Vitamin K4_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0696091
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0553958
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0475621
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0431784
YAP1 Yes-associated protein 1 0.0351782
RNF43 ring finger protein 43 0.0323208
SPRED1 sprouty-related, EVH1 domain containing 1 0.0321033
GOLGB1 golgin B1 0.0288799
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.026511
NRIP1 nuclear receptor interacting protein 1 0.0255748
MON2 MON2 homolog (S. cerevisiae) 0.0240137
RUNX1 runt-related transcription factor 1 0.0223418
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0219756
HDLBP high density lipoprotein binding protein 0.0209044
SHB Src homology 2 domain containing adaptor protein B 0.0208635
COPA coatomer protein complex, subunit alpha 0.0200809
TC2N tandem C2 domains, nuclear 0.0199622
BICRAL BICRA like chromatin remodeling complex associated protein 0.0199451
SMYD3 SET and MYND domain containing 3 0.0198856
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0195914
SPRED2 sprouty-related, EVH1 domain containing 2 0.0186234
DST dystonin 0.0184486
SCFD1 sec1 family domain containing 1 0.0184149
SOD2 superoxide dismutase 2, mitochondrial 0.018291
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.018274
DUSP16 dual specificity phosphatase 16 0.01762
ZNF841 zinc finger protein 841 0.0173448
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0173328
NCOA3 nuclear receptor coactivator 3 0.0172233
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0172051
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0170675
TOP1 topoisomerase (DNA) I 0.0169919
TM9SF2 transmembrane 9 superfamily member 2 0.0165011
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0164612
AOPEP aminopeptidase O (putative) 0.0162855
PNPLA7 patatin-like phospholipase domain containing 7 0.0161931
ZNF652 zinc finger protein 652 0.0154512
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0153616
GOSR2 golgi SNAP receptor complex member 2 0.0152113
AHNAK AHNAK nucleoprotein 0.0149586
KIAA0232 KIAA0232 0.0144745
EPB41 erythrocyte membrane protein band 4.1 0.0142791
PADI1 peptidyl arginine deiminase, type I 0.0142079
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0141291
SEC24D SEC24 family member D 0.0140872
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0140624
GOLGA3 golgin A3 0.0137753
TMEM39A transmembrane protein 39A 0.013689
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0136882
HBS1L HBS1-like translational GTPase 0.013668
ANKRD11 ankyrin repeat domain 11 0.0136202
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0134083
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0134073
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0133559
RBM39 RNA binding motif protein 39 0.0130948
PLSCR2 phospholipid scramblase 2 0.0130566
OSBPL9 oxysterol binding protein-like 9 0.0130069
CFDP1 craniofacial development protein 1 0.0129968
AEBP2 AE binding protein 2 0.0128887
TMCO3 transmembrane and coiled-coil domains 3 0.0128672
MTAP methylthioadenosine phosphorylase 0.0128323
UBAP1 ubiquitin associated protein 1 0.0127928
COG6 component of oligomeric golgi complex 6 0.0126621
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0125797
CCDC14 coiled-coil domain containing 14 0.0125763
ZNF146 zinc finger protein 146 0.0125543
PDIA5 protein disulfide isomerase family A, member 5 0.012546
DIDO1 death inducer-obliterator 1 0.0124953
SLMAP sarcolemma associated protein 0.0124839
USO1 USO1 vesicle transport factor 0.0124819
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0124728
WDR26 WD repeat domain 26 0.0123938
CEMIP2 cell migration inducing hyaluronidase 2 0.012278
BRWD1 bromodomain and WD repeat domain containing 1 0.0121291
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0121153
BLCAP bladder cancer associated protein 0.0119958
XRRA1 X-ray radiation resistance associated 1 0.0119701
AVL9 AVL9 homolog (S. cerevisiase) 0.0119492
ZNF432 zinc finger protein 432 0.0118673
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0118446
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 0.0118282
ERO1B endoplasmic reticulum oxidoreductase 1 beta 0.0116984
SLC39A9 solute carrier family 39, member 9 0.0116919
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0116863
SEC24A SEC24 family member A 0.0115016
NEK7 NIMA-related kinase 7 0.0114943
FAM120B family with sequence similarity 120B 0.0114149
NCOA1 nuclear receptor coactivator 1 0.0113945
LARP1B La ribonucleoprotein domain family, member 1B 0.0113829
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.011314
USPL1 ubiquitin specific peptidase like 1 0.0112881
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0112678
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0112516
PTGR1 prostaglandin reductase 1 0.0112
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0111774
CHIC2 cysteine-rich hydrophobic domain 2 0.0110762
RALY RALY heterogeneous nuclear ribonucleoprotein 0.011027
ANKRD17 ankyrin repeat domain 17 0.0109996
ZNRF3 zinc and ring finger 3 0.0109631
