Vismodegib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vismodegib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vismodegib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.105811
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0685835
EXT1 exostosin glycosyltransferase 1 0.0679967
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.057111
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0568605
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0543863
COPA coatomer protein complex, subunit alpha 0.049534
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0485908
RNF145 ring finger protein 145 0.0478717
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0437705
EPS8 epidermal growth factor receptor pathway substrate 8 0.0429703
HELZ helicase with zinc finger 0.0428296
ETNK1 ethanolamine kinase 1 0.0427512
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0420684
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0419971
CXCL8 chemokine (C-X-C motif) ligand 8 0.040496
CENPF centromere protein F, 350/400kDa 0.0398168
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0396156
SUCO SUN domain containing ossification factor 0.0390933
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0385249
SMAD3 SMAD family member 3 0.0385061
TFG TRK-fused gene 0.0381763
MYH9 myosin, heavy chain 9, non-muscle 0.038059
VCL vinculin 0.0375668
ASPH aspartate beta-hydroxylase 0.0369195
AHR aryl hydrocarbon receptor 0.036275
GLIS3 GLIS family zinc finger 3 0.0361316
RICTOR RPTOR independent companion of MTOR, complex 2 0.0360418
MKI67 marker of proliferation Ki-67 0.0359148
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.035786
PTK2 protein tyrosine kinase 2 0.0356759
DOCK5 dedicator of cytokinesis 5 0.0355524
OGA O-GlcNAcase 0.0344879
SHB Src homology 2 domain containing adaptor protein B 0.0343099
NRIP1 nuclear receptor interacting protein 1 0.034304
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.034131
PUM2 pumilio RNA-binding family member 2 0.0336602
NEK7 NIMA-related kinase 7 0.0335882
VMP1 vacuole membrane protein 1 0.033005
DSCAM Down syndrome cell adhesion molecule 0.0329652
CDC73 cell division cycle 73 0.0326659
RANBP2 RAN binding protein 2 0.0322286
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0312869
CAB39 calcium binding protein 39 0.0308903
TENT2 terminal nucleotidyltransferase 2 0.0308546
PICALM phosphatidylinositol binding clathrin assembly protein 0.0305647
DST dystonin 0.0304377
ZSWIM6 zinc finger, SWIM-type containing 6 0.0302247
APLP2 amyloid beta (A4) precursor-like protein 2 0.0299295
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0296838
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0287404
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0287385
PRELID2 PRELI domain containing 2 0.0287068
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.028352
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0282072
SEPTIN9 septin 9 0.0281048
AFDN afadin, adherens junction formation factor 0.0279654
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0278796
RUNX2 runt-related transcription factor 2 0.0278567
TOP1 topoisomerase (DNA) I 0.0278172
RAB31 RAB31, member RAS oncogene family 0.0275362
WAC WW domain containing adaptor with coiled-coil 0.0273934
PTBP3 polypyrimidine tract binding protein 3 0.0273128
SOD2 superoxide dismutase 2, mitochondrial 0.0271292
CUL3 cullin 3 0.0270954
ZC3H11A zinc finger CCCH-type containing 11A 0.0268732
RCOR1 REST corepressor 1 0.0268162
ZFAND6 zinc finger, AN1-type domain 6 0.026751
TAS2R14 taste receptor, type 2, member 14 0.0266483
HMGB3 high mobility group box 3 0.0266449
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0263031
TMF1 TATA element modulatory factor 1 0.0261809
MCTP2 multiple C2 domains, transmembrane 2 0.0258524
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0255644
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0255024
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0253201
RBM39 RNA binding motif protein 39 0.025315
SMOX spermine oxidase 0.0252896
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0252228
BIRC6 baculoviral IAP repeat containing 6 0.0251272
NAMPT nicotinamide phosphoribosyltransferase 0.0250935
ZC3H12C zinc finger CCCH-type containing 12C 0.0250852
UBA6 ubiquitin-like modifier activating enzyme 6 0.0250807
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0249609
ELL2 elongation factor, RNA polymerase II, 2 0.0247685
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0247427
KDM6A lysine (K)-specific demethylase 6A 0.0244502
SFPQ splicing factor proline/glutamine-rich 0.024287
MAPK8 mitogen-activated protein kinase 8 0.0241357
KMT2C lysine (K)-specific methyltransferase 2C 0.0240457
SPRED1 sprouty-related, EVH1 domain containing 1 0.0240235
STRN3 striatin, calmodulin binding protein 3 0.0240207
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.023939
