Vinblastine (sulfate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vinblastine (sulfate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.167816
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0960932
SDK1 sidekick cell adhesion molecule 1 0.0756652
CDH13 cadherin 13 0.07133
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0690692
PTMA prothymosin, alpha 0.0672228
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0595948
NAV2 neuron navigator 2 0.056869
VCL vinculin 0.0514999
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.046679
CDK6 cyclin-dependent kinase 6 0.0447367
RAD51B RAD51 paralog B 0.0438869
CCND1 cyclin D1 0.0438462
GMDS GDP-mannose 4,6-dehydratase 0.040254
WWOX WW domain containing oxidoreductase 0.0391183
SPATA13 spermatogenesis associated 13 0.0385205
ASPH aspartate beta-hydroxylase 0.0379264
CANX calnexin 0.0362798
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0341425
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0341203
BACE2 beta-site APP-cleaving enzyme 2 0.0337629
ADGRL2 adhesion G protein-coupled receptor L2 0.0333282
TAS2R14 taste receptor, type 2, member 14 0.0323594
INTS6 integrator complex subunit 6 0.0317158
EXOC4 exocyst complex component 4 0.0308702
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0303517
MRPS6 mitochondrial ribosomal protein S6 0.0298947
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0289698
KRT18 keratin 18, type I 0.0285571
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0285456
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.028532
GLI3 GLI family zinc finger 3 0.0272968
ACTN1 actinin, alpha 1 0.0272341
FHIT fragile histidine triad 0.0271158
UBAP2 ubiquitin associated protein 2 0.0267211
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0258038
SQSTM1 sequestosome 1 0.0255102
MACF1 microtubule-actin crosslinking factor 1 0.0251098
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.025043
CUX1 cut-like homeobox 1 0.0246362
LRMDA leucine rich melanocyte differentiation associated 0.024209
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0240558
CDK13 cyclin-dependent kinase 13 0.0237289
PDE4D phosphodiesterase 4D, cAMP-specific 0.0235475
PA2G4 proliferation-associated 2G4, 38kDa 0.0233312
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0231801
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0229161
ENO1 enolase 1, (alpha) 0.0228998
SENP5 SUMO1/sentrin specific peptidase 5 0.0228091
DSPP dentin sialophosphoprotein 0.0225653
CD44 CD44 molecule (Indian blood group) 0.022553
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0224851
MTAP methylthioadenosine phosphorylase 0.0224766
FNIP1 folliculin interacting protein 1 0.0224429
RBP1 retinol binding protein 1, cellular 0.0222485
PUM3 pumilio RNA binding family member 3 0.0217952
SET SET nuclear proto-oncogene 0.0215057
BZW1 basic leucine zipper and W2 domains 1 0.0213836
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0211367
TNRC6B trinucleotide repeat containing 6B 0.0210069
WDR43 WD repeat domain 43 0.0209951
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0205958
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0205234
LDHA lactate dehydrogenase A 0.0202045
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0201903
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0197078
NPAS2 neuronal PAS domain protein 2 0.0197002
OSBPL3 oxysterol binding protein-like 3 0.0195914
CLSTN2 calsyntenin 2 0.0195818
TBC1D4 TBC1 domain family, member 4 0.0192799
ANO1 anoctamin 1, calcium activated chloride channel 0.0191661
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0189968
ZNF704 zinc finger protein 704 0.0189667
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0189515
PDIA3 protein disulfide isomerase family A, member 3 0.0189379
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0189191
ANXA3 annexin A3 0.0187775
FNDC3B fibronectin type III domain containing 3B 0.0187564
ACACA acetyl-CoA carboxylase alpha 0.0186267
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0186054
TCF12 transcription factor 12 0.0184622
CTBP2 C-terminal binding protein 2 0.0183226
MSI2 musashi RNA-binding protein 2 0.0182462
SKAP1 src kinase associated phosphoprotein 1 0.0182444
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0181798
AATF apoptosis antagonizing transcription factor 0.0180371
IGF1R insulin-like growth factor 1 receptor 0.0180277
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0179884
ATM ATM serine/threonine kinase 0.0179652
TFRC transferrin receptor 0.0179201
MYOF myoferlin 0.0178637
PCDH9 protocadherin 9 0.0178226
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0178058
SMYD3 SET and MYND domain containing 3 0.017766
GTF2IRD1 GTF2I repeat domain containing 1 0.0177414
