Vismodegib_NCI-H596 Gene Set
Genes
58 genes differentially expressed following the Vismodegib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
LRRTM4
|
leucine rich repeat transmembrane neuronal 4
|
0.210645
|
|
TXNRD1
|
thioredoxin reductase 1
|
0.181283
|
|
GCLC
|
glutamate-cysteine ligase, catalytic subunit
|
0.175357
|
|
NLGN1
|
neuroligin 1
|
0.163439
|
|
PDE8A
|
phosphodiesterase 8A
|
0.136798
|
|
NKD1
|
naked cuticle homolog 1 (Drosophila)
|
0.126762
|
|
KDM4C
|
lysine (K)-specific demethylase 4C
|
0.119989
|
|
PDE4D
|
phosphodiesterase 4D, cAMP-specific
|
0.106401
|
|
HSP90AB1
|
heat shock protein 90kDa alpha (cytosolic), class B member 1
|
0.104894
|
|
ROBO2
|
roundabout, axon guidance receptor, homolog 2 (Drosophila)
|
0.0992025
|
|
NFAT5
|
nuclear factor of activated T-cells 5, tonicity-responsive
|
0.0932962
|
|
CANX
|
calnexin
|
0.0914776
|
|
HSP90B1
|
heat shock protein 90kDa beta (Grp94), member 1
|
0.0815731
|
|
WDR43
|
WD repeat domain 43
|
0.0661853
|
|
FNDC3B
|
fibronectin type III domain containing 3B
|
0.0639873
|
|
PPP2R5E
|
protein phosphatase 2, regulatory subunit B', epsilon isoform
|
0.0540224
|
|
PRRC2C
|
proline-rich coiled-coil 2C
|
0.0402532
|
|
UBR5
|
ubiquitin protein ligase E3 component n-recognin 5
|
0.0391769
|
|
DST
|
dystonin
|
0.0317069
|
|
TRA2A
|
transformer 2 alpha homolog (Drosophila)
|
0.0230438
|
|
COPA
|
coatomer protein complex, subunit alpha
|
0.018954
|
|
OSBPL8
|
oxysterol binding protein-like 8
|
0.0181388
|
|
CDC73
|
cell division cycle 73
|
0.0181311
|
|
NAP1L1
|
nucleosome assembly protein 1-like 1
|
0.0160683
|
|
RPS6
|
ribosomal protein S6
|
0.00384685
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
-0.256155
|
|
VIM
|
vimentin
|
-0.174629
|
|
EXT1
|
exostosin glycosyltransferase 1
|
-0.110247
|
|
PTMA
|
prothymosin, alpha
|
-0.109113
|
|
LDHA
|
lactate dehydrogenase A
|
-0.107738
|
|
HMGA2
|
high mobility group AT-hook 2
|
-0.0944749
|
|
IMMP2L
|
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
|
-0.0880226
|
|
TPT1
|
tumor protein, translationally-controlled 1
|
-0.0873854
|
|
PGK1
|
phosphoglycerate kinase 1
|
-0.0863837
|
|
NDRG1
|
N-myc downstream regulated 1
|
-0.0857967
|
|
MT2A
|
metallothionein 2A
|
-0.0827802
|
|
TRIO
|
trio Rho guanine nucleotide exchange factor
|
-0.0744094
|
|
LMO7
|
LIM domain 7
|
-0.0678708
|
|
GBE1
|
glucan (1,4-alpha-), branching enzyme 1
|
-0.0595726
|
|
RPL23
|
ribosomal protein L23
|
-0.0591204
|
|
TMSB10
|
thymosin beta 10
|
-0.0565756
|
|
ASPH
|
aspartate beta-hydroxylase
|
-0.0541515
|
|
IGFBP3
|
insulin-like growth factor binding protein 3
|
-0.0486062
|
|
EGFR
|
epidermal growth factor receptor
|
-0.0441801
|
|
NAMPT
|
nicotinamide phosphoribosyltransferase
|
-0.0391565
|
|
UBC
|
ubiquitin C
|
-0.0383349
|
|
FN1
|
fibronectin 1
|
-0.0350557
|
|
RTN4
|
reticulon 4
|
-0.0313063
|
|
ANXA2
|
annexin A2
|
-0.030487
|
|
ZBTB20
|
zinc finger and BTB domain containing 20
|
-0.0303597
|
|
PABPC1
|
poly(A) binding protein, cytoplasmic 1
|
-0.0271636
|
|
KMT2C
|
lysine (K)-specific methyltransferase 2C
|
-0.0261935
|
|
PTK2
|
protein tyrosine kinase 2
|
-0.0257018
|
|
NAV2
|
neuron navigator 2
|
-0.0233357
|
|
RPS3
|
ribosomal protein S3
|
-0.0172026
|
|
HSP90AA1
|
heat shock protein 90kDa alpha (cytosolic), class A member 1
|
-0.0115284
|
|
KMT2E
|
lysine (K)-specific methyltransferase 2E
|
-0.0105782
|
|
RBPJ
|
recombination signal binding protein for immunoglobulin kappa J region
|
-0.00908224
|
