| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vismodegib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vismodegib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.135458 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0692078 |
| CALD1 | caldesmon 1 | 0.0635946 |
| CD44 | CD44 molecule (Indian blood group) | 0.0626586 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0586778 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0567428 |
| GLIS3 | GLIS family zinc finger 3 | 0.0516169 |
| VEGFC | vascular endothelial growth factor C | 0.0507358 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0464378 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.045367 |
| METTL15 | methyltransferase like 15 | 0.0453395 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0451695 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0450027 |
| MSN | moesin | 0.0448924 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0418607 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0416296 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0410795 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0409372 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0394453 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0393269 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0386205 |
| MED13L | mediator complex subunit 13-like | 0.0385551 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0384137 |
| SEC24B | SEC24 family member B | 0.0372386 |
| LAMB1 | laminin, beta 1 | 0.0371876 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0371474 |
| VEGFA | vascular endothelial growth factor A | 0.0367601 |
| RUNX1 | runt-related transcription factor 1 | 0.0366188 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0357621 |
| NKTR | natural killer cell triggering receptor | 0.0355045 |
| ZNF395 | zinc finger protein 395 | 0.0343187 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.03371 |
| CDK6 | cyclin-dependent kinase 6 | 0.0336573 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0336024 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0334851 |
| KLF12 | Kruppel-like factor 12 | 0.0330406 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | 0.0328047 |
| DSCAM | Down syndrome cell adhesion molecule | 0.032449 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0323715 |
| COL5A1 | collagen, type V, alpha 1 | 0.031789 |
| GOLGB1 | golgin B1 | 0.0312431 |
| HMGA2 | high mobility group AT-hook 2 | 0.0312159 |
| RBM26 | RNA binding motif protein 26 | 0.0310634 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0309376 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0307283 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0306159 |
| FRMD5 | FERM domain containing 5 | 0.030485 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0304716 |
| TAPBP | TAP binding protein (tapasin) | 0.0303862 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0300523 |
| YBX1 | Y box binding protein 1 | 0.0298708 |
| EGFR | epidermal growth factor receptor | 0.0295376 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0293416 |
| PYGL | phosphorylase, glycogen, liver | 0.0292387 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0287966 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0287949 |
| THOC2 | THO complex 2 | 0.0285618 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0283847 |
| B2M | beta-2-microglobulin | 0.0281561 |
| SMYD3 | SET and MYND domain containing 3 | 0.0277562 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0277326 |
| RPS6 | ribosomal protein S6 | 0.0277082 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0276674 |
| TNPO3 | transportin 3 | 0.0275837 |
| ITGAV | integrin, alpha V | 0.0274705 |
| RNF145 | ring finger protein 145 | 0.0274674 |
| ATP13A3 | ATPase type 13A3 | 0.0272072 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0270899 |
| AHNAK | AHNAK nucleoprotein | 0.0270468 |
| ASPH | aspartate beta-hydroxylase | 0.027032 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0269897 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0266857 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.026598 |
| FAM120A | family with sequence similarity 120A | 0.0265395 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0264019 |
| SPOPL | speckle-type POZ protein-like | 0.0262342 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.026175 |
| USP34 | ubiquitin specific peptidase 34 | 0.0259092 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0258563 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.0256149 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0253144 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0253024 |
| RANBP2 | RAN binding protein 2 | 0.0250458 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0250394 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.025026 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0250258 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0250036 |
| PRKCA | protein kinase C, alpha | 0.0249302 |
| KAZN | kazrin, periplakin interacting protein | 0.0247339 |
| METAP2 | methionyl aminopeptidase 2 | 0.0246399 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0245293 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0245128 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0243944 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0243045 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0242076 |
| BBX | bobby sox homolog (Drosophila) | 0.0240402 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.0239934 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0238934 |
