Vitamin K4_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vitamin K4_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.122016
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0900696
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0858378
FTL ferritin, light polypeptide 0.0753786
B2M beta-2-microglobulin 0.0629101
TNS4 tensin 4 0.0616801
RPS6 ribosomal protein S6 0.0586574
DSPP dentin sialophosphoprotein 0.0564478
RPS19 ribosomal protein S19 0.0540339
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0513388
MT2A metallothionein 2A 0.0493423
KRT18 keratin 18, type I 0.0470193
PTMA prothymosin, alpha 0.0431234
RPL35A ribosomal protein L35a 0.042549
EEF2 eukaryotic translation elongation factor 2 0.0380305
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0361712
EIF1 eukaryotic translation initiation factor 1 0.0355903
PTEN phosphatase and tensin homolog 0.0349703
KTN1 kinectin 1 (kinesin receptor) 0.0339095
POTEF POTE ankyrin domain family, member F 0.0329831
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0329107
AREG amphiregulin 0.0328493
S100A6 S100 calcium binding protein A6 0.032837
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0328036
LDHA lactate dehydrogenase A 0.0317596
RPLP0 ribosomal protein, large, P0 0.0316906
KRT8 keratin 8, type II 0.0311947
FOS FBJ murine osteosarcoma viral oncogene homolog 0.030872
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0307491
MLEC malectin 0.0298795
MT1X metallothionein 1X 0.0298651
ABHD2 abhydrolase domain containing 2 0.0292266
ANXA11 annexin A11 0.0287255
TMF1 TATA element modulatory factor 1 0.0277253
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0273338
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0271276
TPM4 tropomyosin 4 0.0269721
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0269081
DDIT4 DNA-damage-inducible transcript 4 0.0267777
RPS3 ribosomal protein S3 0.0263483
RPS12 ribosomal protein S12 0.0262911
TSC22D1 TSC22 domain family, member 1 0.0259593
EIF3A eukaryotic translation initiation factor 3, subunit A 0.02499
PKM pyruvate kinase, muscle 0.0248521
RPS13 ribosomal protein S13 0.0242864
N4BP2L2 NEDD4 binding protein 2-like 2 0.0240649
EEF1G eukaryotic translation elongation factor 1 gamma 0.0238981
BMP4 bone morphogenetic protein 4 0.0238349
RPL31 ribosomal protein L31 0.0235777
TPI1 triosephosphate isomerase 1 0.0227651
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0225187
MT1E metallothionein 1E 0.0222487
OAZ1 ornithine decarboxylase antizyme 1 0.022122
TPM3 tropomyosin 3 0.0220769
ENO1 enolase 1, (alpha) 0.0220617
RPL36A ribosomal protein L36a 0.0216725
S100A14 S100 calcium binding protein A14 0.0216477
PFN1 profilin 1 0.0211267
S100A9 S100 calcium binding protein A9 0.0210741
SOX9 SRY (sex determining region Y)-box 9 0.0208967
CD9 CD9 molecule 0.0207757
APLP2 amyloid beta (A4) precursor-like protein 2 0.0205037
EGR1 early growth response 1 0.0203916
RPL15 ribosomal protein L15 0.0200393
PCM1 pericentriolar material 1 0.0197873
LOC102724023 ES1 protein homolog, mitochondrial 0.0197668
RPL23 ribosomal protein L23 0.0195002
VIM vimentin 0.019268
RPL8 ribosomal protein L8 0.0191198
RPL7A ribosomal protein L7a 0.0190632
KLF3 Kruppel-like factor 3 (basic) 0.0190397
GOLGB1 golgin B1 0.0188409
NKD1 naked cuticle homolog 1 (Drosophila) 0.018717
RPS14 ribosomal protein S14 0.0187097
FTH1 ferritin, heavy polypeptide 1 0.018572
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0184003
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0182286
RPS27 ribosomal protein S27 0.0180266
RPL19 ribosomal protein L19 0.0178826
SET SET nuclear proto-oncogene 0.0176178
SFTPA2 surfactant protein A2 0.0174457
CLDN4 claudin 4 0.0174338
PRDX2 peroxiredoxin 2 0.0173469
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0172369
RPS16 ribosomal protein S16 0.0172362
IFI27 interferon, alpha-inducible protein 27 0.0170043
ANAPC16 anaphase promoting complex subunit 16 0.0168037
RPL12 ribosomal protein L12 0.016779
RPS8 ribosomal protein S8 0.0165684
RPL7 ribosomal protein L7 0.0165427
CCPG1 cell cycle progression 1 0.0165223
ISG15 ISG15 ubiquitin-like modifier 0.0164439
TMEM45B transmembrane protein 45B 0.0164256
UBC ubiquitin C 0.0164222
ACBD3 acyl-CoA binding domain containing 3 0.0162873
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.01616
CADPS Ca++-dependent secretion activator 0.0161323
HLA-A major histocompatibility complex, class I, A 0.0160518
CLDN7 claudin 7 0.0159803
MCFD2 multiple coagulation factor deficiency 2 0.015948

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.247811
NPSR1 neuropeptide S receptor 1 -0.164509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.125183
FLNB filamin B, beta -0.094887
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0856005