OPHN1 oligophrenin 1 0.0108654

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.238783
EPSTI1 epithelial stromal interaction 1 (breast) -0.164814
TPT1 tumor protein, translationally-controlled 1 -0.119669
STS steroid sulfatase (microsomal), isozyme S -0.108597
ZMYND8 zinc finger, MYND-type containing 8 -0.104489
LCN2 lipocalin 2 -0.102175
MACC1 metastasis associated in colon cancer 1 -0.0991828
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0922096
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0890218
EZR ezrin -0.0887307
LYZ lysozyme -0.0824351
PTMA prothymosin, alpha -0.0802542
PGK1 phosphoglycerate kinase 1 -0.079038
TXNIP thioredoxin interacting protein -0.077691
PKM pyruvate kinase, muscle -0.0751158
ERBIN erbb2 interacting protein -0.0750185
ENO1 enolase 1, (alpha) -0.0744783
EGR1 early growth response 1 -0.0742469
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0736486
HLA-B major histocompatibility complex, class I, B -0.0693778
NDRG1 N-myc downstream regulated 1 -0.0693118
PERP PERP, TP53 apoptosis effector -0.0689983
MX2 MX dynamin-like GTPase 2 -0.06891
ITGA6 integrin, alpha 6 -0.0667722
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0608738
TSC22D1 TSC22 domain family, member 1 -0.060184
LIMA1 LIM domain and actin binding 1 -0.0574377
RNF213 ring finger protein 213 -0.0568478
RABGAP1L RAB GTPase activating protein 1-like -0.0565965
PRKCA protein kinase C, alpha -0.0565276
GMDS GDP-mannose 4,6-dehydratase -0.0553802
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0551563
TM4SF1 transmembrane 4 L six family member 1 -0.0551094
TMC5 transmembrane channel-like 5 -0.0549916
STAT1 signal transducer and activator of transcription 1, 91kDa -0.054745
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.054599
HLA-E major histocompatibility complex, class I, E -0.0514833
KLF6 Kruppel-like factor 6 -0.0513097
RIGI RNA sensor RIG-I -0.0506228
AKAP13 A kinase (PRKA) anchor protein 13 -0.0505243
NPSR1 neuropeptide S receptor 1 -0.0502791
TJP1 tight junction protein 1 -0.0500851
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0498638
ARHGAP26 Rho GTPase activating protein 26 -0.049668
FNDC3B fibronectin type III domain containing 3B -0.0494581
TSHZ2 teashirt zinc finger homeobox 2 -0.0493933
IFI27 interferon, alpha-inducible protein 27 -0.0491668
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.049163
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0491158
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0480531
JUN jun proto-oncogene -0.0465288
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.046483
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0462183
IFI6 interferon, alpha-inducible protein 6 -0.0461019
LOC112694756 uncharaterized LOC112694756 -0.0458976
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.045156
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0446008
GCLC glutamate-cysteine ligase, catalytic subunit -0.0442789
UBC ubiquitin C -0.0432434
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0427819
EPCAM epithelial cell adhesion molecule -0.0424827
HLA-A major histocompatibility complex, class I, A -0.0422474
TRIO trio Rho guanine nucleotide exchange factor -0.0409939
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0404252
LPP LIM domain containing preferred translocation partner in lipoma -0.0402472
IGFBP3 insulin-like growth factor binding protein 3 -0.040201
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0401711
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0401492
S100A6 S100 calcium binding protein A6 -0.0395434
TPI1 triosephosphate isomerase 1 -0.0393507
TMSB10 thymosin beta 10 -0.0389704
ZNF292 zinc finger protein 292 -0.038921
OCLN occludin -0.0388162
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0384112
SLC38A1 solute carrier family 38, member 1 -0.0381474
RHOBTB3 Rho-related BTB domain containing 3 -0.037893
WDR45B WD repeat domain 45B -0.0371152
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0368416
SPATA13 spermatogenesis associated 13 -0.0367333
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0365982
KRT19 keratin 19, type I -0.0365322
AHI1 Abelson helper integration site 1 -0.0363751
LY6E lymphocyte antigen 6 complex, locus E -0.0354421
PMP22 peripheral myelin protein 22 -0.0347073
SP100 SP100 nuclear antigen -0.034456
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343121
MBNL2 muscleblind-like splicing regulator 2 -0.0341001
FHL2 four and a half LIM domains 2 -0.0339052
FTL ferritin, light polypeptide -0.0334373
RRBP1 ribosome binding protein 1 -0.0333869
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0332944
ABLIM1 actin binding LIM protein 1 -0.0323624
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.032263
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0321256
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0319936
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0318939
RPL35A ribosomal protein L35a -0.031886
ANXA2 annexin A2 -0.0318296
MX1 MX dynamin-like GTPase 1 -0.0316794
IFIH1 interferon induced with helicase C domain 1 -0.0315737