Vitamin K4_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.130526
NALF1 NALCN channel auxiliary factor 1 0.126588
VCL vinculin 0.0804305
NRG1 neuregulin 1 0.0760746
PTPRD protein tyrosine phosphatase, receptor type, D 0.0728329
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0671691
FMN1 formin 1 0.0636286
RNF213 ring finger protein 213 0.0595932
IGFBP3 insulin-like growth factor binding protein 3 0.058901
CADM2 cell adhesion molecule 2 0.0540593
AKAP12 A kinase (PRKA) anchor protein 12 0.0537501
CEMIP cell migration inducing protein, hyaluronan binding 0.053699
BCAS3 breast carcinoma amplified sequence 3 0.0524287
FRMD4A FERM domain containing 4A 0.0511671
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0479207
ANTXR1 anthrax toxin receptor 1 0.0443004
DLC1 DLC1 Rho GTPase activating protein 0.0442005
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0426988
CRH corticotropin releasing hormone 0.0423224
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0419215
VEGFA vascular endothelial growth factor A 0.0400576
THSD4 thrombospondin, type I, domain containing 4 0.0393199
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0390496
GPC5 glypican 5 0.0387205
B2M beta-2-microglobulin 0.0382802
MAML2 mastermind-like 2 (Drosophila) 0.0382367
PACS1 phosphofurin acidic cluster sorting protein 1 0.0372606
EEF2 eukaryotic translation elongation factor 2 0.0364
TIMP3 TIMP metallopeptidase inhibitor 3 0.0358925
COL4A2 collagen, type IV, alpha 2 0.0353894
CNTN4 contactin 4 0.0341201
ENO1 enolase 1, (alpha) 0.0338314
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0336008
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0326863
COL3A1 collagen, type III, alpha 1 0.0326298
TCF12 transcription factor 12 0.0317226
NREP neuronal regeneration related protein 0.0316659
LINGO2 leucine rich repeat and Ig domain containing 2 0.0314099
RPL23 ribosomal protein L23 0.0311818
BICD1 bicaudal D homolog 1 (Drosophila) 0.0307097
EGR1 early growth response 1 0.0305197
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0302733
CUX1 cut-like homeobox 1 0.0302204
NES nestin 0.0299004
EFNA5 ephrin-A5 0.0297218
PTPRG protein tyrosine phosphatase, receptor type, G 0.029279
RAD51B RAD51 paralog B 0.0292652
COL4A5 collagen, type IV, alpha 5 0.028665
MMP2 matrix metallopeptidase 2 0.0280893
PRKCA protein kinase C, alpha 0.0274387
EEF1G eukaryotic translation elongation factor 1 gamma 0.0268489
EGFR epidermal growth factor receptor 0.0268448
DNM3 dynamin 3 0.0264139
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0261882
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0260693
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0258013
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0251539
TPM4 tropomyosin 4 0.0245243
MCL1 myeloid cell leukemia 1 0.0242613
SOX4 SRY (sex determining region Y)-box 4 0.0241583
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0238123
TRIB2 tribbles pseudokinase 2 0.023593
EXT1 exostosin glycosyltransferase 1 0.0235307
RANBP17 RAN binding protein 17 0.0231351
SIK2 salt-inducible kinase 2 0.0228597
RPL35A ribosomal protein L35a 0.0227249
TGFB1 transforming growth factor, beta 1 0.0226532
ASPH aspartate beta-hydroxylase 0.0224305
IGFBP4 insulin-like growth factor binding protein 4 0.0224301
MAPK10 mitogen-activated protein kinase 10 0.0222125
TBC1D22A TBC1 domain family, member 22A 0.0222064
LDHA lactate dehydrogenase A 0.0221662
STK38L serine/threonine kinase 38 like 0.0220833
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0218733
PLPP1 phospholipid phosphatase 1 0.0218268
NPAS2 neuronal PAS domain protein 2 0.0218253
CDH13 cadherin 13 0.0217467
TXNRD1 thioredoxin reductase 1 0.0217112
ZNF146 zinc finger protein 146 0.0216678
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0215758
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0214444
UNC5C unc-5 homolog C (C. elegans) 0.0211765
KCNIP4 Kv channel interacting protein 4 0.0211235
AUTS2 autism susceptibility candidate 2 0.0210094
POTEF POTE ankyrin domain family, member F 0.0209375
FHIT fragile histidine triad 0.0208965
PRKG1 protein kinase, cGMP-dependent, type I 0.0208744
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0208592
HDAC4 histone deacetylase 4 0.020678
AEBP2 AE binding protein 2 0.0205542
CXCL8 chemokine (C-X-C motif) ligand 8 0.020362
SLC39A11 solute carrier family 39, member 11 0.0201517
MSI2 musashi RNA-binding protein 2 0.0201036
ATRNL1 attractin-like 1 0.0200934
PCDH15 protocadherin-related 15 0.0199552
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0199467
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0197547
PBX1 pre-B-cell leukemia homeobox 1 0.0196577
PDE10A phosphodiesterase 10A 0.0192584
PCDH9 protocadherin 9 0.0190003

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.198579
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174904
IGF2 insulin-like growth factor 2 -0.155255
