Vismodegib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.141463
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.108804
ZCCHC7 zinc finger, CCHC domain containing 7 0.0987581
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0813099
TPM3 tropomyosin 3 0.0774359
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0760258
MACF1 microtubule-actin crosslinking factor 1 0.075545
TAS2R14 taste receptor, type 2, member 14 0.071277
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0692696
KTN1 kinectin 1 (kinesin receptor) 0.0657638
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0655563
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0654243
ERRFI1 ERBB receptor feedback inhibitor 1 0.0652198
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0647416
RAD51B RAD51 paralog B 0.0639611
ATXN1 ataxin 1 0.0613952
TRIO trio Rho guanine nucleotide exchange factor 0.0582413
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0579866
DOCK5 dedicator of cytokinesis 5 0.0574246
YBX1 Y box binding protein 1 0.0568405
DST dystonin 0.0558262
SAMD4A sterile alpha motif domain containing 4A 0.054573
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0508608
GRAMD1B GRAM domain containing 1B 0.0496341
CAMTA1 calmodulin binding transcription activator 1 0.0495211
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0494439
ANKRD36 ankyrin repeat domain 36 0.0489426
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0475203
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0475006
PRELID2 PRELI domain containing 2 0.0452677
RTN4 reticulon 4 0.0447328
PUM2 pumilio RNA-binding family member 2 0.0445581
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0441112
JMJD1C jumonji domain containing 1C 0.0433313
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0421933
MARCHF4 membrane associated ring-CH-type finger 4 0.0418094
EXOC4 exocyst complex component 4 0.0408839
SFPQ splicing factor proline/glutamine-rich 0.0405081
SET SET nuclear proto-oncogene 0.0402376
PCM1 pericentriolar material 1 0.0393783
ENO1 enolase 1, (alpha) 0.0392434
MKI67 marker of proliferation Ki-67 0.0391746
MYH9 myosin, heavy chain 9, non-muscle 0.0390814
BBX bobby sox homolog (Drosophila) 0.0376581
CSNK1A1 casein kinase 1, alpha 1 0.0375751
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0372122
RPL3 ribosomal protein L3 0.0370848
FMNL2 formin-like 2 0.0366485
RBM33 RNA binding motif protein 33 0.0365252
ANKRD28 ankyrin repeat domain 28 0.0361701
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0357685
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0357589
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0356665
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0351645
WNK1 WNK lysine deficient protein kinase 1 0.0351043
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0347402
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0345591
RUSC2 RUN and SH3 domain containing 2 0.0341243
SHB Src homology 2 domain containing adaptor protein B 0.0340849
ADAM17 ADAM metallopeptidase domain 17 0.0339883
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.033907
TLN1 talin 1 0.033824
BTBD9 BTB (POZ) domain containing 9 0.0337304
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0335162
HDGF hepatoma-derived growth factor 0.0335138
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0334893
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0329362
JAK1 Janus kinase 1 0.0327076
CEP192 centrosomal protein 192kDa 0.0325831
ZNF148 zinc finger protein 148 0.0324818
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0321627
RRM2 ribonucleotide reductase M2 0.0320733
ESYT2 extended synaptotagmin-like protein 2 0.0319984
SCAF8 SR-related CTD-associated factor 8 0.0318083
RPL4 ribosomal protein L4 0.0312064
COPA coatomer protein complex, subunit alpha 0.0310016
LRP6 low density lipoprotein receptor-related protein 6 0.0310005
PPHLN1 periphilin 1 0.0308363
ACTN1 actinin, alpha 1 0.030711
RASA2 RAS p21 protein activator 2 0.0305288
SRSF4 serine/arginine-rich splicing factor 4 0.0304739
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0304621
NCAPG2 non-SMC condensin II complex, subunit G2 0.0303141
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0296373
CCNL1 cyclin L1 0.0293503
YAP1 Yes-associated protein 1 0.0292127
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0291223
BIRC2 baculoviral IAP repeat containing 2 0.029111
ZBTB1 zinc finger and BTB domain containing 1 0.0287303
NBPF15 neuroblastoma breakpoint family, member 15 0.0286909
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0286189
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0285602
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0285299
VMP1 vacuole membrane protein 1 0.0280582
CKAP5 cytoskeleton associated protein 5 0.0280183
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0279258
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0278628
