Vismodegib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.129473
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0901705
SOD2 superoxide dismutase 2, mitochondrial 0.0852764
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0635194
PID1 phosphotyrosine interaction domain containing 1 0.0544545
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0520551
ATP13A3 ATPase type 13A3 0.0520434
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0486781
PCBP2 poly(rC) binding protein 2 0.0485921
DSCAM Down syndrome cell adhesion molecule 0.0469441
FAM107B family with sequence similarity 107, member B 0.0460056
RICTOR RPTOR independent companion of MTOR, complex 2 0.0459115
SIK3 SIK family kinase 3 0.0453701
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0441949
TRIO trio Rho guanine nucleotide exchange factor 0.0431512
YBX1 Y box binding protein 1 0.0417763
DOCK4 dedicator of cytokinesis 4 0.0417456
STRN3 striatin, calmodulin binding protein 3 0.0410756
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0394623
USP47 ubiquitin specific peptidase 47 0.0388556
KYNU kynureninase 0.0378765
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.03755
GLCCI1 glucocorticoid induced 1 0.0365856
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0357998
RBM39 RNA binding motif protein 39 0.0350186
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0348903
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0344824
CHD1 chromodomain helicase DNA binding protein 1 0.0343145
RAB27B RAB27B, member RAS oncogene family 0.0340975
MYH9 myosin, heavy chain 9, non-muscle 0.0339472
GOLGA4 golgin A4 0.0337595
EPS8 epidermal growth factor receptor pathway substrate 8 0.0334752
PCNX1 pecanex 1 0.0326554
OGA O-GlcNAcase 0.0326317
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0323234
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0321536
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0321144
FMNL2 formin-like 2 0.0316951
OSMR oncostatin M receptor 0.0316561
USP15 ubiquitin specific peptidase 15 0.0314313
TRA2A transformer 2 alpha homolog (Drosophila) 0.0312215
CTNND1 catenin (cadherin-associated protein), delta 1 0.0312102
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0311447
PARD3 par-3 family cell polarity regulator 0.0307743
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0306672
ZEB2 zinc finger E-box binding homeobox 2 0.0304439
RB1CC1 RB1-inducible coiled-coil 1 0.0298989
RBM33 RNA binding motif protein 33 0.0297146
CHIC2 cysteine-rich hydrophobic domain 2 0.0296388
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0296258
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0296184
MYO1B myosin IB 0.0294789
ARHGAP42 Rho GTPase activating protein 42 0.0293018
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0289171
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0288314
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0283854
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0282276
TRIP12 thyroid hormone receptor interactor 12 0.0280937
PUM2 pumilio RNA-binding family member 2 0.0277806
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0268472
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0261109
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0259626
RNF145 ring finger protein 145 0.0255533
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0252693
QKI QKI, KH domain containing, RNA binding 0.0251839
YTHDC1 YTH domain containing 1 0.0249803
RPL4 ribosomal protein L4 0.024749
HELZ helicase with zinc finger 0.0247248
MAPK8 mitogen-activated protein kinase 8 0.0245253
PICALM phosphatidylinositol binding clathrin assembly protein 0.0243175
MARCHF6 membrane associated ring-CH-type finger 6 0.0241715
TGFB2 transforming growth factor, beta 2 0.024112
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0240947
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0239694
USP3 ubiquitin specific peptidase 3 0.0238951
WAC WW domain containing adaptor with coiled-coil 0.0238244
ANKRD28 ankyrin repeat domain 28 0.0235088
GLS2 glutaminase 2 (liver, mitochondrial) 0.0231967
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0230987
RASA2 RAS p21 protein activator 2 0.0225828
TOP2B topoisomerase (DNA) II beta 180kDa 0.0225085
PNN pinin, desmosome associated protein 0.0224306
CUL3 cullin 3 0.02239
SUCO SUN domain containing ossification factor 0.0223854
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0221709
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0220937
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0219663
SETD5 SET domain containing 5 0.021913
CEP95 centrosomal protein 95kDa 0.0213133
TOP1 topoisomerase (DNA) I 0.0212707
SEC23A Sec23 homolog A (S. cerevisiae) 0.0211823
FOXJ3 forkhead box J3 0.0211722
YME1L1 YME1-like 1 ATPase 0.0211475
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0210024
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0209556
RPL3 ribosomal protein L3 0.020914
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0207896