FAM13A family with sequence similarity 13, member A -0.100145
HELZ helicase with zinc finger -0.0938904
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0759694
FNBP1 formin binding protein 1 -0.0691947
MEIS2 Meis homeobox 2 -0.0640262
KDM3A lysine (K)-specific demethylase 3A -0.0635629
TLE4 transducin-like enhancer of split 4 -0.0631613
LPIN1 lipin 1 -0.0624688
ZMYM2 zinc finger, MYM-type 2 -0.057288
MED13 mediator complex subunit 13 -0.0568128
NPEPPS aminopeptidase puromycin sensitive -0.0532843
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0532436
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0521497
KMT2C lysine (K)-specific methyltransferase 2C -0.0510827
SOS1 son of sevenless homolog 1 (Drosophila) -0.050659
ADGRG6 adhesion G protein-coupled receptor G6 -0.0473944
WDR45B WD repeat domain 45B -0.0473944
RPS2 ribosomal protein S2 -0.0469767
CLTC clathrin, heavy chain (Hc) -0.0457685
ITPRID2 ITPR interacting domain containing 2 -0.0452584
TRIO trio Rho guanine nucleotide exchange factor -0.0451452
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0443489
HAND2 heart and neural crest derivatives expressed 2 -0.0436619
MEF2A myocyte enhancer factor 2A -0.0422881
MARCHF6 membrane associated ring-CH-type finger 6 -0.0417759
WSB1 WD repeat and SOCS box containing 1 -0.0406572
NEK7 NIMA-related kinase 7 -0.0403483
GOLGA4 golgin A4 -0.0392082
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0390603
ZNF292 zinc finger protein 292 -0.038942
XPO1 exportin 1 -0.0388046
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0383749
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.038168
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0375395
TPST1 tyrosylprotein sulfotransferase 1 -0.0371139
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0370855
NAMPT nicotinamide phosphoribosyltransferase -0.036878
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0365743
SPAG9 sperm associated antigen 9 -0.0364708
CDC27 cell division cycle 27 -0.0364319
RPL38 ribosomal protein L38 -0.0345049
MXI1 MAX interactor 1, dimerization protein -0.0344676
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0340166
PHIP pleckstrin homology domain interacting protein -0.0338602
SEC24D SEC24 family member D -0.0338005
NF1 neurofibromin 1 -0.0333668
MBD5 methyl-CpG binding domain protein 5 -0.0330957
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0330832
OGA O-GlcNAcase -0.0326551
MBNL2 muscleblind-like splicing regulator 2 -0.0323898
PCBP2 poly(rC) binding protein 2 -0.0316103
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0308089
FNDC3B fibronectin type III domain containing 3B -0.0304665
SQSTM1 sequestosome 1 -0.0302946
TENT2 terminal nucleotidyltransferase 2 -0.0302268
CASC3 cancer susceptibility candidate 3 -0.0298514
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.029726
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0295091
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0292285
TET2 tet methylcytosine dioxygenase 2 -0.0291373
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0290677
SREBF2 sterol regulatory element binding transcription factor 2 -0.0289867
TRA2A transformer 2 alpha homolog (Drosophila) -0.0289547
LMNA lamin A/C -0.0286199
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0285252
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0284182
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0282492
PTK2 protein tyrosine kinase 2 -0.0279957
FBXL20 F-box and leucine-rich repeat protein 20 -0.0278915
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0278439
SRP54 signal recognition particle 54kDa -0.0277048
SETD5 SET domain containing 5 -0.027622
NBAS neuroblastoma amplified sequence -0.0275969
PUM2 pumilio RNA-binding family member 2 -0.0274154
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0272812
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0271825
SON SON DNA binding protein -0.0271007
ZNF148 zinc finger protein 148 -0.0269709
PKM pyruvate kinase, muscle -0.0267508
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0266493
RIOK3 RIO kinase 3 -0.0266407
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0263936
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0262753
MTDH metadherin -0.0262512
FBXO11 F-box protein 11 -0.0262219
PRRC2C proline-rich coiled-coil 2C -0.0258845
PRPF8 pre-mRNA processing factor 8 -0.0257617
H1-4 H1.4 linker histone, cluster member -0.0257096
DTNA dystrobrevin, alpha -0.0256027
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0255988
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0252948
DNMBP dynamin binding protein -0.0252689
UBE2O ubiquitin-conjugating enzyme E2O -0.0252557
TENT5A terminal nucleotidyltransferase 5A -0.0251989
ZNF207 zinc finger protein 207 -0.0251075
USPL1 ubiquitin specific peptidase like 1 -0.0250812
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0250336