Vitamin K4_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in Hs 766T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vitamin K4_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.0222398
CEMIP cell migration inducing protein, hyaluronan binding 0.0181282
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0155938
FN1 fibronectin 1 0.0155274
VEGFA vascular endothelial growth factor A 0.0144307
MSN moesin 0.0135436
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.01318
SLC45A4 solute carrier family 45, member 4 0.0131309
CYB5R3 cytochrome b5 reductase 3 0.0128917
SEPTIN9 septin 9 0.0128761
PCDH1 protocadherin 1 0.0125357
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0120886
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0111069
LAMA5 laminin, alpha 5 0.0107426
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.010219
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0096617
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.00956937
LUZP1 leucine zipper protein 1 0.00892083
PGAM4 phosphoglycerate mutase family member 4 0.00868461
EGR1 early growth response 1 0.00863142
NTSR1 neurotensin receptor 1 (high affinity) 0.00851344
BCL3 B-cell CLL/lymphoma 3 0.00831461
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.00785167
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00781962
KCTD12 potassium channel tetramerization domain containing 12 0.00767492
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.00766994
ACER3 alkaline ceramidase 3 0.00766047
SYNPO synaptopodin 0.00719649
DDB2 damage-specific DNA binding protein 2, 48kDa 0.00718674
CCNL1 cyclin L1 0.00704334
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.00703502
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.00699077
ZBTB20 zinc finger and BTB domain containing 20 0.00695855
MRPS6 mitochondrial ribosomal protein S6 0.0069205
PLAAT3 phospholipase A and acyltransferase 3 0.00668915
EFNA5 ephrin-A5 0.00662914
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.00654054
RNPS1 RNA binding protein S1, serine-rich domain 0.00653596
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00652451
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 0.00634928
FOSL2 FOS-like antigen 2 0.00625907
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.00621157
ZFP36 ZFP36 ring finger protein 0.00618231
ANKH ANKH inorganic pyrophosphate transport regulator 0.00617936
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.00610162
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00608095
SREBF2 sterol regulatory element binding transcription factor 2 0.00588084
SS18 synovial sarcoma translocation, chromosome 18 0.00586469
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.00584321
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.00581622
LOC102724023 ES1 protein homolog, mitochondrial 0.00580744
MIDEAS mitotic deacetylase associated SANT domain protein 0.0057961
ZNF146 zinc finger protein 146 0.00573024
IRAK2 interleukin-1 receptor-associated kinase 2 0.0057222
RPL21 ribosomal protein L21 0.00563671
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.00561134
MED4 mediator complex subunit 4 0.00559994
TGM2 transglutaminase 2 0.00555012
NBEA neurobeachin 0.00548643
DPY19L1 dpy-19-like 1 (C. elegans) 0.00540003
CD46 CD46 molecule, complement regulatory protein 0.00539438
CNOT3 CCR4-NOT transcription complex, subunit 3 0.00534486
SETBP1 SET binding protein 1 0.00533863
AAMDC adipogenesis associated, Mth938 domain containing 0.00533094
PLPP3 phospholipid phosphatase 3 0.00529502
CERK ceramide kinase 0.00528169
NCEH1 neutral cholesterol ester hydrolase 1 0.00525983
ZBTB44 zinc finger and BTB domain containing 44 0.00522686
SH3PXD2A SH3 and PX domains 2A 0.0052156
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00519552
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.0051695
CWF19L2 CWF19-like 2, cell cycle control (S. pombe) 0.00511395
YOD1 YOD1 deubiquitinase 0.00508487
GRAMD1B GRAM domain containing 1B 0.00505856
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 0.00504614
CREB3L1 cAMP responsive element binding protein 3-like 1 0.00504374
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.00503067
ETNK1 ethanolamine kinase 1 0.0050235
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.00502261
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.00501306
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 0.00497689
APH1A APH1A gamma secretase subunit 0.00495086
LIFR leukemia inhibitory factor receptor alpha 0.00494025
SIK2 salt-inducible kinase 2 0.00492873
GPC6 glypican 6 0.00492494
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.00487888
EFHD2 EF-hand domain family, member D2 0.00486557
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.00485086
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.00484743
ITGB5 integrin, beta 5 0.00484729
AKAP9 A kinase (PRKA) anchor protein 9 0.00483437
NUCB2 nucleobindin 2 0.00481239
TCAF1 TRPM8 channel-associated factor 1 0.00481031
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.00479877
