Vismodegib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0655127
PUM2 pumilio RNA-binding family member 2 0.0613508
CCNL1 cyclin L1 0.0523563
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0474845
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0460929
PDGFC platelet derived growth factor C 0.045721
ECT2 epithelial cell transforming 2 0.0447635
ZBTB20 zinc finger and BTB domain containing 20 0.0441095
PDE4D phosphodiesterase 4D, cAMP-specific 0.0423099
NEK7 NIMA-related kinase 7 0.0421065
YAP1 Yes-associated protein 1 0.040149
GSK3B glycogen synthase kinase 3 beta 0.0389308
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0376708
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0371408
BIRC2 baculoviral IAP repeat containing 2 0.0370841
MED13L mediator complex subunit 13-like 0.0370037
YBX1 Y box binding protein 1 0.0363977
ERRFI1 ERBB receptor feedback inhibitor 1 0.0355046
PSME4 proteasome (prosome, macropain) activator subunit 4 0.035078
CHD1 chromodomain helicase DNA binding protein 1 0.034194
ETNK1 ethanolamine kinase 1 0.0334731
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0330155
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0326536
CELF2 CUGBP, Elav-like family member 2 0.0323866
CEP192 centrosomal protein 192kDa 0.0319585
MMP12 matrix metallopeptidase 12 0.0306707
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0305482
ATP11A ATPase, class VI, type 11A 0.0304485
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0302336
AXIN2 axin 2 0.0298117
FXR1 fragile X mental retardation, autosomal homolog 1 0.0295022
ADAM17 ADAM metallopeptidase domain 17 0.0292227
TSC22D2 TSC22 domain family, member 2 0.0282551
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0280335
RNF13 ring finger protein 13 0.0278866
USP15 ubiquitin specific peptidase 15 0.027774
CPOX coproporphyrinogen oxidase 0.0272804
EXOC6B exocyst complex component 6B 0.0270647
PCBP2 poly(rC) binding protein 2 0.0267639
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0262879
DSCAM Down syndrome cell adhesion molecule 0.0260937
LRP6 low density lipoprotein receptor-related protein 6 0.0259273
LEMD3 LEM domain containing 3 0.0257481
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0254657
BLTP1 bridge-like lipid transfer protein family member 1 0.0246267
PCM1 pericentriolar material 1 0.0245463
GASK1B golgi associated kinase 1B 0.0244652
RBM39 RNA binding motif protein 39 0.0243819
TAS2R14 taste receptor, type 2, member 14 0.024277
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0242447
KDM6A lysine (K)-specific demethylase 6A 0.0242418
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0240633
EIF4A2 eukaryotic translation initiation factor 4A2 0.0240331
KIF5B kinesin family member 5B 0.0240261
WDR43 WD repeat domain 43 0.0237758
NBAS neuroblastoma amplified sequence 0.0236297
PICALM phosphatidylinositol binding clathrin assembly protein 0.0235418
NCKAP1 NCK-associated protein 1 0.0230329
PNN pinin, desmosome associated protein 0.0228457
KDM3A lysine (K)-specific demethylase 3A 0.022837
PRR16 proline rich 16 0.0227147
TFG TRK-fused gene 0.0226693
RICTOR RPTOR independent companion of MTOR, complex 2 0.0225216
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.022501
QKI QKI, KH domain containing, RNA binding 0.0224571
RB1CC1 RB1-inducible coiled-coil 1 0.0222343
PCNX1 pecanex 1 0.0220615
KLHL24 kelch-like family member 24 0.0217494
OXR1 oxidation resistance 1 0.0216745
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0215273
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0214121
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0213415
ATAD2B ATPase family, AAA domain containing 2B 0.0213089
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0213042
SET SET nuclear proto-oncogene 0.0208458
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0206946
RNF145 ring finger protein 145 0.020647
CEP95 centrosomal protein 95kDa 0.0205598
CLDND1 claudin domain containing 1 0.0204329
RPL3 ribosomal protein L3 0.0201916
AKAP9 A kinase (PRKA) anchor protein 9 0.0201324
DST dystonin 0.0200851
EPHA6 EPH receptor A6 0.0198978
RASA2 RAS p21 protein activator 2 0.0196885
ADGRG6 adhesion G protein-coupled receptor G6 0.0195409
ARHGAP12 Rho GTPase activating protein 12 0.0195231
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0194806
RHBDD1 rhomboid domain containing 1 0.0194392
ICE1 interactor of little elongation complex ELL subunit 1 0.0194208
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0193309
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0193207
ATL2 atlastin GTPase 2 0.0192784
PUM1 pumilio RNA-binding family member 1 0.0189875
WRN Werner syndrome, RecQ helicase-like 0.0188733
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0188089
HMGB2 high mobility group box 2 0.0187592
