Vismodegib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.17537
GDA guanine deaminase 0.121745
DST dystonin 0.108248
PDLIM5 PDZ and LIM domain 5 0.0925617
PDE10A phosphodiesterase 10A 0.0897508
PCBP3 poly(rC) binding protein 3 0.0846703
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0839876
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0733877
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0617612
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0609434
KYNU kynureninase 0.0579872
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0556887
SMOC1 SPARC related modular calcium binding 1 0.051437
P3H2 prolyl 3-hydroxylase 2 0.0492028
PM20D1 peptidase M20 domain containing 1 0.0468474
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0457734
DOCK5 dedicator of cytokinesis 5 0.0457468
ADGRD1 adhesion G protein-coupled receptor D1 0.0452813
ZEB2 zinc finger E-box binding homeobox 2 0.0432604
SAMD4A sterile alpha motif domain containing 4A 0.0416242
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.040089
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0395938
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.038042
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0379794
COL5A2 collagen, type V, alpha 2 0.0374568
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0371233
PSD3 pleckstrin and Sec7 domain containing 3 0.0366634
DOCK4 dedicator of cytokinesis 4 0.0362255
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0355619
FMNL2 formin-like 2 0.0348113
FNDC3B fibronectin type III domain containing 3B 0.0343403
AKAP13 A kinase (PRKA) anchor protein 13 0.0313667
ZSWIM6 zinc finger, SWIM-type containing 6 0.0285495
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0279384
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0267949
CHL1 cell adhesion molecule L1-like 0.0261801
SMAD2 SMAD family member 2 0.0254162
NTN4 netrin 4 0.0250856
CTNND2 catenin (cadherin-associated protein), delta 2 0.0247524
RTN1 reticulon 1 0.0247221
ITPRID2 ITPR interacting domain containing 2 0.0246681
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0244362
GLIS3 GLIS family zinc finger 3 0.0242034
SDK1 sidekick cell adhesion molecule 1 0.0241537
VCL vinculin 0.0241453
COL4A6 collagen, type IV, alpha 6 0.0240046
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0230193
MCL1 myeloid cell leukemia 1 0.0227718
BMP6 bone morphogenetic protein 6 0.0221935
AUTS2 autism susceptibility candidate 2 0.021228
CHD1 chromodomain helicase DNA binding protein 1 0.0210036
COL4A5 collagen, type IV, alpha 5 0.0204625
NCAM1 neural cell adhesion molecule 1 0.0203796
PTEN phosphatase and tensin homolog 0.0199865
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0193672
NCOR2 nuclear receptor corepressor 2 0.0193086
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0191997
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0191397
HDAC4 histone deacetylase 4 0.0190519
BCAR3 breast cancer anti-estrogen resistance 3 0.0184272
FNDC3A fibronectin type III domain containing 3A 0.0183423
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0179017
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0177569
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0175214
NEK7 NIMA-related kinase 7 0.0174553
ARHGAP29 Rho GTPase activating protein 29 0.0173312
RAB31 RAB31, member RAS oncogene family 0.0170375
GPC6 glypican 6 0.0170086
TBXT T-box transcription factor T 0.0168391
CD109 CD109 molecule 0.0167356
WWTR1 WW domain containing transcription regulator 1 0.0167252
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0167054
DNER delta/notch-like EGF repeat containing 0.0166166
MACF1 microtubule-actin crosslinking factor 1 0.0165928
CDH13 cadherin 13 0.0164305
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0163861
EPHA4 EPH receptor A4 0.0156981
AGTPBP1 ATP/GTP binding protein 1 0.0156
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0154126
CTSC cathepsin C 0.0153723
ANKRD36 ankyrin repeat domain 36 0.0153312
CTIF CBP80/20-dependent translation initiation factor 0.0151693
COL8A1 collagen, type VIII, alpha 1 0.0150565
IGFBP3 insulin-like growth factor binding protein 3 0.0149481
RAB3B RAB3B, member RAS oncogene family 0.0148657
FAM107B family with sequence similarity 107, member B 0.0146813
ATXN1 ataxin 1 0.0145069
INTS6 integrator complex subunit 6 0.0144898
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.0144608
VMP1 vacuole membrane protein 1 0.0143267
PDE7B phosphodiesterase 7B 0.0140709
RPL3 ribosomal protein L3 0.0140511
PTPRM protein tyrosine phosphatase, receptor type, M 0.0134482
MYPN myopalladin 0.0133665
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.013247
MYH9 myosin, heavy chain 9, non-muscle 0.0132362
TGFBR1 transforming growth factor, beta receptor 1 0.0132121
