| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vismodegib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Vismodegib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| OSMR | oncostatin M receptor | 0.0368727 |
| CES1 | carboxylesterase 1 | 0.0351426 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0315544 |
| LAMA4 | laminin, alpha 4 | 0.0291162 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0290704 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0289509 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0280925 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0275629 |
| NGLY1 | N-glycanase 1 | 0.0268978 |
| SLTM | SAFB-like, transcription modulator | 0.0265615 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0249573 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0240648 |
| RASA2 | RAS p21 protein activator 2 | 0.0222827 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0221941 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0218385 |
| KIAA1328 | KIAA1328 | 0.0214891 |
| OGA | O-GlcNAcase | 0.0214248 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0213383 |
| NPC1 | Niemann-Pick disease, type C1 | 0.021165 |
| RTN4 | reticulon 4 | 0.020993 |
| TMEM165 | transmembrane protein 165 | 0.0201808 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0200319 |
| FNIP1 | folliculin interacting protein 1 | 0.019922 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0196492 |
| ZNF638 | zinc finger protein 638 | 0.0195921 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0179197 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0174566 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0173246 |
| WDR26 | WD repeat domain 26 | 0.017077 |
| MKI67 | marker of proliferation Ki-67 | 0.0170494 |
| RUNX1 | runt-related transcription factor 1 | 0.0170129 |
| PRELID2 | PRELI domain containing 2 | 0.0169305 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0168152 |
| ATP13A3 | ATPase type 13A3 | 0.01677 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0166902 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0166811 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0164172 |
| GPATCH2L | G patch domain containing 2-like | 0.0163692 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0162042 |
| FRY | furry homolog (Drosophila) | 0.0162018 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0161767 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0161614 |
| KIAA1217 | KIAA1217 | 0.0160544 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0160211 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0156137 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0155984 |
| USP34 | ubiquitin specific peptidase 34 | 0.0153269 |
| CCNL1 | cyclin L1 | 0.0150884 |
| NABP1 | nucleic acid binding protein 1 | 0.0146899 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0146838 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0145856 |
| ANO6 | anoctamin 6 | 0.0145604 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.013876 |
| PTEN | phosphatase and tensin homolog | 0.0138296 |
| RNF169 | ring finger protein 169 | 0.0137427 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0137118 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0136705 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.013583 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0135582 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0135107 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0134609 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0134295 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0130252 |
| ABI1 | abl-interactor 1 | 0.0129229 |
| YEATS2 | YEATS domain containing 2 | 0.0129029 |
| SP3 | Sp3 transcription factor | 0.0128725 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0128229 |
| KLC1 | kinesin light chain 1 | 0.0127193 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.012693 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.012608 |
| ATP11A | ATPase, class VI, type 11A | 0.0122689 |
| TMEM39A | transmembrane protein 39A | 0.0122283 |
| CEP95 | centrosomal protein 95kDa | 0.0121149 |
| CAB39 | calcium binding protein 39 | 0.0118675 |
| TMF1 | TATA element modulatory factor 1 | 0.011845 |
| MYO1B | myosin IB | 0.011813 |
| LAMC2 | laminin, gamma 2 | 0.0116644 |
| SEPTIN10 | septin 10 | 0.0115924 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0115817 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0115804 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0115446 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0115164 |
| EP300 | E1A binding protein p300 | 0.0114751 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0113996 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0112035 |
| METTL15 | methyltransferase like 15 | 0.011148 |
| NAPB | N-ethylmaleimide-sensitive factor attachment protein, beta | 0.0111433 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0111227 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0110769 |
| MED13 | mediator complex subunit 13 | 0.0110317 |
| LEMD3 | LEM domain containing 3 | 0.0110248 |
| DTNA | dystrobrevin, alpha | 0.0109397 |
| RBM26 | RNA binding motif protein 26 | 0.0108676 |
