Vismodegib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.136417
CDH10 cadherin 10, type 2 (T2-cadherin) 0.11214
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.111418
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.109828
COL5A2 collagen, type V, alpha 2 0.104536
PGAP1 post-GPI attachment to proteins 1 0.103335
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0961401
PDGFC platelet derived growth factor C 0.0810807
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0787656
KMT2E lysine (K)-specific methyltransferase 2E 0.0778213
HDAC9 histone deacetylase 9 0.0740267
PRTG protogenin 0.0689509
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0672557
ADAM9 ADAM metallopeptidase domain 9 0.0669796
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0662437
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0661082
H1-4 H1.4 linker histone, cluster member 0.06443
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0612565
ZNF608 zinc finger protein 608 0.0609227
ZNF292 zinc finger protein 292 0.059461
QKI QKI, KH domain containing, RNA binding 0.0574622
CENPF centromere protein F, 350/400kDa 0.0574129
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0567521
ZEB2 zinc finger E-box binding homeobox 2 0.0554769
MKI67 marker of proliferation Ki-67 0.0545173
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0526255
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0520937
ZFAND3 zinc finger, AN1-type domain 3 0.0503805
DST dystonin 0.048094
STAG2 stromal antigen 2 0.0479888
PEG10 paternally expressed 10 0.0472924
BCLAF1 BCL2-associated transcription factor 1 0.0469442
ARHGAP15 Rho GTPase activating protein 15 0.0466706
SET SET nuclear proto-oncogene 0.046429
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0446979
PLPP1 phospholipid phosphatase 1 0.0434884
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0430057
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0428407
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0421894
CDC73 cell division cycle 73 0.0412776
HMGB2 high mobility group box 2 0.0408932
UBQLN1 ubiquilin 1 0.040506
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0402823
UTRN utrophin 0.0401107
SP3 Sp3 transcription factor 0.040082
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.039342
FAM171B family with sequence similarity 171, member B 0.039291
MTF2 metal response element binding transcription factor 2 0.0392561
EVI5 ecotropic viral integration site 5 0.0386196
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0382381
PAPOLA poly(A) polymerase alpha 0.0382209
WDR43 WD repeat domain 43 0.0375414
ADGRV1 adhesion G protein-coupled receptor V1 0.037402
NCOR1 nuclear receptor corepressor 1 0.0372776
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0371779
SRP54 signal recognition particle 54kDa 0.0368464
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0363685
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0362934
MRPS30 mitochondrial ribosomal protein S30 0.0362652
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.035777
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0356875
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0355855
SAMD4A sterile alpha motif domain containing 4A 0.0355654
TENM3 teneurin transmembrane protein 3 0.0354409
CCNA2 cyclin A2 0.0349581
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0348363
ENAH enabled homolog (Drosophila) 0.0347197
RYBP RING1 and YY1 binding protein 0.0343691
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0342821
YAP1 Yes-associated protein 1 0.0340899
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0336698
USP15 ubiquitin specific peptidase 15 0.0332978
PTK2 protein tyrosine kinase 2 0.0330928
TSC22D2 TSC22 domain family, member 2 0.0329943
KIF11 kinesin family member 11 0.0327759
HSPA4 heat shock 70kDa protein 4 0.0326174
RTN4 reticulon 4 0.0324843
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0323268
ANLN anillin, actin binding protein 0.031641
MB21D2 Mab-21 domain containing 2 0.0314479
CKAP5 cytoskeleton associated protein 5 0.0314255
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0313295
USP9X ubiquitin specific peptidase 9, X-linked 0.0309456
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0308376
GLS2 glutaminase 2 (liver, mitochondrial) 0.0307977
TRPS1 trichorhinophalangeal syndrome I 0.0302684
CRY1 cryptochrome circadian clock 1 0.0302244
CLTC clathrin, heavy chain (Hc) 0.0302087
TPR translocated promoter region, nuclear basket protein 0.0301063
USP33 ubiquitin specific peptidase 33 0.0298256
FIGN fidgetin 0.0294559
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0293769
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0293736
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0293258
MEF2C myocyte enhancer factor 2C 0.0291171
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0290126
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0289703
