Vitamin K4_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRELID2 PRELI domain containing 2 0.0263951
ANKRD36 ankyrin repeat domain 36 0.0246482
PSD3 pleckstrin and Sec7 domain containing 3 0.0237286
MACROD2 MACRO domain containing 2 0.0225825
OSBPL10 oxysterol binding protein-like 10 0.0215638
LPP LIM domain containing preferred translocation partner in lipoma 0.0176792
ZBTB20 zinc finger and BTB domain containing 20 0.0169926
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0166316
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0163211
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0159304
CFAP44 cilia and flagella associated protein 44 0.015727
BCAR3 breast cancer anti-estrogen resistance 3 0.0153825
KDM6A lysine (K)-specific demethylase 6A 0.0148714
DOCK1 dedicator of cytokinesis 1 0.0147738
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0147071
BTBD10 BTB (POZ) domain containing 10 0.0143469
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0142722
MYEOV myeloma overexpressed 0.0141087
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0140401
PICALM phosphatidylinositol binding clathrin assembly protein 0.0138567
ATXN1 ataxin 1 0.013792
AFDN afadin, adherens junction formation factor 0.0137485
FNIP1 folliculin interacting protein 1 0.013461
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0132348
GSK3B glycogen synthase kinase 3 beta 0.013
PARD3B par-3 family cell polarity regulator beta 0.0129891
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0128072
NBEA neurobeachin 0.0127216
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0127127
STAU2 staufen double-stranded RNA binding protein 2 0.0127071
GPC5 glypican 5 0.0126153
CLASP2 cytoplasmic linker associated protein 2 0.0124614
DOCK3 dedicator of cytokinesis 3 0.0122751
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0121459
SMYD3 SET and MYND domain containing 3 0.0121317
ZNF638 zinc finger protein 638 0.011937
NFIB nuclear factor I/B 0.0117959
METTL15 methyltransferase like 15 0.0116469
ERBIN erbb2 interacting protein 0.0116301
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0113708
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0112316
SVIL supervillin 0.0112139
NCEH1 neutral cholesterol ester hydrolase 1 0.0111947
SMC5 structural maintenance of chromosomes 5 0.0111932
KIAA1328 KIAA1328 0.0111671
RAD51B RAD51 paralog B 0.0111596
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0110106
ATXN7 ataxin 7 0.0109423
SP3 Sp3 transcription factor 0.0108903
GDA guanine deaminase 0.0107296
DNAH14 dynein, axonemal, heavy chain 14 0.010719
RPTOR regulatory associated protein of MTOR, complex 1 0.0106939
FER fer (fps/fes related) tyrosine kinase 0.0106207
FSD1L fibronectin type III and SPRY domain containing 1-like 0.0106034
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0105462
MMS22L MMS22-like, DNA repair protein 0.0105004
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.010491
CEP128 centrosomal protein 128kDa 0.0104507
SCAPER S-phase cyclin A-associated protein in the ER 0.0103607
TMCC1 transmembrane and coiled-coil domain family 1 0.0102763
DENND1A DENN/MADD domain containing 1A 0.010243
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0102326
AEBP2 AE binding protein 2 0.0101712
TBC1D5 TBC1 domain family, member 5 0.010131
PCNX1 pecanex 1 0.0100909
TRAPPC9 trafficking protein particle complex 9 0.0100726
RABGAP1L RAB GTPase activating protein 1-like 0.00996001
ANKRD17 ankyrin repeat domain 17 0.0099432
FANCL Fanconi anemia, complementation group L 0.00990152
ZNF618 zinc finger protein 618 0.00984391
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.00979727
DMXL1 Dmx-like 1 0.00976612
RANBP17 RAN binding protein 17 0.00968549
VCL vinculin 0.009479
DIDO1 death inducer-obliterator 1 0.00933404
PDLIM5 PDZ and LIM domain 5 0.0093058
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 0.00928883
ANO6 anoctamin 6 0.00922492
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00921861
ATAD2 ATPase family, AAA domain containing 2 0.00921025
ZFC3H1 zinc finger, C3H1-type containing 0.00919714
SGMS1 sphingomyelin synthase 1 0.00918596
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.00915536
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.00902266
SFMBT1 Scm-like with four mbt domains 1 0.00898495
TFDP1 transcription factor Dp-1 0.00888567
RTTN rotatin 0.00885794
BIRC6 baculoviral IAP repeat containing 6 0.00866564
EXOC6B exocyst complex component 6B 0.00865436
NECTIN3 nectin cell adhesion molecule 3 0.00864062
PATJ PATJ crumbs cell polarity complex component 0.00857052
ZC3H11A zinc finger CCCH-type containing 11A 0.00856654
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.00852709
LRP12 low density lipoprotein receptor-related protein 12 0.00851983
