Vinblastine (sulfate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vinblastine (sulfate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vinblastine (sulfate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.207919
HMGA2 high mobility group AT-hook 2 0.206109
NALF1 NALCN channel auxiliary factor 1 0.194652
FN1 fibronectin 1 0.141067
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0931995
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0872358
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0868729
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0831196
COL1A1 collagen, type I, alpha 1 0.0736875
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.0666817
VCL vinculin 0.062688
MYO10 myosin X 0.062071
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0593296
NAV1 neuron navigator 1 0.0584905
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0580027
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0567799
ADGRB3 adhesion G protein-coupled receptor B3 0.0562877
JARID2 jumonji, AT rich interactive domain 2 0.0556109
COL1A2 collagen, type I, alpha 2 0.054665
ASPH aspartate beta-hydroxylase 0.0521865
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0507561
AKAP12 A kinase (PRKA) anchor protein 12 0.0483283
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0482547
PRKG1 protein kinase, cGMP-dependent, type I 0.0477087
GLIS3 GLIS family zinc finger 3 0.0437364
FBN1 fibrillin 1 0.0433749
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0433619
EMP1 epithelial membrane protein 1 0.0421737
LTBP1 latent transforming growth factor beta binding protein 1 0.0395262
OXR1 oxidation resistance 1 0.0393895
TIMP1 TIMP metallopeptidase inhibitor 1 0.0376989
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0347121
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0345942
PRELID2 PRELI domain containing 2 0.0332734
ABI3BP ABI family, member 3 (NESH) binding protein 0.0331196
MED13L mediator complex subunit 13-like 0.0321631
CALD1 caldesmon 1 0.0320429
PDLIM5 PDZ and LIM domain 5 0.0315086
ZSWIM6 zinc finger, SWIM-type containing 6 0.0313774
KIAA1549L KIAA1549-like 0.030837
INTS6 integrator complex subunit 6 0.0304765
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0289976
AHNAK AHNAK nucleoprotein 0.0284056
DIAPH2 diaphanous-related formin 2 0.027602
HDAC9 histone deacetylase 9 0.0266378
LPP LIM domain containing preferred translocation partner in lipoma 0.0266123
RAI14 retinoic acid induced 14 0.0265999
COL5A2 collagen, type V, alpha 2 0.0261538
HIPK2 homeodomain interacting protein kinase 2 0.0257552
MAML2 mastermind-like 2 (Drosophila) 0.0255129
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0254446
FRMD4A FERM domain containing 4A 0.0254168
MAML3 mastermind-like 3 (Drosophila) 0.0252667
FNDC3B fibronectin type III domain containing 3B 0.0252232
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.025142
EXT1 exostosin glycosyltransferase 1 0.0249203
BBS9 Bardet-Biedl syndrome 9 0.0248813
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0248011
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0239711
PRR16 proline rich 16 0.0234536
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.023439
NRP1 neuropilin 1 0.0231328
EGFR epidermal growth factor receptor 0.0229655
ANO6 anoctamin 6 0.0224156
COL6A2 collagen, type VI, alpha 2 0.0223162
COL5A3 collagen, type V, alpha 3 0.0218313
MACF1 microtubule-actin crosslinking factor 1 0.0217173
EFCAB13 EF-hand calcium binding domain 13 0.0215356
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0213482
NUMB numb homolog (Drosophila) 0.0208272
CUX1 cut-like homeobox 1 0.0207772
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0205477
CAV1 caveolin 1, caveolae protein, 22kDa 0.0203867
CHD9 chromodomain helicase DNA binding protein 9 0.0203853
FNDC3A fibronectin type III domain containing 3A 0.0202436
CCDC102B coiled-coil domain containing 102B 0.0202376
SASH1 SAM and SH3 domain containing 1 0.019878
PRSS23 protease, serine, 23 0.0198326
SH3RF1 SH3 domain containing ring finger 1 0.0196539
DSPP dentin sialophosphoprotein 0.0194691
RAD51B RAD51 paralog B 0.0193543
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0192893
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0187126
LYST lysosomal trafficking regulator 0.0187033
WWTR1 WW domain containing transcription regulator 1 0.0185039
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0184579
CLIC4 chloride intracellular channel 4 0.0184428
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0184226
SH3PXD2A SH3 and PX domains 2A 0.0180539
MBD5 methyl-CpG binding domain protein 5 0.0178822
IPO9 importin 9 0.0177712
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0176719
CDK14 cyclin-dependent kinase 14 0.0176608
ITGA11 integrin, alpha 11 0.0176197
ATXN1 ataxin 1 0.0170544
