| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Vitamin K4 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Vitamin K4_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0655966 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0545656 |
| RBM39 | RNA binding motif protein 39 | 0.0386316 |
| RBM25 | RNA binding motif protein 25 | 0.0351219 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0326634 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0308877 |
| MT2A | metallothionein 2A | 0.0295918 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0293729 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.028813 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.028644 |
| SLC23A1 | solute carrier family 23 (ascorbic acid transporter), member 1 | 0.0276035 |
| TOP1 | topoisomerase (DNA) I | 0.0261504 |
| BCL2L1 | BCL2-like 1 | 0.0258103 |
| VCL | vinculin | 0.025421 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0247518 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0246053 |
| ENAH | enabled homolog (Drosophila) | 0.0235841 |
| ITGB5 | integrin, beta 5 | 0.0232627 |
| RPL4 | ribosomal protein L4 | 0.0231046 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0227572 |
| ANKRD11 | ankyrin repeat domain 11 | 0.022304 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0222402 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0206202 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0205156 |
| ITGAV | integrin, alpha V | 0.0201037 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0197933 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0195929 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0191011 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0190888 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0189969 |
| WDR43 | WD repeat domain 43 | 0.0189532 |
| GOLGA4 | golgin A4 | 0.0185864 |
| CUL3 | cullin 3 | 0.018381 |
| KIF5B | kinesin family member 5B | 0.0183726 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.01833 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0182002 |
| CCNL1 | cyclin L1 | 0.0181552 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0179492 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0168482 |
| TRIM26 | tripartite motif containing 26 | 0.0164976 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0162852 |
| LRRC1 | leucine rich repeat containing 1 | 0.0162335 |
| VMP1 | vacuole membrane protein 1 | 0.0162282 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0161746 |
| MRTFA | myocardin related transcription factor A | 0.0161504 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0160162 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0158586 |
| PCBP2 | poly(rC) binding protein 2 | 0.0158373 |
| MED13L | mediator complex subunit 13-like | 0.0157684 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0157659 |
| JMJD1C | jumonji domain containing 1C | 0.0155783 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0155527 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0154454 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0150943 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0145449 |
| KLHL5 | kelch-like family member 5 | 0.0144454 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0143374 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0140245 |
| PNN | pinin, desmosome associated protein | 0.0139775 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.0137973 |
| RPS6 | ribosomal protein S6 | 0.0135697 |
| AFDN | afadin, adherens junction formation factor | 0.0134954 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0134391 |
| PHKB | phosphorylase kinase, beta | 0.0132735 |
| TXNRD1 | thioredoxin reductase 1 | 0.013225 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0130836 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0129781 |
| SEPTIN9 | septin 9 | 0.0129688 |
| SDC4 | syndecan 4 | 0.0128448 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0127801 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.0126986 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0125751 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0125028 |
| LUZP1 | leucine zipper protein 1 | 0.0124574 |
| CRLS1 | cardiolipin synthase 1 | 0.01245 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0124269 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0122186 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0120073 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0119147 |
| TMEM41B | transmembrane protein 41B | 0.0119006 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0118981 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.0116581 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0115702 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0113848 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0112248 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0112067 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0112045 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0111298 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0111197 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.011056 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0110331 |
| TPR | translocated promoter region, nuclear basket protein | 0.011011 |
| PELO | pelota homolog (Drosophila) | 0.0110065 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0109805 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0109412 |
| OLA1 | Obg-like ATPase 1 | 0.0109217 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0108533 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0106976 |
| SYNJ2 | synaptojanin 2 | 0.0106672 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0106609 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.594875 |
| FN1 | fibronectin 1 | -0.107589 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0784596 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0663699 |
| ENO1 | enolase 1, (alpha) | -0.0619531 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0584754 |
| GPC6 | glypican 6 | -0.0543454 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.05056 |
| NDRG1 | N-myc downstream regulated 1 | -0.0479175 |
| PEG3 | paternally expressed 3 | -0.0479093 |
| DSPP | dentin sialophosphoprotein | -0.0463627 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.04555 |
| C3 | complement component 3 | -0.0415481 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0353943 |
| CP | ceruloplasmin (ferroxidase) | -0.0346819 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.032728 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0318228 |
| TF | transferrin | -0.031464 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0299617 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0294803 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0294332 |
| EHBP1 | EH domain binding protein 1 | -0.0264681 |
| ASPH | aspartate beta-hydroxylase | -0.0262316 |
| AHSG | alpha-2-HS-glycoprotein | -0.0256624 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0245238 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.024121 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0239264 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0237902 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0236107 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0236065 |
| PLIN2 | perilipin 2 | -0.0229487 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.022928 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0226755 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.02113 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0209372 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0206285 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0204285 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0202241 |
| GK | glycerol kinase | -0.0199308 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0192599 |
| ATP10A | ATPase, class V, type 10A | -0.01879 |
| GPC3 | glypican 3 | -0.0186752 |
| FAM13A | family with sequence similarity 13, member A | -0.0179459 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0174231 |
| KIAA1217 | KIAA1217 | -0.0173004 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0172012 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0168932 |
| ATXN1 | ataxin 1 | -0.016793 |
| LDHA | lactate dehydrogenase A | -0.0165312 |
| BBX | bobby sox homolog (Drosophila) | -0.0161815 |
| INTS6 | integrator complex subunit 6 | -0.0160818 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0160522 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0160498 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0159707 |
| CTSB | cathepsin B | -0.0159156 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0157099 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.015409 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0153075 |
| ARFGEF3 | ARFGEF family member 3 | -0.0151931 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0151847 |
| UBC | ubiquitin C | -0.0147681 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0143037 |
| JUN | jun proto-oncogene | -0.0142614 |
| PKM | pyruvate kinase, muscle | -0.0142345 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0140317 |
| CALR | calreticulin | -0.0139973 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0139543 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0135921 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.013072 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0130623 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0129704 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0128144 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.012744 |
| APOA1 | apolipoprotein A-I | -0.0126421 |
| RAD51B | RAD51 paralog B | -0.0126401 |
| RNF213 | ring finger protein 213 | -0.0126326 |
| NGLY1 | N-glycanase 1 | -0.012563 |
| GSE1 | Gse1 coiled-coil protein | -0.0124042 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | -0.0123315 |
| RNASET2 | ribonuclease T2 | -0.0122939 |
| APOE | apolipoprotein E | -0.0122912 |
| RPS24 | ribosomal protein S24 | -0.0122635 |
| H1-0 | H1.0 linker histone | -0.0122077 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0120505 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0119203 |
| TMSB10 | thymosin beta 10 | -0.0118515 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.011777 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0117366 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0116652 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0116358 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0115798 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0114919 |
| KRT23 | keratin 23, type I | -0.0114523 |
| ATF3 | activating transcription factor 3 | -0.0114285 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0113151 |
| DTNA | dystrobrevin, alpha | -0.0112454 |
| CMIP | c-Maf inducing protein | -0.0112005 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0111541 |
| RPS8 | ribosomal protein S8 | -0.0111041 |
| SFTPA2 | surfactant protein A2 | -0.011097 |
