Vismodegib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0705368
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0639378
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0625954
NRIP1 nuclear receptor interacting protein 1 0.058247
TXNIP thioredoxin interacting protein 0.0559308
RNF43 ring finger protein 43 0.0539044
IFNGR1 interferon gamma receptor 1 0.0534417
BTBD9 BTB (POZ) domain containing 9 0.0524901
SPRED1 sprouty-related, EVH1 domain containing 1 0.0509875
PTBP3 polypyrimidine tract binding protein 3 0.0449821
ZMYM2 zinc finger, MYM-type 2 0.0438423
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0414613
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0413479
RBM26 RNA binding motif protein 26 0.0401613
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0350573
N4BP2L2 NEDD4 binding protein 2-like 2 0.0344417
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0334135
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0311132
MCTP2 multiple C2 domains, transmembrane 2 0.0308422
ABHD2 abhydrolase domain containing 2 0.0303428
SREBF2 sterol regulatory element binding transcription factor 2 0.0297812
PTEN phosphatase and tensin homolog 0.0297679
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0288524
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0285418
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0278246
LRRC1 leucine rich repeat containing 1 0.0273394
DSCAM Down syndrome cell adhesion molecule 0.0270742
USP54 ubiquitin specific peptidase 54 0.0269801
NCKAP5 NCK-associated protein 5 0.0267249
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0262581
UBAC2 UBA domain containing 2 0.0262164
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0261058
IL20RA interleukin 20 receptor, alpha 0.0260341
FNDC3A fibronectin type III domain containing 3A 0.0255441
TMEM62 transmembrane protein 62 0.0253177
ZBTB20 zinc finger and BTB domain containing 20 0.0250223
OARD1 O-acyl-ADP-ribose deacylase 1 0.0247193
EHF ets homologous factor 0.0241451
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0239374
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0237759
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.023574
RNF149 ring finger protein 149 0.0235236
MON2 MON2 homolog (S. cerevisiae) 0.0231665
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0231416
SPRED2 sprouty-related, EVH1 domain containing 2 0.0231277
CTNND1 catenin (cadherin-associated protein), delta 1 0.0230937
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0226973
DENND4C DENN/MADD domain containing 4C 0.0226375
PUM2 pumilio RNA-binding family member 2 0.0225872
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0221412
PHF3 PHD finger protein 3 0.0218454
YAP1 Yes-associated protein 1 0.0217795
ZDHHC20 zinc finger, DHHC-type containing 20 0.02144
UBL3 ubiquitin-like 3 0.0214364
ARHGAP32 Rho GTPase activating protein 32 0.0213692
ADAM10 ADAM metallopeptidase domain 10 0.0209016
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0206971
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0205074
CANX calnexin 0.0202102
CD46 CD46 molecule, complement regulatory protein 0.0201573
TENT2 terminal nucleotidyltransferase 2 0.020105
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0199912
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0199662
BRWD1 bromodomain and WD repeat domain containing 1 0.0199482
OGA O-GlcNAcase 0.0199478
MBNL2 muscleblind-like splicing regulator 2 0.019931
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0198793
ARGLU1 arginine and glutamate rich 1 0.0197525
BICRAL BICRA like chromatin remodeling complex associated protein 0.0196104
CDC42SE2 CDC42 small effector 2 0.0195009
ITCH itchy E3 ubiquitin protein ligase 0.0193212
SBF2 SET binding factor 2 0.0193147
AVL9 AVL9 homolog (S. cerevisiase) 0.0192988
PLS1 plastin 1 0.0188681
AOPEP aminopeptidase O (putative) 0.0186142
RARS1 arginyl-tRNA synthetase 1 0.0185891
MICU2 mitochondrial calcium uptake 2 0.0183445
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.018306
EXOC1 exocyst complex component 1 0.018267
SACK1B scaffolding CK1 anchoring protein B 0.018234
AHI1 Abelson helper integration site 1 0.0181902
RNF145 ring finger protein 145 0.0180677
ARHGAP5 Rho GTPase activating protein 5 0.0180062
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0179896
TMEM51 transmembrane protein 51 0.0179227
STEAP2 STEAP family member 2, metalloreductase 0.0178641
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0177658
PDZD8 PDZ domain containing 8 0.017633
ATM ATM serine/threonine kinase 0.0175357
KLF3 Kruppel-like factor 3 (basic) 0.0175085
ESRP1 epithelial splicing regulatory protein 1 0.0175073
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0173504
ATP10B ATPase, class V, type 10B 0.017325
RAD23B RAD23 homolog B (S. cerevisiae) 0.0173239
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0172172
METTL15 methyltransferase like 15 0.0171514
ZNF148 zinc finger protein 148 0.0171429
