Vismodegib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.117648
FNDC3B fibronectin type III domain containing 3B 0.0837884
SAMD4A sterile alpha motif domain containing 4A 0.0833935
DSCAM Down syndrome cell adhesion molecule 0.0741652
EXT1 exostosin glycosyltransferase 1 0.0663316
MYH9 myosin, heavy chain 9, non-muscle 0.0614631
TRIO trio Rho guanine nucleotide exchange factor 0.06083
ERBIN erbb2 interacting protein 0.0602742
FN1 fibronectin 1 0.0582644
MYO6 myosin VI 0.0561159
EFNA5 ephrin-A5 0.0525517
LPP LIM domain containing preferred translocation partner in lipoma 0.0512885
AKAP13 A kinase (PRKA) anchor protein 13 0.0495459
ZSWIM6 zinc finger, SWIM-type containing 6 0.0482281
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0460607
PTK2 protein tyrosine kinase 2 0.0448056
PPARD peroxisome proliferator-activated receptor delta 0.0420684
PDLIM5 PDZ and LIM domain 5 0.0411231
LIMCH1 LIM and calponin homology domains 1 0.0410765
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0408467
KDM6A lysine (K)-specific demethylase 6A 0.0391561
DUSP10 dual specificity phosphatase 10 0.038735
TMF1 TATA element modulatory factor 1 0.0373612
RCOR1 REST corepressor 1 0.0371876
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.035727
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0353664
ELL2 elongation factor, RNA polymerase II, 2 0.0350948
LMO7 LIM domain 7 0.0349684
MACF1 microtubule-actin crosslinking factor 1 0.0344165
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0333389
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0333231
FNIP1 folliculin interacting protein 1 0.0331757
MYO5B myosin VB 0.0328101
VCL vinculin 0.0320314
DTNA dystrobrevin, alpha 0.0315224
VMP1 vacuole membrane protein 1 0.0312051
MYO1E myosin IE 0.0303761
ITCH itchy E3 ubiquitin protein ligase 0.0300644
CTNND1 catenin (cadherin-associated protein), delta 1 0.0296971
USP9X ubiquitin specific peptidase 9, X-linked 0.0296162
UBE2H ubiquitin-conjugating enzyme E2H 0.0296132
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0295554
FBXO32 F-box protein 32 0.0279656
TENT2 terminal nucleotidyltransferase 2 0.02785
CCNL1 cyclin L1 0.0275234
OCLN occludin 0.0270819
ZNF148 zinc finger protein 148 0.0268321
RASA2 RAS p21 protein activator 2 0.026804
GLS2 glutaminase 2 (liver, mitochondrial) 0.026475
GRB10 growth factor receptor-bound protein 10 0.0263957
CDC73 cell division cycle 73 0.0262703
JMJD1C jumonji domain containing 1C 0.0262651
APLP2 amyloid beta (A4) precursor-like protein 2 0.0261082
KMT2E lysine (K)-specific methyltransferase 2E 0.0251397
FBXO34 F-box protein 34 0.0249044
TPM3 tropomyosin 3 0.0248285
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0244094
VGLL3 vestigial-like family member 3 0.0243165
COPA coatomer protein complex, subunit alpha 0.024201
GOLGB1 golgin B1 0.0238488
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0236208
TMEM39A transmembrane protein 39A 0.023433
TMEM165 transmembrane protein 165 0.023362
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0231796
RAI14 retinoic acid induced 14 0.0231479
NIPBL Nipped-B homolog (Drosophila) 0.0228269
AFF1 AF4/FMR2 family, member 1 0.0227943
FAM3C family with sequence similarity 3, member C 0.0227435
CLTC clathrin, heavy chain (Hc) 0.0225831
BLTP1 bridge-like lipid transfer protein family member 1 0.0224641
KLC1 kinesin light chain 1 0.0223936
CDCP1 CUB domain containing protein 1 0.0223191
ZNF644 zinc finger protein 644 0.0222401
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.022113
KDM2A lysine (K)-specific demethylase 2A 0.0220879
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0220809
ARHGAP20 Rho GTPase activating protein 20 0.0220751
PGBD5 piggyBac transposable element derived 5 0.0220308
NRIP1 nuclear receptor interacting protein 1 0.0219475
ANKRD17 ankyrin repeat domain 17 0.0217437
TUFT1 tuftelin 1 0.0213513
SH3RF1 SH3 domain containing ring finger 1 0.0213377
ERRFI1 ERBB receptor feedback inhibitor 1 0.0210422
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0209618
USP15 ubiquitin specific peptidase 15 0.02084
PICALM phosphatidylinositol binding clathrin assembly protein 0.0208381
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0207296
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.020683
MCU mitochondrial calcium uniporter 0.02068
CTBP2 C-terminal binding protein 2 0.0206047
SEC23A Sec23 homolog A (S. cerevisiae) 0.0204915
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0203397
DST dystonin 0.020211
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0202018
MSN moesin 0.0201502
TJP1 tight junction protein 1 0.0200918
PATJ PATJ crumbs cell polarity complex component 0.0200813