MEF2D myocyte enhancer factor 2D 0.00478524
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 0.00477557
KDM3B lysine (K)-specific demethylase 3B 0.00477135
FBXO28 F-box protein 28 0.00474978
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.00474837
CBR4 carbonyl reductase 4 0.0046723

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.250064
FLNB filamin B, beta -0.180132
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.143659
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.141868
AHNAK AHNAK nucleoprotein -0.140611
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.122809
ENO1 enolase 1, (alpha) -0.119074
PTMA prothymosin, alpha -0.102999
MYOF myoferlin -0.0861271
TMSB10 thymosin beta 10 -0.0832056
UBC ubiquitin C -0.0820069
EMP1 epithelial membrane protein 1 -0.0802645
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0799323
ITGA6 integrin, alpha 6 -0.0772906
DPYD dihydropyrimidine dehydrogenase -0.0771647
PGK1 phosphoglycerate kinase 1 -0.0763534
ANXA1 annexin A1 -0.0728699
CANX calnexin -0.0687752
RBM39 RNA binding motif protein 39 -0.0670064
CD44 CD44 molecule (Indian blood group) -0.0666802
MTSS1 metastasis suppressor 1 -0.0660461
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.063438
NAMPT nicotinamide phosphoribosyltransferase -0.0595722
TMSB4X thymosin beta 4, X-linked -0.059538
KRT17 keratin 17, type I -0.0574923
CALU calumenin -0.0557112
TRIO trio Rho guanine nucleotide exchange factor -0.0555567
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.05534
RPS27A ribosomal protein S27a -0.0543479
PODXL podocalyxin-like -0.0522055
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0508173
MYH9 myosin, heavy chain 9, non-muscle -0.0506345
ALCAM activated leukocyte cell adhesion molecule -0.050582
SLC35F3 solute carrier family 35, member F3 -0.0495815
MACF1 microtubule-actin crosslinking factor 1 -0.0481073
SULF1 sulfatase 1 -0.0478693
ANXA2 annexin A2 -0.0463122
RPS21 ribosomal protein S21 -0.0460567
LMNA lamin A/C -0.0457184
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0454465
PSD3 pleckstrin and Sec7 domain containing 3 -0.0454133
EZR ezrin -0.0452879
ASPH aspartate beta-hydroxylase -0.0452833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.045082
CAV1 caveolin 1, caveolae protein, 22kDa -0.0449887
NAP1L1 nucleosome assembly protein 1-like 1 -0.0443262
PTK2 protein tyrosine kinase 2 -0.0440434
TPT1 tumor protein, translationally-controlled 1 -0.0439022
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.043684
GNAS GNAS complex locus -0.0434777
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0432353
ANO1 anoctamin 1, calcium activated chloride channel -0.042956
KDM3A lysine (K)-specific demethylase 3A -0.042938
TOP1 topoisomerase (DNA) I -0.0427177
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0425656
S100A10 S100 calcium binding protein A10 -0.0411031
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0409788
SULF2 sulfatase 2 -0.0408016
CALR calreticulin -0.040307
GRB10 growth factor receptor-bound protein 10 -0.0398437
MARCHF6 membrane associated ring-CH-type finger 6 -0.039794
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0388109
NAV2 neuron navigator 2 -0.0383876
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0380528
LDHA lactate dehydrogenase A -0.0379999
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0379964
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0378185
H1-0 H1.0 linker histone -0.0377378
DOCK5 dedicator of cytokinesis 5 -0.037713
ABI3BP ABI family, member 3 (NESH) binding protein -0.0365215
ZMYND8 zinc finger, MYND-type containing 8 -0.0363915
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0363696
KRT6A keratin 6A, type II -0.0363465
CDK6 cyclin-dependent kinase 6 -0.0362626
MYO10 myosin X -0.0359024
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0358126
GARS1 glycyl-tRNA synthetase 1 -0.0357941
APP amyloid beta (A4) precursor protein -0.0354622
RPS3 ribosomal protein S3 -0.0354377
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0352735
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0352244
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0347528
RASAL2 RAS protein activator like 2 -0.0347409
B2M beta-2-microglobulin -0.0346757
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0344217
PRRC2C proline-rich coiled-coil 2C -0.0343953
PRSS23 protease, serine, 23 -0.0341755
HM13 histocompatibility (minor) 13 -0.0338241
LAMC2 laminin, gamma 2 -0.0337725
CAPN2 calpain 2, (m/II) large subunit -0.0337106
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0323486
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0322469
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0322178
TM4SF1 transmembrane 4 L six family member 1 -0.0321737
ZEB1 zinc finger E-box binding homeobox 1 -0.0321368
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0318234
RPL23 ribosomal protein L23 -0.0314679
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0312054
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0310492
MORF4L2 mortality factor 4 like 2 -0.0309551