Vitamin K4_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.0428279
DOCK5 dedicator of cytokinesis 5 0.0327857
EGFR epidermal growth factor receptor 0.0318232
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0265929
PDE4D phosphodiesterase 4D, cAMP-specific 0.0259753
IGFBP3 insulin-like growth factor binding protein 3 0.0252409
THSD4 thrombospondin, type I, domain containing 4 0.0245061
EHBP1 EH domain binding protein 1 0.0234962
GRB10 growth factor receptor-bound protein 10 0.0224628
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0224042
PDLIM5 PDZ and LIM domain 5 0.0200986
SOD2 superoxide dismutase 2, mitochondrial 0.0188856
SLC35F3 solute carrier family 35, member F3 0.018372
AUTS2 autism susceptibility candidate 2 0.0181487
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0177571
TNS3 tensin 3 0.0176365
MACF1 microtubule-actin crosslinking factor 1 0.0176037
DST dystonin 0.0174611
RAI14 retinoic acid induced 14 0.016853
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0166814
VMP1 vacuole membrane protein 1 0.0164942
VCL vinculin 0.0159543
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0159472
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0155375
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0155145
HIPK2 homeodomain interacting protein kinase 2 0.0149948
DSCAM Down syndrome cell adhesion molecule 0.014982
ABTB3 ankyrin repeat and BTB domain containing 3 0.0143543
EXT1 exostosin glycosyltransferase 1 0.0142686
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0142538
NRIP1 nuclear receptor interacting protein 1 0.0142115
AKAP13 A kinase (PRKA) anchor protein 13 0.0140825
LAMC2 laminin, gamma 2 0.0139896
ANO6 anoctamin 6 0.013983
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0138161
ZBTB20 zinc finger and BTB domain containing 20 0.0137807
PRKCA protein kinase C, alpha 0.0135101
NRG1 neuregulin 1 0.0133125
RIN2 Ras and Rab interactor 2 0.0131466
MSN moesin 0.0130658
CEMIP cell migration inducing protein, hyaluronan binding 0.0130273
TNS1 tensin 1 0.0129549
USP47 ubiquitin specific peptidase 47 0.0128778
FNIP1 folliculin interacting protein 1 0.0126865
COPA coatomer protein complex, subunit alpha 0.0126681
NPAS2 neuronal PAS domain protein 2 0.0125208
GLS2 glutaminase 2 (liver, mitochondrial) 0.0124943
KYNU kynureninase 0.0123712
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0123477
CAPRIN2 caprin family member 2 0.0121975
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0121899
PTPRM protein tyrosine phosphatase, receptor type, M 0.011865
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0116361
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0112246
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0111839
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0111165
BTBD10 BTB (POZ) domain containing 10 0.0110317
VEGFA vascular endothelial growth factor A 0.0107816
TBC1D5 TBC1 domain family, member 5 0.0107601
CARD16 caspase recruitment domain family, member 16 0.0107334
RAD51B RAD51 paralog B 0.0106967
HMGA2 high mobility group AT-hook 2 0.0106614
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0106457
DAPK1 death-associated protein kinase 1 0.0106165
SETX senataxin 0.0106115
PSD3 pleckstrin and Sec7 domain containing 3 0.0105281
SAMD4A sterile alpha motif domain containing 4A 0.0103723
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0100584
TCF12 transcription factor 12 0.0100183
ZSWIM6 zinc finger, SWIM-type containing 6 0.00999195
MON2 MON2 homolog (S. cerevisiae) 0.0099867
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.00998106
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00986002
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.00978103
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00975818
ZCCHC7 zinc finger, CCHC domain containing 7 0.009627
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.00962089
NTN4 netrin 4 0.00956607
LUZP1 leucine zipper protein 1 0.00956408
GOLGB1 golgin B1 0.00948729
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00946625
PDE10A phosphodiesterase 10A 0.00939757
FMNL2 formin-like 2 0.00931036
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00928805
OSMR oncostatin M receptor 0.00927904
TTC28 tetratricopeptide repeat domain 28 0.00923444
KIRREL3 kin of IRRE like 3 (Drosophila) 0.00923292
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.00922754
KIF16B kinesin family member 16B 0.00921979
MCU mitochondrial calcium uniporter 0.00904423
MCL1 myeloid cell leukemia 1 0.00897504
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00883671
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.00880738
SBF2 SET binding factor 2 0.00872193
CHD9 chromodomain helicase DNA binding protein 9 0.00871896
