Vitamin K4_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Vitamin K4_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.265069
ASPH aspartate beta-hydroxylase 0.10131
CCNL1 cyclin L1 0.0841466
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0721818
VEGFA vascular endothelial growth factor A 0.0605195
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.059096
NAMPT nicotinamide phosphoribosyltransferase 0.0573268
DSCAM Down syndrome cell adhesion molecule 0.05707
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0567966
EPS8 epidermal growth factor receptor pathway substrate 8 0.0540048
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0516714
GPBP1 GC-rich promoter binding protein 1 0.0492226
ELL2 elongation factor, RNA polymerase II, 2 0.0482744
ADAM9 ADAM metallopeptidase domain 9 0.0462174
RNF145 ring finger protein 145 0.0456372
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.044875
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0441589
ZNF148 zinc finger protein 148 0.0437665
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0434515
KMT2E lysine (K)-specific methyltransferase 2E 0.043433
NRIP1 nuclear receptor interacting protein 1 0.043388
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0423375
FNDC3B fibronectin type III domain containing 3B 0.0417591
COPA coatomer protein complex, subunit alpha 0.0414938
FAM3C family with sequence similarity 3, member C 0.0412683
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0399137
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0398358
TXNRD1 thioredoxin reductase 1 0.0394132
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0390644
LMO7 LIM domain 7 0.038397
ERBIN erbb2 interacting protein 0.037919
CDC73 cell division cycle 73 0.0377552
TFG TRK-fused gene 0.0370195
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0369004
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.035632
KDM6A lysine (K)-specific demethylase 6A 0.0352561
YTHDC1 YTH domain containing 1 0.0347985
NEK7 NIMA-related kinase 7 0.0346448
NCKAP1 NCK-associated protein 1 0.0346219
ZFAND3 zinc finger, AN1-type domain 3 0.0345456
WDFY3 WD repeat and FYVE domain containing 3 0.0343508
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0341187
PAPOLA poly(A) polymerase alpha 0.0339496
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0339143
MARCHF6 membrane associated ring-CH-type finger 6 0.033801
FXR1 fragile X mental retardation, autosomal homolog 1 0.0335878
RTN4 reticulon 4 0.0330671
RAD21 RAD21 homolog (S. pombe) 0.0330145
CD109 CD109 molecule 0.0325143
TPM3 tropomyosin 3 0.0325039
STRN3 striatin, calmodulin binding protein 3 0.0324562
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0322411
USP9X ubiquitin specific peptidase 9, X-linked 0.031977
MATR3 matrin 3 0.0315364
PUM2 pumilio RNA-binding family member 2 0.0314415
NPEPPS aminopeptidase puromycin sensitive 0.030746
EEF2 eukaryotic translation elongation factor 2 0.0305953
ANXA1 annexin A1 0.0305421
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0300354
ARRDC3 arrestin domain containing 3 0.0300157
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.029899
CSDE1 cold shock domain containing E1, RNA-binding 0.0296828
NUP58 nucleoporin 58 0.0296817
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0294859
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.029299
RBM25 RNA binding motif protein 25 0.0285678
APP amyloid beta (A4) precursor protein 0.0283994
TSC22D2 TSC22 domain family, member 2 0.0283083
DOCK5 dedicator of cytokinesis 5 0.0282986
GSK3B glycogen synthase kinase 3 beta 0.0282655
VMP1 vacuole membrane protein 1 0.0281743
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0281648
JMJD1C jumonji domain containing 1C 0.0277698
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0276787
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0272472
SETD5 SET domain containing 5 0.0268049
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0265718
DUSP10 dual specificity phosphatase 10 0.0264037
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0263078
SDC4 syndecan 4 0.0260576
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0259683
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0258625
TMEM39A transmembrane protein 39A 0.0258412
TMF1 TATA element modulatory factor 1 0.0258264
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0257797
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0256594
CPNE8 copine VIII 0.0254979
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.025444
FTH1 ferritin, heavy polypeptide 1 0.0254142
ZNF654 zinc finger protein 654 0.0252106
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0249377
TMEM131L transmembrane 131 like 0.0247769
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0245879
MSMO1 methylsterol monooxygenase 1 0.024549
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0245469
PTBP2 polypyrimidine tract binding protein 2 0.0243738