CDC73 cell division cycle 73 0.0206698
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0204478
ATXN1 ataxin 1 0.020132

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.238527
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.229987
TMSB10 thymosin beta 10 -0.187772
FN1 fibronectin 1 -0.122634
NDRG1 N-myc downstream regulated 1 -0.108047
FTL ferritin, light polypeptide -0.0941012
MT2A metallothionein 2A -0.0919399
STC1 stanniocalcin 1 -0.0837616
LOX lysyl oxidase -0.0813811
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0724588
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0652632
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0646584
RPLP1 ribosomal protein, large, P1 -0.0608456
AKAP12 A kinase (PRKA) anchor protein 12 -0.0595457
IER3 immediate early response 3 -0.0584421
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0568384
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0567701
S100A6 S100 calcium binding protein A6 -0.0541502
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0534899
ENO1 enolase 1, (alpha) -0.0533853
CA12 carbonic anhydrase XII -0.0518094
EFNA5 ephrin-A5 -0.0511706
RPS19 ribosomal protein S19 -0.0511193
BTG1 B-cell translocation gene 1, anti-proliferative -0.0508127
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0502782
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0493382
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0469109
CDH13 cadherin 13 -0.0465797
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0457211
DLG1 discs, large homolog 1 (Drosophila) -0.0453287
C15ORF48 chromosome 15 open reading frame 48 -0.0451599
TPT1 tumor protein, translationally-controlled 1 -0.0421935
B2M beta-2-microglobulin -0.0408919
RPL35A ribosomal protein L35a -0.0403111
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0401624
PTMA prothymosin, alpha -0.0401209
TFPI2 tissue factor pathway inhibitor 2 -0.0389807
HMGA1 high mobility group AT-hook 1 -0.0384281
ANGPTL4 angiopoietin-like 4 -0.038383
PKM pyruvate kinase, muscle -0.0381757
KTN1 kinectin 1 (kinesin receptor) -0.0378896
RPS13 ribosomal protein S13 -0.0374596
MAP1B microtubule-associated protein 1B -0.0371624
RPL31 ribosomal protein L31 -0.0363293
S100A10 S100 calcium binding protein A10 -0.0362092
EIF1 eukaryotic translation initiation factor 1 -0.0359031
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0351186
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0348898
IFI6 interferon, alpha-inducible protein 6 -0.0346972
CDCP1 CUB domain containing protein 1 -0.0344785
LDHA lactate dehydrogenase A -0.0344522
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0341301
LMAN1 lectin, mannose-binding, 1 -0.0335702
SOX4 SRY (sex determining region Y)-box 4 -0.0334305
RPLP2 ribosomal protein, large, P2 -0.0325065
ZMYND8 zinc finger, MYND-type containing 8 -0.0324493
RPS24 ribosomal protein S24 -0.0318467
PGK1 phosphoglycerate kinase 1 -0.0318351
HLA-B major histocompatibility complex, class I, B -0.0317956
TM4SF1 transmembrane 4 L six family member 1 -0.0315308
SYT1 synaptotagmin I -0.0311469
LOXL2 lysyl oxidase-like 2 -0.0307985
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0306605
RPL36 ribosomal protein L36 -0.030453
NAP1L1 nucleosome assembly protein 1-like 1 -0.0302036
GNAS GNAS complex locus -0.0299335
RPS6 ribosomal protein S6 -0.0299079
EGR1 early growth response 1 -0.0287228
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0286482
RPS29 ribosomal protein S29 -0.0284995
MEF2A myocyte enhancer factor 2A -0.0284081
VDAC1 voltage-dependent anion channel 1 -0.0280595
RPS21 ribosomal protein S21 -0.0280186
RPLP0 ribosomal protein, large, P0 -0.0279141
ARL4C ADP-ribosylation factor-like 4C -0.0279053
ANKRD12 ankyrin repeat domain 12 -0.0278823
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0278068
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0277971
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0276315
FBN1 fibrillin 1 -0.0273052
TXNIP thioredoxin interacting protein -0.0270593
TMSB4X thymosin beta 4, X-linked -0.0264154
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0259341
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0258036
SNX9 sorting nexin 9 -0.0256904
SAMD9 sterile alpha motif domain containing 9 -0.0255657
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0254805
RPS23 ribosomal protein S23 -0.0253803
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0252909
RPL37 ribosomal protein L37 -0.0249545
OXR1 oxidation resistance 1 -0.0248728
WSB1 WD repeat and SOCS box containing 1 -0.0248588
IL6ST interleukin 6 signal transducer -0.0247327
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0246797
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0246643
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0245107
RPL28 ribosomal protein L28 -0.0244104
IGFBP3 insulin-like growth factor binding protein 3 -0.0243081
BPTF bromodomain PHD finger transcription factor -0.0239924
MYADM myeloid-associated differentiation marker -0.0237244