WDR43 WD repeat domain 43 0.0278612
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.027784
TTC17 tetratricopeptide repeat domain 17 0.0276947

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.154711
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0863113
TMSB10 thymosin beta 10 -0.0701825
RAB7A RAB7A, member RAS oncogene family -0.0677078
EGR1 early growth response 1 -0.0670563
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0628032
VIM vimentin -0.056764
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0544594
TPI1 triosephosphate isomerase 1 -0.053156
IGF1R insulin-like growth factor 1 receptor -0.0525894
RPLP0 ribosomal protein, large, P0 -0.0524346
DENND5B DENN/MADD domain containing 5B -0.0479663
RIMS2 regulating synaptic membrane exocytosis 2 -0.0465362
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0457884
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0424906
STC1 stanniocalcin 1 -0.0424099
RPL35A ribosomal protein L35a -0.0404603
VDAC1 voltage-dependent anion channel 1 -0.0403821
FTL ferritin, light polypeptide -0.0390688
LOC102724023 ES1 protein homolog, mitochondrial -0.0390364
RPL23 ribosomal protein L23 -0.0371239
MYL12B myosin, light chain 12B, regulatory -0.0364059
NAP1L1 nucleosome assembly protein 1-like 1 -0.036266
RPS24 ribosomal protein S24 -0.0361208
RPS21 ribosomal protein S21 -0.0357102
RPL12 ribosomal protein L12 -0.035482
CLIP1 CAP-GLY domain containing linker protein 1 -0.0342723
DNAH14 dynein, axonemal, heavy chain 14 -0.0342668
GLO1 glyoxalase I -0.0328641
RPLP1 ribosomal protein, large, P1 -0.0324456
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0321613
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0318174
ZFAND3 zinc finger, AN1-type domain 3 -0.0316789
CBX3 chromobox homolog 3 -0.031006
RNF213 ring finger protein 213 -0.0304798
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0303136
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0301916
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0300163
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0295133
RPS4X ribosomal protein S4, X-linked -0.0294045
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0292382
MT2A metallothionein 2A -0.0290231
GNAS GNAS complex locus -0.0284047
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0283751
KLF6 Kruppel-like factor 6 -0.0281281
PMP22 peripheral myelin protein 22 -0.0280505
RIGI RNA sensor RIG-I -0.0278909
TMEM41B transmembrane protein 41B -0.0278676
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0276102
PRRC2B proline-rich coiled-coil 2B -0.0271366
RPL36A ribosomal protein L36a -0.0269969
PFN1 profilin 1 -0.0268188
H3-3B H3.3 histone B -0.0259744
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0259291
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0259113
S100A6 S100 calcium binding protein A6 -0.0256332
ZNFX1 zinc finger, NFX1-type containing 1 -0.02557
RPL28 ribosomal protein L28 -0.0254557
EML4 echinoderm microtubule associated protein like 4 -0.0253341
RPS25 ribosomal protein S25 -0.0252992
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0252682
RPL30 ribosomal protein L30 -0.0251813
R3HDM2 R3H domain containing 2 -0.0251247
B2M beta-2-microglobulin -0.024946
ACTG1 actin gamma 1 -0.0249442
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0248531
NEMF nuclear export mediator factor -0.024336
FLOT1 flotillin 1 -0.0239222
UBTF upstream binding transcription factor, RNA polymerase I -0.0238097
RPL8 ribosomal protein L8 -0.0237843
STX8 syntaxin 8 -0.0237506
MT1X metallothionein 1X -0.0237348
KPNB1 karyopherin (importin) beta 1 -0.0236315
PRH1 proline-rich protein HaeIII subfamily 1 -0.0234764
HMGA1 high mobility group AT-hook 1 -0.0234256
E2F3 E2F transcription factor 3 -0.0232105
RPL19 ribosomal protein L19 -0.0230082
RBM39 RNA binding motif protein 39 -0.0229653
BSG basigin (Ok blood group) -0.0228811
EHBP1 EH domain binding protein 1 -0.0226272
RPS5 ribosomal protein S5 -0.0224943
RHEB Ras homolog enriched in brain -0.0224926
RAD21 RAD21 homolog (S. pombe) -0.0222759
GSTP1 glutathione S-transferase pi 1 -0.0220887
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.022054
DHFR dihydrofolate reductase -0.0219826
BPTF bromodomain PHD finger transcription factor -0.0219523
WNT2B wingless-type MMTV integration site family, member 2B -0.0218964
RPN2 ribophorin II -0.0218422
ARMH4 armadillo like helical domain containing 4 -0.0217319
RPL32 ribosomal protein L32 -0.0216565
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0215339
RPL38 ribosomal protein L38 -0.0214725
IER3 immediate early response 3 -0.0214709
RPS23 ribosomal protein S23 -0.021243
PLSCR1 phospholipid scramblase 1 -0.0211268
RSL1D1 ribosomal L1 domain containing 1 -0.0210441
GATAD2B GATA zinc finger domain containing 2B -0.0210265
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0208239
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0207865