RASA2 RAS p21 protein activator 2 0.0241055
IL6ST interleukin 6 signal transducer 0.0240726
FAM13A family with sequence similarity 13, member A 0.0239599
BHLHE40 basic helix-loop-helix family, member e40 0.0237153

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.256779
ACTG1 actin gamma 1 -0.186715
FTL ferritin, light polypeptide -0.177748
TMSB10 thymosin beta 10 -0.161635
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.147912
LPP LIM domain containing preferred translocation partner in lipoma -0.132761
NDRG1 N-myc downstream regulated 1 -0.10555
IFI27 interferon, alpha-inducible protein 27 -0.0947308
MT2A metallothionein 2A -0.090012
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0859363
PTMA prothymosin, alpha -0.0834151
SAMD4A sterile alpha motif domain containing 4A -0.0784864
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0754648
S100A10 S100 calcium binding protein A10 -0.0716745
ISG15 ISG15 ubiquitin-like modifier -0.0650038
ENO1 enolase 1, (alpha) -0.0631917
HMGA1 high mobility group AT-hook 1 -0.0630733
RPS19 ribosomal protein S19 -0.0619529
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0601517
RPLP1 ribosomal protein, large, P1 -0.0593035
IFI16 interferon, gamma-inducible protein 16 -0.057355
RPS8 ribosomal protein S8 -0.0557485
WSB1 WD repeat and SOCS box containing 1 -0.0549979
TPT1 tumor protein, translationally-controlled 1 -0.0545709
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0544501
LMNA lamin A/C -0.0533251
FBXO32 F-box protein 32 -0.0527862
CCND1 cyclin D1 -0.0518499
KRT7 keratin 7, type II -0.0518236
RNF213 ring finger protein 213 -0.0515172
AHNAK AHNAK nucleoprotein -0.0514132
RPL8 ribosomal protein L8 -0.0507993
IFITM1 interferon induced transmembrane protein 1 -0.0489917
IFI6 interferon, alpha-inducible protein 6 -0.0479096
IFITM3 interferon induced transmembrane protein 3 -0.0467441
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0465907
G0S2 G0/G1 switch 2 -0.0460319
FHIT fragile histidine triad -0.0455778
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0455158
PKM pyruvate kinase, muscle -0.0452587
RPLP2 ribosomal protein, large, P2 -0.0447757
RIGI RNA sensor RIG-I -0.0445461
TM4SF1 transmembrane 4 L six family member 1 -0.0432642
RAI14 retinoic acid induced 14 -0.0430817
RPL37A ribosomal protein L37a -0.0428755
RRBP1 ribosome binding protein 1 -0.0425893
RPS29 ribosomal protein S29 -0.0424574
SQSTM1 sequestosome 1 -0.0415608
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0401903
NAV2 neuron navigator 2 -0.0401404
GOLGB1 golgin B1 -0.0399528
RPL35A ribosomal protein L35a -0.0396355
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0389258
LIMCH1 LIM and calponin homology domains 1 -0.0386039
RPL9 ribosomal protein L9 -0.0383205
RAD51B RAD51 paralog B -0.0376529
MX2 MX dynamin-like GTPase 2 -0.0374625
RPL34 ribosomal protein L34 -0.0372322
CSTB cystatin B (stefin B) -0.03688
RAB7A RAB7A, member RAS oncogene family -0.0364053
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.036074
RPL32 ribosomal protein L32 -0.0359262
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0357689
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0356352
SP100 SP100 nuclear antigen -0.0350107
RPL19 ribosomal protein L19 -0.0349118
RPL36 ribosomal protein L36 -0.0348947
IFIH1 interferon induced with helicase C domain 1 -0.0342735
MX1 MX dynamin-like GTPase 1 -0.0340216
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0339907
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0337848
RPS13 ribosomal protein S13 -0.0337668
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0337024
RPL28 ribosomal protein L28 -0.0334353
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0319959
S100A11 S100 calcium binding protein A11 -0.0319077
S100A9 S100 calcium binding protein A9 -0.0313796
RPS6 ribosomal protein S6 -0.0311896
RPS14 ribosomal protein S14 -0.0309142
RPS27A ribosomal protein S27a -0.030625
EXT1 exostosin glycosyltransferase 1 -0.0304069
RPS27 ribosomal protein S27 -0.0303396
HMGB1 high mobility group box 1 -0.0302295
LY6E lymphocyte antigen 6 complex, locus E -0.0301074
HLA-A major histocompatibility complex, class I, A -0.0300468
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.028985
CCSER1 coiled-coil serine-rich protein 1 -0.0286455
H1-0 H1.0 linker histone -0.0286304
EFNA5 ephrin-A5 -0.0284061
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0283458
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0283339
HSPB1 heat shock 27kDa protein 1 -0.028221
KRT19 keratin 19, type I -0.0282127
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0280812
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0280436
HLA-B major histocompatibility complex, class I, B -0.0277958
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0274977
RPL23 ribosomal protein L23 -0.0274289
KDM5B lysine (K)-specific demethylase 5B -0.0273214
ANXA2 annexin A2 -0.0271657