Vitamin K4_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Vitamin K4 perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Vitamin K4_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.104467
TMSB4X thymosin beta 4, X-linked 0.0664814
MAML2 mastermind-like 2 (Drosophila) 0.0594002
FN1 fibronectin 1 0.0554312
ASPH aspartate beta-hydroxylase 0.0513904
ACTG1 actin gamma 1 0.0509393
LAMB3 laminin, beta 3 0.0495495
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0475326
SVIL supervillin 0.0454768
MACF1 microtubule-actin crosslinking factor 1 0.0442466
TPM4 tropomyosin 4 0.0427218
RNF213 ring finger protein 213 0.0412208
IGFBP3 insulin-like growth factor binding protein 3 0.0400827
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0395123
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0392252
CD44 CD44 molecule (Indian blood group) 0.0369547
TPT1 tumor protein, translationally-controlled 1 0.0361021
EMP1 epithelial membrane protein 1 0.0358883
TRIO trio Rho guanine nucleotide exchange factor 0.0346478
SAMD4A sterile alpha motif domain containing 4A 0.0345326
SYT14 synaptotagmin XIV 0.0336345
LAMC2 laminin, gamma 2 0.0331562
SMAD3 SMAD family member 3 0.0329547
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.032136
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0321202
ZSWIM6 zinc finger, SWIM-type containing 6 0.0317525
DSG2 desmoglein 2 0.0311574
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0309349
LAMA4 laminin, alpha 4 0.0304642
RAD51B RAD51 paralog B 0.0304151
AHNAK AHNAK nucleoprotein 0.0302947
GOLGB1 golgin B1 0.030235
RUNX1 runt-related transcription factor 1 0.0299668
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0298459
HLA-B major histocompatibility complex, class I, B 0.0294893
VEGFA vascular endothelial growth factor A 0.0294875
RPS3 ribosomal protein S3 0.0292926
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0292072
ZBTB20 zinc finger and BTB domain containing 20 0.0291745
RPL23 ribosomal protein L23 0.0288306
DST dystonin 0.0282687
DSPP dentin sialophosphoprotein 0.0282146
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0281989
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0277572
SQSTM1 sequestosome 1 0.0277522
EGFR epidermal growth factor receptor 0.0272768
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0271834
EHBP1 EH domain binding protein 1 0.026899
SULF2 sulfatase 2 0.026615
RPS8 ribosomal protein S8 0.0265564
MX1 MX dynamin-like GTPase 1 0.0259782
HDAC9 histone deacetylase 9 0.025675
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0251956
FAM107B family with sequence similarity 107, member B 0.0251411
JARID2 jumonji, AT rich interactive domain 2 0.0248355
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.024718
NAV2 neuron navigator 2 0.0246624
B2M beta-2-microglobulin 0.0246143
HMGA2 high mobility group AT-hook 2 0.0244897
ANXA1 annexin A1 0.023805
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0236902
ANXA2 annexin A2 0.0233975
PTMA prothymosin, alpha 0.0233916
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0227859
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.022734
ARHGAP5 Rho GTPase activating protein 5 0.0226215
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0225876
F3 coagulation factor III (thromboplastin, tissue factor) 0.0225412
KLF5 Kruppel-like factor 5 (intestinal) 0.022499
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0223301
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.02198
SH3KBP1 SH3-domain kinase binding protein 1 0.0219517
THSD4 thrombospondin, type I, domain containing 4 0.0218601
RPL37A ribosomal protein L37a 0.0217998
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0217514
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0215421
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0215199
PTK2 protein tyrosine kinase 2 0.0215119
INTS6 integrator complex subunit 6 0.0213633
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0213512
PATJ PATJ crumbs cell polarity complex component 0.0212752
AKAP13 A kinase (PRKA) anchor protein 13 0.0211492
RIGI RNA sensor RIG-I 0.0211357
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0210718
LPP LIM domain containing preferred translocation partner in lipoma 0.0209885
PTPRK protein tyrosine phosphatase, receptor type, K 0.0206975
RPL37 ribosomal protein L37 0.0206728
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0206503
RPS17 ribosomal protein S17 0.0204841
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0204831
IFI27 interferon, alpha-inducible protein 27 0.0204399
BACE2 beta-site APP-cleaving enzyme 2 0.0200366
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.020018
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.019841
CAPN2 calpain 2, (m/II) large subunit 0.0197748
MUC16 mucin 16, cell surface associated 0.0193059
KRT18 keratin 18, type I 0.0192801
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0192457
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0191439
DAPK1 death-associated protein kinase 1 0.0190748

