Vitamin K4_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0835887
SAMD4A sterile alpha motif domain containing 4A 0.0694153
CCNL1 cyclin L1 0.049299
APLP2 amyloid beta (A4) precursor-like protein 2 0.0398388
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0388749
TGM2 transglutaminase 2 0.0384127
POTEF POTE ankyrin domain family, member F 0.0350042
BRD2 bromodomain containing 2 0.0317829
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0316366
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0314606
MYH9 myosin, heavy chain 9, non-muscle 0.0310023
ZSWIM6 zinc finger, SWIM-type containing 6 0.0308913
NABP1 nucleic acid binding protein 1 0.0297964
MCL1 myeloid cell leukemia 1 0.0288697
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0270962
DST dystonin 0.0260201
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0258906
GLS2 glutaminase 2 (liver, mitochondrial) 0.0248709
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0245681
ADAM9 ADAM metallopeptidase domain 9 0.0218676
INTS6 integrator complex subunit 6 0.0213485
TPM3 tropomyosin 3 0.0205029
NOTCH2 notch 2 0.0190736
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0188974
VMP1 vacuole membrane protein 1 0.0188775
RUNX1 runt-related transcription factor 1 0.0188232
UBASH3B ubiquitin associated and SH3 domain containing B 0.0186258
RASAL2 RAS protein activator like 2 0.0185059
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.01831
SEPTIN9 septin 9 0.018087
CATSPERB catsper channel auxiliary subunit beta 0.0179639
MSN moesin 0.01789
MAML2 mastermind-like 2 (Drosophila) 0.0177476
HDAC9 histone deacetylase 9 0.017672
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.017579
EEF1G eukaryotic translation elongation factor 1 gamma 0.0174956
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0171431
FOSL2 FOS-like antigen 2 0.0169828
PCBP2 poly(rC) binding protein 2 0.0168484
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0163607
NFE2L1 nuclear factor, erythroid 2-like 1 0.0158638
BCL2L1 BCL2-like 1 0.0156008
PICALM phosphatidylinositol binding clathrin assembly protein 0.0155532
SFPQ splicing factor proline/glutamine-rich 0.0152458
RPL3 ribosomal protein L3 0.0149605
GPATCH2L G patch domain containing 2-like 0.0146398
RAD51B RAD51 paralog B 0.0143357
TRIO trio Rho guanine nucleotide exchange factor 0.0142743
ADAM32 ADAM metallopeptidase domain 32 0.014254
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0142458
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0140298
EIF5 eukaryotic translation initiation factor 5 0.0137927
PNN pinin, desmosome associated protein 0.0136002
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0135589
LCOR ligand dependent nuclear receptor corepressor 0.013303
TJP1 tight junction protein 1 0.0132527
AGRN agrin 0.0131676
KDM6A lysine (K)-specific demethylase 6A 0.0130948
HDGF hepatoma-derived growth factor 0.013005
PRELID2 PRELI domain containing 2 0.0129586
ANXA1 annexin A1 0.0127343
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0125758
DIAPH1 diaphanous-related formin 1 0.0124853
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0123365
HKDC1 hexokinase domain containing 1 0.0122476
STC2 stanniocalcin 2 0.0122433
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0121984
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0121051
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0119837
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0119762
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0117373
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0116153
BCL9L B-cell CLL/lymphoma 9-like 0.0115002
BICC1 BicC family RNA binding protein 1 0.011286
PDLIM5 PDZ and LIM domain 5 0.011161
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0111521
CAPRIN2 caprin family member 2 0.0111022
EEF2 eukaryotic translation elongation factor 2 0.0109264
TPM1 tropomyosin 1 (alpha) 0.0106999
TUFT1 tuftelin 1 0.0106752
NTN4 netrin 4 0.0105945
NCEH1 neutral cholesterol ester hydrolase 1 0.0105864
TRIP12 thyroid hormone receptor interactor 12 0.0105845
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0105631
SVIL supervillin 0.0105545
PCNX4 pecanex 4 0.0105516
DUOX2 dual oxidase 2 0.0104518
MBD5 methyl-CpG binding domain protein 5 0.0103405
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0103195
EGR1 early growth response 1 0.0102974
WWTR1 WW domain containing transcription regulator 1 0.010248
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0102164
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0101864
NRIP1 nuclear receptor interacting protein 1 0.0101704
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0101419
NCOR2 nuclear receptor corepressor 2 0.0101242
EXOC6B exocyst complex component 6B 0.0101199
PAPOLA poly(A) polymerase alpha 0.0100456
GPHN gephyrin 0.00997181
ACTN1 actinin, alpha 1 0.00989928