ANKRD36 ankyrin repeat domain 36 0.0187586
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.018734
FBXO11 F-box protein 11 0.0186918
ZFC3H1 zinc finger, C3H1-type containing 0.0185798

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.394622
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.261985
TMSB10 thymosin beta 10 -0.161488
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.148855
NLGN1 neuroligin 1 -0.10519
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100389
ACTG1 actin gamma 1 -0.0928713
FTL ferritin, light polypeptide -0.0861577
MYL12B myosin, light chain 12B, regulatory -0.0712704
TPT1 tumor protein, translationally-controlled 1 -0.07035
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0675149
PTMA prothymosin, alpha -0.0668439
RPL35A ribosomal protein L35a -0.0572563
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0553413
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0552605
TPI1 triosephosphate isomerase 1 -0.0534669
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0532557
HMGA1 high mobility group AT-hook 1 -0.0512651
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0484845
TUBA1B tubulin, alpha 1b -0.0484359
HSPB1 heat shock 27kDa protein 1 -0.0467538
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0427427
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0425749
S100A6 S100 calcium binding protein A6 -0.0423609
IFIH1 interferon induced with helicase C domain 1 -0.0408857
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0394739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0393899
RPS27A ribosomal protein S27a -0.0392813
RPLP1 ribosomal protein, large, P1 -0.0387154
S100A10 S100 calcium binding protein A10 -0.038579
RPL23 ribosomal protein L23 -0.0380351
ANXA1 annexin A1 -0.0380146
KPNB1 karyopherin (importin) beta 1 -0.0380036
GCG glucagon -0.0377135
RPS19 ribosomal protein S19 -0.037633
CCND1 cyclin D1 -0.0372164
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0365579
LDHA lactate dehydrogenase A -0.0360584
RPS8 ribosomal protein S8 -0.0352252
VDAC1 voltage-dependent anion channel 1 -0.0352012
AKAP12 A kinase (PRKA) anchor protein 12 -0.03436
RPLP0 ribosomal protein, large, P0 -0.0342572
PFN1 profilin 1 -0.0327421
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0326953
RASAL2 RAS protein activator like 2 -0.0323929
RPS24 ribosomal protein S24 -0.032033
GJA1 gap junction protein, alpha 1, 43kDa -0.0319161
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0304539
RPS13 ribosomal protein S13 -0.0300718
CALR calreticulin -0.0297682
RPL31 ribosomal protein L31 -0.0293445
RPL38 ribosomal protein L38 -0.0293235
RPL34 ribosomal protein L34 -0.0280241
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0279911
MKI67 marker of proliferation Ki-67 -0.0277081
RPL36A ribosomal protein L36a -0.027289
CANX calnexin -0.0268376
PCDH9 protocadherin 9 -0.0266627
BRI3BP BRI3 binding protein -0.0264773
CUX1 cut-like homeobox 1 -0.026375
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0262628
RPLP2 ribosomal protein, large, P2 -0.0261568
CNRIP1 cannabinoid receptor interacting protein 1 -0.0252955
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0252939
PRDX1 peroxiredoxin 1 -0.0252189
GNAS GNAS complex locus -0.024973
RPL12 ribosomal protein L12 -0.0249656
TMEM123 transmembrane protein 123 -0.0246234
TPM4 tropomyosin 4 -0.0244088
ENO1 enolase 1, (alpha) -0.0243176
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.02427
RPL37A ribosomal protein L37a -0.0242221
RPS29 ribosomal protein S29 -0.0239388
RPS6 ribosomal protein S6 -0.0238956
PA2G4 proliferation-associated 2G4, 38kDa -0.0238182
DTNA dystrobrevin, alpha -0.0235337
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0233881
PKM pyruvate kinase, muscle -0.0232699
RPL37 ribosomal protein L37 -0.0231688
BIRC3 baculoviral IAP repeat containing 3 -0.0231459
KLF6 Kruppel-like factor 6 -0.0231212
RPS3 ribosomal protein S3 -0.0228268
AHNAK AHNAK nucleoprotein -0.0224703
RPS27 ribosomal protein S27 -0.0224614
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0224354
PDIA3 protein disulfide isomerase family A, member 3 -0.0221598
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0218749
RPS25 ribosomal protein S25 -0.0215958
FAM162A family with sequence similarity 162, member A -0.0214785
PGK1 phosphoglycerate kinase 1 -0.0214272
DEK DEK proto-oncogene -0.0213429
MAP1B microtubule-associated protein 1B -0.0209261
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0207622
CAVIN1 caveolae associated protein 1 -0.0206724
RACK1 receptor for activated C kinase 1 -0.0206426
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0206159
TGM2 transglutaminase 2 -0.0205573
H3-3B H3.3 histone B -0.0203174
FDPS farnesyl diphosphate synthase -0.0203129
EGR1 early growth response 1 -0.0201124