| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vismodegib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vismodegib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.150458 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0976522 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0925628 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0738093 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0588256 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0574264 |
| SDC4 | syndecan 4 | 0.0551625 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0547634 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0515346 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0483262 |
| CAPRIN2 | caprin family member 2 | 0.0466502 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0462859 |
| PARD3 | par-3 family cell polarity regulator | 0.043468 |
| PDE8A | phosphodiesterase 8A | 0.0429988 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0427401 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.042351 |
| TMF1 | TATA element modulatory factor 1 | 0.0403015 |
| RNF111 | ring finger protein 111 | 0.0399622 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0381186 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0373894 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0371018 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0366599 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0365213 |
| TMSB10 | thymosin beta 10 | 0.0364227 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0334777 |
| CUL3 | cullin 3 | 0.0330179 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0324349 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0321882 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0317314 |
| FAM3C | family with sequence similarity 3, member C | 0.0315603 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0310764 |
| ECT2 | epithelial cell transforming 2 | 0.0309672 |
| GPR107 | G protein-coupled receptor 107 | 0.0307726 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0303006 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0299872 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0295893 |
| NBAS | neuroblastoma amplified sequence | 0.0293572 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0292107 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0290497 |
| FMNL2 | formin-like 2 | 0.028866 |
| PYGL | phosphorylase, glycogen, liver | 0.028611 |
| SEPTIN2 | septin 2 | 0.0280558 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0278141 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.0276512 |
| ATP13A3 | ATPase type 13A3 | 0.027632 |
| DNER | delta/notch-like EGF repeat containing | 0.0275514 |
| CUL5 | cullin 5 | 0.0274688 |
| FLNB | filamin B, beta | 0.0267925 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0267626 |
| ITSN2 | intersectin 2 | 0.0264502 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0262433 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0257425 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.0255878 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0252012 |
| MTREX | Mtr4 exosome RNA helicase | 0.0248359 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0247618 |
| KAT2B | K(lysine) acetyltransferase 2B | 0.0246005 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0245874 |
| EXOC6B | exocyst complex component 6B | 0.0245581 |
| FTO | fat mass and obesity associated | 0.0244385 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0241307 |
| GOLIM4 | golgi integral membrane protein 4 | 0.02405 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0239754 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0238767 |
| KIAA1958 | KIAA1958 | 0.0238108 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0237168 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0236097 |
| H1-4 | H1.4 linker histone, cluster member | 0.0234682 |
| IER3 | immediate early response 3 | 0.0233669 |
| XPO1 | exportin 1 | 0.0232702 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0231246 |
| INSIG1 | insulin induced gene 1 | 0.0230838 |
| TCP1 | t-complex 1 | 0.0230658 |
| COG6 | component of oligomeric golgi complex 6 | 0.0228807 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0224297 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0221562 |
| NALCN | sodium leak channel, non selective | 0.0221276 |
| TMEM263 | transmembrane protein 263 | 0.0220452 |
| NEDD1 | neural precursor cell expressed, developmentally down-regulated 1 | 0.0218058 |
| CDK19 | cyclin-dependent kinase 19 | 0.0217619 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0215172 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0213108 |
| TMEM106B | transmembrane protein 106B | 0.0211716 |
| PDSS2 | prenyl (decaprenyl) diphosphate synthase, subunit 2 | 0.0210025 |
| HLTF | helicase-like transcription factor | 0.02093 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.020853 |
| SMAD5 | SMAD family member 5 | 0.0208356 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | 0.0207172 |
| PRKD1 | protein kinase D1 | 0.0205975 |
| ZBTB25 | zinc finger and BTB domain containing 25 | 0.0204982 |
| DIAPH3 | diaphanous-related formin 3 | 0.0204439 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0204436 |
| ANXA5 | annexin A5 | 0.0204354 |
| HDLBP | high density lipoprotein binding protein | 0.0204336 |
| FAF2 | Fas associated factor family member 2 | 0.0204323 |