VCL vinculin -0.0813955
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0598194
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0594412
KLF5 Kruppel-like factor 5 (intestinal) -0.0583747
GMDS GDP-mannose 4,6-dehydratase -0.0561522
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0555148
GREB1L growth regulation by estrogen in breast cancer-like -0.0536013
AHNAK AHNAK nucleoprotein -0.0535569
KDM3A lysine (K)-specific demethylase 3A -0.0512169
ARHGAP32 Rho GTPase activating protein 32 -0.0511362
PTPRK protein tyrosine phosphatase, receptor type, K -0.0507875
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0505686
PUM2 pumilio RNA-binding family member 2 -0.0500006
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0499913
NALF1 NALCN channel auxiliary factor 1 -0.0494692
EXT1 exostosin glycosyltransferase 1 -0.0489349
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0479919
RAB1A RAB1A, member RAS oncogene family -0.0478846
PDLIM5 PDZ and LIM domain 5 -0.047582
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.047037
ANTXR2 anthrax toxin receptor 2 -0.0458965
ANXA2 annexin A2 -0.0456743
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0455007
MED13L mediator complex subunit 13-like -0.0453777
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.044293
NCOR1 nuclear receptor corepressor 1 -0.0442104
FAT1 FAT atypical cadherin 1 -0.042235
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.041878
MBNL2 muscleblind-like splicing regulator 2 -0.0417911
LMO7 LIM domain 7 -0.0406465
WAC WW domain containing adaptor with coiled-coil -0.0401355
ZFAND3 zinc finger, AN1-type domain 3 -0.0396086
SEC31A SEC31 homolog A (S. cerevisiae) -0.038581
H1-0 H1.0 linker histone -0.0383718
FRMD5 FERM domain containing 5 -0.0375518
PARD3 par-3 family cell polarity regulator -0.0372803
POF1B premature ovarian failure, 1B -0.0371251
RBM39 RNA binding motif protein 39 -0.0366114
SLC35F3 solute carrier family 35, member F3 -0.0365484
ACTG1 actin gamma 1 -0.0364618
MBNL1 muscleblind-like splicing regulator 1 -0.0362926
ALCAM activated leukocyte cell adhesion molecule -0.0361767
LAMA4 laminin, alpha 4 -0.0361618
MACF1 microtubule-actin crosslinking factor 1 -0.0359555
USP53 ubiquitin specific peptidase 53 -0.0357359
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0340158
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0333256
MED13 mediator complex subunit 13 -0.0333099
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0331417
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0330771
TFG TRK-fused gene -0.0329846
ACTN4 actinin, alpha 4 -0.0327224
IFRD1 interferon-related developmental regulator 1 -0.0321199
RRBP1 ribosome binding protein 1 -0.0318508
CLTC clathrin, heavy chain (Hc) -0.0318012
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0317326
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0315239
PTPRB protein tyrosine phosphatase, receptor type, B -0.0315197
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0313065
PSD3 pleckstrin and Sec7 domain containing 3 -0.0312881
SLC38A2 solute carrier family 38, member 2 -0.0312809
ECT2 epithelial cell transforming 2 -0.0307366
MBD5 methyl-CpG binding domain protein 5 -0.0303877
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0302772
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0301146
ARHGAP6 Rho GTPase activating protein 6 -0.029892
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0298536
MYO1D myosin ID -0.0297081
RAP1B RAP1B, member of RAS oncogene family -0.0295295
KITLG KIT ligand -0.0294253
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0289682
TBC1D22A TBC1 domain family, member 22A -0.0288666
NDRG1 N-myc downstream regulated 1 -0.0288424
DENND1A DENN/MADD domain containing 1A -0.028739
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0287242
TRIO trio Rho guanine nucleotide exchange factor -0.0284105
SERINC5 serine incorporator 5 -0.02839
MORF4L2 mortality factor 4 like 2 -0.0282283
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0282277
EMP1 epithelial membrane protein 1 -0.0282075
ZMYM2 zinc finger, MYM-type 2 -0.0280814
IARS1 isoleucyl-tRNA synthetase 1 -0.0280212
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0277069
EFNB2 ephrin-B2 -0.0276615
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0276147
SBF2 SET binding factor 2 -0.027512
ANXA1 annexin A1 -0.0271417
COG5 component of oligomeric golgi complex 5 -0.0268324
EWSR1 EWS RNA-binding protein 1 -0.026571
AGR2 anterior gradient 2 -0.0264346
PGK1 phosphoglycerate kinase 1 -0.0263988
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0259162
LPP LIM domain containing preferred translocation partner in lipoma -0.0258451
ARHGAP21 Rho GTPase activating protein 21 -0.0257575
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0256218