TPM1 tropomyosin 1 (alpha) 0.00863594
ZFC3H1 zinc finger, C3H1-type containing 0.0086271
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.00851398
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0084593
RABGAP1L RAB GTPase activating protein 1-like 0.00840098

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.256851
MT2A metallothionein 2A -0.204456
TMSB10 thymosin beta 10 -0.201885
FTL ferritin, light polypeptide -0.163946
RPS19 ribosomal protein S19 -0.127887
RPLP1 ribosomal protein, large, P1 -0.119699
ACTG1 actin gamma 1 -0.115713
VIM vimentin -0.11563
RPS6 ribosomal protein S6 -0.105651
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0948856
MT1X metallothionein 1X -0.0850091
PTMA prothymosin, alpha -0.0841318
EIF1 eukaryotic translation initiation factor 1 -0.0775642
RPS16 ribosomal protein S16 -0.0758387
RPL23 ribosomal protein L23 -0.0701597
RPL19 ribosomal protein L19 -0.069254
RPL12 ribosomal protein L12 -0.0663585
RPL26 ribosomal protein L26 -0.0603673
TPT1 tumor protein, translationally-controlled 1 -0.0581254
RPS24 ribosomal protein S24 -0.0567417
RPS8 ribosomal protein S8 -0.0563408
KRT81 keratin 81, type II -0.0534275
RPS3 ribosomal protein S3 -0.0520751
RPLP2 ribosomal protein, large, P2 -0.0514527
TM4SF1 transmembrane 4 L six family member 1 -0.050998
RPL28 ribosomal protein L28 -0.0501994
RPS27A ribosomal protein S27a -0.0484028
RPLP0 ribosomal protein, large, P0 -0.0478617
STC1 stanniocalcin 1 -0.0475719
AKAP12 A kinase (PRKA) anchor protein 12 -0.0472037
RPL37A ribosomal protein L37a -0.0470032
RPL35A ribosomal protein L35a -0.0466773
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0465884
RPS13 ribosomal protein S13 -0.0460818
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0459943
RPL32 ribosomal protein L32 -0.0456589
BASP1 brain abundant, membrane attached signal protein 1 -0.0454355
NAP1L1 nucleosome assembly protein 1-like 1 -0.0451686
NDRG1 N-myc downstream regulated 1 -0.0445069
S100A10 S100 calcium binding protein A10 -0.044105
ANXA2 annexin A2 -0.0436702
RPL31 ribosomal protein L31 -0.043548
S100A6 S100 calcium binding protein A6 -0.0428833
RPL8 ribosomal protein L8 -0.0422646
RPS23 ribosomal protein S23 -0.0422598
RPS29 ribosomal protein S29 -0.0415659
RACK1 receptor for activated C kinase 1 -0.0414285
RPL13A ribosomal protein L13a -0.0400666
RPS5 ribosomal protein S5 -0.0395764
IGFBP4 insulin-like growth factor binding protein 4 -0.0393811
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0388608
RPS11 ribosomal protein S11 -0.0381622
RPL7A ribosomal protein L7a -0.0363389
RPL11 ribosomal protein L11 -0.0359091
RPL34 ribosomal protein L34 -0.0356972
PKM pyruvate kinase, muscle -0.0352717
PFN1 profilin 1 -0.0344897
RPS17 ribosomal protein S17 -0.0329685
RPL18 ribosomal protein L18 -0.0320445
RPS4X ribosomal protein S4, X-linked -0.0319696
KDM3A lysine (K)-specific demethylase 3A -0.0313377
USP3 ubiquitin specific peptidase 3 -0.0313143
PGK1 phosphoglycerate kinase 1 -0.0310616
RPL7 ribosomal protein L7 -0.0308868
LMNA lamin A/C -0.0302875
RPS12 ribosomal protein S12 -0.0300495
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0299731
NAMPT nicotinamide phosphoribosyltransferase -0.0298055
RPL38 ribosomal protein L38 -0.0296283
RPS21 ribosomal protein S21 -0.0290288
KLF6 Kruppel-like factor 6 -0.028898
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.028884
RPL36A ribosomal protein L36a -0.0288135
C15ORF48 chromosome 15 open reading frame 48 -0.0288029
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0287877
RPL37 ribosomal protein L37 -0.0287414
RPL5 ribosomal protein L5 -0.0285266
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0282044
RPL9 ribosomal protein L9 -0.0276106
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0275947
ENO1 enolase 1, (alpha) -0.0274268
VDAC1 voltage-dependent anion channel 1 -0.0271704
RPL36 ribosomal protein L36 -0.027125
TKT transketolase -0.0271145
RPL35 ribosomal protein L35 -0.0268801
RPS25 ribosomal protein S25 -0.0266138
UBC ubiquitin C -0.0266037
KPNB1 karyopherin (importin) beta 1 -0.0261056
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0257542
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0256793
TPI1 triosephosphate isomerase 1 -0.0253611
RPL30 ribosomal protein L30 -0.0253284
RPS14 ribosomal protein S14 -0.0253147
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0251169
EEF2 eukaryotic translation elongation factor 2 -0.0246246
LOC112694756 uncharaterized LOC112694756 -0.0239202
BTG1 B-cell translocation gene 1, anti-proliferative -0.023898
HMGA1 high mobility group AT-hook 1 -0.0229167
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0228707
RPL27A ribosomal protein L27a -0.0225717