Vismodegib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 0.0556167
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0394047
FAM107B family with sequence similarity 107, member B 0.0368441
AKAP12 A kinase (PRKA) anchor protein 12 0.0364514
PDE4D phosphodiesterase 4D, cAMP-specific 0.0336742
CENPF centromere protein F, 350/400kDa 0.0291876
BIRC3 baculoviral IAP repeat containing 3 0.0286052
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0276752
VMP1 vacuole membrane protein 1 0.0261362
TTC3 tetratricopeptide repeat domain 3 0.025701
GLS2 glutaminase 2 (liver, mitochondrial) 0.0245817
ERRFI1 ERBB receptor feedback inhibitor 1 0.0240229
MCL1 myeloid cell leukemia 1 0.0234948
POTEF POTE ankyrin domain family, member F 0.0232446
PM20D1 peptidase M20 domain containing 1 0.0220078
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0219431
BMP6 bone morphogenetic protein 6 0.0206725
PDLIM5 PDZ and LIM domain 5 0.0203731
SAMD4A sterile alpha motif domain containing 4A 0.0200285
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.019159
GOLGA4 golgin A4 0.0186985
EGR1 early growth response 1 0.0185346
CENPE centromere protein E, 312kDa 0.0182222
COPA coatomer protein complex, subunit alpha 0.0180759
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0177001
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0170744
MKI67 marker of proliferation Ki-67 0.0169449
RCOR1 REST corepressor 1 0.0166407
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.016006
ZCCHC7 zinc finger, CCHC domain containing 7 0.0159138
RFWD3 ring finger and WD repeat domain 3 0.0157511
DOCK5 dedicator of cytokinesis 5 0.0154837
WDPCP WD repeat containing planar cell polarity effector 0.0154232
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0154152
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0153486
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0150822
GDI2 GDP dissociation inhibitor 2 0.0148294
AURKA aurora kinase A 0.0147429
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0146721
TASOR2 transcription activation suppressor family member 2 0.0145113
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0143766
ATXN1 ataxin 1 0.0142194
SEC31A SEC31 homolog A (S. cerevisiae) 0.0142044
ATP11A ATPase, class VI, type 11A 0.0140612
PMM2 phosphomannomutase 2 0.0138621
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0137165
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0136681
RRM2 ribonucleotide reductase M2 0.0135505
UBA6 ubiquitin-like modifier activating enzyme 6 0.0132717
NBAS neuroblastoma amplified sequence 0.0131529
TPX2 TPX2, microtubule-associated 0.0126973
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0125088
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0123385
MSN moesin 0.0121958
SMC4 structural maintenance of chromosomes 4 0.01211
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0120065
RPL3 ribosomal protein L3 0.0119167
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0117775
WWOX WW domain containing oxidoreductase 0.0117682
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0117461
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0116594
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0116442
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0116008
PCNX1 pecanex 1 0.0115741
BRD2 bromodomain containing 2 0.0115711
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0115444
OSMR oncostatin M receptor 0.0115124
MON2 MON2 homolog (S. cerevisiae) 0.0114702
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0113942
ARHGAP11A Rho GTPase activating protein 11A 0.0112758
TENT5A terminal nucleotidyltransferase 5A 0.0111707
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0110095
PNN pinin, desmosome associated protein 0.0109217
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0109094
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.010887
FNIP1 folliculin interacting protein 1 0.0107857
KIAA0319 KIAA0319 0.0107801
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.010707
TPR translocated promoter region, nuclear basket protein 0.0106146
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0105966
ZNF644 zinc finger protein 644 0.0105908
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.0105774
CEP70 centrosomal protein 70kDa 0.0105765
PCM1 pericentriolar material 1 0.010558
TENT4A terminal nucleotidyltransferase 4A 0.0105288
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0104893
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0104815
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.010384
JMJD1C jumonji domain containing 1C 0.0102
KIF23 kinesin family member 23 0.0101873
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.0100709
USP34 ubiquitin specific peptidase 34 0.0100432
DIAPH1 diaphanous-related formin 1 0.00985664
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00985367
THOC2 THO complex 2 0.00980781
DCAF8 DDB1 and CUL4 associated factor 8 0.0097691