| ANXA5 | annexin A5 | 0.0237212 |
| UST | uronyl-2-sulfotransferase | 0.0236133 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.276641 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184719 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.159371 |
| STC1 | stanniocalcin 1 | -0.104317 |
| FN1 | fibronectin 1 | -0.0978942 |
| MT2A | metallothionein 2A | -0.0950725 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0770718 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0640804 |
| LOX | lysyl oxidase | -0.0557717 |
| PRSS23 | protease, serine, 23 | -0.055309 |
| HLA-C | major histocompatibility complex, class I, C | -0.0552171 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0539513 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0538953 |
| HLA-A | major histocompatibility complex, class I, A | -0.052918 |
| MT1X | metallothionein 1X | -0.052777 |
| COL1A1 | collagen, type I, alpha 1 | -0.0524845 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0516282 |
| CANX | calnexin | -0.0516046 |
| ARF1 | ADP-ribosylation factor 1 | -0.0515061 |
| VIM | vimentin | -0.050467 |
| ANXA2 | annexin A2 | -0.0496166 |
| CAVIN1 | caveolae associated protein 1 | -0.0490263 |
| LOXL2 | lysyl oxidase-like 2 | -0.0480383 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.047625 |
| OGA | O-GlcNAcase | -0.0463756 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0462025 |
| FTL | ferritin, light polypeptide | -0.0455213 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0445775 |
| COL1A2 | collagen, type I, alpha 2 | -0.0441555 |
| TMSB10 | thymosin beta 10 | -0.0436537 |
| PTMA | prothymosin, alpha | -0.0429125 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0418527 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0398592 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0395674 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0393913 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.039308 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0389401 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0383524 |
| CALU | calumenin | -0.0382381 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0365042 |
| NDRG1 | N-myc downstream regulated 1 | -0.0361484 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0349454 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0348968 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0344964 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0331897 |
| VDAC1 | voltage-dependent anion channel 1 | -0.033188 |
| EMP1 | epithelial membrane protein 1 | -0.0329727 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0324303 |
| MORF4L2 | mortality factor 4 like 2 | -0.0319951 |
| TUBB | tubulin, beta class I | -0.0316325 |
| ANLN | anillin, actin binding protein | -0.0313871 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0313419 |
| ACTG1 | actin gamma 1 | -0.0308759 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0305711 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0301949 |
| HDLBP | high density lipoprotein binding protein | -0.030162 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0299353 |
| RPL28 | ribosomal protein L28 | -0.0294143 |
| RPL35A | ribosomal protein L35a | -0.0293963 |
| HMGB1 | high mobility group box 1 | -0.0288173 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -0.0286576 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0285051 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.02829 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0282467 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0277568 |
| S100A10 | S100 calcium binding protein A10 | -0.0277232 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0273516 |
| PMM2 | phosphomannomutase 2 | -0.027258 |
| CCNI | cyclin I | -0.0272265 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0270286 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0269217 |
| TPX2 | TPX2, microtubule-associated | -0.026891 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.026286 |
| HM13 | histocompatibility (minor) 13 | -0.0260304 |
| RLF | rearranged L-myc fusion | -0.0259672 |
| GNAS | GNAS complex locus | -0.0259298 |
| ZNF217 | zinc finger protein 217 | -0.0258346 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0253668 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0253279 |
| HLA-E | major histocompatibility complex, class I, E | -0.0248267 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0247419 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0240991 |
| LDHA | lactate dehydrogenase A | -0.0239446 |
| TXNIP | thioredoxin interacting protein | -0.0237839 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0235415 |
| FUS | FUS RNA binding protein | -0.0233429 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0231887 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0231876 |
| SPAG9 | sperm associated antigen 9 | -0.0231813 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.023135 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0230577 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0227305 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0224771 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.022424 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0222699 |
| DNPEP | aspartyl aminopeptidase | -0.0222578 |
| S100A9 | S100 calcium binding protein A9 | -0.0222294 |
| CIRSR | corepressor of RBPJ and splicing regulator | -0.0221474 |
| TUBA1B | tubulin, alpha 1b | -0.022145 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0220629 |