SNX13 sorting nexin 13 0.0238803
WWTR1 WW domain containing transcription regulator 1 0.0237885
PAPOLA poly(A) polymerase alpha 0.0237257
NPTN neuroplastin 0.0236829
FRYL FRY-like 0.0236379
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0234762
CD44 CD44 molecule (Indian blood group) 0.0231372

decreased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.317568
FN1 fibronectin 1 -0.250368
NRG1 neuregulin 1 -0.187854
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17155
FTL ferritin, light polypeptide -0.143898
TMSB10 thymosin beta 10 -0.143041
HLA-B major histocompatibility complex, class I, B -0.136829
SQSTM1 sequestosome 1 -0.134967
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.118937
NDRG1 N-myc downstream regulated 1 -0.117005
PTMA prothymosin, alpha -0.115849
MT2A metallothionein 2A -0.0965192
TPT1 tumor protein, translationally-controlled 1 -0.0951023
S100A6 S100 calcium binding protein A6 -0.0940347
IFI27 interferon, alpha-inducible protein 27 -0.0933317
SOX4 SRY (sex determining region Y)-box 4 -0.075858
VIM vimentin -0.0738416
TMSB4X thymosin beta 4, X-linked -0.0726964
STC2 stanniocalcin 2 -0.0703498
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0677351
LOC102724023 ES1 protein homolog, mitochondrial -0.0653882
HMGA2 high mobility group AT-hook 2 -0.0651088
ACTG1 actin gamma 1 -0.0638362
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0609861
RPL35A ribosomal protein L35a -0.0602589
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0568537
S100A10 S100 calcium binding protein A10 -0.0566615
B2M beta-2-microglobulin -0.056435
RPL31 ribosomal protein L31 -0.0474732
IER3 immediate early response 3 -0.0474667
HLA-A major histocompatibility complex, class I, A -0.0469097
LMNA lamin A/C -0.0455655
RPS29 ribosomal protein S29 -0.044778
SYT1 synaptotagmin I -0.0447019
ITGA1 integrin, alpha 1 -0.0442105
MRPS6 mitochondrial ribosomal protein S6 -0.0439658
PLIN2 perilipin 2 -0.0433781
RPLP1 ribosomal protein, large, P1 -0.0413994
ENO1 enolase 1, (alpha) -0.0408961
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.040304
RPS8 ribosomal protein S8 -0.0398927
GNAS GNAS complex locus -0.0398344
S100A9 S100 calcium binding protein A9 -0.0394205
RPL37A ribosomal protein L37a -0.0393298
LIMCH1 LIM and calponin homology domains 1 -0.0387376
RPL38 ribosomal protein L38 -0.0384782
IFI6 interferon, alpha-inducible protein 6 -0.0383216
HMGA1 high mobility group AT-hook 1 -0.037705
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0364623
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0361123
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0357501
KLHL5 kelch-like family member 5 -0.0351462
RPS24 ribosomal protein S24 -0.0350759
RPL9 ribosomal protein L9 -0.0349769
AKAP12 A kinase (PRKA) anchor protein 12 -0.0349257
RPL26 ribosomal protein L26 -0.0333963
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0330935
RPS19 ribosomal protein S19 -0.0320995
DUSP6 dual specificity phosphatase 6 -0.0312769
PKM pyruvate kinase, muscle -0.030873
SFTPA2 surfactant protein A2 -0.0300621
RPL34 ribosomal protein L34 -0.0297855
TFPI2 tissue factor pathway inhibitor 2 -0.0297473
RPS27 ribosomal protein S27 -0.0296315
EIF1 eukaryotic translation initiation factor 1 -0.0289917
RPLP0 ribosomal protein, large, P0 -0.0287749
ETV1 ets variant 1 -0.0287383
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0281804
TM4SF1 transmembrane 4 L six family member 1 -0.0281393
WSB1 WD repeat and SOCS box containing 1 -0.0277293
EGR1 early growth response 1 -0.0277149
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0275184
LOC112694756 uncharaterized LOC112694756 -0.0273493
RPS6 ribosomal protein S6 -0.0271437
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0269237
UBC ubiquitin C -0.026801
CD63 CD63 molecule -0.0266451
RPS21 ribosomal protein S21 -0.0266384
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.026518
CALR calreticulin -0.0264763
RPS27A ribosomal protein S27a -0.0263934
RPL36 ribosomal protein L36 -0.0262973
JUN jun proto-oncogene -0.0262153
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0257907
KPNB1 karyopherin (importin) beta 1 -0.0256746
RACK1 receptor for activated C kinase 1 -0.0256168
RNF213 ring finger protein 213 -0.025578
SLC38A1 solute carrier family 38, member 1 -0.0253565
RPL30 ribosomal protein L30 -0.024963
MX2 MX dynamin-like GTPase 2 -0.0249013
RPS16 ribosomal protein S16 -0.0248867
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0246849
RPL23 ribosomal protein L23 -0.0246736
SKAP2 src kinase associated phosphoprotein 2 -0.024595
BZW1 basic leucine zipper and W2 domains 1 -0.0243471
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0242914
IFITM1 interferon induced transmembrane protein 1 -0.0242877
RPS11 ribosomal protein S11 -0.0242634
RPLP2 ribosomal protein, large, P2 -0.0241817
TENM4 teneurin transmembrane protein 4 -0.0241618