YLPM1 YLP motif containing 1 0.00971724
SRSF1 serine/arginine-rich splicing factor 1 0.00968035
SCAF8 SR-related CTD-associated factor 8 0.00968004
RTN4 reticulon 4 0.00965494

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.175782
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.136655
TMSB10 thymosin beta 10 -0.125382
MT2A metallothionein 2A -0.108846
PARD3 par-3 family cell polarity regulator -0.0794555
RPL23 ribosomal protein L23 -0.0668573
TXNRD1 thioredoxin reductase 1 -0.0665476
THSD4 thrombospondin, type I, domain containing 4 -0.0663288
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0660078
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0658563
RPL19 ribosomal protein L19 -0.0623064
RPLP1 ribosomal protein, large, P1 -0.0612754
VIM vimentin -0.0580182
EIF1 eukaryotic translation initiation factor 1 -0.0572603
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0539374
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0490992
PTMA prothymosin, alpha -0.0478562
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0476587
FGB fibrinogen beta chain -0.0470544
NRG1 neuregulin 1 -0.0459825
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0450383
APP amyloid beta (A4) precursor protein -0.0429875
RPL36 ribosomal protein L36 -0.0425897
RPS8 ribosomal protein S8 -0.0425805
SVIL supervillin -0.0423421
ZFAND3 zinc finger, AN1-type domain 3 -0.0417103
IER3 immediate early response 3 -0.0404091
HDAC9 histone deacetylase 9 -0.0397487
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.039439
ANKRD11 ankyrin repeat domain 11 -0.0383107
CAVIN1 caveolae associated protein 1 -0.0380712
S100A10 S100 calcium binding protein A10 -0.0378958
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.037535
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0365311
RPS19 ribosomal protein S19 -0.036388
BASP1 brain abundant, membrane attached signal protein 1 -0.03629
S100A6 S100 calcium binding protein A6 -0.0355353
RPS21 ribosomal protein S21 -0.0353094
BHLHE40 basic helix-loop-helix family, member e40 -0.0351769
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0338307
ACTG1 actin gamma 1 -0.0336209
RPS29 ribosomal protein S29 -0.0329644
RPL8 ribosomal protein L8 -0.0323334
RAD21 RAD21 homolog (S. pombe) -0.0319491
CUX1 cut-like homeobox 1 -0.0318294
MACF1 microtubule-actin crosslinking factor 1 -0.0317176
RBM39 RNA binding motif protein 39 -0.0314497
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0314232
PUM1 pumilio RNA-binding family member 1 -0.0310846
RPS12 ribosomal protein S12 -0.0308053
RPS27A ribosomal protein S27a -0.0307981
PKM pyruvate kinase, muscle -0.0305078
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0302659
AHNAK AHNAK nucleoprotein -0.02907
RPL37A ribosomal protein L37a -0.0290385
STC1 stanniocalcin 1 -0.0290093
EFNA5 ephrin-A5 -0.0288167
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0282477
BICC1 BicC family RNA binding protein 1 -0.0278642
USP3 ubiquitin specific peptidase 3 -0.0270794
TRIO trio Rho guanine nucleotide exchange factor -0.0270014
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0269256
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0268296
PAWR PRKC, apoptosis, WT1, regulator -0.0263151
C15ORF48 chromosome 15 open reading frame 48 -0.0257128
CALR calreticulin -0.0256056
UGCG UDP-glucose ceramide glucosyltransferase -0.0255927
RPS6 ribosomal protein S6 -0.0254528
RPS27 ribosomal protein S27 -0.0254345
SLC38A1 solute carrier family 38, member 1 -0.0252909
RPL35A ribosomal protein L35a -0.0252517
NEGR1 neuronal growth regulator 1 -0.0243984
RPL7 ribosomal protein L7 -0.024337
ANXA2 annexin A2 -0.0240511
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0238082
ZNF207 zinc finger protein 207 -0.0236404
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0236078
ACACA acetyl-CoA carboxylase alpha -0.0235955
RPS3 ribosomal protein S3 -0.0233835
EHBP1 EH domain binding protein 1 -0.0233557
RSL1D1 ribosomal L1 domain containing 1 -0.0232902
RPL18 ribosomal protein L18 -0.0230805
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0229571
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0226531
RPLP0 ribosomal protein, large, P0 -0.022634
RPL31 ribosomal protein L31 -0.0224972
BABAM2 BRISC and BRCA1 A complex member 2 -0.0224528
GRAMD1B GRAM domain containing 1B -0.0223286
KMT2E lysine (K)-specific methyltransferase 2E -0.0222928
RPL34 ribosomal protein L34 -0.0222922
ZNF292 zinc finger protein 292 -0.0222621
SIK3 SIK family kinase 3 -0.0221044
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0220566
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0220082
ANXA1 annexin A1 -0.0220049
RPS23 ribosomal protein S23 -0.0219211
EEF2 eukaryotic translation elongation factor 2 -0.021899
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0216748
CYRIB CYFIP related Rac1 interactor B -0.0216122
NAP1L1 nucleosome assembly protein 1-like 1 -0.0215107