Vitamin K4_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) 0.122984
TENM3 teneurin transmembrane protein 3 0.10401
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0602414
CADM2 cell adhesion molecule 2 0.0503524
RERE arginine-glutamic acid dipeptide (RE) repeats 0.037609
COL5A2 collagen, type V, alpha 2 0.0355148
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0351396
ZNF608 zinc finger protein 608 0.0339377
DST dystonin 0.0329397
MCTP1 multiple C2 domains, transmembrane 1 0.0297642
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0290874
NEBL nebulette 0.0286611
CDH18 cadherin 18, type 2 0.0286217
FMNL2 formin-like 2 0.0279165
TOX thymocyte selection-associated high mobility group box 0.0274523
NPAS3 neuronal PAS domain protein 3 0.0273344
OSBPL10 oxysterol binding protein-like 10 0.0266431
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.0235479
ARHGAP32 Rho GTPase activating protein 32 0.0217024
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0205314
FAT1 FAT atypical cadherin 1 0.0204656
RABGAP1L RAB GTPase activating protein 1-like 0.0200372
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0185051
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0184441
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0181161
PTK2 protein tyrosine kinase 2 0.0177044
LIMS1 LIM and senescent cell antigen-like domains 1 0.0176392
ANKRD36 ankyrin repeat domain 36 0.0170238
EIF4B eukaryotic translation initiation factor 4B 0.016943
VMP1 vacuole membrane protein 1 0.0160564
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0159271
TTC28 tetratricopeptide repeat domain 28 0.0153187
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0150274
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0146606
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0145781
PANK3 pantothenate kinase 3 0.0143653
TNRC18 trinucleotide repeat containing 18 0.013918
RANBP17 RAN binding protein 17 0.0138503
TRIO trio Rho guanine nucleotide exchange factor 0.0138039
ALMS1 Alstrom syndrome protein 1 0.0135438
ADGRG6 adhesion G protein-coupled receptor G6 0.0135329
IARS1 isoleucyl-tRNA synthetase 1 0.0132286
WDR43 WD repeat domain 43 0.0130974
PCDH9 protocadherin 9 0.0130281
SHROOM3 shroom family member 3 0.0127324
NRG1 neuregulin 1 0.0126731
MTAP methylthioadenosine phosphorylase 0.0126364
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0125825
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0125401
SUGCT succinyl-CoA:glutarate-CoA transferase 0.0122694
DENND1A DENN/MADD domain containing 1A 0.0122305
CELF2 CUGBP, Elav-like family member 2 0.0121601
AUTS2 autism susceptibility candidate 2 0.0121133
NF1 neurofibromin 1 0.0119746
HMGA2 high mobility group AT-hook 2 0.0119689
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0119108
ZNF146 zinc finger protein 146 0.0118128
YAP1 Yes-associated protein 1 0.0117424
SYNE1 spectrin repeat containing, nuclear envelope 1 0.011723
ZNF407 zinc finger protein 407 0.011569
AGO3 argonaute RISC catalytic component 3 0.0114386
SOX5 SRY (sex determining region Y)-box 5 0.0112271
PSAT1 phosphoserine aminotransferase 1 0.0111792
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.0111596
ATM ATM serine/threonine kinase 0.0110766
ZCCHC7 zinc finger, CCHC domain containing 7 0.0110078
GRID2 glutamate receptor, ionotropic, delta 2 0.0109683
SPIDR scaffolding protein involved in DNA repair 0.0108591
CTBP2 C-terminal binding protein 2 0.0108568
TMEM117 transmembrane protein 117 0.0107459
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0106629
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0104843
QSER1 glutamine and serine rich 1 0.0104561
CBR4 carbonyl reductase 4 0.010427
ATP9A ATPase, class II, type 9A 0.0104139
PSPC1 paraspeckle component 1 0.0102923
MCU mitochondrial calcium uniporter 0.010101
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.0100784
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0100333
SMG6 SMG6 nonsense mediated mRNA decay factor 0.00995699
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.00992106
SPIRE1 spire-type actin nucleation factor 1 0.00983327
TOR1AIP2 torsin A interacting protein 2 0.00981079
MSRB3 methionine sulfoxide reductase B3 0.00978712
SRSF1 serine/arginine-rich splicing factor 1 0.00975365
ITSN1 intersectin 1 (SH3 domain protein) 0.00963795
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.00961779
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.00953568
DDHD1 DDHD domain containing 1 0.00952607
TBC1D32 TBC1 domain family, member 32 0.00947324
PCNX1 pecanex 1 0.00938112
DHFR dihydrofolate reductase 0.00936814
ADAM9 ADAM metallopeptidase domain 9 0.00936116
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.00929746
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0092486