MED13 mediator complex subunit 13 0.0177105
SORBS1 sorbin and SH3 domain containing 1 0.0175246
TPT1 tumor protein, translationally-controlled 1 0.0174242
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0174109
SERINC5 serine incorporator 5 0.0173198

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.329323
AKAP12 A kinase (PRKA) anchor protein 12 -0.246594
TMSB10 thymosin beta 10 -0.143536
RPL35A ribosomal protein L35a -0.111707
RPS6 ribosomal protein S6 -0.0958983
RPS19 ribosomal protein S19 -0.0916405
RPLP1 ribosomal protein, large, P1 -0.0882121
MT2A metallothionein 2A -0.0680841
EEF2 eukaryotic translation elongation factor 2 -0.0661778
RPLP2 ribosomal protein, large, P2 -0.06523
RPS23 ribosomal protein S23 -0.06448
EGR1 early growth response 1 -0.0638734
RPL23 ribosomal protein L23 -0.063229
RPL32 ribosomal protein L32 -0.0604453
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.059778
RPL19 ribosomal protein L19 -0.0548018
RPS3 ribosomal protein S3 -0.0537324
EIF1 eukaryotic translation initiation factor 1 -0.0537169
RPS13 ribosomal protein S13 -0.0528795
ACTG1 actin gamma 1 -0.0527984
RPS21 ribosomal protein S21 -0.0520107
RPL5 ribosomal protein L5 -0.0501048
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0487172
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0480979
SYT1 synaptotagmin I -0.0470307
RPL12 ribosomal protein L12 -0.0464236
RPS11 ribosomal protein S11 -0.0461065
RPL11 ribosomal protein L11 -0.045547
VIM vimentin -0.0433416
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0432461
RPL28 ribosomal protein L28 -0.0429991
RPL34 ribosomal protein L34 -0.0414141
RPS8 ribosomal protein S8 -0.040706
TXNIP thioredoxin interacting protein -0.0401319
RPS29 ribosomal protein S29 -0.0377007
RPL36 ribosomal protein L36 -0.0376276
RPS4X ribosomal protein S4, X-linked -0.0373957
RPL26 ribosomal protein L26 -0.0373952
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0372278
RPS5 ribosomal protein S5 -0.0370536
RPL31 ribosomal protein L31 -0.0362106
RPL8 ribosomal protein L8 -0.0356802
GARS1 glycyl-tRNA synthetase 1 -0.0356548
RACK1 receptor for activated C kinase 1 -0.0349687
ATXN1 ataxin 1 -0.0348329
PGK1 phosphoglycerate kinase 1 -0.0343715
RPS14 ribosomal protein S14 -0.0335994
TUBB4B tubulin, beta 4B class IVb -0.0327687
TUBA1B tubulin, alpha 1b -0.0326716
PFN1 profilin 1 -0.0323999
PLEC plectin -0.0323431
RPS25 ribosomal protein S25 -0.0322901
RPL18 ribosomal protein L18 -0.0320957
RPS16 ribosomal protein S16 -0.0319596
RPL37A ribosomal protein L37a -0.0312575
LOC112694756 uncharaterized LOC112694756 -0.0310973
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0307641
RPS15 ribosomal protein S15 -0.0305067
LMO7 LIM domain 7 -0.0302138
POTEF POTE ankyrin domain family, member F -0.0296855
ATP5F1B ATP synthase F1 subunit beta -0.0296847
ESYT2 extended synaptotagmin-like protein 2 -0.0295147
RPL37 ribosomal protein L37 -0.0294873
RPL35 ribosomal protein L35 -0.0294231
FTL ferritin, light polypeptide -0.0286423
RPL36A ribosomal protein L36a -0.0285386
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0283075
SOX4 SRY (sex determining region Y)-box 4 -0.0282821
RPS27 ribosomal protein S27 -0.0281901
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.0280906
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0277124
RPL13A ribosomal protein L13a -0.0276311
NDRG1 N-myc downstream regulated 1 -0.0274947
EEF1G eukaryotic translation elongation factor 1 gamma -0.0272469
PDE8A phosphodiesterase 8A -0.0270322
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0269634
RPLP0 ribosomal protein, large, P0 -0.0266123
HMGA1 high mobility group AT-hook 1 -0.0260024
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0258535
RPL27A ribosomal protein L27a -0.0258184
PCBP2 poly(rC) binding protein 2 -0.0258047
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0258034
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0257411
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.025634
RPL7A ribosomal protein L7a -0.0256036
MT1X metallothionein 1X -0.0253566
WDFY2 WD repeat and FYVE domain containing 2 -0.0250945
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0249491
ABHD2 abhydrolase domain containing 2 -0.0247443
ATF4 activating transcription factor 4 -0.024404
RPL7 ribosomal protein L7 -0.0243822
RPS12 ribosomal protein S12 -0.0240725
RPS27A ribosomal protein S27a -0.0237312
MORF4L2 mortality factor 4 like 2 -0.0237152
S100A10 S100 calcium binding protein A10 -0.0236363
RBM39 RNA binding motif protein 39 -0.0235548
RPS24 ribosomal protein S24 -0.0234837
PCLO piccolo presynaptic cytomatrix protein -0.0234425
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.023358
RPS20 ribosomal protein S20 -0.0233532