| CIRSR | corepressor of RBPJ and splicing regulator | 0.0203258 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 0.0203128 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0202731 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0202186 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0201825 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.212179 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.127982 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120863 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0782157 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0764928 |
| SMYD3 | SET and MYND domain containing 3 | -0.0748824 |
| GOLGA4 | golgin A4 | -0.0664148 |
| RBM39 | RNA binding motif protein 39 | -0.0639265 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0606335 |
| LDHA | lactate dehydrogenase A | -0.0587186 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0585117 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0575817 |
| DST | dystonin | -0.0552797 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0546462 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.053611 |
| RPLP1 | ribosomal protein, large, P1 | -0.0535416 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0502124 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0485698 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0472666 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0456721 |
| SQSTM1 | sequestosome 1 | -0.0450486 |
| RPL26 | ribosomal protein L26 | -0.0430977 |
| RRBP1 | ribosome binding protein 1 | -0.0414023 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.041055 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0403587 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0384717 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0381232 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0376356 |
| INTS6 | integrator complex subunit 6 | -0.0374031 |
| CPNE1 | copine I | -0.0369854 |
| NDRG1 | N-myc downstream regulated 1 | -0.0365112 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0364476 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0364346 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | -0.0364231 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.036422 |
| CD44 | CD44 molecule (Indian blood group) | -0.0360686 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0358034 |
| PKM | pyruvate kinase, muscle | -0.0357024 |
| LMNA | lamin A/C | -0.0355858 |
| ATG7 | autophagy related 7 | -0.0355707 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0352504 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0352243 |
| FLNA | filamin A, alpha | -0.0349553 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0345131 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0335062 |
| RDX | radixin | -0.0331412 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0326975 |
| RPS25 | ribosomal protein S25 | -0.0325183 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0319474 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0319237 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0316968 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0314969 |
| RPLP2 | ribosomal protein, large, P2 | -0.0311283 |
| VIM | vimentin | -0.0310372 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.030988 |
| GNAS | GNAS complex locus | -0.0309864 |
| RPL12 | ribosomal protein L12 | -0.0309743 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0309196 |
| SEPTIN9 | septin 9 | -0.0307702 |
| ZNF638 | zinc finger protein 638 | -0.0304737 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0303622 |
| RPL27 | ribosomal protein L27 | -0.0302815 |
| PRELID2 | PRELI domain containing 2 | -0.0301878 |
| KIF5B | kinesin family member 5B | -0.0301437 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0301171 |
| RPS20 | ribosomal protein S20 | -0.0300185 |
| USP34 | ubiquitin specific peptidase 34 | -0.029962 |
| PRKCA | protein kinase C, alpha | -0.0299055 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0298397 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0297633 |
| RPL9 | ribosomal protein L9 | -0.0297516 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0293029 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0288948 |
| CTTN | cortactin | -0.028789 |
| NUP58 | nucleoporin 58 | -0.0281787 |
| FUS | FUS RNA binding protein | -0.0281477 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -0.0280604 |
| ZCCHC8 | zinc finger, CCHC domain containing 8 | -0.027779 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0276257 |
| HMGA2 | high mobility group AT-hook 2 | -0.0275641 |
| AK1 | adenylate kinase 1 | -0.0274284 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0274001 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0272831 |
| TMEM123 | transmembrane protein 123 | -0.0272744 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0269876 |
| ETV1 | ets variant 1 | -0.026937 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0265465 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0264872 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.026434 |
| FBXO11 | F-box protein 11 | -0.0263669 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0262693 |
| HM13 | histocompatibility (minor) 13 | -0.026147 |
| TMEM14B | transmembrane protein 14B | -0.0261037 |
| PHF20 | PHD finger protein 20 | -0.0257609 |
| METTL15 | methyltransferase like 15 | -0.0255704 |
| RPL37 | ribosomal protein L37 | -0.025543 |
| RPL36 | ribosomal protein L36 | -0.0251757 |
| RPL38 | ribosomal protein L38 | -0.0251139 |
| NUP98 | nucleoporin 98kDa | -0.024951 |
| TPM4 | tropomyosin 4 | -0.0249309 |