VEGFC vascular endothelial growth factor C 0.0170405
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0168927
EXOC4 exocyst complex component 4 0.0167948
ARHGAP22 Rho GTPase activating protein 22 0.0167305
MYO1E myosin IE 0.0165273

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.18377
MT2A metallothionein 2A -0.132148
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127348
NDRG1 N-myc downstream regulated 1 -0.112357
TMSB10 thymosin beta 10 -0.095142
FTL ferritin, light polypeptide -0.0777884
RPS6 ribosomal protein S6 -0.0718939
B2M beta-2-microglobulin -0.0709232
STC1 stanniocalcin 1 -0.0671042
GOLGA4 golgin A4 -0.0575287
EIF1 eukaryotic translation initiation factor 1 -0.0572675
HLA-B major histocompatibility complex, class I, B -0.0527887
RPS12 ribosomal protein S12 -0.0500172
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0500007
ADM adrenomedullin -0.049932
TPT1 tumor protein, translationally-controlled 1 -0.049267
INHBA inhibin, beta A -0.0487638
SPAG9 sperm associated antigen 9 -0.0449706
RPL23 ribosomal protein L23 -0.0439077
PRRC2C proline-rich coiled-coil 2C -0.0438571
RPLP1 ribosomal protein, large, P1 -0.0425667
CXCL8 chemokine (C-X-C motif) ligand 8 -0.042058
RPL12 ribosomal protein L12 -0.0408468
YBX3 Y box binding protein 3 -0.0406857
RPS19 ribosomal protein S19 -0.0387124
RPL37A ribosomal protein L37a -0.0371262
RPL34 ribosomal protein L34 -0.0370179
HLA-A major histocompatibility complex, class I, A -0.0362098
RPS8 ribosomal protein S8 -0.036068
RPL26 ribosomal protein L26 -0.0356266
RPL35A ribosomal protein L35a -0.0349326
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0330879
TM4SF1 transmembrane 4 L six family member 1 -0.0330054
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0325058
RPS17 ribosomal protein S17 -0.0321694
RPL9 ribosomal protein L9 -0.0321267
UGCG UDP-glucose ceramide glucosyltransferase -0.0317271
RPL11 ribosomal protein L11 -0.03122
RPS16 ribosomal protein S16 -0.0312042
RPS3 ribosomal protein S3 -0.0307848
EEF2 eukaryotic translation elongation factor 2 -0.0300145
POTEF POTE ankyrin domain family, member F -0.0297018
GARS1 glycyl-tRNA synthetase 1 -0.0293744
RPL28 ribosomal protein L28 -0.0285806
RPLP2 ribosomal protein, large, P2 -0.0285791
ADAM9 ADAM metallopeptidase domain 9 -0.0278182
RACK1 receptor for activated C kinase 1 -0.0274543
PTMA prothymosin, alpha -0.0273425
PCBP2 poly(rC) binding protein 2 -0.0269323
RPS14 ribosomal protein S14 -0.0268947
SOD2 superoxide dismutase 2, mitochondrial -0.0268795
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0268042
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0264654
RPL21 ribosomal protein L21 -0.0259153
RPL31 ribosomal protein L31 -0.025809
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0255993
RPL36 ribosomal protein L36 -0.0255832
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0251959
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0251467
RPL19 ribosomal protein L19 -0.0240588
WDR45B WD repeat domain 45B -0.0233411
RPS27 ribosomal protein S27 -0.0232139
NAMPT nicotinamide phosphoribosyltransferase -0.0229552
RPLP0 ribosomal protein, large, P0 -0.0228097
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0227944
ZNF292 zinc finger protein 292 -0.0225603
NUP58 nucleoporin 58 -0.0222447
RTN4 reticulon 4 -0.0219828
RPL30 ribosomal protein L30 -0.0219174
IER3 immediate early response 3 -0.0218442
NOP58 NOP58 ribonucleoprotein -0.021836
RPL32 ribosomal protein L32 -0.0217995
ATF4 activating transcription factor 4 -0.0217843
PFN1 profilin 1 -0.0213542
RPL37 ribosomal protein L37 -0.0213041
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0212172
RPS13 ribosomal protein S13 -0.021214
ACTG1 actin gamma 1 -0.0210629
TPI1 triosephosphate isomerase 1 -0.0209713
RPS27A ribosomal protein S27a -0.0209547
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0209491
RPS23 ribosomal protein S23 -0.0208779
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0208526
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0206746
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0205909
FAM13A family with sequence similarity 13, member A -0.020448
RB1CC1 RB1-inducible coiled-coil 1 -0.0199281
RPL5 ribosomal protein L5 -0.0198868
VEGFA vascular endothelial growth factor A -0.0197553
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0196147
TNPO1 transportin 1 -0.0195771
PHIP pleckstrin homology domain interacting protein -0.0195284
NAP1L1 nucleosome assembly protein 1-like 1 -0.0195239
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0193504
TMSB4X thymosin beta 4, X-linked -0.0192321
RPS21 ribosomal protein S21 -0.0190666
RPL13A ribosomal protein L13a -0.0190053
AKAP9 A kinase (PRKA) anchor protein 9 -0.0189764
RPS2 ribosomal protein S2 -0.0188411
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0187593