0.0244672
MXI1 MAX interactor 1, dimerization protein 0.0244168
ZMYM2 zinc finger, MYM-type 2 0.0243118
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0241409
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0240843
FAR1 fatty acyl CoA reductase 1 0.0237925
ZNF292 zinc finger protein 292 0.0236769
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0235377
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0234993
NEMF nuclear export mediator factor 0.0233915
RREB1 ras responsive element binding protein 1 0.0233584
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0232555
MED13L mediator complex subunit 13-like 0.02324
NCOR1 nuclear receptor corepressor 1 0.0232208
CLTC clathrin, heavy chain (Hc) 0.0229077
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0228222
TSC22D2 TSC22 domain family, member 2 0.0228196
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.022738

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.183252
ACTG1 actin gamma 1 -0.169225
TMSB10 thymosin beta 10 -0.145187
VCL vinculin -0.126963
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.12525
HMGA2 high mobility group AT-hook 2 -0.115653
TPT1 tumor protein, translationally-controlled 1 -0.113002
FLOT1 flotillin 1 -0.103412
EGR1 early growth response 1 -0.0981975
FHIT fragile histidine triad -0.0885553
RPL35A ribosomal protein L35a -0.0880252
RAD51B RAD51 paralog B -0.0785778
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0681632
RPL34 ribosomal protein L34 -0.0680608
RPS24 ribosomal protein S24 -0.0665424
IER3 immediate early response 3 -0.0652691
RPL26 ribosomal protein L26 -0.0643371
LAMB3 laminin, beta 3 -0.0631398
RPS19 ribosomal protein S19 -0.0626259
RPL37A ribosomal protein L37a -0.0624183
RCOR1 REST corepressor 1 -0.0621582
LAMA4 laminin, alpha 4 -0.0620877
RPL9 ribosomal protein L9 -0.0602995
RPS3 ribosomal protein S3 -0.0562541
PTMA prothymosin, alpha -0.0561117
RPS6 ribosomal protein S6 -0.0550702
CD9 CD9 molecule -0.0501744
RPL12 ribosomal protein L12 -0.050116
RPS8 ribosomal protein S8 -0.0489301
RPLP2 ribosomal protein, large, P2 -0.0475893
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0467326
RPS12 ribosomal protein S12 -0.0458587
MTAP methylthioadenosine phosphorylase -0.045187
RPLP1 ribosomal protein, large, P1 -0.0451352
MPRIP myosin phosphatase Rho interacting protein -0.0450193
ACTN4 actinin, alpha 4 -0.0442357
GPC5 glypican 5 -0.0435788
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0418354
RPL31 ribosomal protein L31 -0.041716
RPL23 ribosomal protein L23 -0.0410705
RPS17 ribosomal protein S17 -0.041052
RPL36 ribosomal protein L36 -0.0408739
SEPTIN9 septin 9 -0.0398364
CMIP c-Maf inducing protein -0.0397711
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0394409
RPS13 ribosomal protein S13 -0.0385478
CCND1 cyclin D1 -0.0382933
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0378471
RPS21 ribosomal protein S21 -0.0374341
HDAC2 histone deacetylase 2 -0.0370935
AKAP12 A kinase (PRKA) anchor protein 12 -0.0367455
CCSER1 coiled-coil serine-rich protein 1 -0.036641
S100A6 S100 calcium binding protein A6 -0.0364867
RPS5 ribosomal protein S5 -0.0361652
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0349454
DOCK5 dedicator of cytokinesis 5 -0.034656
FERMT1 fermitin family member 1 -0.0344379
RPL27 ribosomal protein L27 -0.0343542
RPS27A ribosomal protein S27a -0.0341526
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0340425
NTSR1 neurotensin receptor 1 (high affinity) -0.0338931
RPL5 ribosomal protein L5 -0.0335939
RACK1 receptor for activated C kinase 1 -0.0332591
ITGB4 integrin, beta 4 -0.033247
RPS29 ribosomal protein S29 -0.0327537
RPL32 ribosomal protein L32 -0.0322671
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0319581
SMYD3 SET and MYND domain containing 3 -0.0319522
RPS25 ribosomal protein S25 -0.031886
AKAP13 A kinase (PRKA) anchor protein 13 -0.0315657
ITPKC inositol-trisphosphate 3-kinase C -0.0313071
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0311006
LAMC2 laminin, gamma 2 -0.0309864
RPL30 ribosomal protein L30 -0.0305004
RPLP0 ribosomal protein, large, P0 -0.0298619
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0297171
RPS23 ribosomal protein S23 -0.029295
SAMD4A sterile alpha motif domain containing 4A -0.0292054
FTL ferritin, light polypeptide -0.0290164
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0281336
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0280934
EHBP1 EH domain binding protein 1 -0.0274646
CUX1 cut-like homeobox 1 -0.027449
S100A11 S100 calcium binding protein A11 -0.027043
SMAD3 SMAD family member 3 -0.0269331
TPM4 tropomyosin 4 -0.026839
POTEF POTE ankyrin domain family, member F -0.0268235
ZBTB7C zinc finger and BTB domain containing 7C -0.0267423
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0265333
ABR active BCR-related -0.0264237
RPS14 ribosomal protein S14 -0.026381
RASAL2 RAS protein activator like 2 -0.0261434
KRT18 keratin 18, type I -0.0261261
RPL28 ribosomal protein L28 -0.0257016
FHL2 four and a half LIM domains 2 -0.0256273
FOXP1 forkhead box P1 -0.0255047
LOC102724023 ES1 protein homolog, mitochondrial -0.0253205
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.025256
RPL19 ribosomal protein L19 -0.0252207
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0251713