| MYO6 | myosin VI | 0.010864 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.010852 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0106189 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0105776 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.0105206 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.0105113 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0104216 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.484613 |
| TMSB10 | thymosin beta 10 | -0.17733 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.158996 |
| PTMA | prothymosin, alpha | -0.129316 |
| S100A10 | S100 calcium binding protein A10 | -0.093708 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0936745 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.093304 |
| FTL | ferritin, light polypeptide | -0.089642 |
| PKM | pyruvate kinase, muscle | -0.0896091 |
| ACTG1 | actin gamma 1 | -0.0885644 |
| ASPH | aspartate beta-hydroxylase | -0.0794562 |
| LDHA | lactate dehydrogenase A | -0.0783977 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0741816 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0739405 |
| MT2A | metallothionein 2A | -0.0730413 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0721319 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.072117 |
| EGFR | epidermal growth factor receptor | -0.0702521 |
| RPLP1 | ribosomal protein, large, P1 | -0.0697099 |
| SEC61G | Sec61 gamma subunit | -0.0674875 |
| ENO1 | enolase 1, (alpha) | -0.0654346 |
| RPS3 | ribosomal protein S3 | -0.063181 |
| NDRG1 | N-myc downstream regulated 1 | -0.0619417 |
| KRT18 | keratin 18, type I | -0.0616038 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0592906 |
| ANXA2 | annexin A2 | -0.0579396 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0564708 |
| RPL35A | ribosomal protein L35a | -0.055909 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0551991 |
| MYOF | myoferlin | -0.0540195 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0535557 |
| RPS6 | ribosomal protein S6 | -0.0510885 |
| KRT7 | keratin 7, type II | -0.0509811 |
| RPS8 | ribosomal protein S8 | -0.0506557 |
| RPS25 | ribosomal protein S25 | -0.0494536 |
| RPL37A | ribosomal protein L37a | -0.0491676 |
| CST3 | cystatin C | -0.0474023 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.046941 |
| EGR1 | early growth response 1 | -0.0465839 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0431047 |
| RPL34 | ribosomal protein L34 | -0.0414138 |
| RPS24 | ribosomal protein S24 | -0.041324 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0402049 |
| RPS27A | ribosomal protein S27a | -0.0395698 |
| B2M | beta-2-microglobulin | -0.0384288 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0381307 |
| CCND1 | cyclin D1 | -0.0375155 |
| RPL31 | ribosomal protein L31 | -0.0373582 |
| RPL19 | ribosomal protein L19 | -0.0372846 |
| GRAMD1B | GRAM domain containing 1B | -0.0372616 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0370506 |
| RPLP0 | ribosomal protein, large, P0 | -0.0359764 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0357742 |
| RPS12 | ribosomal protein S12 | -0.0355458 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0349469 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0342461 |
| STC1 | stanniocalcin 1 | -0.0340964 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0335854 |
| RPL8 | ribosomal protein L8 | -0.0335267 |
| RPL12 | ribosomal protein L12 | -0.033302 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0332958 |
| RPL11 | ribosomal protein L11 | -0.0330066 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0325393 |
| IER3 | immediate early response 3 | -0.0322362 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0320564 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0319684 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0312125 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0312082 |
| RPL30 | ribosomal protein L30 | -0.0311465 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0310212 |
| S100A6 | S100 calcium binding protein A6 | -0.0308491 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0308053 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0307051 |
| S100P | S100 calcium binding protein P | -0.0306894 |
| TPM4 | tropomyosin 4 | -0.0300373 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.029896 |
| S100A9 | S100 calcium binding protein A9 | -0.0294302 |
| RPS29 | ribosomal protein S29 | -0.0292876 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0287577 |
| UBC | ubiquitin C | -0.028597 |
| S100A11 | S100 calcium binding protein A11 | -0.0284805 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0283695 |
| RPS23 | ribosomal protein S23 | -0.0281496 |
| KRT8 | keratin 8, type II | -0.0281435 |
| CAV2 | caveolin 2 | -0.0281072 |
| SCEL | sciellin | -0.0279639 |
| GNAS | GNAS complex locus | -0.0279238 |
| RPL37 | ribosomal protein L37 | -0.0279197 |
| INTS6 | integrator complex subunit 6 | -0.0278502 |
| HMGA1 | high mobility group AT-hook 1 | -0.0276741 |
| RPL23 | ribosomal protein L23 | -0.0276058 |
| RNF213 | ring finger protein 213 | -0.0274956 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.027091 |
| RPLP2 | ribosomal protein, large, P2 | -0.0270745 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0270293 |
| RPS17 | ribosomal protein S17 | -0.0268155 |
| CANX | calnexin | -0.0268138 |
| MORF4L2 | mortality factor 4 like 2 | -0.0259663 |
| TPI1 | triosephosphate isomerase 1 | -0.0259126 |
| ATF4 | activating transcription factor 4 | -0.0256689 |
