Vismodegib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vismodegib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.191259
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.135932
TENT5A terminal nucleotidyltransferase 5A 0.0571268
LPIN1 lipin 1 0.0551711
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0506626
SOS1 son of sevenless homolog 1 (Drosophila) 0.0503211
CD36 CD36 molecule (thrombospondin receptor) 0.0469744
TPST1 tyrosylprotein sulfotransferase 1 0.0468073
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.043022
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0425142
ITPRID2 ITPR interacting domain containing 2 0.0423507
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0405635
ZFC3H1 zinc finger, C3H1-type containing 0.0388124
PSD3 pleckstrin and Sec7 domain containing 3 0.0378046
ADGRG6 adhesion G protein-coupled receptor G6 0.0330735
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0317992
PTPRE protein tyrosine phosphatase, receptor type, E 0.0306081
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0303932
PTEN phosphatase and tensin homolog 0.0303261
SIK2 salt-inducible kinase 2 0.0285821
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0281286
HMBOX1 homeobox containing 1 0.0276194
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0272632
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0266104
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0259317
ZMYM2 zinc finger, MYM-type 2 0.0255914
SRSF1 serine/arginine-rich splicing factor 1 0.0255913
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0252343
CD46 CD46 molecule, complement regulatory protein 0.0249778
HELZ helicase with zinc finger 0.0249055
PGAP1 post-GPI attachment to proteins 1 0.0246706
TOX thymocyte selection-associated high mobility group box 0.0246602
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0245889
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0241414
ADARB1 adenosine deaminase, RNA-specific, B1 0.0235146
OGA O-GlcNAcase 0.023256
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0230507
CENPC centromere protein C 0.0229739
SYT1 synaptotagmin I 0.0229227
DENND4C DENN/MADD domain containing 4C 0.0228474
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0227355
DISP1 dispatched homolog 1 (Drosophila) 0.0226464
USPL1 ubiquitin specific peptidase like 1 0.0224978
RUNX1 runt-related transcription factor 1 0.0224574
PELI1 pellino E3 ubiquitin protein ligase 1 0.0222339
PICALM phosphatidylinositol binding clathrin assembly protein 0.0220716
LONRF2 LON peptidase N-terminal domain and ring finger 2 0.0220601
CEP95 centrosomal protein 95kDa 0.0218974
RFX7 regulatory factor X, 7 0.0218906
ANGPT1 angiopoietin 1 0.0212944
SCAF11 SR-related CTD-associated factor 11 0.021191
RPL4 ribosomal protein L4 0.0209466
CHD1 chromodomain helicase DNA binding protein 1 0.0209031
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0205256
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.020453
TMF1 TATA element modulatory factor 1 0.020272
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0199633
AHR aryl hydrocarbon receptor 0.0199453
MAP1B microtubule-associated protein 1B 0.0191455
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0191396
PCM1 pericentriolar material 1 0.0188225
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0187389
SENP6 SUMO1/sentrin specific peptidase 6 0.0186099
CCNY cyclin Y 0.0185754
YEATS2 YEATS domain containing 2 0.0184231
CSNK1G1 casein kinase 1, gamma 1 0.0182826
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0180635
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0180143
KCTD3 potassium channel tetramerization domain containing 3 0.0179628
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0178831
TENT4A terminal nucleotidyltransferase 4A 0.0178632
LEMD3 LEM domain containing 3 0.0178392
XPO1 exportin 1 0.0178283
DST dystonin 0.0178206
RAB30 RAB30, member RAS oncogene family 0.0174293
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0172137
ANKRD50 ankyrin repeat domain 50 0.0170933
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0170877
WAC WW domain containing adaptor with coiled-coil 0.0170008
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0169934
PCBP3 poly(rC) binding protein 3 0.0169346
LNPK lunapark, ER junction formation factor 0.016881
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0166887
HAS2 hyaluronan synthase 2 0.0166773
OTUD7B OTU deubiquitinase 7B 0.0166438
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0164451
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0163484
SLC38A2 solute carrier family 38, member 2 0.0163153
NF1 neurofibromin 1 0.0162373
CDC73 cell division cycle 73 0.0162371
ADGRL2 adhesion G protein-coupled receptor L2 0.0161996
PHKB phosphorylase kinase, beta 0.0161507
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.0161479
NUP153 nucleoporin 153kDa 0.0161197
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0160021
