Vismodegib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.185529
TRIO trio Rho guanine nucleotide exchange factor 0.145195
COL6A3 collagen, type VI, alpha 3 0.129899
FNDC3B fibronectin type III domain containing 3B 0.118754
SOD2 superoxide dismutase 2, mitochondrial 0.112522
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.105903
NAV2 neuron navigator 2 0.105108
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0993517
DST dystonin 0.0954593
GLIS3 GLIS family zinc finger 3 0.0818513
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0751659
CD44 CD44 molecule (Indian blood group) 0.0712124
SDK1 sidekick cell adhesion molecule 1 0.0698651
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0693259
FRMD4A FERM domain containing 4A 0.0674686
IGFBP3 insulin-like growth factor binding protein 3 0.063962
ZNF292 zinc finger protein 292 0.062715
CADM1 cell adhesion molecule 1 0.0623086
CDH13 cadherin 13 0.0621459
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0594056
MYH9 myosin, heavy chain 9, non-muscle 0.057118
FRMPD4 FERM and PDZ domain containing 4 0.0564866
AHNAK AHNAK nucleoprotein 0.0535998
KYNU kynureninase 0.0520113
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0491507
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0480164
IGF2R insulin-like growth factor 2 receptor 0.0475636
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0471712
NAMPT nicotinamide phosphoribosyltransferase 0.0463042
BACE2 beta-site APP-cleaving enzyme 2 0.0444121
ASPH aspartate beta-hydroxylase 0.0438041
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0425292
ESYT2 extended synaptotagmin-like protein 2 0.0423131
SPTBN1 spectrin, beta, non-erythrocytic 1 0.041687
PCBP3 poly(rC) binding protein 3 0.0416309
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0410896
TNS3 tensin 3 0.040848
MMP12 matrix metallopeptidase 12 0.0408398
TENT5A terminal nucleotidyltransferase 5A 0.040784
EFNA5 ephrin-A5 0.0407329
OGA O-GlcNAcase 0.0407253
NAV1 neuron navigator 1 0.0406222
ZMYND8 zinc finger, MYND-type containing 8 0.0404993
AFF3 AF4/FMR2 family, member 3 0.0380476
PHF10 PHD finger protein 10 0.037762
ELL2 elongation factor, RNA polymerase II, 2 0.0375481
USP9X ubiquitin specific peptidase 9, X-linked 0.0373003
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0366603
EGFR epidermal growth factor receptor 0.0361916
USP47 ubiquitin specific peptidase 47 0.0356835
MYOF myoferlin 0.0354423
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0345784
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0345462
COL5A1 collagen, type V, alpha 1 0.0344676
LPP LIM domain containing preferred translocation partner in lipoma 0.0338975
ZBTB38 zinc finger and BTB domain containing 38 0.033893
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0338775
MLPH melanophilin 0.0334735
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0332217
PLIN2 perilipin 2 0.0330234
SMYD3 SET and MYND domain containing 3 0.0329557
JMJD1C jumonji domain containing 1C 0.0326387
EXT1 exostosin glycosyltransferase 1 0.0325803
CCBE1 collagen and calcium binding EGF domains 1 0.032471
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0324308
MKI67 marker of proliferation Ki-67 0.0321636
BNC2 basonuclin 2 0.0319799
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0317866
TMEM132D transmembrane protein 132D 0.0317457
PTPRK protein tyrosine phosphatase, receptor type, K 0.0317033
ZCCHC7 zinc finger, CCHC domain containing 7 0.0312519
FMNL2 formin-like 2 0.0305277
HDAC9 histone deacetylase 9 0.0303902
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0302872
RB1CC1 RB1-inducible coiled-coil 1 0.0302483
PRELID2 PRELI domain containing 2 0.0300953
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0299473
MXI1 MAX interactor 1, dimerization protein 0.0298362
CERT1 ceramide transporter 1 0.0295471
CKAP5 cytoskeleton associated protein 5 0.0293678
ATP13A3 ATPase type 13A3 0.0291777
CD109 CD109 molecule 0.0291396
FOXO3 forkhead box O3 0.0286799
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0284601
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.028101
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0277879
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0277002
CEP250 centrosomal protein 250kDa 0.0275807
UTRN utrophin 0.0273741
KAZN kazrin, periplakin interacting protein 0.0271877
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0271327
MACF1 microtubule-actin crosslinking factor 1 0.0270162
FAM20C family with sequence similarity 20, member C 0.0269331
ABI3BP ABI family, member 3 (NESH) binding protein 0.0267343
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0266359
ANO6 anoctamin 6 0.02657