CHD1 chromodomain helicase DNA binding protein 1 0.0200678
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0197885
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0197263

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.276974
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.254099
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.242646
PTMA prothymosin, alpha -0.188044
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.17967
TMSB10 thymosin beta 10 -0.137604
TPT1 tumor protein, translationally-controlled 1 -0.125712
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.117705
S100A6 S100 calcium binding protein A6 -0.115428
RPL35A ribosomal protein L35a -0.0962483
RPLP1 ribosomal protein, large, P1 -0.0875672
HMGA1 high mobility group AT-hook 1 -0.0865456
S100A10 S100 calcium binding protein A10 -0.0857952
MT2A metallothionein 2A -0.0767121
ACTG1 actin gamma 1 -0.0761459
RPL23 ribosomal protein L23 -0.0728978
NDRG1 N-myc downstream regulated 1 -0.0694807
RPL8 ribosomal protein L8 -0.0661352
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0645353
RPS19 ribosomal protein S19 -0.06452
RPS8 ribosomal protein S8 -0.0641788
RPLP0 ribosomal protein, large, P0 -0.0633589
RPLP2 ribosomal protein, large, P2 -0.060194
RPS23 ribosomal protein S23 -0.0593301
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.058663
RPL34 ribosomal protein L34 -0.0575101
G0S2 G0/G1 switch 2 -0.0565134
RPL12 ribosomal protein L12 -0.054371
IFI27 interferon, alpha-inducible protein 27 -0.051763
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0510974
FAM162A family with sequence similarity 162, member A -0.0494887
ISG15 ISG15 ubiquitin-like modifier -0.0493551
IFITM3 interferon induced transmembrane protein 3 -0.0493165
EIF1 eukaryotic translation initiation factor 1 -0.0488399
RPS3 ribosomal protein S3 -0.048603
RPS6 ribosomal protein S6 -0.0482306
VIM vimentin -0.0472847
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0471258
RPS29 ribosomal protein S29 -0.0470111
RPS13 ribosomal protein S13 -0.0469505
RPL32 ribosomal protein L32 -0.0456843
RPS14 ribosomal protein S14 -0.0445436
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0442721
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0436402
SLC38A1 solute carrier family 38, member 1 -0.0433814
TMSB4X thymosin beta 4, X-linked -0.0418713
RPS25 ribosomal protein S25 -0.041536
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0405147
RPS24 ribosomal protein S24 -0.0404608
TM4SF1 transmembrane 4 L six family member 1 -0.0395769
LDHA lactate dehydrogenase A -0.0395234
RPL28 ribosomal protein L28 -0.0389303
RPS27A ribosomal protein S27a -0.0382524
S100A9 S100 calcium binding protein A9 -0.0379158
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0374078
GNAS GNAS complex locus -0.0370695
BHLHE40 basic helix-loop-helix family, member e40 -0.0370523
RPL9 ribosomal protein L9 -0.0367798
CSTB cystatin B (stefin B) -0.0363239
LAMB3 laminin, beta 3 -0.0357963
RPL19 ribosomal protein L19 -0.0356
RPL36 ribosomal protein L36 -0.0354368
UBC ubiquitin C -0.0350994
ANXA2 annexin A2 -0.0340499
UPP1 uridine phosphorylase 1 -0.0328707
C15ORF48 chromosome 15 open reading frame 48 -0.0326694
ENO1 enolase 1, (alpha) -0.0326534
RPL11 ribosomal protein L11 -0.0321787
RPS27 ribosomal protein S27 -0.0319475
RPL27A ribosomal protein L27a -0.0314902
RPS10 ribosomal protein S10 -0.0314875
PKM pyruvate kinase, muscle -0.0314148
CALR calreticulin -0.0313505
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0309245
GARS1 glycyl-tRNA synthetase 1 -0.0304867
TPI1 triosephosphate isomerase 1 -0.0298776
LY6E lymphocyte antigen 6 complex, locus E -0.0295958
RPS21 ribosomal protein S21 -0.0293197
RPL31 ribosomal protein L31 -0.0290909
RPL38 ribosomal protein L38 -0.0290172
HMGB1 high mobility group box 1 -0.0288669
IFITM1 interferon induced transmembrane protein 1 -0.0285175
RPS5 ribosomal protein S5 -0.0282376
RPL37 ribosomal protein L37 -0.0278788
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0278541
RPL36A ribosomal protein L36a -0.0271139
RPL37A ribosomal protein L37a -0.0270422
SQSTM1 sequestosome 1 -0.0268944
IFI6 interferon, alpha-inducible protein 6 -0.026768
WSB1 WD repeat and SOCS box containing 1 -0.0265813
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0264361
IFI16 interferon, gamma-inducible protein 16 -0.0261218
RPL18 ribosomal protein L18 -0.0260755
RPS11 ribosomal protein S11 -0.0258396
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0257113
DDIT4 DNA-damage-inducible transcript 4 -0.0256828
NPC2 Niemann-Pick disease, type C2 -0.0254738
RAD21 RAD21 homolog (S. pombe) -0.0254709
GPX4 glutathione peroxidase 4 -0.0254436
PGK1 phosphoglycerate kinase 1 -0.0253678