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0170448
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0169085
ZNF638 zinc finger protein 638 0.0168462

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.167877
INTS6 integrator complex subunit 6 -0.144023
B2M beta-2-microglobulin -0.140947
ANXA2 annexin A2 -0.131629
EZR ezrin -0.128626
TPT1 tumor protein, translationally-controlled 1 -0.123196
RNF213 ring finger protein 213 -0.11995
EGR1 early growth response 1 -0.116806
SQSTM1 sequestosome 1 -0.11508
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0997899
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0935757
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.087879
RIGI RNA sensor RIG-I -0.0753234
EPSTI1 epithelial stromal interaction 1 (breast) -0.075285
PTMA prothymosin, alpha -0.0737306
SP100 SP100 nuclear antigen -0.072274
EXT1 exostosin glycosyltransferase 1 -0.0697803
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0693341
RAB7A RAB7A, member RAS oncogene family -0.0683305
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0682754
GCLC glutamate-cysteine ligase, catalytic subunit -0.0669084
PERP PERP, TP53 apoptosis effector -0.0658939
IRF1 interferon regulatory factor 1 -0.0643068
GMDS GDP-mannose 4,6-dehydratase -0.0639872
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0636108
MX1 MX dynamin-like GTPase 1 -0.061782
JUN jun proto-oncogene -0.0596952
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0587502
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0576088
IFI6 interferon, alpha-inducible protein 6 -0.056936
AREG amphiregulin -0.0564598
LOC102724023 ES1 protein homolog, mitochondrial -0.0558757
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0549551
PLSCR2 phospholipid scramblase 2 -0.0547058
MX2 MX dynamin-like GTPase 2 -0.0544329
HLA-B major histocompatibility complex, class I, B -0.0539022
RRBP1 ribosome binding protein 1 -0.0536225
LCN2 lipocalin 2 -0.0534037
PKM pyruvate kinase, muscle -0.0530759
ENO1 enolase 1, (alpha) -0.0502799
NPSR1 neuropeptide S receptor 1 -0.0489467
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0489111
XAF1 XIAP associated factor 1 -0.0481587
EFNB2 ephrin-B2 -0.0469171
ACTG1 actin gamma 1 -0.046628
NDRG1 N-myc downstream regulated 1 -0.045534
MCL1 myeloid cell leukemia 1 -0.0453135
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0446861
FTL ferritin, light polypeptide -0.0432911
STS steroid sulfatase (microsomal), isozyme S -0.0426216
TMSB10 thymosin beta 10 -0.0414163
ANXA1 annexin A1 -0.0409659
DDIT3 DNA-damage-inducible transcript 3 -0.0409239
SPDYA speedy/RINGO cell cycle regulator family member A -0.0408527
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0405237
VCL vinculin -0.0404117
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0396906
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0396036
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0390498
IFI27 interferon, alpha-inducible protein 27 -0.0389857
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0372301
RPL35A ribosomal protein L35a -0.037224
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0365922
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0358551
LYZ lysozyme -0.0356028
RPL23 ribosomal protein L23 -0.0354646
MUC20 mucin 20, cell surface associated -0.0354568
TSHZ2 teashirt zinc finger homeobox 2 -0.035182
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0349545
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0349187
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0348198
TJP1 tight junction protein 1 -0.0347799
S100A10 S100 calcium binding protein A10 -0.034628
NABP1 nucleic acid binding protein 1 -0.0343995
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343106
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0343088
PLSCR1 phospholipid scramblase 1 -0.0341579
MYO1E myosin IE -0.0341056
VMP1 vacuole membrane protein 1 -0.0334663
EPS8 epidermal growth factor receptor pathway substrate 8 -0.033313
LOC112694756 uncharaterized LOC112694756 -0.0331187
MCTP1 multiple C2 domains, transmembrane 1 -0.0327956
LMNA lamin A/C -0.0327228
LAMA4 laminin, alpha 4 -0.0326811
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0325147
S100A6 S100 calcium binding protein A6 -0.0324037
TM4SF19 transmembrane 4 L six family member 19 -0.0316428
RPL34 ribosomal protein L34 -0.0314527
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.031334
CATSPERB catsper channel auxiliary subunit beta -0.0313124
ADM adrenomedullin -0.0311832
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0311575
MAML2 mastermind-like 2 (Drosophila) -0.0309419
RPS6 ribosomal protein S6 -0.0306054
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0303544
BLZF1 basic leucine zipper nuclear factor 1 -0.0303354
SDCBP syndecan binding protein (syntenin) -0.0301767
IRS2 insulin receptor substrate 2 -0.0299368
ITPKC inositol-trisphosphate 3-kinase C -0.0297828
RPLP1 ribosomal protein, large, P1 -0.0294293