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0131857
ZNF644 zinc finger protein 644 0.0130084
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.0128674

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194879
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.171115
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.158458
FN1 fibronectin 1 -0.13505
NAMPT nicotinamide phosphoribosyltransferase -0.118956
TMSB10 thymosin beta 10 -0.107726
VIM vimentin -0.0857424
FTL ferritin, light polypeptide -0.0813863
TXNRD1 thioredoxin reductase 1 -0.0791526
TPT1 tumor protein, translationally-controlled 1 -0.0715387
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0706374
PTMA prothymosin, alpha -0.0685611
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0682924
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0679113
RPS24 ribosomal protein S24 -0.0660339
RPLP1 ribosomal protein, large, P1 -0.0637405
RPS6 ribosomal protein S6 -0.0614957
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0600814
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0581326
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0511189
NAP1L1 nucleosome assembly protein 1-like 1 -0.0502234
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0495086
RPL23 ribosomal protein L23 -0.0493471
RPLP0 ribosomal protein, large, P0 -0.0489923
LDHA lactate dehydrogenase A -0.0488316
RPL35A ribosomal protein L35a -0.0456122
RPL12 ribosomal protein L12 -0.0454087
NDRG1 N-myc downstream regulated 1 -0.0450186
RPS4X ribosomal protein S4, X-linked -0.0447431
TFPI2 tissue factor pathway inhibitor 2 -0.0447012
GNAS GNAS complex locus -0.0444126
S100A6 S100 calcium binding protein A6 -0.0439727
RPS8 ribosomal protein S8 -0.0433099
CANX calnexin -0.0426341
S100A10 S100 calcium binding protein A10 -0.0425214
RPL26 ribosomal protein L26 -0.0416541
EIF1 eukaryotic translation initiation factor 1 -0.0415993
ACTG1 actin gamma 1 -0.0411311
PGK1 phosphoglycerate kinase 1 -0.0408102
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0399602
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0392546
BZW1 basic leucine zipper and W2 domains 1 -0.038626
EEF2 eukaryotic translation elongation factor 2 -0.0382333
ANXA2 annexin A2 -0.0368288
VDAC1 voltage-dependent anion channel 1 -0.0359421
TM4SF1 transmembrane 4 L six family member 1 -0.0346478
RPL31 ribosomal protein L31 -0.0338352
RPL36A ribosomal protein L36a -0.0329985
RPS21 ribosomal protein S21 -0.0327814
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.032595
RPL34 ribosomal protein L34 -0.0325777
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0320774
PDIA3 protein disulfide isomerase family A, member 3 -0.0320597
RACK1 receptor for activated C kinase 1 -0.0318669
PKM pyruvate kinase, muscle -0.0313083
RPS19 ribosomal protein S19 -0.0312861
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0311736
RPL37A ribosomal protein L37a -0.0310996
RPS27A ribosomal protein S27a -0.0308266
ANXA1 annexin A1 -0.0307884
TNPO1 transportin 1 -0.0307536
RPL7A ribosomal protein L7a -0.0306101
ENO1 enolase 1, (alpha) -0.0304261
DDIT4 DNA-damage-inducible transcript 4 -0.0303741
PTGR1 prostaglandin reductase 1 -0.0302192
LOC112694756 uncharaterized LOC112694756 -0.0300603
NCOA7 nuclear receptor coactivator 7 -0.0298984
RPL38 ribosomal protein L38 -0.0298872
RPS23 ribosomal protein S23 -0.0296655
RPL19 ribosomal protein L19 -0.0296038
RPL11 ribosomal protein L11 -0.0291399
RPL37 ribosomal protein L37 -0.0284318
KPNB1 karyopherin (importin) beta 1 -0.0283438
RPL9 ribosomal protein L9 -0.0279504
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0277544
SRGN serglycin -0.0273758
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0268987
RPL5 ribosomal protein L5 -0.0268138
RPS3 ribosomal protein S3 -0.0264656
HLA-B major histocompatibility complex, class I, B -0.0257602
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0255513
LMAN1 lectin, mannose-binding, 1 -0.0254861
RPLP2 ribosomal protein, large, P2 -0.0252601
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0252459
MORF4L2 mortality factor 4 like 2 -0.0250819
RPL36 ribosomal protein L36 -0.0249543
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0243236
RPS25 ribosomal protein S25 -0.0242802
RPL35 ribosomal protein L35 -0.0242587
RPS16 ribosomal protein S16 -0.0241811
ARF1 ADP-ribosylation factor 1 -0.0239136
RPS12 ribosomal protein S12 -0.0238717
RPS27 ribosomal protein S27 -0.0236547
TMSB4X thymosin beta 4, X-linked -0.0236231
RPS14 ribosomal protein S14 -0.0234609
B2M beta-2-microglobulin -0.0234174
SERBP1 SERPINE1 mRNA binding protein 1 -0.0233733
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0229989
BZW2 basic leucine zipper and W2 domains 2 -0.0229734
SQSTM1 sequestosome 1 -0.0229643