ADGRA3 adhesion G protein-coupled receptor A3 0.00923206
WWC2 WW and C2 domain containing 2 0.0092286
RIMKLB ribosomal modification protein rimK-like family member B 0.00919411
ANKRD17 ankyrin repeat domain 17 0.00916603
SCAF8 SR-related CTD-associated factor 8 0.00915087

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.199112
RPS8 ribosomal protein S8 -0.109891
PTMA prothymosin, alpha -0.109328
RPS6 ribosomal protein S6 -0.102782
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0999701
TMSB10 thymosin beta 10 -0.0987706
RPLP1 ribosomal protein, large, P1 -0.0963489
RPL11 ribosomal protein L11 -0.0860493
ACTG1 actin gamma 1 -0.071184
RPS19 ribosomal protein S19 -0.0677674
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.067127
IFI6 interferon, alpha-inducible protein 6 -0.0633378
RPL23 ribosomal protein L23 -0.0618593
RPS4X ribosomal protein S4, X-linked -0.0602147
RPL31 ribosomal protein L31 -0.0586383
SOX4 SRY (sex determining region Y)-box 4 -0.0577043
RPL28 ribosomal protein L28 -0.0571288
RPL36 ribosomal protein L36 -0.0567294
RPLP2 ribosomal protein, large, P2 -0.0563184
B2M beta-2-microglobulin -0.056249
RPL26 ribosomal protein L26 -0.0562354
RPL37A ribosomal protein L37a -0.0558377
RPL12 ribosomal protein L12 -0.055666
RPS21 ribosomal protein S21 -0.0543225
RPL34 ribosomal protein L34 -0.0526908
RPL19 ribosomal protein L19 -0.0523529
RPS3 ribosomal protein S3 -0.0521915
RPL5 ribosomal protein L5 -0.0518633
RPS29 ribosomal protein S29 -0.0516466
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0510206
TPT1 tumor protein, translationally-controlled 1 -0.0504326
RPL35A ribosomal protein L35a -0.0501036
RPS5 ribosomal protein S5 -0.0494071
GNAS GNAS complex locus -0.0491699
RPS11 ribosomal protein S11 -0.0486732
ENO1 enolase 1, (alpha) -0.0486372
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0464339
RPS13 ribosomal protein S13 -0.0455701
RPS12 ribosomal protein S12 -0.0449593
RPL13A ribosomal protein L13a -0.0442513
RPL32 ribosomal protein L32 -0.0437486
RPS24 ribosomal protein S24 -0.0436645
FAM162A family with sequence similarity 162, member A -0.0421553
HMGB1 high mobility group box 1 -0.0420552
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0420362
ISG15 ISG15 ubiquitin-like modifier -0.0418654
RPL9 ribosomal protein L9 -0.0417236
PNISR PNN-interacting serine/arginine-rich protein -0.0412241
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0406377
RPLP0 ribosomal protein, large, P0 -0.0404173
PGK1 phosphoglycerate kinase 1 -0.0403107
RPS17 ribosomal protein S17 -0.0395044
RPL7A ribosomal protein L7a -0.0386005
RPL38 ribosomal protein L38 -0.0385745
EEF2 eukaryotic translation elongation factor 2 -0.0368326
RPL30 ribosomal protein L30 -0.0365826
TPI1 triosephosphate isomerase 1 -0.0365709
RPL37 ribosomal protein L37 -0.0362228
MYL12B myosin, light chain 12B, regulatory -0.0358785
RPS25 ribosomal protein S25 -0.0357381
RPS27A ribosomal protein S27a -0.0356451
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0354624
FTL ferritin, light polypeptide -0.035392
VIM vimentin -0.0352665
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0351783
MT2A metallothionein 2A -0.0349723
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0342628
NAP1L1 nucleosome assembly protein 1-like 1 -0.0341027
RPL18 ribosomal protein L18 -0.0340839
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0335129
RPS23 ribosomal protein S23 -0.0332675
DEK DEK proto-oncogene -0.0331718
RPL36A ribosomal protein L36a -0.0329981
RBM25 RNA binding motif protein 25 -0.0326649
RPS15 ribosomal protein S15 -0.0326537
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0326042
RPS16 ribosomal protein S16 -0.0324209
SEPTIN7 septin 7 -0.032385
WSB1 WD repeat and SOCS box containing 1 -0.031696
LOC112694756 uncharaterized LOC112694756 -0.0315427
EIF1 eukaryotic translation initiation factor 1 -0.0308457
RPL8 ribosomal protein L8 -0.0305147
ATP5F1E ATP synthase F1 subunit epsilon -0.030463
S100A9 S100 calcium binding protein A9 -0.0302742
EGR1 early growth response 1 -0.029819
YBX1 Y box binding protein 1 -0.0285456
PKM pyruvate kinase, muscle -0.0283768
RPS10 ribosomal protein S10 -0.0280665
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0278422
PHIP pleckstrin homology domain interacting protein -0.0278283
WDR45B WD repeat domain 45B -0.0276782
RPS20 ribosomal protein S20 -0.0271968
RACK1 receptor for activated C kinase 1 -0.0265069
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0263699
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0263471
CENPF centromere protein F, 350/400kDa -0.0259438
TUBA1B tubulin, alpha 1b -0.0257529
HMGB2 high mobility group box 2 -0.0257287
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0254333
HLA-B major histocompatibility complex, class I, B -0.0252482