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206695
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0843984
FAM3C family with sequence similarity 3, member C -0.043117
TGM2 transglutaminase 2 -0.0343171
TSC22D2 TSC22 domain family, member 2 -0.033202
PCLO piccolo presynaptic cytomatrix protein -0.0233767
NDRG1 N-myc downstream regulated 1 -0.0233622
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0220908
IL1RAP interleukin 1 receptor accessory protein -0.021673
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0195818
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0189129
PLAT plasminogen activator, tissue -0.0180535
SMC4 structural maintenance of chromosomes 4 -0.0180202
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0173196
WWC1 WW and C2 domain containing 1 -0.0172372
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0168618
UGCG UDP-glucose ceramide glucosyltransferase -0.0165066
LOC112694756 uncharaterized LOC112694756 -0.0164246
ATP5F1B ATP synthase F1 subunit beta -0.0160131
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0156381
FOSL1 FOS-like antigen 1 -0.015128
MUC4 mucin 4, cell surface associated -0.0150558
TRA2B transformer 2 beta homolog (Drosophila) -0.0150221
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0149352
LY6E lymphocyte antigen 6 complex, locus E -0.0148213
KRT17 keratin 17, type I -0.0145662
ARHGAP29 Rho GTPase activating protein 29 -0.01427
EGR1 early growth response 1 -0.0141815
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.013591
HMGB2 high mobility group box 2 -0.0133822
BCL2L1 BCL2-like 1 -0.013363
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0133299
PDIA3 protein disulfide isomerase family A, member 3 -0.012051
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -0.0113182
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0111875
LATS2 large tumor suppressor kinase 2 -0.0110976
USP3 ubiquitin specific peptidase 3 -0.0110255
ADAM9 ADAM metallopeptidase domain 9 -0.0110169
ZFAND3 zinc finger, AN1-type domain 3 -0.0108799
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.010685
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0103528
ECT2 epithelial cell transforming 2 -0.0102758
C3 complement component 3 -0.0102638
BSG basigin (Ok blood group) -0.0102213
CCNI cyclin I -0.0101707
PHIP pleckstrin homology domain interacting protein -0.00972317
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.00966987
DUSP5 dual specificity phosphatase 5 -0.00948258
BHLHE40 basic helix-loop-helix family, member e40 -0.00932067
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00925345
RIOK3 RIO kinase 3 -0.00922449
NDFIP1 Nedd4 family interacting protein 1 -0.00918974
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.00918099
ANXA11 annexin A11 -0.0091693
PARD6B par-6 family cell polarity regulator beta -0.00916174
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.00910084
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.00897868
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.00895451
DIAPH3 diaphanous-related formin 3 -0.00891207
THBS1 thrombospondin 1 -0.00887949
BRD4 bromodomain containing 4 -0.00882572
MIS18BP1 MIS18 binding protein 1 -0.00882178
PCBP2 poly(rC) binding protein 2 -0.00880552
ATP11B ATPase, class VI, type 11B -0.00875747
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.00873618
ADM adrenomedullin -0.00863149
OSMR oncostatin M receptor -0.0086292
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00854161
ACTN4 actinin, alpha 4 -0.00850288
UBE2H ubiquitin-conjugating enzyme E2H -0.00844895
UBE2B ubiquitin-conjugating enzyme E2B -0.00832655
MT1X metallothionein 1X -0.00817774
NAMPT nicotinamide phosphoribosyltransferase -0.00802635
PDCD10 programmed cell death 10 -0.00799911
FAR1 fatty acyl CoA reductase 1 -0.00799281
TFG TRK-fused gene -0.00781596
AKAP9 A kinase (PRKA) anchor protein 9 -0.0077923
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.00769818
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.00764489
RB1CC1 RB1-inducible coiled-coil 1 -0.00761444
SHROOM3 shroom family member 3 -0.00759953
PICALM phosphatidylinositol binding clathrin assembly protein -0.00759107
STRN3 striatin, calmodulin binding protein 3 -0.00757509
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0075714
AXL AXL receptor tyrosine kinase -0.00755383
PHC3 polyhomeotic homolog 3 (Drosophila) -0.00745763
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.00738034
NUP54 nucleoporin 54kDa -0.00732637
KIF2C kinesin family member 2C -0.00728502
ADAM17 ADAM metallopeptidase domain 17 -0.00727593
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.00725471
ARRDC3 arrestin domain containing 3 -0.00724745
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.00723263
SMAD5 SMAD family member 5 -0.00722444
UPP1 uridine phosphorylase 1 -0.00720452
ATP13A3 ATPase type 13A3 -0.00718205
DEPP1 DEPP autophagy regulator 1 -0.00715803
PLS3 plastin 3 -0.00712126
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.00708171
HP1BP3 heterochromatin protein 1, binding protein 3 -0.00707251