UBAP2L ubiquitin associated protein 2-like 0.0159789
FAM120B family with sequence similarity 120B 0.015865
CAB39 calcium binding protein 39 0.0157568
MEIS1 Meis homeobox 1 0.0157535
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0156647

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.230357
LSAMP limbic system-associated membrane protein -0.193134
VCL vinculin -0.168353
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.134372
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128692
PTMA prothymosin, alpha -0.100773
AKAP12 A kinase (PRKA) anchor protein 12 -0.100721
VIM vimentin -0.0966083
NRG1 neuregulin 1 -0.0965679
NALF1 NALCN channel auxiliary factor 1 -0.0929619
EXT1 exostosin glycosyltransferase 1 -0.0744848
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0689664
TPM1 tropomyosin 1 (alpha) -0.0666018
RPL19 ribosomal protein L19 -0.0651578
ACTG1 actin gamma 1 -0.0630353
RPS6 ribosomal protein S6 -0.0623162
PTPRD protein tyrosine phosphatase, receptor type, D -0.0608486
RPLP1 ribosomal protein, large, P1 -0.0564405
TPT1 tumor protein, translationally-controlled 1 -0.0557131
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0556631
COL1A1 collagen, type I, alpha 1 -0.0534514
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0524074
MSI2 musashi RNA-binding protein 2 -0.0519978
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0515653
TPM4 tropomyosin 4 -0.0502432
FTL ferritin, light polypeptide -0.0501403
RPL23 ribosomal protein L23 -0.0501364
EGR1 early growth response 1 -0.0497695
B2M beta-2-microglobulin -0.0490782
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0487346
RPL35A ribosomal protein L35a -0.0482065
THSD4 thrombospondin, type I, domain containing 4 -0.0469994
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0469279
RPL38 ribosomal protein L38 -0.0466673
NDRG1 N-myc downstream regulated 1 -0.0460291
SLIT2 slit homolog 2 (Drosophila) -0.0451242
CUX1 cut-like homeobox 1 -0.044136
SP100 SP100 nuclear antigen -0.0437659
TMSB10 thymosin beta 10 -0.043274
PRKCA protein kinase C, alpha -0.0418231
RPS3 ribosomal protein S3 -0.0412499
RPL34 ribosomal protein L34 -0.0411523
CENPF centromere protein F, 350/400kDa -0.0407277
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0406075
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0399746
HILPDA hypoxia inducible lipid droplet-associated -0.0397952
KPNB1 karyopherin (importin) beta 1 -0.0390967
FERMT2 fermitin family member 2 -0.0390443
RPL37A ribosomal protein L37a -0.0389294
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.038793
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0386291
DDIT4 DNA-damage-inducible transcript 4 -0.0380772
TLE4 transducin-like enhancer of split 4 -0.0380412
LRP1B low density lipoprotein receptor-related protein 1B -0.0376805
NAP1L1 nucleosome assembly protein 1-like 1 -0.0367272
PTPRM protein tyrosine phosphatase, receptor type, M -0.0365779
RPS27A ribosomal protein S27a -0.0363934
PDIA3 protein disulfide isomerase family A, member 3 -0.0353072
IER3 immediate early response 3 -0.0352036
RACK1 receptor for activated C kinase 1 -0.0349491
RPS12 ribosomal protein S12 -0.0349288
BCAS3 breast carcinoma amplified sequence 3 -0.0348587
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0344212
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0341112
BPTF bromodomain PHD finger transcription factor -0.0332504
NPAS2 neuronal PAS domain protein 2 -0.033073
S100A9 S100 calcium binding protein A9 -0.0330506
MBNL1 muscleblind-like splicing regulator 1 -0.0327338
IGFBP3 insulin-like growth factor binding protein 3 -0.0326798
RPL36 ribosomal protein L36 -0.0321222
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.031588
RPL28 ribosomal protein L28 -0.0313723
EPAS1 endothelial PAS domain protein 1 -0.0313045
SMAD3 SMAD family member 3 -0.0312848
RNF213 ring finger protein 213 -0.0312558
RPL26 ribosomal protein L26 -0.0311983
TRIB2 tribbles pseudokinase 2 -0.030768
CNTN4 contactin 4 -0.0305883
MYO1E myosin IE -0.0303221
LIMA1 LIM domain and actin binding 1 -0.030071
DNAH14 dynein, axonemal, heavy chain 14 -0.0298065
LDHA lactate dehydrogenase A -0.0296859
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0294278
RAB7A RAB7A, member RAS oncogene family -0.0291229
CANX calnexin -0.028735
EIF1 eukaryotic translation initiation factor 1 -0.0285693
FUS FUS RNA binding protein -0.0285025
PDLIM5 PDZ and LIM domain 5 -0.028501
RAD51B RAD51 paralog B -0.0283336
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0277701
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0277537
CCDC57 coiled-coil domain containing 57 -0.0277422
SOX4 SRY (sex determining region Y)-box 4 -0.0276052
FMN1 formin 1 -0.0275911
RPS25 ribosomal protein S25 -0.0274771
RPS8 ribosomal protein S8 -0.0272271
KDM5B lysine (K)-specific demethylase 5B -0.0271587
MCL1 myeloid cell leukemia 1 -0.0271285
MAPK10 mitogen-activated protein kinase 10 -0.0268609
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0268196