Vitamin K4_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vitamin K4_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0763182
SMAD3 SMAD family member 3 0.0221388
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0192426
WWTR1 WW domain containing transcription regulator 1 0.0172392
MYH9 myosin, heavy chain 9, non-muscle 0.0171631
HMGA2 high mobility group AT-hook 2 0.0129809
DOCK5 dedicator of cytokinesis 5 0.0128522
ARRDC3 arrestin domain containing 3 0.0124777
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0118436
PLEC plectin 0.0103433
TNS1 tensin 1 0.0103236
ANTXR2 anthrax toxin receptor 2 0.00997731
ATP13A3 ATPase type 13A3 0.00984227
CCNL1 cyclin L1 0.00977927
DPYSL3 dihydropyrimidinase-like 3 0.00919806
MSN moesin 0.00897907
VMP1 vacuole membrane protein 1 0.00880818
TMF1 TATA element modulatory factor 1 0.00872019
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00869923
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00854947
HAS2 hyaluronan synthase 2 0.00827839
NFE2L1 nuclear factor, erythroid 2-like 1 0.00819046
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.00811334
OGA O-GlcNAcase 0.00807028
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00772992
NRIP1 nuclear receptor interacting protein 1 0.00741268
RASA2 RAS p21 protein activator 2 0.00724628
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.00713353
ARHGAP29 Rho GTPase activating protein 29 0.00713205
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.00712472
SDC4 syndecan 4 0.00707788
SOD2 superoxide dismutase 2, mitochondrial 0.00704801
USP24 ubiquitin specific peptidase 24 0.00689596
KMT2E lysine (K)-specific methyltransferase 2E 0.00684944
GIGYF2 GRB10 interacting GYF protein 2 0.00673505
CNOT12 CCR4-NOT transcription complex subunit 12 0.00669891
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.00667408
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.00665117
SAMD9 sterile alpha motif domain containing 9 0.00656796
AOPEP aminopeptidase O (putative) 0.00646709
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00641059
TPM3 tropomyosin 3 0.00623792
RBM25 RNA binding motif protein 25 0.00623126
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.00619087
HSPA8 heat shock 70kDa protein 8 0.00617498
SOCS5 suppressor of cytokine signaling 5 0.00612648
CASC3 cancer susceptibility candidate 3 0.00602571
SHB Src homology 2 domain containing adaptor protein B 0.0060216
CEP192 centrosomal protein 192kDa 0.00598781
XPO1 exportin 1 0.0059873
ANKH ANKH inorganic pyrophosphate transport regulator 0.00591716
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.00584322
FAM20C family with sequence similarity 20, member C 0.00583647
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.00576685
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00576273
EHBP1L1 EH domain binding protein 1-like 1 0.00572254
COL4A1 collagen, type IV, alpha 1 0.0057225
SEPTIN9 septin 9 0.00567924
CSF1 colony stimulating factor 1 (macrophage) 0.005612
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.00559066
TXNRD1 thioredoxin reductase 1 0.00557067
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00556662
CAPRIN2 caprin family member 2 0.00550113
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0054968
GLS2 glutaminase 2 (liver, mitochondrial) 0.00546746
ICAM1 intercellular adhesion molecule 1 0.00545513
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.00544881
CAMKMT calmodulin-lysine N-methyltransferase 0.00543327
SPAG9 sperm associated antigen 9 0.00540739
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.00537011
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.00536913
SETD2 SET domain containing 2 0.00536341
LNPEP leucyl/cystinyl aminopeptidase 0.00535231
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.00533687
PTBP2 polypyrimidine tract binding protein 2 0.00529029
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.00523065
KIF16B kinesin family member 16B 0.00521672
IGSF9B immunoglobulin superfamily, member 9B 0.00518553
ANKRD36 ankyrin repeat domain 36 0.00514826
FAM107B family with sequence similarity 107, member B 0.00513567
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00503912
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.00502158
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.00499472
FAT1 FAT atypical cadherin 1 0.00495577
ADAR adenosine deaminase, RNA-specific 0.00488972
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00486352
SNX4 sorting nexin 4 0.00484247
RB1CC1 RB1-inducible coiled-coil 1 0.00482219
SS18 synovial sarcoma translocation, chromosome 18 0.00476427
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.00470852
ECT2 epithelial cell transforming 2 0.00467424
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.00466322
JCAD junctional cadherin 5 associated 0.00465957
PARP8 poly (ADP-ribose) polymerase family, member 8 0.00464147