RAD51B RAD51 paralog B 0.0263868
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0263406
ADAM12 ADAM metallopeptidase domain 12 0.0260928
DIAPH2 diaphanous-related formin 2 0.0258667

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134696
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.131589
FN1 fibronectin 1 -0.126895
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.098796
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0725152
FTL ferritin, light polypeptide -0.0664133
RPS6 ribosomal protein S6 -0.0574333
BICC1 BicC family RNA binding protein 1 -0.051824
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0495354
RPL23 ribosomal protein L23 -0.0431952
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0416638
VCL vinculin -0.040885
TMSB10 thymosin beta 10 -0.0406919
RPS4X ribosomal protein S4, X-linked -0.0400872
EEF2 eukaryotic translation elongation factor 2 -0.039237
RPLP0 ribosomal protein, large, P0 -0.0372394
RPS24 ribosomal protein S24 -0.034404
RACK1 receptor for activated C kinase 1 -0.0341889
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0340559
EEF1G eukaryotic translation elongation factor 1 gamma -0.0337837
RPS3 ribosomal protein S3 -0.0334325
POTEF POTE ankyrin domain family, member F -0.0330501
DSTN destrin (actin depolymerizing factor) -0.0326046
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0320338
RPL32 ribosomal protein L32 -0.0319361
TPT1 tumor protein, translationally-controlled 1 -0.0312402
THBS1 thrombospondin 1 -0.030759
RPS19 ribosomal protein S19 -0.0301389
FLNB filamin B, beta -0.0297652
SLC38A2 solute carrier family 38, member 2 -0.029178
RPS8 ribosomal protein S8 -0.0289825
ACTG1 actin gamma 1 -0.0289162
EIF1 eukaryotic translation initiation factor 1 -0.0283612
WAC WW domain containing adaptor with coiled-coil -0.0282252
NABP1 nucleic acid binding protein 1 -0.0281382
LOC112694756 uncharaterized LOC112694756 -0.0279114
MT2A metallothionein 2A -0.0276244
B2M beta-2-microglobulin -0.0271853
HMGA1 high mobility group AT-hook 1 -0.0270888
RPS12 ribosomal protein S12 -0.0269498
RPS23 ribosomal protein S23 -0.0264735
RPLP1 ribosomal protein, large, P1 -0.0264389
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0264103
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259687
RPL35A ribosomal protein L35a -0.0257301
RPL27A ribosomal protein L27a -0.0255871
PALLD palladin, cytoskeletal associated protein -0.0249155
S100A9 S100 calcium binding protein A9 -0.0242019
PCBP2 poly(rC) binding protein 2 -0.0234483
RPS5 ribosomal protein S5 -0.0234102
YBX1 Y box binding protein 1 -0.0233037
ASTN2 astrotactin 2 -0.0227405
NAP1L1 nucleosome assembly protein 1-like 1 -0.0226942
RPL8 ribosomal protein L8 -0.0226718
RPL36A ribosomal protein L36a -0.0226512
RPS13 ribosomal protein S13 -0.0226225
RPL37A ribosomal protein L37a -0.0223378
EZR ezrin -0.0220636
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0218996
RPS21 ribosomal protein S21 -0.0214814
RPL19 ribosomal protein L19 -0.0212219
RPS27A ribosomal protein S27a -0.0210377
FLNA filamin A, alpha -0.0204996
KMT2E lysine (K)-specific methyltransferase 2E -0.0203205
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0201953
ANXA2 annexin A2 -0.0201113
CSDE1 cold shock domain containing E1, RNA-binding -0.0199306
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0197209
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0196297
RPL11 ribosomal protein L11 -0.0194215
CTSD cathepsin D -0.0194033
RPS10 ribosomal protein S10 -0.0193981
RPS14 ribosomal protein S14 -0.0189857
GBP1 guanylate binding protein 1, interferon-inducible -0.0189766
PDLIM5 PDZ and LIM domain 5 -0.0189202
GLIPR1 GLI pathogenesis-related 1 -0.0187984
ATXN2 ataxin 2 -0.0187618
PFN1 profilin 1 -0.0185895
BSG basigin (Ok blood group) -0.0181598
UBC ubiquitin C -0.018078
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0178821
RPS25 ribosomal protein S25 -0.017873
RPL7A ribosomal protein L7a -0.0177199
RPL12 ribosomal protein L12 -0.017537
TMEM41B transmembrane protein 41B -0.0173886
RPLP2 ribosomal protein, large, P2 -0.0173053
RPS11 ribosomal protein S11 -0.0171599
RPL31 ribosomal protein L31 -0.0171308
SGMS1 sphingomyelin synthase 1 -0.0168978
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0168078
RPL28 ribosomal protein L28 -0.0167948
IFITM3 interferon induced transmembrane protein 3 -0.0167512
TAPBP TAP binding protein (tapasin) -0.0166871
RPL30 ribosomal protein L30 -0.0164874
EGR1 early growth response 1 -0.016475
RPL18 ribosomal protein L18 -0.016378
RPS29 ribosomal protein S29 -0.0163322
RPS20 ribosomal protein S20 -0.0162334
TKT transketolase -0.0161998
PKM pyruvate kinase, muscle -0.0159118