Vismodegib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

122 genes differentially expressed following the Vismodegib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRELID2 PRELI domain containing 2 0.194616
NALF1 NALCN channel auxiliary factor 1 0.160361
FNDC3B fibronectin type III domain containing 3B 0.148686
NDRG1 N-myc downstream regulated 1 0.148436
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.127526
NEK7 NIMA-related kinase 7 0.125924
STC1 stanniocalcin 1 0.114699
MYO1E myosin IE 0.11301
ELL2 elongation factor, RNA polymerase II, 2 0.109695
FAM13A family with sequence similarity 13, member A 0.104296
OGA O-GlcNAcase 0.0998278
FNDC3A fibronectin type III domain containing 3A 0.0840233
ERRFI1 ERBB receptor feedback inhibitor 1 0.0828215
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0707365
PTK2 protein tyrosine kinase 2 0.0695851
PTGES2 prostaglandin E synthase 2 0.0634061
RYBP RING1 and YY1 binding protein 0.0628711
ERBIN erbb2 interacting protein 0.0618165
DSCAM Down syndrome cell adhesion molecule 0.0592826
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0592392
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0581479
AGO3 argonaute RISC catalytic component 3 0.0566025
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0544642
DTNA dystrobrevin, alpha 0.0537955
LAMB3 laminin, beta 3 0.0529148
RICTOR RPTOR independent companion of MTOR, complex 2 0.0524677
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0521282
RBM39 RNA binding motif protein 39 0.0515292
IER3 immediate early response 3 0.0483996
PICALM phosphatidylinositol binding clathrin assembly protein 0.046793
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0398827
JMJD1C jumonji domain containing 1C 0.0385798
MYO6 myosin VI 0.0343932
NCOA3 nuclear receptor coactivator 3 0.0334809
MYOF myoferlin 0.0318346
NAV2 neuron navigator 2 0.0303062
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.030141
UBE2B ubiquitin-conjugating enzyme E2B 0.0274152
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0241216
USP15 ubiquitin specific peptidase 15 0.0233827
NPEPPS aminopeptidase puromycin sensitive 0.0208663
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0151521
BACE2 beta-site APP-cleaving enzyme 2 0.0140293
ARHGAP26 Rho GTPase activating protein 26 0.0114053
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0110715
SMG7 SMG7 nonsense mediated mRNA decay factor 0.010628
KDM6A lysine (K)-specific demethylase 6A 0.00973103
PELI1 pellino E3 ubiquitin protein ligase 1 0.00885221
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00863724
KRT17 keratin 17, type I 0.00758842
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.00730871
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00709852
AKAP13 A kinase (PRKA) anchor protein 13 0.00635338
FTL ferritin, light polypeptide 0.00375967
SYNE2 spectrin repeat containing, nuclear envelope 2 0.00272455
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.10916E-4

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.185354
FN1 fibronectin 1 -0.175372
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.150316
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.140175
ZNF292 zinc finger protein 292 -0.137801
PTMA prothymosin, alpha -0.117056
MCTP1 multiple C2 domains, transmembrane 1 -0.111653
VIM vimentin -0.108544
KIF5B kinesin family member 5B -0.104023
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.103734
NAMPT nicotinamide phosphoribosyltransferase -0.102334
RPS6 ribosomal protein S6 -0.0957494
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0940934
ZFAND3 zinc finger, AN1-type domain 3 -0.0894498
RUNX1 runt-related transcription factor 1 -0.0874406
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0859668
RNF145 ring finger protein 145 -0.079852
SRPK2 SRSF protein kinase 2 -0.0713439
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0713388
EEF2 eukaryotic translation elongation factor 2 -0.0585261
MACF1 microtubule-actin crosslinking factor 1 -0.0563328
ASPH aspartate beta-hydroxylase -0.0557993
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0542862
NHSL1 NHS-like 1 -0.0519504
GRB10 growth factor receptor-bound protein 10 -0.0512269
PKM pyruvate kinase, muscle -0.0497698
UBC ubiquitin C -0.0491734
SPAG9 sperm associated antigen 9 -0.0478382
ARHGAP21 Rho GTPase activating protein 21 -0.0476131
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0469251
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0405746
GOLGA4 golgin A4 -0.0394739
PDE4D phosphodiesterase 4D, cAMP-specific -0.0352369
ANXA2 annexin A2 -0.0344847
PUM2 pumilio RNA-binding family member 2 -0.0343056
PDE10A phosphodiesterase 10A -0.034052
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0326476
TRIO trio Rho guanine nucleotide exchange factor -0.031563
RTN4 reticulon 4 -0.0307384
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0286123
DENND4A DENN/MADD domain containing 4A -0.0278788
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0278667
RPL26 ribosomal protein L26 -0.0268323
ARL5B ADP-ribosylation factor-like 5B -0.0261233
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0252407
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.023733
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0232649
AHNAK AHNAK nucleoprotein -0.0220015
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0210816
PCBP2 poly(rC) binding protein 2 -0.0203384
B2M beta-2-microglobulin -0.0173344
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0172009
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0170912
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0133951
MARCHF6 membrane associated ring-CH-type finger 6 -0.011749
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0113426
AFF4 AF4/FMR2 family, member 4 -0.0108452
BBX bobby sox homolog (Drosophila) -0.0097545
MXD1 MAX dimerization protein 1 -0.00950236
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.00837425
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.00823299
ANXA1 annexin A1 -0.00284028
CHD1 chromodomain helicase DNA binding protein 1 -0.0028114
LMO7 LIM domain 7 -0.00164179
KIF1B kinesin family member 1B -0.00159224
RNF149 ring finger protein 149 -3.54663E-4