PLSCR1 phospholipid scramblase 1 0.00462197
CAB39 calcium binding protein 39 0.00461071
JAK2 Janus kinase 2 0.0045675
CKAP5 cytoskeleton associated protein 5 0.00456628
LMO7 LIM domain 7 0.00455899
ZNF148 zinc finger protein 148 0.00454538

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.203408
COL1A1 collagen, type I, alpha 1 -0.187023
IGFBP3 insulin-like growth factor binding protein 3 -0.186243
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.181008
NDRG1 N-myc downstream regulated 1 -0.180582
FN1 fibronectin 1 -0.131887
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.121488
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117108
TIMP3 TIMP metallopeptidase inhibitor 3 -0.115861
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.114701
TMSB10 thymosin beta 10 -0.106148
COL1A2 collagen, type I, alpha 2 -0.102413
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0921998
TGFBI transforming growth factor, beta-induced, 68kDa -0.0833771
IER3 immediate early response 3 -0.0705348
ENO1 enolase 1, (alpha) -0.065257
FTL ferritin, light polypeptide -0.0636245
ACTG1 actin gamma 1 -0.0627538
RPL35A ribosomal protein L35a -0.0585599
MT2A metallothionein 2A -0.0558764
RPS8 ribosomal protein S8 -0.0557536
PTMA prothymosin, alpha -0.0522234
CDH13 cadherin 13 -0.0514935
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0496153
CALR calreticulin -0.0492254
TPM4 tropomyosin 4 -0.0485389
FBN1 fibrillin 1 -0.046653
LOX lysyl oxidase -0.0435884
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0429652
TPT1 tumor protein, translationally-controlled 1 -0.0420585
RPS6 ribosomal protein S6 -0.0395361
S100A9 S100 calcium binding protein A9 -0.0392796
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0389526
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0384141
STC1 stanniocalcin 1 -0.0379021
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0367484
COL5A1 collagen, type V, alpha 1 -0.0364408
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0352962
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0340463
HLA-B major histocompatibility complex, class I, B -0.0339594
F3 coagulation factor III (thromboplastin, tissue factor) -0.0311778
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0311544
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.031111
CALD1 caldesmon 1 -0.030774
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0300913
MTDH metadherin -0.0299722
TM4SF1 transmembrane 4 L six family member 1 -0.02922
LOXL2 lysyl oxidase-like 2 -0.0289232
TRIO trio Rho guanine nucleotide exchange factor -0.0280287
RPL11 ribosomal protein L11 -0.0279804
UBC ubiquitin C -0.0279166
S100A10 S100 calcium binding protein A10 -0.0278767
CD44 CD44 molecule (Indian blood group) -0.0270719
S100A6 S100 calcium binding protein A6 -0.0270385
PGK1 phosphoglycerate kinase 1 -0.0269213
RPL28 ribosomal protein L28 -0.026811
COL6A1 collagen, type VI, alpha 1 -0.0264148
ASPH aspartate beta-hydroxylase -0.0262792
RPL37A ribosomal protein L37a -0.0259914
RPLP1 ribosomal protein, large, P1 -0.0255843
RPS13 ribosomal protein S13 -0.0255545
RRBP1 ribosome binding protein 1 -0.0254008
RPL23 ribosomal protein L23 -0.025387
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.025181
EXT1 exostosin glycosyltransferase 1 -0.0250848
CAVIN1 caveolae associated protein 1 -0.0247996
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0247399
PKM pyruvate kinase, muscle -0.0246931
RPL8 ribosomal protein L8 -0.0246689
ADM adrenomedullin -0.0246002
LMAN1 lectin, mannose-binding, 1 -0.0244348
RACK1 receptor for activated C kinase 1 -0.0244126
CALU calumenin -0.0243007
RPL34 ribosomal protein L34 -0.024086
GNAS GNAS complex locus -0.0240021
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0239442
COL6A2 collagen, type VI, alpha 2 -0.0238905
RPLP2 ribosomal protein, large, P2 -0.023229
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0232104
PSD3 pleckstrin and Sec7 domain containing 3 -0.0231502
CANX calnexin -0.0224815
RPS24 ribosomal protein S24 -0.0224587
RPS19 ribosomal protein S19 -0.0224494
IFI6 interferon, alpha-inducible protein 6 -0.0224212
ANXA2 annexin A2 -0.0219491
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0217103
INHBA inhibin, beta A -0.0212888
RPL26 ribosomal protein L26 -0.0211338
RPL19 ribosomal protein L19 -0.0211014
RPS25 ribosomal protein S25 -0.0211
LMNA lamin A/C -0.020988
VDAC1 voltage-dependent anion channel 1 -0.0208334
EIF1 eukaryotic translation initiation factor 1 -0.0208095
RPL5 ribosomal protein L5 -0.020648
RPS3 ribosomal protein S3 -0.0198156
SLC38A2 solute carrier family 38, member 2 -0.0196725
HLA-A major histocompatibility complex, class I, A -0.0195642
HILPDA hypoxia inducible lipid droplet-associated -0.0194685
ARL4C ADP-ribosylation factor-like 4C -0.0194628
FAM162A family with sequence similarity 162, member A -0.0194412