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.306449
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204307
MMP7 matrix metallopeptidase 7 -0.165798
LAMB3 laminin, beta 3 -0.148079
TMSB10 thymosin beta 10 -0.142076
HLA-B major histocompatibility complex, class I, B -0.123917
PTMA prothymosin, alpha -0.121775
NAMPT nicotinamide phosphoribosyltransferase -0.118291
TPT1 tumor protein, translationally-controlled 1 -0.114922
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.104326
CP ceruloplasmin (ferroxidase) -0.10304
KRT19 keratin 19, type I -0.0939415
APOL1 apolipoprotein L, 1 -0.087191
NDRG1 N-myc downstream regulated 1 -0.0862878
TM4SF1 transmembrane 4 L six family member 1 -0.0808036
S100A6 S100 calcium binding protein A6 -0.0797384
PGK1 phosphoglycerate kinase 1 -0.0781277
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0779413
MT2A metallothionein 2A -0.0771035
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0731844
NPEPPS aminopeptidase puromycin sensitive -0.0722044
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0720039
ACTG1 actin gamma 1 -0.0709871
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0706224
WSB1 WD repeat and SOCS box containing 1 -0.0675023
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0664551
VIM vimentin -0.0656612
SLC38A1 solute carrier family 38, member 1 -0.0632653
ANXA2 annexin A2 -0.0628202
LAMC2 laminin, gamma 2 -0.0601171
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0578346
UBC ubiquitin C -0.0573046
KLF6 Kruppel-like factor 6 -0.0562791
AHNAK AHNAK nucleoprotein -0.0543181
S100A10 S100 calcium binding protein A10 -0.0538391
C15ORF48 chromosome 15 open reading frame 48 -0.0532095
IGFBP3 insulin-like growth factor binding protein 3 -0.0531543
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0522257
ISG15 ISG15 ubiquitin-like modifier -0.0515664
RPLP1 ribosomal protein, large, P1 -0.0511392
IFI27 interferon, alpha-inducible protein 27 -0.0505065
CSTB cystatin B (stefin B) -0.0501785
ESYT2 extended synaptotagmin-like protein 2 -0.0494098
F3 coagulation factor III (thromboplastin, tissue factor) -0.0494084
RRBP1 ribosome binding protein 1 -0.0491979
HLA-A major histocompatibility complex, class I, A -0.0483657
RPL35A ribosomal protein L35a -0.0479632
LOC112694756 uncharaterized LOC112694756 -0.0466218
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0464806
ENO1 enolase 1, (alpha) -0.0459115
HLA-E major histocompatibility complex, class I, E -0.0450888
EIF1 eukaryotic translation initiation factor 1 -0.0448444
IER3 immediate early response 3 -0.0435448
RPS8 ribosomal protein S8 -0.04354
PDIA3 protein disulfide isomerase family A, member 3 -0.0431039
TMSB4X thymosin beta 4, X-linked -0.0429459
GCC2 GRIP and coiled-coil domain containing 2 -0.0404199
RAB1A RAB1A, member RAS oncogene family -0.0379292
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0377982
MT1X metallothionein 1X -0.0376518
RPL34 ribosomal protein L34 -0.0376113
PLAT plasminogen activator, tissue -0.0375919
WDR45B WD repeat domain 45B -0.0375914
KLF5 Kruppel-like factor 5 (intestinal) -0.0373889
RPS24 ribosomal protein S24 -0.037082
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0370138
LAMA4 laminin, alpha 4 -0.0369237
GNAS GNAS complex locus -0.0368081
PLAUR plasminogen activator, urokinase receptor -0.0365747
ZMYND8 zinc finger, MYND-type containing 8 -0.0357949
CD2AP CD2-associated protein -0.0353171
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0352777
KDM3A lysine (K)-specific demethylase 3A -0.0351011
BZW1 basic leucine zipper and W2 domains 1 -0.0350413
RPL11 ribosomal protein L11 -0.0349197
AHNAK2 AHNAK nucleoprotein 2 -0.0340775
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0339594
RPS21 ribosomal protein S21 -0.033871
IFI16 interferon, gamma-inducible protein 16 -0.0330222
DSG2 desmoglein 2 -0.0323856
FAM162A family with sequence similarity 162, member A -0.0317473
RPS29 ribosomal protein S29 -0.0313341
LMNA lamin A/C -0.0308646
TPM4 tropomyosin 4 -0.0306402
IFITM1 interferon induced transmembrane protein 1 -0.0303167
KPNB1 karyopherin (importin) beta 1 -0.0302126
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0290142
SPAG9 sperm associated antigen 9 -0.0287772
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0284911
KDM5B lysine (K)-specific demethylase 5B -0.0284653
VDAC1 voltage-dependent anion channel 1 -0.0283906
ADAM28 ADAM metallopeptidase domain 28 -0.028369
RPL19 ribosomal protein L19 -0.0280406
RPS27A ribosomal protein S27a -0.0279439
LCN2 lipocalin 2 -0.0277878
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0276299
ELL2 elongation factor, RNA polymerase II, 2 -0.0275711
PARD3 par-3 family cell polarity regulator -0.0274864
FAM13A family with sequence similarity 13, member A -0.0274451
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0271932