| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vismodegib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vismodegib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.236739 |
| FN1 | fibronectin 1 | 0.174922 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.170768 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0875059 |
| AHNAK | AHNAK nucleoprotein | 0.0808967 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0795582 |
| ARRDC3 | arrestin domain containing 3 | 0.0766975 |
| CADM1 | cell adhesion molecule 1 | 0.0740348 |
| CD44 | CD44 molecule (Indian blood group) | 0.072442 |
| FBN1 | fibrillin 1 | 0.0637721 |
| COL1A1 | collagen, type I, alpha 1 | 0.0628967 |
| ATP13A3 | ATPase type 13A3 | 0.0602598 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0597599 |
| COL1A2 | collagen, type I, alpha 2 | 0.0590163 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0586371 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0585333 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0583862 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0554129 |
| MTSS1 | metastasis suppressor 1 | 0.0546834 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0545468 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0539903 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0539761 |
| NAV2 | neuron navigator 2 | 0.0532925 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0527184 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0508331 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0497847 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0495333 |
| HIP1 | huntingtin interacting protein 1 | 0.0486884 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0469825 |
| MYO10 | myosin X | 0.0459271 |
| EGFR | epidermal growth factor receptor | 0.0450479 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0445895 |
| COL5A1 | collagen, type V, alpha 1 | 0.0445857 |
| SPAG9 | sperm associated antigen 9 | 0.0441349 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0435443 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0434633 |
| SMAD3 | SMAD family member 3 | 0.04181 |
| FMNL2 | formin-like 2 | 0.0415894 |
| UBC | ubiquitin C | 0.0406178 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0405024 |
| LDHA | lactate dehydrogenase A | 0.040488 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0389677 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0383589 |
| ANXA2 | annexin A2 | 0.0377919 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0375048 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0369398 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0363456 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0363003 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0359811 |
| DST | dystonin | 0.0355555 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0355318 |
| PLEC | plectin | 0.0353661 |
| OGA | O-GlcNAcase | 0.0352439 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0351323 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0351047 |
| MAP4 | microtubule-associated protein 4 | 0.0348856 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0346605 |
| QKI | QKI, KH domain containing, RNA binding | 0.0346581 |
| TNS1 | tensin 1 | 0.03447 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0339714 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0335088 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0330436 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0327907 |
| H1-0 | H1.0 linker histone | 0.0319562 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0315489 |
| MYO1B | myosin IB | 0.0313735 |
| CENPF | centromere protein F, 350/400kDa | 0.0313428 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0313425 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0307785 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0307377 |
| LOXL2 | lysyl oxidase-like 2 | 0.0298634 |
| USP3 | ubiquitin specific peptidase 3 | 0.0296137 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0295275 |
| YEATS2 | YEATS domain containing 2 | 0.0294927 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0289734 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0288708 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0288006 |
| RASA2 | RAS p21 protein activator 2 | 0.0287748 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0284001 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0279769 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0279262 |
| SDC2 | syndecan 2 | 0.0278187 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0277754 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0276282 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0273831 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0271984 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0270543 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.026966 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0269445 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0269112 |
| PRELID2 | PRELI domain containing 2 | 0.0268189 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0267595 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0267527 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0266674 |
| NAV1 | neuron navigator 1 | 0.0266253 |
| CEP192 | centrosomal protein 192kDa | 0.026592 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0265906 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0262238 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0260939 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0260108 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.229714 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.17827 |
| NDRG1 | N-myc downstream regulated 1 | -0.132396 |
| VIM | vimentin | -0.110953 |
| EGR1 | early growth response 1 | -0.0904157 |
| VEGFA | vascular endothelial growth factor A | -0.0698804 |
| TMSB10 | thymosin beta 10 | -0.0682707 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0655132 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0609227 |
| RRBP1 | ribosome binding protein 1 | -0.0520053 |
| STC1 | stanniocalcin 1 | -0.0512249 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0508975 |
| TPM4 | tropomyosin 4 | -0.0501085 |
| CDH13 | cadherin 13 | -0.0486344 |
| ACTG1 | actin gamma 1 | -0.0426292 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0410513 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0400885 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0389901 |
| IL6 | interleukin 6 | -0.0377864 |
| PALLD | palladin, cytoskeletal associated protein | -0.0368383 |
| LOX | lysyl oxidase | -0.0364217 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0353935 |
| RPS8 | ribosomal protein S8 | -0.0344456 |
| MT1X | metallothionein 1X | -0.0340627 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0337838 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0332917 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0330305 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0327043 |
| LIMA1 | LIM domain and actin binding 1 | -0.03268 |
| POTEF | POTE ankyrin domain family, member F | -0.0326393 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0319209 |
| TPM1 | tropomyosin 1 (alpha) | -0.0319095 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0312316 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0309525 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0308734 |
| RPL26 | ribosomal protein L26 | -0.0292715 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0287407 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0281769 |
| ANKRD12 | ankyrin repeat domain 12 | -0.028073 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0275083 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0269614 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0267609 |
| INSIG1 | insulin induced gene 1 | -0.0263529 |
| HM13 | histocompatibility (minor) 13 | -0.0262222 |
| IER3 | immediate early response 3 | -0.0258691 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0257191 |
| HLA-B | major histocompatibility complex, class I, B | -0.0253328 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0247767 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0246115 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0242588 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.024169 |
| RPS12 | ribosomal protein S12 | -0.0240696 |
| FTL | ferritin, light polypeptide | -0.024013 |
| PLAU | plasminogen activator, urokinase | -0.0237126 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0236309 |
| RSU1 | Ras suppressor protein 1 | -0.0235594 |
| RPS3 | ribosomal protein S3 | -0.0235142 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 | -0.023345 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.023126 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0230914 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0227771 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0227175 |
| RPL8 | ribosomal protein L8 | -0.0225577 |
| CFDP1 | craniofacial development protein 1 | -0.0223073 |
| YBX1 | Y box binding protein 1 | -0.0223053 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0222758 |
| PTMA | prothymosin, alpha | -0.0221947 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0221035 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.022079 |
| RPL18 | ribosomal protein L18 | -0.0219131 |
| LAMA5 | laminin, alpha 5 | -0.0218686 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0215977 |
| NABP1 | nucleic acid binding protein 1 | -0.0213637 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.021173 |
| COG5 | component of oligomeric golgi complex 5 | -0.0210973 |
| PITPNB | phosphatidylinositol transfer protein, beta | -0.0210716 |
| RPS6 | ribosomal protein S6 | -0.0207385 |
| SEC24A | SEC24 family member A | -0.0207191 |
| MYADM | myeloid-associated differentiation marker | -0.0207132 |
| IER2 | immediate early response 2 | -0.0206817 |
| TUBB6 | tubulin, beta 6 class V | -0.0206735 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0206682 |
| HEATR5A | HEAT repeat containing 5A | -0.0206382 |
| RAB7A | RAB7A, member RAS oncogene family | -0.020607 |
| TFG | TRK-fused gene | -0.0204761 |
| MT2A | metallothionein 2A | -0.0204382 |
| DUSP6 | dual specificity phosphatase 6 | -0.0204163 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0203421 |
| RPL19 | ribosomal protein L19 | -0.0203112 |
| PGM3 | phosphoglucomutase 3 | -0.0202581 |
| RHOA | ras homolog family member A | -0.0202363 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0202269 |
| RPL5 | ribosomal protein L5 | -0.0200596 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0200498 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.0199534 |
| NEK10 | NIMA-related kinase 10 | -0.0199437 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0197915 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0197314 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0196975 |
| UBE4B | ubiquitination factor E4B | -0.0194314 |