PCDH18 protocadherin 18 0.0284289
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0283471
ARHGAP21 Rho GTPase activating protein 21 0.0282392

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.165144
TMSB10 thymosin beta 10 -0.0948689
RPS16 ribosomal protein S16 -0.0932942
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0905636
RPL23 ribosomal protein L23 -0.0714887
RPL35A ribosomal protein L35a -0.0692495
PCDH9 protocadherin 9 -0.0628538
WSB1 WD repeat and SOCS box containing 1 -0.0607071
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0595939
ACTG1 actin gamma 1 -0.0589129
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0563467
RPLP1 ribosomal protein, large, P1 -0.0519525
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0515233
MDK midkine (neurite growth-promoting factor 2) -0.0474655
RPLP0 ribosomal protein, large, P0 -0.0448913
RPS6 ribosomal protein S6 -0.0447312
FTL ferritin, light polypeptide -0.0436804
RPS27A ribosomal protein S27a -0.0436429
TPT1 tumor protein, translationally-controlled 1 -0.0433706
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0432332
FN1 fibronectin 1 -0.0427637
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.041394
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0413139
LOC102724023 ES1 protein homolog, mitochondrial -0.0407841
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0405129
PARD3B par-3 family cell polarity regulator beta -0.0402334
SNX6 sorting nexin 6 -0.0400764
PFN1 profilin 1 -0.0390614
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0382203
MRPS6 mitochondrial ribosomal protein S6 -0.0381791
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0367558
RPS19 ribosomal protein S19 -0.0367372
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0364534
MT2A metallothionein 2A -0.0362852
RPS13 ribosomal protein S13 -0.0359106
S100A10 S100 calcium binding protein A10 -0.0356915
ISG15 ISG15 ubiquitin-like modifier -0.0347802
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0343734
CAVIN1 caveolae associated protein 1 -0.0341888
LRRC4C leucine rich repeat containing 4C -0.0338705
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0338452
ANXA2 annexin A2 -0.0337292
RPL30 ribosomal protein L30 -0.0332351
HMGA1 high mobility group AT-hook 1 -0.0331145
GNAS GNAS complex locus -0.0330014
TXNRD1 thioredoxin reductase 1 -0.0323831
RPL37 ribosomal protein L37 -0.0323392
RPS25 ribosomal protein S25 -0.0319383
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0307086
PKM pyruvate kinase, muscle -0.0305899
MYL12B myosin, light chain 12B, regulatory -0.0302771
ENO1 enolase 1, (alpha) -0.0300659
RPS15 ribosomal protein S15 -0.0292905
USP34 ubiquitin specific peptidase 34 -0.0290864
PARD3 par-3 family cell polarity regulator -0.0290454
COTL1 coactosin-like F-actin binding protein 1 -0.0289662
UBE2H ubiquitin-conjugating enzyme E2H -0.028891
TUBA1B tubulin, alpha 1b -0.0287351
PHIP pleckstrin homology domain interacting protein -0.0284475
FLNB filamin B, beta -0.0281803
LMAN1 lectin, mannose-binding, 1 -0.0281678
COL1A2 collagen, type I, alpha 2 -0.027552
RPL31 ribosomal protein L31 -0.0270893
HSPB1 heat shock 27kDa protein 1 -0.0270244
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.027007
RPLP2 ribosomal protein, large, P2 -0.0266865
NDRG1 N-myc downstream regulated 1 -0.0266179
RPL34 ribosomal protein L34 -0.0265456
EEF2 eukaryotic translation elongation factor 2 -0.0264577
RPS5 ribosomal protein S5 -0.0262316
RPS4X ribosomal protein S4, X-linked -0.0261947
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.026135
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0260752
EMP1 epithelial membrane protein 1 -0.026055
CBX3 chromobox homolog 3 -0.0254936
CADM2 cell adhesion molecule 2 -0.0252159
FBXO17 F-box protein 17 -0.0251917
RPL36 ribosomal protein L36 -0.0251486
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0248317
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0247843
RPL37A ribosomal protein L37a -0.0247037
RPL36A ribosomal protein L36a -0.0246252
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0245649
TMOD3 tropomodulin 3 (ubiquitous) -0.0244047
PDIA3 protein disulfide isomerase family A, member 3 -0.024035
RACK1 receptor for activated C kinase 1 -0.0240096
LPP LIM domain containing preferred translocation partner in lipoma -0.0238816
GPC3 glypican 3 -0.02386
RPS8 ribosomal protein S8 -0.0234335
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0233785
BABAM2 BRISC and BRCA1 A complex member 2 -0.0233022
RAD51B RAD51 paralog B -0.0232685
RPS28 ribosomal protein S28 -0.0231619
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0230641
RPL28 ribosomal protein L28 -0.0230531
DDIT4 DNA-damage-inducible transcript 4 -0.0230464
CNRIP1 cannabinoid receptor interacting protein 1 -0.0229899
RPS21 ribosomal protein S21 -0.0229016
TRIO trio Rho guanine nucleotide exchange factor -0.0228058
FGF13 fibroblast growth factor 13 -0.0228015