DNHD1 dynein heavy chain domain 1 0.00851759
JAZF1 JAZF zinc finger 1 0.00848961
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.00847195
RFC3 replication factor C (activator 1) 3, 38kDa 0.00843157
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.00839587
SETX senataxin 0.00839144

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232176
TMSB10 thymosin beta 10 -0.161627
FTL ferritin, light polypeptide -0.150465
MT2A metallothionein 2A -0.122334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108891
PTMA prothymosin, alpha -0.105437
ACTG1 actin gamma 1 -0.103272
TPT1 tumor protein, translationally-controlled 1 -0.102056
NDRG1 N-myc downstream regulated 1 -0.100957
ENO1 enolase 1, (alpha) -0.0924213
B2M beta-2-microglobulin -0.0903641
RPL35A ribosomal protein L35a -0.0902971
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.083341
RPS8 ribosomal protein S8 -0.0799583
RPS6 ribosomal protein S6 -0.0793698
PKM pyruvate kinase, muscle -0.0769199
RPL19 ribosomal protein L19 -0.0745641
RPL23 ribosomal protein L23 -0.0731639
RPS19 ribosomal protein S19 -0.0729614
RPL31 ribosomal protein L31 -0.0653735
RPLP1 ribosomal protein, large, P1 -0.0652103
LDHA lactate dehydrogenase A -0.0634389
RPL12 ribosomal protein L12 -0.0630098
IGFBP3 insulin-like growth factor binding protein 3 -0.0598306
S100A10 S100 calcium binding protein A10 -0.0566806
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0560178
PGK1 phosphoglycerate kinase 1 -0.055028
RPL32 ribosomal protein L32 -0.0531031
RPS3 ribosomal protein S3 -0.0530784
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.052662
LAMB3 laminin, beta 3 -0.0514291
ANXA1 annexin A1 -0.0509754
CCND1 cyclin D1 -0.0507008
KRT7 keratin 7, type II -0.0490705
ANXA2 annexin A2 -0.0481111
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0467236
RPL34 ribosomal protein L34 -0.0465667
RPL11 ribosomal protein L11 -0.0465351
RACK1 receptor for activated C kinase 1 -0.0463523
RPL28 ribosomal protein L28 -0.0443923
TMSB4X thymosin beta 4, X-linked -0.0437346
S100A6 S100 calcium binding protein A6 -0.0434762
EIF1 eukaryotic translation initiation factor 1 -0.0434129
RPL35 ribosomal protein L35 -0.0428739
TPI1 triosephosphate isomerase 1 -0.0426093
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0416085
RPLP2 ribosomal protein, large, P2 -0.0413489
RPL5 ribosomal protein L5 -0.0404809
RPS12 ribosomal protein S12 -0.0404642
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0399789
SEPTIN7 septin 7 -0.0396358
APP amyloid beta (A4) precursor protein -0.0395755
RPS14 ribosomal protein S14 -0.0395251
RPLP0 ribosomal protein, large, P0 -0.0394832
RPS16 ribosomal protein S16 -0.0383818
EZR ezrin -0.0381649
GNAS GNAS complex locus -0.0379049
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0378638
RPL9 ribosomal protein L9 -0.0378062
RPS27A ribosomal protein S27a -0.0376606
RPS11 ribosomal protein S11 -0.0372958
RPL8 ribosomal protein L8 -0.0370079
RPS25 ribosomal protein S25 -0.0362018
RPL37A ribosomal protein L37a -0.035846
YBX1 Y box binding protein 1 -0.035503
POTEF POTE ankyrin domain family, member F -0.0352019
RPS29 ribosomal protein S29 -0.0348883
EGR1 early growth response 1 -0.0347509
RPL7A ribosomal protein L7a -0.0343483
RPS4X ribosomal protein S4, X-linked -0.0342478
FAM162A family with sequence similarity 162, member A -0.0338806
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0335173
DDIT4 DNA-damage-inducible transcript 4 -0.033052
RPS13 ribosomal protein S13 -0.0325616
RPL36 ribosomal protein L36 -0.0324011
RPL26 ribosomal protein L26 -0.0322806
UGCG UDP-glucose ceramide glucosyltransferase -0.0318686
RPS24 ribosomal protein S24 -0.0318246
RPL13A ribosomal protein L13a -0.0317978
CANX calnexin -0.0316651
RPS23 ribosomal protein S23 -0.031515
RPS5 ribosomal protein S5 -0.0314331
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0307734
EEF2 eukaryotic translation elongation factor 2 -0.0306907
KDM3A lysine (K)-specific demethylase 3A -0.0299312
TRA2A transformer 2 alpha homolog (Drosophila) -0.029836
WSB1 WD repeat and SOCS box containing 1 -0.0297078
WDR45B WD repeat domain 45B -0.0295046
LMAN1 lectin, mannose-binding, 1 -0.0293975
VDAC1 voltage-dependent anion channel 1 -0.0292685
LOC112694756 uncharaterized LOC112694756 -0.0292553
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0290701
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0288779
DSG2 desmoglein 2 -0.0285531
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0284741
BHLHE40 basic helix-loop-helix family, member e40 -0.0280652
NAP1L1 nucleosome assembly protein 1-like 1 -0.0280272
RPS15 ribosomal protein S15 -0.027772
RPL38 ribosomal protein L38 -0.0277538
RPS10 ribosomal protein S10 -0.0275328