| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vismodegib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vismodegib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.158198 |
| SLC38A2 | solute carrier family 38, member 2 | 0.141141 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.13646 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.114095 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0833711 |
| ITGAV | integrin, alpha V | 0.0832131 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0791461 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0736189 |
| VCL | vinculin | 0.0731218 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0718392 |
| FAM107B | family with sequence similarity 107, member B | 0.069965 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0681028 |
| ENO1 | enolase 1, (alpha) | 0.0608448 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0606862 |
| EHBP1 | EH domain binding protein 1 | 0.0603419 |
| STK17A | serine/threonine kinase 17a | 0.0593545 |
| FN1 | fibronectin 1 | 0.0579721 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0541752 |
| DST | dystonin | 0.053575 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0532124 |
| ZNF644 | zinc finger protein 644 | 0.0513466 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0468773 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0457496 |
| SDC4 | syndecan 4 | 0.0455642 |
| PEG3 | paternally expressed 3 | 0.0455463 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.044609 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0427757 |
| KIF1B | kinesin family member 1B | 0.0424521 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.040544 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0396462 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0389728 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0385963 |
| GK | glycerol kinase | 0.0377662 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0376332 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0375188 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.037441 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0369283 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0365958 |
| RAI14 | retinoic acid induced 14 | 0.0361627 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0357351 |
| MSI2 | musashi RNA-binding protein 2 | 0.0354517 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0348966 |
| PLIN2 | perilipin 2 | 0.0345842 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0343185 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0340823 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0340527 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0339928 |
| AFDN | afadin, adherens junction formation factor | 0.0336225 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0332668 |
| LRRC1 | leucine rich repeat containing 1 | 0.0330834 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0325306 |
| FAT1 | FAT atypical cadherin 1 | 0.032199 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0320313 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0319774 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0317145 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0315466 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0314649 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0313031 |
| PHF3 | PHD finger protein 3 | 0.0310589 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0307874 |
| PTK2 | protein tyrosine kinase 2 | 0.0305963 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0303762 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0300887 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0293179 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0292484 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0289628 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0286437 |
| CRY1 | cryptochrome circadian clock 1 | 0.0283975 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0280599 |
| MALT1 | MALT1 paracaspase | 0.027697 |
| CP | ceruloplasmin (ferroxidase) | 0.0270843 |
| AHSG | alpha-2-HS-glycoprotein | 0.027063 |
| SIK3 | SIK family kinase 3 | 0.0269515 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0266329 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0265347 |
| FRMD5 | FERM domain containing 5 | 0.0265048 |
| ASPH | aspartate beta-hydroxylase | 0.0264231 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0262376 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0262252 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0260586 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0259984 |
| ANXA5 | annexin A5 | 0.0255825 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0255015 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0253345 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0252156 |
| MYO1E | myosin IE | 0.0251326 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0250808 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0249935 |
| GPC3 | glypican 3 | 0.0248547 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0248487 |
| RBPMS | RNA binding protein with multiple splicing | 0.0248166 |
| ENAH | enabled homolog (Drosophila) | 0.0246874 |
| FOXO1 | forkhead box O1 | 0.0246305 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0245361 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0242572 |
| FMNL2 | formin-like 2 | 0.0238244 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0236774 |
| PEG10 | paternally expressed 10 | 0.0236255 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0235758 |
| FILIP1L | filamin A interacting protein 1-like | 0.0235616 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.185112 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.176848 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.161628 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.126808 |
| MT2A | metallothionein 2A | -0.112746 |
| C3 | complement component 3 | -0.103128 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0870277 |
| SVIL | supervillin | -0.0763062 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0759792 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.057204 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0544346 |
| RPS2 | ribosomal protein S2 | -0.0501191 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0501079 |
| RPS6 | ribosomal protein S6 | -0.0490059 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0486716 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0484269 |
| RPS24 | ribosomal protein S24 | -0.0432988 |
| RBM39 | RNA binding motif protein 39 | -0.0424747 |
| RPL23 | ribosomal protein L23 | -0.04221 |
| TRIM26 | tripartite motif containing 26 | -0.0419298 |
| ZFR | zinc finger RNA binding protein | -0.0414941 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0414815 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0414607 |
| RPL37A | ribosomal protein L37a | -0.0412397 |
| SPAG9 | sperm associated antigen 9 | -0.0405676 |
| RPL38 | ribosomal protein L38 | -0.0394281 |
| RPLP2 | ribosomal protein, large, P2 | -0.0390254 |
| RPS8 | ribosomal protein S8 | -0.037731 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0365272 |
| RPS12 | ribosomal protein S12 | -0.0362317 |
| NDRG1 | N-myc downstream regulated 1 | -0.033872 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0338583 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0334254 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0331649 |
| RPL11 | ribosomal protein L11 | -0.0319459 |
| RPL9 | ribosomal protein L9 | -0.0318801 |
| RPLP0 | ribosomal protein, large, P0 | -0.0318364 |
| MED13L | mediator complex subunit 13-like | -0.0311934 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0310796 |
| MRTFA | myocardin related transcription factor A | -0.0310257 |
| LCN2 | lipocalin 2 | -0.0308664 |
| RPS19 | ribosomal protein S19 | -0.0304799 |
| RPLP1 | ribosomal protein, large, P1 | -0.0304308 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0302171 |
| RPL26 | ribosomal protein L26 | -0.0296123 |
| APOE | apolipoprotein E | -0.0293294 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.0291863 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0290348 |
| HLF | hepatic leukemia factor | -0.0287214 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0286483 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0286038 |
| RRBP1 | ribosome binding protein 1 | -0.0279677 |
| KYNU | kynureninase | -0.0276916 |
| CLTC | clathrin, heavy chain (Hc) | -0.026861 |
| RPL7 | ribosomal protein L7 | -0.0266599 |
| RPS21 | ribosomal protein S21 | -0.0261002 |
| RPL7A | ribosomal protein L7a | -0.0260412 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0256814 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0256413 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0253159 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.02515 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0251462 |
| RPS25 | ribosomal protein S25 | -0.0248926 |
| RPL19 | ribosomal protein L19 | -0.0248668 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0244999 |
| RPL36 | ribosomal protein L36 | -0.0241445 |
| RPL37 | ribosomal protein L37 | -0.0237493 |
| KAZN | kazrin, periplakin interacting protein | -0.0237252 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0235877 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0234355 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0233981 |
| JMJD1C | jumonji domain containing 1C | -0.0231097 |
| XPO1 | exportin 1 | -0.0230348 |
| RPS13 | ribosomal protein S13 | -0.0229704 |
| FBXO31 | F-box protein 31 | -0.0229493 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0229455 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.022659 |
| RPL30 | ribosomal protein L30 | -0.0225822 |
| RLF | rearranged L-myc fusion | -0.0225421 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0225018 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0223944 |
| RPS3 | ribosomal protein S3 | -0.0221985 |
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | -0.0219742 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0219498 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0219129 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0217454 |
| OSMR | oncostatin M receptor | -0.0216593 |
| BBX | bobby sox homolog (Drosophila) | -0.021525 |
| UBXN4 | UBX domain protein 4 | -0.0214443 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0213379 |
| CDC27 | cell division cycle 27 | -0.0212316 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0211368 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0211263 |
| CTSB | cathepsin B | -0.0210211 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0209354 |
| PHIP | pleckstrin homology domain interacting protein | -0.0207054 |
| CRLS1 | cardiolipin synthase 1 | -0.0206912 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0205721 |
| MATR3 | matrin 3 | -0.0205569 |
| KLF6 | Kruppel-like factor 6 | -0.0204686 |
